Institutional 13F holdings sum to 101.4% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 4,230,439 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 9,905,0459.9M | $397M | 22.01% | — |
| 2 | TPG GP A, LLC | 6,494,9626.5M | $260M | 14.43% | TRIM -4% |
| 3 | ORBIMED ADVISORS LLC | 3,530,7023.5M | $142M | 7.85% | — |
| 4 | VIKING GLOBAL INVESTORS LPtracked | 3,195,1813.2M | $128M | 7.10% | — |
| 5 | Atlas Venture Life Science Advisors, LLC | 2,995,6023.0M | $120M | 6.66% | — |
| 6 | ENAVATE SCIENCES GP, LLC | 2,478,0302.5M | $99M | 5.51% | — |
| 7 | JENNISON ASSOCIATES LLC | 1,451,2201.5M | $58M | 3.23% | ADD 30% |
| 8 | JPMORGAN CHASE & CO | 1,465,0141.5M | $54M | 3.26% | ADD 19% |
| 9 | BlackRock, Inc. | 1,295,8671.3M | $52M | 2.88% | — |
| 10 | CITADEL ADVISORS LLC | 1,166,9311.2M | $47M | 2.59% | ADD 7% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1,029,4971.0M | $41M | 2.29% | NEW† |
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 970,590970,590 | $39M | 2.16% | — |
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 756,376756,376 | $30M | 1.68% | TRIM -9% |
| 14 | STATE STREET CORP | 756,227756,227 | $30M | 1.68% | ADD 9% |
| 15 | PERCEPTIVE ADVISORS LLC | 658,439658,439 | $26M | 1.46% | TRIM -44% |
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 645,530645,530 | $26M | 1.43% | — |
| 17 | Aberdeen Group plc | 564,175564,175 | $23M | 1.25% | TRIM -33% |
| 18 | BAKER BROS. ADVISORS LP | 400,000400,000 | $16M | 0.89% | — |
| 19 | Kalehua Capital Management LLC | 394,144394,144 | $16M | 0.88% | ADD 100% |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 389,872389,872 | $16M | 0.87% | ADD 3% |
| 21 | Siren, L.L.C. | 300,000300,000 | $12M | 0.67% | — |
| 22 | Sio Capital Management, LLC | 294,340294,340 | $12M | 0.65% | NEW |
| 23 | Soleus Capital Management, L.P. | 293,500293,500 | $12M | 0.65% | ADD 9% |
| 24 | GOLDMAN SACHS GROUP INC | 263,174263,174 | $11M | 0.58% | ADD 626% |
| 25 | Ensign Peak Advisors, Inc | 255,636255,636 | $10M | 0.57% | ADD 220% |
| 26 | Candriam S.C.A. | 236,813236,813 | $9M | 0.53% | NEW |
| 27 | FRANKLIN RESOURCES INC | 175,483175,483 | $7M | 0.39% | — |
| 28 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000150,000 | $6M | 0.33% | NEW |
| 29 | UBS Group AG | 147,641147,641 | $6M | 0.33% | ADD 66% |
| 30 | VANGUARD PORTFOLIO MANAGEMENT LLC | 142,081142,081 | $6M | 0.32% | NEW |
| 31 | SUPERSTRING CAPITAL MANAGEMENT LP | 141,024141,024 | $6M | 0.31% | TRIM -22% |
| 32 | MILLENNIUM MANAGEMENT LLC | 140,641140,641 | $6M | 0.31% | ADD 75% |
| 33 | Point72 Asset Management, L.P. | 136,549136,549 | $5M | 0.30% | NEW |
| 34 | Alyeska Investment Group, L.P. | 136,222136,222 | $5M | 0.30% | — |
| 35 | GordonMD Global Investments LP | 136,000136,000 | $5M | 0.30% | NEW |
| 36 | MORGAN STANLEY | 133,023133,023 | $5M | 0.30% | ADD 167% |
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,253120,253 | $5M | 0.27% | TRIM -3% |
| 38 | Artia Global Partners LP | 119,741119,741 | $5M | 0.27% | — |
| 39 | NORTHERN TRUST CORP | 116,776116,776 | $5M | 0.26% | ADD 4% |
| 40 | VANGUARD FIDUCIARY TRUST CO | 112,175112,175 | $4M | 0.25% | NEW |
| 41 | Rock Springs Capital Management LP | 99,42999,429 | $4M | 0.22% | — |
| 42 | Rhenman & Partners Asset Management AB | 87,50087,500 | $4M | 0.19% | NEW |
| 43 | TD Asset Management Inc | 82,99682,996 | $3M | 0.18% | TRIM -27% |
| 44 | AMERIPRISE FINANCIAL INC | 81,97481,974 | $3M | 0.18% | TRIM -19% |
| 45 | FMR LLC | 81,39581,395 | $3M | 0.18% | ADD 21097% |
| 46 | Driehaus Capital Management LLC | 76,63376,633 | $3M | 0.17% | TRIM -9% |
| 47 | STEMPOINT CAPITAL LP | 73,08073,080 | $3M | 0.16% | NEW |
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,45864,458 | $3M | 0.14% | TRIM -7% |
| 49 | BANK OF AMERICA CORP /DE/ | 50,87050,870 | $2M | 0.11% | ADD 17% |
| 50 | Integral Health Asset Management, LLC | 50,00050,000 | $2M | 0.11% | NEW |
| 51 | SEVEN GRAND MANAGERS, LLC | 50,00050,000 | $2M | 0.11% | — |
| 52 | Ishara Investments LP | 49,20049,200 | $2M | 0.11% | NEW |
| 53 | Russell Investments Group, Ltd. | 48,41948,419 | $2M | 0.11% | ADD 121% |
| 54 | WELLINGTON MANAGEMENT GROUP LLP | 46,07946,079 | $2M | 0.10% | ADD 20% |
| 55 | Qube Research & Technologies Ltd | 42,24242,242 | $2M | 0.09% | NEW |
| 56 | BNP PARIBAS FINANCIAL MARKETS | 40,57040,570 | $2M | 0.09% | ADD 1692% |
| 57 | SILVERARC CAPITAL MANAGEMENT, LLC | 39,41739,417 | $2M | 0.09% | TRIM -5% |
| 58 | ALPS ADVISORS INC | 36,62836,628 | $1M | 0.08% | — |
| 59 | Bank of New York Mellon Corp | 33,77833,778 | $1M | 0.08% | TRIM -4% |
| 60 | POLEN CAPITAL MANAGEMENT LLCtracked | 26,77526,775 | $1M | 0.06% | TRIM -14% |
| 61 | Maven Securities LTD | 25,00025,000 | $1M | 0.06% | NEW |
| 62 | Nuveen, LLC | 23,73423,734 | $951,496 | 0.05% | — |
| 63 | XTX Topco Ltd | 23,55123,551 | $944,160 | 0.05% | ADD 378% |
| 64 | Rafferty Asset Management, LLC | 22,13722,137 | $887,472 | 0.05% | TRIM -10% |
| 65 | BARCLAYS PLC | 18,38518,385 | $737,056 | 0.04% | TRIM -62% |
| 66 | RHUMBLINE ADVISERS | 18,30818,308 | $733,958 | 0.04% | ADD 3% |
| 67 | CITIGROUP INC | 18,05818,058 | $723,945 | 0.04% | ADD 248% |
| 68 | ALLIANCEBERNSTEIN L.P. | 16,41016,410 | $675,107 | 0.04% | ADD 5% |
| 69 | Squarepoint Ops LLC | 15,21715,217 | $610,050 | 0.03% | TRIM -7% |
| 70 | Walleye Capital LLC | 15,09715,097 | $605,239 | 0.03% | NEW |
| 71 | DEUTSCHE BANK AG\ | 13,24913,249 | $531,153 | 0.03% | ADD 32% |
| 72 | Longaeva Partners L.P. | 12,69312,693 | $508,862 | 0.03% | TRIM -84% |
| 73 | KENNEDY CAPITAL MANAGEMENT LLC | 12,28412,284 | $492,466 | 0.03% | ADD 82% |
| 74 | Vanguard Global Advisers, LLC | 11,19111,191 | $448,647 | 0.02% | NEW |
| 75 | Invesco Ltd. | 10,78710,787 | $432,451 | 0.02% | TRIM -90% |
| 76 | PROFUND ADVISORS LLC | 9,9399,939 | $398,455 | 0.02% | ADD 8% |
| 77 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,1859,185 | $362,944 | 0.02% | ADD 3% |
| 78 | MetLife Investment Management, LLC | 8,5658,565 | $343,371 | 0.02% | — |
| 79 | China Universal Asset Management Co., Ltd. | 7,9207,920 | $317,513 | 0.02% | TRIM -23% |
| 80 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7,3107,310 | $293,058 | 0.02% | NEW |
| 81 | ExodusPoint Capital Management, LP | 7,1907,190 | $288,247 | 0.02% | NEW |
| 82 | VARCOV Co. | 6,5716,571 | $263,431 | 0.01% | NEW |
| 83 | Virtus Investment Advisers, LLC | 6,3746,374 | $255,534 | 0.01% | ADD 2% |
| 84 | Quarry LP | 6,3046,304 | $252,727 | 0.01% | NEW |
| 85 | Hudson Bay Capital Management LP | 6,1806,180 | $247,756 | 0.01% | NEW |
| 86 | WELLS FARGO & COMPANY/MN | 5,8945,894 | $236,291 | 0.01% | TRIM -66% |
| 87 | TWO SIGMA INVESTMENTS, LP | 5,5005,500 | $220,495 | 0.01% | TRIM -14% |
| 88 | INTECH INVESTMENT MANAGEMENT LLC | 5,4895,489 | $220,054 | 0.01% | TRIM -28% |
| 89 | NEW YORK STATE COMMON RETIREMENT FUND | 5,3005,300 | $212,477 | 0.01% | — |
| 90 | AlphaCentric Advisors LLC | 4,8184,818 | $193,154 | 0.01% | ADD 77% |
| 91 | Police & Firemen's Retirement System of New Jersey | 4,2324,232 | $169,661 | 0.01% | — |
| 92 | LOS ANGELES CAPITAL MANAGEMENT LLC | 4,1164,116 | $165,010 | 0.01% | TRIM -21% |
| 93 | Cygnus Capital Advisors, LLC | 3,8003,800 | $152,000 | 0.01% | ADD 58% |
| 94 | STRS OHIO | 2,9002,900 | $116,261 | 0.01% | NEW |
| 95 | Tower Research Capital LLC (TRC) | 2,3522,352 | $94,292 | 0.01% | ADD 108% |
| 96 | Mirae Asset Global Investments Co., Ltd. | 2,3282,328 | $93,330 | 0.01% | ADD 7% |
| 97 | Legal & General Group Plc | 1,4321,432 | $57,352 | 0.00% | TRIM -15% |
| 98 | Ameritas Investment Partners, Inc. | 1,3021,302 | $52,197 | 0.00% | — |
| 99 | GF FUND MANAGEMENT CO. LTD. | 1,0031,003 | $40,210 | 0.00% | ADD 14% |
| 100 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 868868 | $34,798 | 0.00% | TRIM -12% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | — | 10.4M | 10.4M | 10.4M | 9.9M | 9.9M | $397M |
| TPG GP A, LLC | — | 6.7M | 6.7M | 6.7M | 6.7M | 6.5M | $260M |
| ORBIMED ADVISORS LLC | — | 3.7M | 3.7M | 3.7M | 3.6M | 3.5M | $142M |
| VIKING GLOBAL INVESTORS LPtracked | — | 3.0M | 3.2M | 3.2M | 3.2M | 3.2M | $128M |
| Atlas Venture Life Science Advisors, LLC | — | 3.7M | 3.7M | 3.6M | 3.0M | 3.0M | $120M |
| ENAVATE SCIENCES GP, LLC | — | 2.5M | 2.5M | 2.5M | 2.5M | 2.5M | $99M |
| JENNISON ASSOCIATES LLC | — | 860K | 753K | 997K | 1.1M | 1.5M | $58M |
| JPMORGAN CHASE & CO | — | 2.2M | 2.2M | 4.0M | 1.2M | 1.5M | $54M |
| BlackRock, Inc. | — | 198K | 637K | 845K | 1.3M | 1.3M | $52M |
| CITADEL ADVISORS LLC | — | 327K | 130K | 36K | 1.1M | 1.2M | $47M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.0M | $41M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | 747K | 971K | 971K | 971K | 971K | $39M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | 996K | 861K | 638K | 831K | 756K | $30M |
| STATE STREET CORP | — | 14K | 125K | 240K | 693K | 756K | $30M |
| PERCEPTIVE ADVISORS LLC | — | 1.3M | 1.2M | 1.2M | 1.2M | 658K | $26M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 122 | 45,640,924 | 101.4% | $1.8B |
| 2025-Q4 | 101 | 43,950,895 | 98.5% | $1.8B |
| 2025-Q3 | 78 | 44,819,191 | 101.5% | $1.3B |
| 2025-Q2 | 65 | 43,448,455 | 98.5% | $754M |
| 2025-Q1 | 47 | 41,491,947 | 94.0% | $434M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Initial Public Offering On February 6, 2025, the Issuer entered into an underwriting agreement (the "Underwriting Agreement") with Goldman Sachs & Co. LLC, TD Securities (USA) LLC, Stifel, Nicolaus & Company, Incorporated and Guggenheim Securities, LLC (the "Underwriters") providing for the offer and sale by the Issuer (the "Offering”
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +1,029,497 | $41M | OPEN |
| JENNISON ASSOCIATES LLC | +335,942 | $13M | ADD |
| Sio Capital Management, LLC | +294,340 | $12M | OPEN |
| Candriam S.C.A. | +236,813 | $9M | OPEN |
| JPMORGAN CHASE & CO | +233,195 | $9M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,184,951 | $48M | CLOSE |
| PERCEPTIVE ADVISORS LLC | −520,659 | $21M | TRIM |
| Aberdeen Group plc | −275,785 | $11M | TRIM |
| TPG GP A, LLC | −250,000 | $10M | TRIM |
| Invesco Ltd. | −100,375 | $4M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
“The Reporting Persons purchased the aforementioned securities for investment purposes with the aim of increasing the value of their investments and the Issuer. Subject to applicable legal requirements, one or more of the Reporting Persons may purchase additional securities of the Issuer from time to time in open market or private transactions, depending on its evaluation of the Issuer's business, prospects and financial condition, the market for the Issuer's securities, other developments concer”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
