| 1 | 1JPMORGAN CHASE & CO | 24,150,49924.2M | $3.7B | 11.14% | ADD 4% |
| 2 | 2BlackRock, Inc. | 16,678,14616.7M | $2.7B | 7.69% | ADD 11% |
| 3 | 3Darwin Global Management, Ltd. | 16,805,18416.8M | $2.6B | 7.75% | TRIM -20% |
| 4 | 4FMR LLC | 13,160,16713.2M | $2.2B | 6.07% | ADD 33% |
| 5 | 5VANGUARD PORTFOLIO MANAGEMENT LLC | 10,371,80210.4M | $1.7B | 4.79% | NEW† |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 9,642,1319.6M | $1.6B | 4.45% | NEW† |
| 7 | 7BAKER BROS. ADVISORS LP | 7,421,1117.4M | $1.2B | 3.42% | ADD 13% |
| 8 | 8Artisan Partners Limited Partnership | 6,527,3016.5M | $1.1B | 3.01% | ADD 35% |
| 9 | 9D. E. Shaw & Co., Inc. | 5,625,8255.6M | $920M | 2.60% | ADD 29% |
| 10 | 10Capital International Investors | 5,595,1945.6M | $915M | 2.58% | ADD 9% |
| 11 | 11STATE STREET CORP | 5,551,6995.6M | $908M | 2.56% | ADD 7% |
| 12 | 12RTW INVESTMENTS, LP | 4,842,8804.8M | $792M | 2.23% | — |
| 13 | 13GEODE CAPITAL MANAGEMENT, LLC | 4,450,3894.5M | $733M | 2.05% | ADD 4% |
| 14 | 14PRICE T ROWE ASSOCIATES INC /MD/ | 3,092,8073.1M | $506M | 1.43% | TRIM -23% |
| 15 | 15AMERIPRISE FINANCIAL INC | 3,057,7183.1M | $500M | 1.41% | ADD 55% |
| 16 | 16FRANKLIN RESOURCES INC | 2,617,2512.6M | $428M | 1.21% | TRIM -5% |
| 17 | 17CITADEL ADVISORS LLC | 2,182,5712.2M | $357M | 1.01% | ADD 89% |
| 18 | 18Invesco Ltd. | 1,988,9682.0M | $325M | 0.92% | TRIM -27% |
| 19 | 19Orbis Allan Gray Ltd | 1,872,8241.9M | $306M | 0.86% | TRIM -55% |
| 20 | 20UBS Group AG | 1,737,4811.7M | $284M | 0.80% | TRIM -7% |
| 21 | 21BANK OF AMERICA CORP /DE/ | 1,502,2811.5M | $246M | 0.69% | TRIM -13% |
| 22 | 22Integral Health Asset Management, LLC | 1,500,0001.5M | $245M | 0.69% | ADD 20% |
| 23 | 23WESTFIELD CAPITAL MANAGEMENT CO LP | 1,468,4591.5M | $240M | 0.68% | ADD 240% |
| 24 | 24SEI INVESTMENTS CO | 1,395,7941.4M | $228M | 0.64% | ADD 57% |
| 25 | 25Capital World Investors | 1,362,2911.4M | $223M | 0.63% | NEW |
| 26 | 26VANGUARD FIDUCIARY TRUST CO | 1,354,5161.4M | $221M | 0.62% | NEW |
| 27 | 27MORGAN STANLEY | 1,331,5421.3M | $218M | 0.61% | TRIM -18% |
| 28 | 28NORTHERN TRUST CORP | 1,294,0001.3M | $212M | 0.60% | ADD 4% |
| 29 | 29Castle Hook Partners LP | 1,269,7541.3M | $208M | 0.59% | — |
| 30 | 30Bank of New York Mellon Corp | 1,262,7491.3M | $206M | 0.58% | TRIM -9% |
| 31 | 31Paradigm Biocapital Advisors LP | 1,254,4881.3M | $205M | 0.58% | NEW |
| 32 | 32UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,215,0251.2M | $199M | 0.56% | ADD 29% |
| 33 | 33MILLENNIUM MANAGEMENT LLC | 1,157,7861.2M | $189M | 0.53% | TRIM -12% |
| 34 | 34Duquesne Family Office LLC | 1,154,0901.2M | $189M | 0.53% | TRIM -22% |
| 35 | 35NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,143,7391.1M | $187M | 0.53% | TRIM -3% |
| 36 | 36Pictet Asset Management Holding SA | 1,102,2481.1M | $179M | 0.51% | ADD 15% |
| 37 | 37CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,069,3901.1M | $175M | 0.49% | ADD 4% |
| 38 | 38Fiera Capital Corp | 1,021,9701.0M | $167M | 0.47% | ADD 3% |
| 39 | 39NWI MANAGEMENT LP | 1,014,0001.0M | $166M | 0.47% | ADD 3% |
| 40 | 40GOLDMAN SACHS GROUP INC | 942,646942,646 | $154M | 0.43% | TRIM -24% |
| 41 | 41AMERICAN CENTURY COMPANIES INC | 925,799925,799 | $151M | 0.43% | ADD 400% |
| 42 | 42PRINCIPAL FINANCIAL GROUP INC | 916,464916,464 | $150M | 0.42% | ADD 19% |
| 43 | 43WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 902,666902,666 | $148M | 0.42% | TRIM -26% |
| 44 | 44ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000900,000 | $147M | 0.42% | ADD 200% |
| 45 | 45FIL Ltd | 828,947828,947 | $136M | 0.38% | — |
| 46 | 46Amundi | 804,977804,977 | $132M | 0.37% | TRIM -12% |
| 47 | 47Legal & General Group Plc | 787,079787,079 | $129M | 0.36% | ADD 46% |
| 48 | 48RAYMOND JAMES FINANCIAL INC | 775,148775,148 | $121M | 0.36% | — |
| 49 | 49ALLIANCEBERNSTEIN L.P. | 688,734688,734 | $120M | 0.32% | ADD 7% |
| 50 | 50Hood River Capital Management LLC | 688,554688,554 | $113M | 0.32% | ADD 8% |
| 51 | 51AQR CAPITAL MANAGEMENT LLC | 675,485675,485 | $109M | 0.31% | ADD 44% |
| 52 | 52SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 653,445653,445 | $107M | 0.30% | TRIM -28% |
| 53 | 53Clearbridge Investments, LLC | 643,435643,435 | $105M | 0.30% | TRIM -21% |
| 54 | 54Artia Global Partners LP | 628,712628,712 | $103M | 0.29% | TRIM -8% |
| 55 | 55Swiss National Bank | 625,912625,912 | $102M | 0.29% | ADD 8% |
| 56 | 56GW&K Investment Management, LLC | 623,048623,048 | $102M | 0.29% | ADD 29% |
| 57 | 57JENNISON ASSOCIATES LLC | 604,694604,694 | $99M | 0.28% | ADD 8% |
| 58 | 58BNP PARIBAS FINANCIAL MARKETS | 604,600604,600 | $99M | 0.28% | TRIM -34% |
| 59 | 59WELLS FARGO & COMPANY/MN | 597,384597,384 | $98M | 0.28% | — |
| 60 | 60TimesSquare Capital Management, LLC | 584,798584,798 | $96M | 0.27% | ADD 19% |
| 61 | 61DEUTSCHE BANK AG\ | 562,474562,474 | $92M | 0.26% | TRIM -5% |
| 62 | 62EVENTIDE ASSET MANAGEMENT, LLC | 546,310546,310 | $89M | 0.25% | ADD 13% |
| 63 | 63FEDERATED HERMES, INC. | 538,257538,257 | $88M | 0.25% | TRIM -15% |
| 64 | 64Nuveen, LLC | 534,750534,750 | $87M | 0.25% | TRIM -18% |
| 65 | 65ROYAL BANK OF CANADA | 523,101523,101 | $86M | 0.24% | ADD 3% |
| 66 | 66Sumitomo Mitsui Trust Group, Inc. | 501,282501,282 | $82M | 0.23% | ADD 15% |
| 67 | 67Ensign Peak Advisors, Inc | 499,756499,756 | $82M | 0.23% | ADD 31% |
| 68 | 68Affinity Asset Advisors, LLC | 480,000480,000 | $78M | 0.22% | ADD 7% |
| 69 | 69FRONTIER CAPITAL MANAGEMENT CO LLC | 469,561469,561 | $77M | 0.22% | ADD 65% |
| 70 | 70BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 467,753467,753 | $76M | 0.22% | ADD 42% |
| 71 | 71JANUS HENDERSON GROUP PLC | 419,304419,304 | $69M | 0.19% | TRIM -48% |
| 72 | 72SAMLYN CAPITAL, LLC | 417,205417,205 | $68M | 0.19% | ADD 13% |
| 73 | 73Palo Alto Investors LP | 415,269415,269 | $68M | 0.19% | TRIM -15% |
| 74 | 74Candriam S.C.A. | 401,735401,735 | $66M | 0.19% | — |
| 75 | 75DIMENSIONAL FUND ADVISORS LP | 400,900400,900 | $65M | 0.18% | — |
| 76 | 76WELLINGTON MANAGEMENT GROUP LLP | 399,044399,044 | $65M | 0.18% | TRIM -18% |
| 77 | 77LORD, ABBETT & CO. LLC | 397,261397,261 | $65M | 0.18% | TRIM -45% |
| 78 | 78VICTORY CAPITAL MANAGEMENT INC | 396,245396,245 | $65M | 0.18% | TRIM -39% |
| 79 | 79Polar Capital Holdings Plc | 368,107368,107 | $60M | 0.17% | ADD 7% |
| 80 | 80GATEWAY INVESTMENT ADVISERS LLC | 365,000365,000 | $60M | 0.17% | — |
| 81 | 81VANGUARD ASSET MANAGEMENT, Ltd | 360,075360,075 | $59M | 0.17% | NEW |
| 82 | 82Sofinnova Investments, Inc. | 346,075346,075 | $57M | 0.16% | ADD 121% |
| 83 | 83California Public Employees Retirement System | 344,612344,612 | $56M | 0.16% | TRIM -3% |
| 84 | 84Rock Springs Capital Management LP | 314,300314,300 | $51M | 0.15% | — |
| 85 | 85MARSHALL WACE, LLP | 312,565312,565 | $51M | 0.14% | TRIM -20% |
| 86 | 86National Pension Service | 311,881311,881 | $51M | 0.14% | ADD 11% |
| 87 | 87CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 303,182303,182 | $50M | 0.14% | TRIM -2% |
| 88 | 88Nearwater Capital Markets, Ltd | 300,000300,000 | $49M | 0.14% | TRIM -40% |
| 89 | 89ENVESTNET ASSET MANAGEMENT INC | 299,925299,925 | $49M | 0.14% | ADD 9% |
| 90 | 90Bridgewater Associates, LP | 295,579295,579 | $48M | 0.14% | NEW |
| 91 | 91NEW YORK STATE COMMON RETIREMENT FUND | 293,546293,546 | $48M | 0.14% | ADD 6% |
| 92 | 92Allspring Global Investments Holdings, LLC | 282,734282,734 | $47M | 0.13% | ADD 28% |
| 93 | 93ProShare Advisors LLC | 283,141283,141 | $46M | 0.13% | TRIM -17% |
| 94 | 94Aberdeen Group plc | 277,016277,016 | $45M | 0.13% | ADD 9% |
| 95 | 95BARCLAYS PLC | 275,731275,731 | $45M | 0.13% | TRIM -38% |
| 96 | 96RHUMBLINE ADVISERS | 272,615272,615 | $45M | 0.13% | — |
| 97 | 97NEUBERGER BERMAN GROUP LLC | 270,700270,700 | $44M | 0.12% | ADD 30% |
| 98 | 98TANG CAPITAL MANAGEMENT LLC | 260,000260,000 | $43M | 0.12% | ADD 333% |
| 99 | 99Mitsubishi UFJ Asset Management Co., Ltd. | 255,247255,247 | $42M | 0.12% | ADD 15% |
| 100 | 100First Turn Management, LLC | 248,475248,475 | $41M | 0.11% | TRIM -6% |
