CIK 1224962
Long positions in SEC Section 13(f) securities (US-listed stocks, ADRs and ETFs), largest first · Δ vs 2025-Q4. A lagged quarterly snapshot (filed ≤45 days after quarter-end); excludes shorts, options, cash, and shares listed only on non-US exchanges — foreign companies held via a US listing or ADR (e.g. Alibaba, TSMC) ARE included.
As filed = each book applied at its quarter-end (what the reported book did) · As copyable = applied at its statutory 45-day filing deadline (what a 13F follower could have earned).
Computing…
Hypothetical modeled performance constructed with hindsight — not actual results, and not indicative of future results. See the Disclaimer.
| Industry group | Weight | Names |
|---|---|---|
| Pharmaceuticals & Biotechnology | 79.03% | 65 |
| Unclassified | 8.09% | 10 |
| Health Care Providers & Services | 7.97% | 5 |
| Health Care Equipment & Supplies | 3.95% | 10 |
| Life Sciences Tools & Services | 0.97% | 1 |
| # | Ticker | Name | Sector | Weight |
|---|---|---|---|---|
| 1 | PRAX | Praxis Precision Medicines, Inc. | Health Care | 13.00% |
| 2 | CELC | Celcuity Inc. | Health Care | 7.07% |
| 3 | ASND | Ascendis Pharma A/S | Health Care | 6.94% |
| 4 | ROIV | Roivant Sciences Ltd. | Health Care | 4.55% |
| 5 | CENTESSA PHARMACEUTICALS PLC | Unclassified | 4.14% | |
| 6 | RYTM | RHYTHM PHARMACEUTICALS, INC. | Health Care | 4.09% |
| 7 | SYRE | Spyre Therapeutics, Inc. | Health Care | 3.78% |
| 8 | NUVL | Nuvalent, Inc. | Health Care | 3.21% |
| 9 | EWTX | Edgewise Therapeutics, Inc. | Health Care | 2.76% |
| 10 | PTGX | Protagonist Therapeutics, Inc | Health Care | 2.57% |
81/91 names classified · sector 91.9% of weight · industry 91.9% · mkt cap 83.1%; unclassified names shown, never dropped.
Sector is classified on each name's CURRENT fundamentals, not point-in-time — apparent sector drift can reflect the market re-rating a holding, not a manager trade. 13F is a lagged quarterly snapshot of long positions in US-listed securities only — foreign companies held via a US listing or ADR ARE included, but shares listed only on non-US exchanges (plus shorts, options and cash) are not. Latest quarter: 91.9% of the book is sector-classified (unclassified names shown, never dropped).
Only 4% of book weight classified — the grid is NOT representative of the whole book.
Classified: 4.3% of book weight (7/88 names) · unclassified 95.7%: PRAX, CELC, ASND, , ROIV, RYTM, SYRE, NUVL, EWTX, PTGX +71 more. Size: cap 70/20/10 bands; style: value/growth composite on our own metrics — not Morningstar's model.
No contribution data for this period.
| # | Security | Shares | Value | Weight | Δ QoQ |
|---|---|---|---|---|---|
| 1 | PRAXPRAXIS PRECISION MEDICINES I | 2,035,986 | $656M | 13.0% | ADD 2% |
| 2 | CELCCELCUITY INC | 3,127,200 | $357M | 7.1% | HOLD |
| 3 | ASNDASCENDIS PHARMA A/S | 1,531,421 | $350M | 6.9% | ADD 42% |
| 4 | ROIVROIVANT SCIENCES LTD | 8,285,461 | $230M | 4.5% | ADD 4% |
| 5 | CENTESSA PHARMACEUTICALS PLC | 5,258,903 | $209M | 4.1% | ADD 80% |
| 6 | RYTMRHYTHM PHARMACEUTICALS INC | 2,373,795 | $206M | 4.1% | TRIM −7% |
| 7 | SYRESPYRE THERAPEUTICS INC | 3,783,225 | $191M | 3.8% | ADD 23% |
| 8 | NUVLNUVALENT INC | 1,580,505 | $162M | 3.2% | TRIM −5% |
| 9 | EWTXEDGEWISE THERAPEUTICS INC | 4,423,974 | $139M | 2.8% | HOLD |
| 10 | PTGXPROTAGONIST THERAPEUTICS INC | 1,230,879 | $130M | 2.6% | TRIM −9% |
| 11 | APGEAPOGEE THERAPEUTICS INC | 1,540,384 | $130M | 2.6% | TRIM −34% |
| 12 | TVTXTRAVERE THERAPEUTICS INC | 4,142,551 | $123M | 2.4% | TRIM −3% |
| 13 | AMLXAMYLYX PHARMACEUTICALS INC | 8,284,882 | $115M | 2.3% | HOLD |
| 14 | IMTXIMMATICS N.V | 10,383,456 | $102M | 2.0% | HOLD |
| 15 | RLAYRELAY THERAPEUTICS INC | 9,751,141 | $97M | 1.9% | ADD 412% |
| 16 | INBXINHIBRX BIOSCIENCES INC | 1,442,707 | $97M | 1.9% | HOLD |
| 17 | MGTXMEIRAGTX HLDGS PLC | 10,326,103 | $89M | 1.8% | HOLD |
| 18 | ZYMEZYMEWORKS INC | 3,510,078 | $88M | 1.7% | ADD 8% |
| 19 | SLDBSOLID BIOSCIENCES INC | 11,906,646 | $86M | 1.7% | HOLD |
| 20 | DYNDYNE THERAPEUTICS INC | 4,668,839 | $85M | 1.7% | ADD 34% |
| 21 | BCRXBIOCRYST PHARMACEUTICALS INC | 7,434,033 | $71M | 1.4% | ADD 135% |
| 22 | ORKAORUKA THERAPEUTICS INC | 1,395,501 | $68M | 1.4% | TRIM −5% |
| 23 | AORTARTIVION INC | 1,637,290 | $60M | 1.2% | TRIM −5% |
| 24 | NRIXNURIX THERAPEUTICS INC | 3,710,877 | $58M | 1.1% | ADD 4% |
| 25 | NAUTNAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $49M | 1.0% | HOLD |
| 26 | CTMXCYTOMX THERAPEUTICS INC. | 10,098,824 | $47M | 0.9% | ADD 4% |
| 27 | ANROALTO NEUROSCIENCE INC | 2,009,893 | $45M | 0.9% | ADD 13% |
| 28 | ENGENE HOLDINGS INC | 5,827,506 | $40M | 0.8% | HOLD |
| 29 | IMVTIMMUNOVANT INC | 1,597,383 | $40M | 0.8% | TRIM −20% |
| 30 | ISRGINTUITIVE SURGICAL INC | 85,419 | $39M | 0.8% | TRIM −3% |
| 31 | IONSIONIS PHARMACEUTICALS INC | 504,000 | $38M | 0.7% | NEW |
| 32 | DAY ONE BIOPHARMACEUTICALS I | 1,755,799 | $38M | 0.7% | NEW |
| 33 | ABVXABIVAX SA | 328,884 | $37M | 0.7% | TRIM −28% |
| 34 | CRVSCORVUS PHARMACEUTICALS INC | 2,292,441 | $34M | 0.7% | ADD 231% |
| 35 | RGENREPLIGEN CORP | 280,541 | $33M | 0.7% | TRIM −11% |
| 36 | JAZZJAZZ PHARMACEUTICALS PLC | 170,000 | $32M | 0.6% | HOLD |
| 37 | DMRADAMORA THERAPEUTICS INC | 1,223,000 | $32M | 0.6% | NEW |
| 38 | XFORX4 PHARMACEUTICALS INC | 6,737,648 | $28M | 0.6% | ADD 7% |
| 39 | GHGUARDANT HEALTH INC | 300,000 | $28M | 0.5% | ADD 88% |
| 40 | DRUGBRIGHT MINDS BIOSCIENCES INC | 377,544 | $28M | 0.5% | TRIM −16% |
| 41 | IVVDINVIVYD INC | 20,859,303 | $27M | 0.5% | TRIM −4% |
| 42 | SIONSIONNA THERAPEUTICS INC | 658,439 | $26M | 0.5% | TRIM −44% |
| 43 | AXSMAXSOME THERAPEUTICS INC. | 149,950 | $25M | 0.5% | HOLD |
| 44 | RVMDREVOLUTION MEDICINES INC | 258,600 | $25M | 0.5% | NEW |
| 45 | SABSSAB BIOTHERAPEUTICS INC | 6,431,743 | $25M | 0.5% | ADD 701% |
| 46 | BLTEBELITE BIO INC | 151,979 | $24M | 0.5% | TRIM −63% |
| 47 | TENXTENAX THERAPEUTICS INC | 1,447,782 | $23M | 0.5% | ADD 230% |
| 48 | AXGNAXOGEN INC | 697,312 | $23M | 0.5% | TRIM −11% |
| 49 | VRDNVIRIDIAN THERAPEUTICS INC | 1,170,829 | $23M | 0.5% | TRIM −62% |
| 50 | OBIOORCHESTRA BIOMED HLDGS INC | 5,037,906 | $21M | 0.4% | HOLD |
| 51 | RAPPRAPPORT THERAPEUTICS INC | 673,923 | $21M | 0.4% | HOLD |
| 52 | DBVTDBV TECHNOLOGIES S A | 964,391 | $20M | 0.4% | NEW |
| 53 | LONALEONABIO INC | 1,859,322 | $19M | 0.4% | HOLD |
| 54 | AVRANTERIS TECHNOLOGIES GLOBAL | 3,425,476 | $19M | 0.4% | ADD 104% |
| 55 | STROSUTRO BIOPHARMA INC | 715,307 | $18M | 0.4% | NEW |
| 56 | TNGXTANGO THERAPEUTICS INC | 808,153 | $17M | 0.3% | ADD 58% |
| 57 | CTNMCONTINEUM THERAPEUTICS INC | 1,255,592 | $16M | 0.3% | TRIM −14% |
| 58 | PALIPALISADE BIO INC | 8,928,149 | $16M | 0.3% | TRIM −26% |
| 59 | OCSOCULIS HOLDING AG | 493,827 | $13M | 0.3% | HOLD |
| 60 | IRTCIRHYTHM HOLDINGS INC | 105,026 | $12M | 0.2% | TRIM −3% |
| 61 | ADGMADAGIO MED HLDGS INC | 9,876,576 | $11M | 0.2% | HOLD |
| 62 | EVMNEVOMMUNE INC | 448,350 | $10M | 0.2% | NEW |
| 63 | PHATPHATHOM PHARMACEUTICALS INC | 925,000 | $10M | 0.2% | NEW |
| 64 | NMRANEUMORA THERAPEUTICS INC. | 5,104,097 | $10M | 0.2% | NEW |
| 65 | OMDAOMADA HEALTH INC | 786,330 | $10M | 0.2% | TRIM −67% |
| 66 | NBIXNEUROCRINE BIOSCIENCES INC | 65,050 | $9M | 0.2% | TRIM −80% |
| 67 | BBNXBETA BIONICS INC | 842,944 | $8M | 0.2% | ADD 40% |
| 68 | IRDOPUS GENETICS INC | 1,835,842 | $8M | 0.2% | TRIM −58% |
| 69 | BLLNBILLIONTOONE INC | 91,812 | $7M | 0.1% | ADD 26% |
| 70 | TWSTTWIST BIOSCIENCE CORP | 150,000 | $7M | 0.1% | NEW |
| 71 | SRZNSURROZEN INC | 229,393 | $7M | 0.1% | NEW |
| 72 | AGMBAGOMAB THERAPEUTICS NV | 600,000 | $6M | 0.1% | NEW |
| 73 | EOLSEVOLUS INC | 1,286,862 | $5M | 0.1% | NEW |
| 74 | COGTCOGENT BIOSCIENCES INC | 121,082 | $5M | 0.1% | HOLD |
| 75 | ADMAADMA BIOLOGICS INC | 467,233 | $4M | 0.1% | TRIM −47% |
| 76 | IKTINHIBIKASE THERAPEUTICS INC | 2,315,000 | $4M | 0.1% | TRIM −57% |
| 77 | CBIOCRESCENT BIOPHARMA INC. | 206,942 | $4M | 0.1% | TRIM −54% |
| 78 | APELLIS PHARMACEUTICALS INC | 80,956 | $3M | 0.1% | NEW |
| 79 | OMOUTSET MED INC | 833,333 | $3M | 0.1% | HOLD |
| 80 | EDSAEDESA BIOTECH INC | 563,239 | $3M | 0.1% | NEW |
| 81 | ADPTADAPTIVE BIOTECHNOLOGIES COR | 152,500 | $2M | 0.0% | NEW |
| 82 | AVTXAVALO THERAPEUTICS INC | 139,667 | $2M | 0.0% | HOLD |
| 83 | CNTBCONNECT BIOPHARMA HLDGS LTD | 792,696 | $2M | 0.0% | HOLD |
| 84 | CORTCORCEPT THERAPEUTICS INC | 50,000 | $2M | 0.0% | NEW |
| 85 | MDLNMEDLINE INC | 28,000 | $1M | 0.0% | HOLD |
| 86 | PTNPALATIN TECHNOLOGIES INC | 61,945 | $1M | 0.0% | TRIM −12% |
| 87 | CPIXCUMBERLAND PHARMACEUTICALS I | 196,978 | $640,179 | 0.0% | TRIM −42% |
| 88 | RVMDWREVOLUTION MEDICINES INC | 250,000 | $447,500 | 0.0% | HOLD |
| 89 | XGNEXAGEN INC | 114,893 | $344,679 | 0.0% | NEW |
| 90 | ENSCENSYSCE BIOSCIENCES INC | 86,666 | $46,670 | 0.0% | HOLD |
| 91 | SRZNWSURROZEN INC | 166,666 | $2,667 | 0.0% | HOLD |
| Security | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| PRAXPRAXIS PRECISION MEDICINES I | 1.3M | 981K | 753K | 1.6M | 2.0M | 2.0M | $656M |
| CELCCELCUITY INC | 2.4M | 2.4M | 1.6M | 3.0M | 3.2M | 3.1M | $357M |
| ASNDASCENDIS PHARMA A/S | — | — | 964K | 1.1M | 1.1M | 1.5M | $350M |
| ROIVROIVANT SCIENCES LTD | — | — | 3.3M | 7.4M | 8.0M | 8.3M | $230M |
| CENTESSA PHARMACEUTICALS PLC | 6.3M | 3.0M | 1.1M | 3.1M | 2.9M | 5.3M | $209M |
| RYTMRHYTHM PHARMACEUTICALS INC | 3.7M | 2.5M | 2.4M | 2.4M | 2.5M | 2.4M | $206M |
| SYRESPYRE THERAPEUTICS INC | 2.6M | 2.3M | 1.5M | 1.2M | 3.1M | 3.8M | $191M |
| NUVLNUVALENT INC | 2.6M | 1.6M | 1.4M | 1.6M | 1.7M | 1.6M | $162M |
| EWTXEDGEWISE THERAPEUTICS INC | 2.7M | 6.5M | 4.6M | 3.8M | 4.5M | 4.4M | $139M |
| PTGXPROTAGONIST THERAPEUTICS INC | 1.3M | 1.1M | 1.1M | 1.0M | 1.4M | 1.2M | $130M |
| APGEAPOGEE THERAPEUTICS INC | 1.0M | 1.1M | 1.2M | 1.4M | 2.3M | 1.5M | $130M |
| TVTXTRAVERE THERAPEUTICS INC | — | — | 834K | 3.8M | 4.3M | 4.1M | $123M |
| AMLXAMYLYX PHARMACEUTICALS INC | 6.8M | 7.9M | 7.9M | 9.0M | 8.3M | 8.3M | $115M |
| IMTXIMMATICS N.V | 9.4M | 9.4M | 9.4M | 9.4M | 10.4M | 10.4M | $102M |
| RLAYRELAY THERAPEUTICS INC | — | — | — | — | 1.9M | 9.8M | $97M |
Shares reported each quarter by the largest current holdings. Green = added vs the prior filing of that name, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Where this firm's principals came from and which firms its alumni went on to found.
