$80.32
+0.12 (+0.15%)
USD · as of 2026-08-19 · marketstack
Institutional 13F holdings sum to 109.8% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 5,668,145 shares (settlement 2026-05-15) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 5,586,8945.6M | $357M | 14.64% | ADD 3% |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 2,450,2212.5M | $157M | 6.42% | ADD 24% |
| 3 | BlackRock, Inc. | 2,273,8312.3M | $145M | 5.96% | — |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,735,3761.7M | $111M | 4.55% | ADD 14% |
| 5 | STATE STREET CORP | 1,698,2441.7M | $109M | 4.45% | ADD 43% |
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,549,3501.5M | $99M | 4.06% | TRIM -9% |
| 7 | Atlas Venture Life Science Advisors, LLC | 1,513,8751.5M | $97M | 3.97% | — |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 1,375,4301.4M | $88M | 3.60% | NEW† |
| 9 | Frazier Life Sciences Management, L.P. | 1,354,8521.4M | $87M | 3.55% | ADD 8% |
| 10 | TCG Crossover Management, LLC | 1,341,8621.3M | $86M | 3.52% | NEW† |
| 11 | JPMORGAN CHASE & CO | 1,371,4801.4M | $83M | 3.59% | TRIM -13% |
| 12 | BVF INC/IL | 1,272,3121.3M | $81M | 3.33% | ADD 96% |
| 13 | ORBIMED ADVISORS LLC | 1,067,5501.1M | $68M | 2.80% | — |
| 14 | Siren, L.L.C. | 988,401988,401 | $63M | 2.59% | — |
| 15 | Woodline Partners LP | 958,281958,281 | $61M | 2.51% | — |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 744,222744,222 | $48M | 1.95% | ADD 9% |
| 17 | Vestal Point Capital, LP | 700,000700,000 | $45M | 1.83% | TRIM -5% |
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 657,000657,000 | $42M | 1.72% | ADD 29% |
| 19 | GOLDMAN SACHS GROUP INC | 639,842639,842 | $41M | 1.68% | TRIM -15% |
| 20 | JENNISON ASSOCIATES LLC | 610,382610,382 | $39M | 1.60% | ADD 15% |
| 21 | Logos Global Management LP | 560,000560,000 | $36M | 1.47% | ADD 10% |
| 22 | Assenagon Asset Management S.A. | 546,247546,247 | $35M | 1.43% | ADD 53% |
| 23 | ARMISTICE CAPITAL, LLC | 536,000536,000 | $34M | 1.40% | ADD 7% |
| 24 | Bellevue Group AG | 459,314459,314 | $29M | 1.20% | NEW |
| 25 | Saturn V Capital Management LP | 449,926449,926 | $29M | 1.18% | ADD 51% |
| 26 | Opaleye Management Inc. | 421,000421,000 | $27M | 1.10% | ADD 111% |
| 27 | Palo Alto Investors LP | 401,719401,719 | $26M | 1.05% | ADD 27% |
| 28 | EVENTIDE ASSET MANAGEMENT, LLC | 395,572395,572 | $25M | 1.04% | — |
| 29 | DIMENSIONAL FUND ADVISORS LP | 394,447394,447 | $25M | 1.03% | ADD 76% |
| 30 | Pictet Asset Management Holding SA | 387,005387,005 | $25M | 1.01% | — |
| 31 | Aberdeen Group plc | 375,614375,614 | $24M | 0.98% | ADD 60% |
| 32 | Foresite Capital Management V, LLC | 374,069374,069 | $24M | 0.98% | ADD 25% |
| 33 | BAKER BROS. ADVISORS LP | 349,657349,657 | $22M | 0.92% | ADD 4% |
| 34 | LOOMIS SAYLES & CO L P | 317,222317,222 | $20M | 0.83% | ADD 12% |
| 35 | Checkpoint Capital L.P. | 286,661286,661 | $18M | 0.75% | TRIM -37% |
| 36 | Octagon Capital Advisors LP | 270,000270,000 | $17M | 0.71% | NEW |
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,195251,195 | $16M | 0.66% | — |
| 38 | VANGUARD PORTFOLIO MANAGEMENT LLC | 247,338247,338 | $16M | 0.65% | NEW |
| 39 | NORTHERN TRUST CORP | 247,195247,195 | $16M | 0.65% | ADD 8% |
| 40 | VANGUARD FIDUCIARY TRUST CO | 217,436217,436 | $14M | 0.57% | NEW |
| 41 | Bank of New York Mellon Corp | 204,968204,968 | $13M | 0.54% | ADD 203% |
| 42 | SILVERARC CAPITAL MANAGEMENT, LLC | 196,028196,028 | $13M | 0.51% | NEW |
| 43 | Ensign Peak Advisors, Inc | 191,487191,487 | $12M | 0.50% | ADD 8% |
| 44 | Integral Health Asset Management, LLC | 170,000170,000 | $11M | 0.45% | NEW |
| 45 | BANK OF AMERICA CORP /DE/ | 166,775166,775 | $11M | 0.44% | ADD 23% |
| 46 | Bain Capital Life Sciences Investors, LLC | 141,234141,234 | $9M | 0.37% | NEW |
| 47 | BNP PARIBAS FINANCIAL MARKETS | 127,737127,737 | $8M | 0.33% | ADD 5% |
| 48 | Alyeska Investment Group, L.P. | 125,000125,000 | $8M | 0.33% | ADD 150% |
| 49 | Catalio Capital Management, LP | 122,978122,978 | $8M | 0.32% | ADD 11% |
| 50 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 110,890110,890 | $7M | 0.29% | TRIM -3% |
| 51 | KENNEDY CAPITAL MANAGEMENT LLC | 108,286108,286 | $7M | 0.28% | ADD 1061% |
| 52 | UBS Group AG | 98,62198,621 | $6M | 0.26% | TRIM -15% |
| 53 | CITADEL ADVISORS LLC | 97,93097,930 | $6M | 0.26% | TRIM -2% |
| 54 | DNB Asset Management AS | 96,75596,755 | $6M | 0.25% | ADD 15% |
| 55 | MORGAN STANLEY | 94,26494,264 | $6M | 0.25% | ADD 26% |
| 56 | MILLENNIUM MANAGEMENT LLC | 83,25983,259 | $5M | 0.22% | TRIM -55% |
| 57 | Jump Financial, LLC | 81,82981,829 | $5M | 0.21% | NEW |
| 58 | Sofinnova Investments, Inc. | 78,32078,320 | $5M | 0.21% | TRIM -29% |
| 59 | Freestone Grove Partners LP | 68,68768,687 | $4M | 0.18% | NEW |
| 60 | iA Global Asset Management Inc. | 66,24366,243 | $4M | 0.17% | — |
| 61 | Sio Capital Management, LLC | 65,20365,203 | $4M | 0.17% | ADD 13% |
| 62 | Casdin Capital, LLC | 65,00065,000 | $4M | 0.17% | NEW |
| 63 | KVP Capital Advisors, LP | 58,25058,250 | $4M | 0.15% | — |
| 64 | MOORE CAPITAL MANAGEMENT, LP | 57,79657,796 | $4M | 0.15% | NEW |
| 65 | Rafferty Asset Management, LLC | 53,86953,869 | $3M | 0.14% | ADD 49% |
| 66 | SPHERA FUNDS MANAGEMENT LTD. | 53,53853,538 | $3M | 0.14% | NEW |
| 67 | NEXTBio Capital Management LP | 52,65552,655 | $3M | 0.14% | ADD 23% |
| 68 | Nuveen, LLC | 51,38051,380 | $3M | 0.13% | ADD 6% |
| 69 | Burkehill Global Management, LP | 50,00050,000 | $3M | 0.13% | — |
| 70 | Atle Fund Management AB | 107,255107,255 | $3M | 0.28% | ADD 124% |
| 71 | SCHRODER INVESTMENT MANAGEMENT GROUP | 50,95950,959 | $3M | 0.13% | — |
| 72 | Swiss National Bank | 48,00048,000 | $3M | 0.13% | — |
| 73 | AMERIPRISE FINANCIAL INC | 45,83745,837 | $3M | 0.12% | TRIM -45% |
| 74 | RAYMOND JAMES FINANCIAL INC | 44,70044,700 | $3M | 0.12% | TRIM -44% |
| 75 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 39,91039,910 | $3M | 0.10% | — |
| 76 | LAZARD ASSET MANAGEMENT LLC | 39,40039,400 | $3M | 0.10% | TRIM -32% |
| 77 | Universal- Beteiligungs- und Servicegesellschaft mbH | 38,00638,006 | $2M | 0.10% | ADD 39% |
| 78 | SEVEN GRAND MANAGERS, LLC | 35,00035,000 | $2M | 0.09% | — |
| 79 | XTX Topco Ltd | 34,41834,418 | $2M | 0.09% | ADD 49% |
| 80 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,38234,382 | $2M | 0.09% | ADD 48% |
| 81 | BARCLAYS PLC | 33,26733,267 | $2M | 0.09% | TRIM -67% |
| 82 | RHUMBLINE ADVISERS | 33,05833,058 | $2M | 0.09% | ADD 11% |
| 83 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,49332,493 | $2M | 0.09% | TRIM -38% |
| 84 | Brevan Howard Capital Management LP | 32,40632,406 | $2M | 0.08% | TRIM -35% |
| 85 | RENAISSANCE TECHNOLOGIES LLC | 31,82031,820 | $2M | 0.08% | TRIM -49% |
| 86 | Squarepoint Ops LLC | 31,70931,709 | $2M | 0.08% | ADD 101% |
| 87 | ALPS ADVISORS INC | 31,05831,058 | $2M | 0.08% | — |
| 88 | TUDOR INVESTMENT CORP ET AL | 31,00231,002 | $2M | 0.08% | TRIM -53% |
| 89 | Invesco Ltd. | 30,63830,638 | $2M | 0.08% | TRIM -50% |
| 90 | ALLIANCEBERNSTEIN L.P. | 24,54024,540 | $2M | 0.06% | — |
| 91 | TD Asset Management Inc | 30,47630,476 | $2M | 0.08% | TRIM -56% |
| 92 | RTW INVESTMENTS, LP | 30,00030,000 | $2M | 0.08% | — |
| 93 | VICTORY CAPITAL MANAGEMENT INC | 29,21829,218 | $2M | 0.08% | TRIM -62% |
| 94 | BANK OF MONTREAL /CAN/ | 28,77328,773 | $2M | 0.08% | ADD 16% |
| 95 | Nantahala Capital Management, LLC | 25,65325,653 | $2M | 0.07% | TRIM -81% |
| 96 | PNC FINANCIAL SERVICES GROUP, INC. | 25,29225,292 | $2M | 0.07% | — |
| 97 | DEUTSCHE BANK AG\ | 24,40124,401 | $2M | 0.06% | ADD 19% |
| 98 | PROFUND ADVISORS LLC | 23,97223,972 | $2M | 0.06% | ADD 78% |
| 99 | ALGERT GLOBAL LLC | 22,68022,680 | $1M | 0.06% | NEW |
| 100 | BOOTHBAY FUND MANAGEMENT, LLC | 21,37821,378 | $1M | 0.06% | NEW |
† NEW this big is usually a rename.
Ranked by each filer’s own reported value, not shares.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +1,375,430 | $88M | OPEN |
| TCG Crossover Management, LLC | +1,341,862 | $86M | OPEN |
| BVF INC/IL | +622,312 | $40M | ADD |
| STATE STREET CORP | +510,253 | $33M | ADD |
| RA CAPITAL MANAGEMENT, L.P. | +474,089 | $30M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,767,680 | $113M | CLOSE |
| First Light Asset Management, LLC | −523,167 | $33M | CLOSE |
| PERCEPTIVE ADVISORS LLC | −450,743 | $29M | CLOSE |
| GREAT POINT PARTNERS LLC | −250,000 | $16M | CLOSE |
| Balyasny Asset Management L.P. | −221,761 | $14M | CLOSE |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1.9M | 3.2M | 3.2M | 4.9M | 5.5M | 5.6M | $357M |
| RA CAPITAL MANAGEMENT, L.P. | — | 1.6M | 1.6M | 1.6M | 2.0M | 2.5M | $157M |
| BlackRock, Inc. | 1.9M | 2.1M | 2.0M | 2.0M | 2.3M | 2.3M | $145M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.4M | 2.3M | 1.4M | 1.4M | 1.5M | 1.7M | $111M |
| STATE STREET CORP | 769K | 919K | 930K | 1.0M | 1.2M | 1.7M | $109M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.4M | 1.4M | 1.5M | 1.3M | 1.7M | 1.5M | $99M |
| Atlas Venture Life Science Advisors, LLC | 2.5M | 2.4M | 2.4M | 2.1M | 1.5M | 1.5M | $97M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.4M | $88M |
| Frazier Life Sciences Management, L.P. | 1.8M | 1.8M | 1.7M | 1.4M | 1.3M | 1.4M | $87M |
| TCG Crossover Management, LLC | 487K | 465K | 465K | 465K | — | 1.3M | $86M |
| JPMORGAN CHASE & CO | 61K | 759K | 844K | 1.5M | 1.6M | 1.4M | $83M |
| BVF INC/IL | — | — | — | — | 650K | 1.3M | $81M |
| ORBIMED ADVISORS LLC | 1.8M | 1.4M | 1.4M | 1.4M | 1.1M | 1.1M | $68M |
| Siren, L.L.C. | — | 1.1M | 1.1M | 913K | 988K | 988K | $63M |
| Woodline Partners LP | 397K | 502K | 867K | 867K | 958K | 958K | $61M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
“The disclosure in Item 4 to the Schedule is hereby supplemented by adding the following at the end thereof: On October 20, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with AI DMI LLC as a selling stockholder and Jefferies LLC, Leerink Partners LLC, Morgan Stanley & Co. LLC and Cantor Fitzgerald & Co. (the "Representatives"), as representatives of the several underwriters listed on Schedule I thereto (the "Underwriters"), related to an underwritten offer”
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
SEC Schedule 13D/G XML · group aggregate.