CIK 1306923
Long positions in SEC Section 13(f) securities (US-listed stocks, ADRs and ETFs), largest first · Δ vs 2025-Q4. A lagged quarterly snapshot (filed ≤45 days after quarter-end); excludes shorts, options, cash, and shares listed only on non-US exchanges — foreign companies held via a US listing or ADR (e.g. Alibaba, TSMC) ARE included.
As filed = each book applied at its quarter-end (what the reported book did) · As copyable = applied at its statutory 45-day filing deadline (what a 13F follower could have earned).
Computing…
Hypothetical modeled performance constructed with hindsight — not actual results, and not indicative of future results. See the Disclaimer.
| Industry group | Weight | Names |
|---|---|---|
| Pharmaceuticals & Biotechnology | 91.98% | 42 |
| Health Care Equipment & Supplies | 3.70% | 4 |
| Unclassified | 2.51% | 2 |
| Health Care Providers & Services | 1.41% | 1 |
| Insurance | 0.40% | 2 |
| # | Ticker | Name | Sector | Weight |
|---|---|---|---|---|
| 1 | INSM | INSMED Inc | Health Care | 10.39% |
| 2 | ACAD | ACADIA PHARMACEUTICALS INC | Health Care | 9.78% |
| 3 | PTCT | PTC THERAPEUTICS, INC. | Health Care | 9.60% |
| 4 | BMRN | BIOMARIN PHARMACEUTICAL INC | Health Care | 5.92% |
| 5 | UTHR | UNITED THERAPEUTICS Corp | Health Care | 5.70% |
| 6 | ANAB | ANAPTYSBIO, INC | Health Care | 5.41% |
| 7 | MIRM | Mirum Pharmaceuticals, Inc. | Health Care | 4.59% |
| 8 | DYN | Dyne Therapeutics, Inc. | Health Care | 4.58% |
| 9 | BIIB | BIOGEN INC. | Health Care | 3.95% |
| 10 | IRON | Disc Medicine, Inc. | Health Care | 3.93% |
49/51 names classified · sector 97.5% of weight · industry 97.5% · mkt cap 97.2%; unclassified names shown, never dropped.
Sector is classified on each name's CURRENT fundamentals, not point-in-time — apparent sector drift can reflect the market re-rating a holding, not a manager trade. 13F is a lagged quarterly snapshot of long positions in US-listed securities only — foreign companies held via a US listing or ADR ARE included, but shares listed only on non-US exchanges (plus shorts, options and cash) are not. Latest quarter: 97.5% of the book is sector-classified (unclassified names shown, never dropped).
Only 38% of book weight classified — the grid is NOT representative of the whole book.
Classified: 38.4% of book weight (12/51 names) · unclassified 61.6%: INSM, ANAB, MIRM, DYN, IRON, IOVA, SNDX, ANNX, , NVCR +29 more. Size: cap 70/20/10 bands; style: value/growth composite on our own metrics — not Morningstar's model.
No contribution data for this period.
| # | Security | Shares | Value | Weight | Δ QoQ |
|---|---|---|---|---|---|
| 1 | INSMINSMED INC | 415,269 | $68M | 10.4% | TRIM −15% |
| 2 | ACADACADIA PHARM | 2,872,695 | $64M | 9.8% | ADD 16% |
| 3 | PTCTPTC THERAPEUTICS INC | 921,607 | $63M | 9.6% | HOLD |
| 4 | BMRNBIOMARIN PHARMACEUTICAL INC | 685,182 | $39M | 5.9% | TRIM −8% |
| 5 | UTHRUnited Therapeutics Corp. | 62,809 | $37M | 5.7% | ADD 8% |
| 6 | ANABANAPTYSBIO INC | 638,161 | $35M | 5.4% | TRIM −8% |
| 7 | MIRMMIRUM PHARMACEUTICALS INC | 325,175 | $30M | 4.6% | ADD 108% |
| 8 | DYNDYNE THERAPEUTICS INC | 1,652,972 | $30M | 4.6% | ADD 12% |
| 9 | BIIBBIOGEN INC | 140,719 | $26M | 3.9% | TRIM −23% |
| 10 | IRONDISC MEDICINE INC | 401,719 | $26M | 3.9% | ADD 27% |
| 11 | IOVAIOVANCE BIOTHERAPEUTICS INC | 6,349,563 | $22M | 3.4% | TRIM −11% |
| 12 | SNDXSYNDAX PHARMACEUTICALS INC | 864,986 | $20M | 3.1% | ADD 9% |
| 13 | ANNXANNEXON INC | 2,948,090 | $16M | 2.5% | ADD 24% |
| 14 | AMICUS THERAPEUTICS INC | 1,113,045 | $16M | 2.5% | TRIM −79% |
| 15 | NVCRNOVOCURE LTD | 1,280,439 | $14M | 2.1% | HOLD |
| 16 | RAREULTRAGENYX PHARMACEUTICAL IN | 596,495 | $12M | 1.9% | ADD 29% |
| 17 | PRTAPROTHENA CORP PLC | 1,208,568 | $12M | 1.8% | TRIM −8% |
| 18 | BCAXBICARA THERAPEUTICS INC | 550,408 | $11M | 1.7% | ADD 84% |
| 19 | CLDXCELLDEX THERAPEUTICS INC NEW | 296,408 | $9M | 1.4% | NEW |
| 20 | CDNACAREDX INC | 531,870 | $9M | 1.4% | ADD 11% |
| 21 | ALKSALKERMES PLC | 242,560 | $9M | 1.3% | HOLD |
| 22 | CMPXCOMPASS THERAPEUTICS INC | 1,514,504 | $8M | 1.2% | TRIM −40% |
| 23 | AGIOAGIOS PHARMACEUTICALS INC | 213,601 | $7M | 1.1% | HOLD |
| 24 | ALGNALIGN TECHNOLOGY INC | 41,520 | $7M | 1.1% | HOLD |
| 25 | CAPRCAPRICOR THERAPEUTICS INC | 229,763 | $7M | 1.1% | HOLD |
| 26 | TVTXTRAVERE THERAPEUTICS INC | 230,453 | $7M | 1.0% | ADD 108% |
| 27 | TSHATAYSHA GENE THERAPIES INC | 1,391,382 | $6M | 1.0% | ADD 18% |
| 28 | ACRSACLARIS THERAPEUTICS INC | 1,613,430 | $6M | 0.9% | ADD 3% |
| 29 | DNLIDENALI THERAPEUTICS INC | 234,582 | $5M | 0.7% | TRIM −63% |
| 30 | XENEXENON PHARMACEUTICALS INC | 51,345 | $3M | 0.5% | TRIM −47% |
| 31 | ORKAORUKA THERAPEUTICS INC | 59,985 | $3M | 0.4% | HOLD |
| 32 | STOKSTOKE THERAPEUTICS INC | 84,631 | $3M | 0.4% | ADD 18% |
| 33 | EWEDWARDS LIFESCIENCES CORP | 33,640 | $3M | 0.4% | HOLD |
| 34 | NBIXNEUROCRINE BIOSCIENCES INC | 18,117 | $2M | 0.4% | HOLD |
| 35 | NUVBNUVATION BIO INC | 508,846 | $2M | 0.3% | TRIM −5% |
| 36 | CYTKCYTOKINETICS INC | 32,195 | $2M | 0.3% | NEW |
| 37 | EHTHEHEALTH INC | 1,482,797 | $2M | 0.3% | TRIM −3% |
| 38 | CRSPCRISPR THERAPEUTICS AG | 39,605 | $2M | 0.3% | TRIM −4% |
| 39 | BNTXBIONTECH SE | 19,614 | $2M | 0.3% | HOLD |
| 40 | PYXSPYXIS ONCOLOGY INC | 1,010,510 | $1M | 0.2% | TRIM −3% |
| 41 | VSTMVERASTEM INC | 246,093 | $1M | 0.2% | NEW |
| 42 | BCYCBICYCLE THERAPEUTICS PLC | 201,890 | $936,770 | 0.1% | TRIM −9% |
| 43 | MDGLMADRIGAL PHARMACEUTICALS INC | 1,787 | $935,441 | 0.1% | NEW |
| 44 | HUMHUMANA INC | 3,985 | $690,959 | 0.1% | HOLD |
| 45 | CMPSCOMPASS PATHWAYS PLC | 115,616 | $639,356 | 0.1% | HOLD |
| 46 | XERSXERIS BIOPHARMA HOLDINGS INC | 104,410 | $605,578 | 0.1% | NEW |
| 47 | ABEOABEONA THERAPEUTICS INC | 108,865 | $487,715 | 0.1% | HOLD |
| 48 | INSPINSPIRE MED SYS INC | 8,772 | $452,460 | 0.1% | HOLD |
| 49 | URGNUROGEN PHARMA LTD | 24,500 | $440,510 | 0.1% | HOLD |
| 50 | PRQRPROQR THRAPEUTICS N V | 188,807 | $305,867 | 0.0% | HOLD |
| 51 | ALDXALDEYRA THERAPEUTICS INC | 155,709 | $263,148 | 0.0% | TRIM −31% |
| Security | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| INSMINSMED INC | 1.6M | 987K | 865K | 492K | 489K | 415K | $68M |
| ACADACADIA PHARM | 2.7M | 2.7M | 2.6M | 2.5M | 2.5M | 2.9M | $64M |
| PTCTPTC THERAPEUTICS INC | 386K | 404K | 406K | 863K | 904K | 922K | $63M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1.1M | 991K | 840K | 754K | 746K | 685K | $39M |
| UTHRUnited Therapeutics Corp. | 156K | 105K | 95K | 58K | 58K | 63K | $37M |
| ANABANAPTYSBIO INC | 844K | 1.0M | 813K | 674K | 690K | 638K | $35M |
| MIRMMIRUM PHARMACEUTICALS INC | 65K | 65K | 65K | 65K | 156K | 325K | $30M |
| DYNDYNE THERAPEUTICS INC | — | 333K | 265K | 1.3M | 1.5M | 1.7M | $30M |
| BIIBBIOGEN INC | 190K | 205K | 206K | 186K | 184K | 141K | $26M |
| IRONDISC MEDICINE INC | — | — | 146K | 224K | 317K | 402K | $26M |
| IOVAIOVANCE BIOTHERAPEUTICS INC | 3.0M | 3.2M | 3.4M | 7.6M | 7.1M | 6.3M | $22M |
| SNDXSYNDAX PHARMACEUTICALS INC | 405K | 444K | 444K | 655K | 795K | 865K | $20M |
| ANNXANNEXON INC | — | — | — | — | 2.4M | 2.9M | $16M |
| AMICUS THERAPEUTICS INC | 7.7M | 7.3M | 5.6M | 5.4M | 5.2M | 1.1M | $16M |
| NVCRNOVOCURE LTD | 814K | 1.0M | 962K | 1.3M | 1.3M | 1.3M | $14M |
Shares reported each quarter by the largest current holdings. Green = added vs the prior filing of that name, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Where this firm's principals came from and which firms its alumni went on to found.
