Sio Capital Management, LLC

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CIK 1482416

13F portfolio (2026-Q1)

$694M

Positions

Implied 1Y CAGR

modeled · as filed

Long positions in SEC Section 13(f) securities (US-listed stocks, ADRs and ETFs), largest first · Δ vs 2025-Q4. A lagged quarterly snapshot (filed ≤45 days after quarter-end); excludes shorts, options, cash, and shares listed only on non-US exchanges — foreign companies held via a US listing or ADR (e.g. Alibaba, TSMC) ARE included.

Implied return what this book implies · modeled, not advice methodology →

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As filed = each book applied at its quarter-end (what the reported book did) · As copyable = applied at its statutory 45-day filing deadline (what a 13F follower could have earned).

Computing…

Hypothetical modeled performance constructed with hindsight — not actual results, and not indicative of future results. See the Disclaimer.

Exposures · what this manager owns, by sector & size (2026-Q1)

Holdings

Top 5

26.7%

Top 10

45.4%

Effective N

33.0

HHI

0.030

This quarter

22 new · 0 exit →

By sector

Health Care75.5%

Industrials8.6%

Information Technology5.8%

Unclassified5.5%

Consumer Discretionary4.6%

By market cap

Mid ($2–10B)39.2%

Small ($300M–2B)25.0%

Large ($10–200B)15.1%

Unknown13.3%

Micro (<$300M)7.3%

By region

North America92.8%

Other5.5%

Europe1.7%

By industry group GICS — finer than sector

Industry group	Weight	Names
Pharmaceuticals & Biotechnology	54.83%	46
Health Care Equipment & Supplies	16.17%	12
Commercial Services & Supplies	8.59%	2
Software & IT Services	5.71%	2
Unclassified	5.50%	7
Distributors	4.57%	1
Health Care Providers & Services	3.19%	1
Life Sciences Tools & Services	1.34%	1
Technology Hardware & Equipment	0.11%	1

Top holdings

#	Ticker	Name	Sector	Weight
1	MMS	MAXIMUS, INC.	Industrials	7.10%
2	WAY	Waystar Holding Corp.	Information Technology	5.71%
3	ICLR	ICON PLC	Unclassified	4.89%
4	COR	Cencora, Inc.	Consumer Discretionary	4.57%
5	DNTH	Dianthus Therapeutics, Inc. /DE/	Health Care	4.48%
6	AVR	Anteris Technologies Global Corp.	Health Care	4.31%
7	CORT	CORCEPT THERAPEUTICS INC	Health Care	3.92%
8	LIVN	LivaNova PLC	Health Care	3.86%
9	TYRA	Tyra Biosciences, Inc.	Health Care	3.34%
10	CELC	Celcuity Inc.	Health Care	3.19%

66/73 names classified · sector 94.5% of weight · industry 94.5% · mkt cap 86.7%; unclassified names shown, never dropped.

Sector allocation over time · how the GICS mix & top names shifted quarter by quarter

top 5/sector, rest → “Other” · 46 quarters

Health CarePHG, LH, BIIB, GEHC, TEVA · other

FinancialsCI, CNC, ELV, UNH, HUM · other

Consumer DiscretionaryCAH, COR, MCK, HLF, HSIC · other

IndustrialsMMS, CCRN, AMN, TNET, HQY · other

Information TechnologyWAY, TMO, VREX, TBRG, OMCL · other

Materials

Consumer StaplesCVS, PETS

UnclassifiedQUOTIENT LTD, LABORATORY CORP AMER HLDGS, CATALYST BIOSCIENCES INC, MIRATI THERAPEUTICS INC, GRACELL BIOTECHNOLOGIES INC · other

Sector is classified on each name's CURRENT fundamentals, not point-in-time — apparent sector drift can reflect the market re-rating a holding, not a manager trade. 13F is a lagged quarterly snapshot of long positions in US-listed securities only — foreign companies held via a US listing or ADR ARE included, but shares listed only on non-US exchanges (plus shorts, options and cash) are not. Latest quarter: 94.5% of the book is sector-classified (unclassified names shown, never dropped).

Style box · size × value-growth placement of the reported book (2026-Q1), classified on current fundamentals (not point-in-time) — load it into PORT to overlay your own portfolio

Only 36% of book weight classified — the grid is NOT representative of the whole book.

holdings, colored by sector (13 classified)Sio Capital Management, LLC centroid (Small Core)

Health CareIndustrialsInformation TechnologyConsumer Discretionary

Style box summary for Sio Capital Management, LLC: centroid Small Core. Heaviest cells: Small Growth 21.3%, Small Value 4.7%, Mid Growth 4.6%.

Classified: 35.9% of book weight (13/72 names) · unclassified 64.1%: ICLR, DNTH, AVR, LIVN, TYRA, CELC, GSK, ABVX, VIR, SION +49 more. Size: cap 70/20/10 bands; style: value/growth composite on our own metrics — not Morningstar's model.

Contribution holdings-based, any period

No contribution data for this period.

Holdings· 73 positions (2026-Q1) · largest first · Δ vs 2025-Q4

#	Security	Shares	Value	Weight	Δ QoQ
1	MMSMAXIMUS INC	768,825	$49M	7.1%	ADD 54%
2	WAYWAYSTAR HLDG CORP	1,642,236	$40M	5.7%	ADD 168%
3	ICLRICON PLC	306,358	$34M	4.9%	ADD 141%
4	CORCENCORA INC	100,894	$32M	4.6%	ADD 535%
5	DNTHDIANTHUS THERAPEUTICS INC	370,045	$31M	4.5%	TRIM −22%
6	AVRANTERIS TECHNOLOGIES GLOBAL	5,382,965	$30M	4.3%	ADD 187%
7	CORTCORCEPT THERAPEUTICS INC	674,759	$27M	3.9%	NEW
8	LIVNLIVANOVA PLC	421,615	$27M	3.9%	ADD 31%
9	TYRATYRA BIOSCIENCES INC	605,439	$23M	3.3%	ADD 15%
10	CELCCELCUITY INC	193,843	$22M	3.2%	TRIM −59%
11	GSKGSK PLC	385,879	$21M	3.1%	NEW
12	ANIPANI PHARMACEUTICALS INC	265,543	$20M	2.9%	ADD 204%
13	ABTABBOTT LABS	186,574	$19M	2.8%	NEW
14	EMBCEMBECTA CORP	1,847,850	$16M	2.4%	NEW
15	ABVXABIVAX SA	135,800	$15M	2.2%	ADD 215%
16	VIRVIR BIOTECHNOLOGY INC	1,498,620	$13M	1.9%	ADD 213%
17	HAEHAEMONETICS CORP	220,672	$12M	1.8%	ADD 138%
18	SIONSIONNA THERAPEUTICS INC	294,340	$12M	1.7%	NEW
19	SNYSANOFI SA	239,671	$12M	1.7%	TRIM −75%
20	RAPPRAPPORT THERAPEUTICS INC	366,809	$11M	1.7%	ADD 98%
21	TFXTELEFLEX INCORPORATED	94,800	$11M	1.6%	ADD 9%
22	BMRNBIOMARIN PHARMACEUTICAL INC	194,226	$11M	1.6%	TRIM −17%
23	CCRNCROSS CTRY HEALTHCARE INC	1,098,393	$10M	1.5%	ADD 3%
24	TARAPROTARA THERAPEUTICS INC	1,969,839	$10M	1.5%	ADD 15%
25	GPCRSTRUCTURE THERAPEUTICS INC	209,093	$10M	1.5%	ADD 4%
26	BHVNBIOHAVEN LTD	1,163,926	$10M	1.4%	TRIM −6%
27	MNPRMONOPAR THERAPEUTICS INC	173,506	$10M	1.4%	NEW
28	EYPTEYEPOINT INC	721,785	$9M	1.3%	NEW
29	CRNXCRINETICS PHARMACEUTICALS IN	249,887	$9M	1.3%	ADD 100%
30	EWTXEDGEWISE THERAPEUTICS INC	268,986	$8M	1.2%	ADD 13%
31	CMPSCOMPASS PATHWAYS PLC	1,506,525	$8M	1.2%	NEW
32	OCULOCULAR THERAPEUTIX INC	968,597	$8M	1.2%	NEW
33	AQSTAQUESTIVE THERAPEUTICS INC	1,922,887	$8M	1.2%	ADD 94%
34	RLMDRELMADA THERAPEUTICS INC	965,000	$7M	1.0%	NEW
35	ORKAORUKA THERAPEUTICS INC	132,496	$6M	0.9%	ADD 12%
36	ZBIOZENAS BIOPHARMA INC	331,730	$6M	0.9%	NEW
37	DRUGBRIGHT MINDS BIOSCIENCES INC	86,083	$6M	0.9%	ADD 5%
38	QDELQUIDELORTHO CORP	359,011	$6M	0.9%	NEW
39	ZBHZIMMER BIOMET HOLDINGS INC	62,613	$6M	0.8%	TRIM −84%
40	REPLREPLIMUNE GROUP INC	720,036	$6M	0.8%	NEW
41	OGNORGANON & CO	865,908	$5M	0.7%	TRIM −75%
42	OKURONKURE THERAPEUTICS INC	1,078,965	$4M	0.6%	NEW
43	IRONDISC MEDICINE INC	65,203	$4M	0.6%	ADD 13%
44	PMVPPMV PHARMACEUTICALS INC	3,076,580	$4M	0.5%	ADD 17%
45	IMNMIMMUNOME INC	165,110	$4M	0.5%	NEW
46	IARTINTEGRA LIFESCIENCES HLDGS C	383,140	$4M	0.5%	NEW
47	SVRASAVARA INC	613,888	$3M	0.5%	HOLD
48	PRQRPROQR THRAPEUTICS N V	1,954,715	$3M	0.5%	TRIM −10%
49	SISHOULDER INNOVATIONS INC	210,641	$3M	0.4%	TRIM −8%
50	OVIDOVID THERAPEUTICS INC	1,252,381	$3M	0.4%	TRIM −12%
51	KYMRKYMERA THERAPEUTICS INC	32,235	$3M	0.4%	HOLD
52	ALGSALIGOS THERAPEUTICS INC	327,237	$2M	0.4%	TRIM −3%
53	CNTXCONTEXT THERAPEUTICS INC	917,922	$2M	0.3%	TRIM −32%
54	ANTXAN2 THERAPEUTICS INC	657,200	$2M	0.3%	NEW
55	SERSERINA THERAPEUTICS INC	1,000,000	$2M	0.3%	NEW
56	IBIOIBIO INC	904,268	$2M	0.2%	ADD 22%
57	ADGMADAGIO MED HLDGS INC	1,288,461	$1M	0.2%	HOLD
58	XLOXILIO THERAPEUTICS INC	152,464	$1M	0.2%	NEW
59	BBOTBRIDGEBIO ONCOLOGY THERAPEUTIC	130,628	$1M	0.2%	HOLD
60	HYPRHYPERFINE INC	1,000,000	$1M	0.2%	TRIM −50%
61	SENSSENSEONICS HLDGS INC	115,784	$771,121	0.1%	HOLD
62	FHTXFOGHORN THERAPEUTICS INC	122,889	$587,409	0.1%	HOLD
63	TERNS PHARMACEUTICALS INC	10,100	$532,472	0.1%	HOLD
64	ENTAENANTA PHARMACEUTICALS INC	40,000	$505,200	0.1%	HOLD
65	TELATELA BIO INC	636,300	$394,506	0.1%	HOLD
66	NEUROONE MED TECHNOLOGIES CO	496,614	$385,621	0.1%	TRIM −56%
67	BOLDBOUNDLESS BIO INC	163,679	$180,047	0.0%	HOLD
68	NYXHNYXOAH S A	50,839	$148,450	0.0%	HOLD
69	MODDMODULAR MED INC	26,190	$138,283	0.0%	NEW
70	ERASERASCA INC	5,000	$80,900	0.0%	NEW
71	RCKTWWTS ROCKET PHARMACEUTICALS INC	400,000	$7,020	0.0%	HOLD
72	HUMAWHUMACYTE INC	49,998	$4,572	0.0%	HOLD
73	SLPSIMULATIONS PLUS INC	200	$2,364	0.0%	NEW

Position trends· top 15 holdings · shares held over 6 quarters

green added · red trimmed

Security

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

MMSMAXIMUS INC

381K

468K

548K

558K

500K

769K

$49M

WAYWAYSTAR HLDG CORP

—

614K

1.6M

$40M

ICLRICON PLC

196K

203K

—

127K

306K

$34M

CORCENCORA INC

—

16K

101K

$32M

DNTHDIANTHUS THERAPEUTICS INC

—

117K

236K

578K

475K

370K

$31M

AVRANTERIS TECHNOLOGIES GLOBAL

2.4M

1.8M

1.9M

5.4M

$30M

CORTCORCEPT THERAPEUTICS INC

—

675K

$27M

LIVNLIVANOVA PLC

—

322K

422K

$27M

TYRATYRA BIOSCIENCES INC

241K

417K

810K

515K

526K

605K

$23M

CELCCELCUITY INC

—

787K

477K

194K

$22M

GSKGSK PLC

—

269K

—

386K

$21M

ANIPANI PHARMACEUTICALS INC

160K

87K

113K

56K

87K

266K

$20M

ABTABBOTT LABS

—

187K

$19M

EMBCEMBECTA CORP

426K

1.1M

31K

—

1.8M

$16M

ABVXABIVAX SA

—

43K

136K

$15M

Shares reported each quarter by the largest current holdings. Green = added vs the prior filing of that name, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

☆Sio Capital Management, LLC