EWTX US Equity

Edgewise Therapeutics, Inc.

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Health Care · Pharmaceutical Preparations · CIK 1710072 · FYE 1231

$39.75

-0.60 (-1.49%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding EWTX · 2026-Q1 methodology → sources →

214 holders

% of shares outstanding held

110.4%

Shares held (13F)

118,823,488

Reporting holders

214

Institutional 13F holdings sum to 110.4% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 10,134,013 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 214 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	ORBIMED ADVISORS LLC	15,518,49215.5M	$489M	14.42%	—
2	RA CAPITAL MANAGEMENT, L.P.	10,428,43710.4M	$328M	9.69%	—
3	Paradigm Biocapital Advisors LP	7,365,0387.4M	$232M	6.85%	ADD 13%
4	BAKER BROS. ADVISORS LP	6,575,9406.6M	$207M	6.11%	—
5	BlackRock, Inc.	6,472,9916.5M	$204M	6.02%	TRIM -2%
6	JANUS HENDERSON GROUP PLC	5,915,5565.9M	$186M	5.50%	ADD 30%
7	NOVO HOLDINGS A/S	5,350,0005.3M	$169M	4.97%	—
8	Driehaus Capital Management LLC	4,477,9424.5M	$141M	4.16%	ADD 7%
9	Siren, L.L.C.	4,430,2634.4M	$140M	4.12%	TRIM -2%
10	PERCEPTIVE ADVISORS LLC	4,423,9744.4M	$139M	4.11%	—
11	VANGUARD CAPITAL MANAGEMENT LLC	3,788,1613.8M	$119M	3.52%	NEW†
12	Cormorant Asset Management, LP	3,260,0003.3M	$103M	3.03%	—
13	BRAIDWELL LP	2,347,5832.3M	$74M	2.18%	TRIM -55%
14	MORGAN STANLEY	2,246,0282.2M	$71M	2.09%	TRIM -23%
15	GEODE CAPITAL MANAGEMENT, LLC	1,789,8191.8M	$56M	1.66%	ADD 2%
16	STATE STREET CORP	1,716,8231.7M	$54M	1.60%	—
17	MPM BIOIMPACT LLC	1,660,6961.7M	$52M	1.54%	—
18	Integral Health Asset Management, LLC	1,600,0001.6M	$50M	1.49%	ADD 7%
19	Bellevue Group AG	1,528,5181.5M	$48M	1.42%	—
20	Soleus Capital Management, L.P.	1,449,9151.4M	$46M	1.35%	ADD 59%
21	ALLIANCEBERNSTEIN L.P.	1,722,1691.7M	$43M	1.60%	ADD 66%
22	BANK OF AMERICA CORP /DE/	1,327,3601.3M	$42M	1.23%	TRIM -10%
23	UBS Group AG	1,311,1251.3M	$41M	1.22%	TRIM -38%
24	DIMENSIONAL FUND ADVISORS LP	1,219,7171.2M	$38M	1.13%	—
25	AMERICAN CENTURY COMPANIES INC	1,147,1761.1M	$36M	1.07%	TRIM -3%
26	FMR LLC	1,017,0521.0M	$32M	0.95%	ADD 47%
27	First Light Asset Management, LLC	1,001,8461.0M	$32M	0.93%	TRIM -36%
28	Aberdeen Group plc	826,059826,059	$26M	0.77%	—
29	Qube Research & Technologies Ltd	825,910825,910	$26M	0.77%	ADD 179%
30	VICTORY CAPITAL MANAGEMENT INC	789,043789,043	$25M	0.73%	ADD 6%
31	Artisan Partners Limited Partnership	659,067659,067	$21M	0.61%	TRIM -6%
32	MARSHALL WACE, LLP	648,393648,393	$20M	0.60%	TRIM -5%
33	GOLDMAN SACHS GROUP INC	629,820629,820	$20M	0.59%	TRIM -12%
34	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	596,310596,310	$19M	0.55%	TRIM -2%
35	STEMPOINT CAPITAL LP	581,728581,728	$18M	0.54%	ADD 61%
36	NORTHERN TRUST CORP	576,556576,556	$18M	0.54%	ADD 3%
37	VANGUARD PORTFOLIO MANAGEMENT LLC	557,260557,260	$18M	0.52%	NEW
38	VANGUARD FIDUCIARY TRUST CO	521,726521,726	$16M	0.48%	NEW
39	Opaleye Management Inc.	500,000500,000	$16M	0.46%	—
40	Candriam S.C.A.	447,416447,416	$14M	0.42%	TRIM -11%
41	CITADEL ADVISORS LLC	429,032429,032	$14M	0.40%	ADD 249%
42	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	404,200404,200	$13M	0.38%	TRIM -37%
43	Sofinnova Investments, Inc.	386,498386,498	$12M	0.36%	TRIM -12%
44	Squadron Capital Management LLC	350,000350,000	$11M	0.33%	—
45	MILLENNIUM MANAGEMENT LLC	342,867342,867	$11M	0.32%	ADD 171%
46	Nuveen, LLC	335,783335,783	$11M	0.31%	ADD 98%
47	Parkman Healthcare Partners LLC	322,828322,828	$10M	0.30%	TRIM -25%
48	Universal- Beteiligungs- und Servicegesellschaft mbH	283,312283,312	$9M	0.26%	ADD 4%
49	Sio Capital Management, LLC	268,986268,986	$8M	0.25%	ADD 13%
50	KENNEDY CAPITAL MANAGEMENT LLC	264,204264,204	$8M	0.25%	ADD 9%
51	Woodline Partners LP	224,290224,290	$7M	0.21%	—
52	DEUTSCHE BANK AG\	221,868221,868	$7M	0.21%	ADD 3%
53	PEREGRINE CAPITAL MANAGEMENT LLC	208,672208,672	$7M	0.19%	NEW
54	SEB Asset Management AB	206,512206,512	$7M	0.19%	NEW
55	Granahan Investment Management, LLC	200,843200,843	$6M	0.19%	TRIM -14%
56	AMERIPRISE FINANCIAL INC	200,661200,661	$6M	0.19%	—
57	Bank of New York Mellon Corp	192,434192,434	$6M	0.18%	TRIM -3%
58	BARCLAYS PLC	177,244177,244	$6M	0.16%	TRIM -52%
59	NEUBERGER BERMAN GROUP LLC	168,678168,678	$5M	0.16%	ADD 33%
60	Ally Bridge Group (NY) LLC	161,000161,000	$5M	0.15%	TRIM -17%
61	EVENTIDE ASSET MANAGEMENT, LLC	149,863149,863	$5M	0.14%	TRIM -74%
62	Freestone Grove Partners LP	148,426148,426	$5M	0.14%	NEW
63	JPMORGAN CHASE & CO	147,573147,573	$4M	0.14%	—
64	SCHRODER INVESTMENT MANAGEMENT GROUP	145,286145,286	$4M	0.14%	—
65	Invesco Ltd.	138,399138,399	$4M	0.13%	ADD 83%
66	KVP Capital Advisors, LP	133,000133,000	$4M	0.12%	—
67	Quantum Private Wealth, LLC	116,624116,624	$4M	0.11%	ADD 10%
68	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	114,720114,720	$4M	0.11%	ADD 17%
69	Moody Aldrich Partners LLC	114,141114,141	$4M	0.11%	ADD 165%
70	DAFNA Capital Management LLC	112,236112,236	$4M	0.10%	TRIM -30%
71	D. E. Shaw & Co., Inc.	104,863104,863	$3M	0.10%	TRIM -73%
72	Swiss National Bank	103,900103,900	$3M	0.10%	—
73	Schonfeld Strategic Advisors LLC	99,07599,075	$3M	0.09%	ADD 67%
74	HighVista Strategies LLC	91,93191,931	$3M	0.09%	TRIM -46%
75	ADAR1 Capital Management, LLC	90,59990,599	$3M	0.08%	—
76	NEW YORK STATE COMMON RETIREMENT FUND	88,93788,937	$3M	0.08%	—
77	ALPS ADVISORS INC	87,32687,326	$3M	0.08%	—
78	RHUMBLINE ADVISERS	83,54083,540	$3M	0.08%	—
79	DekaBank Deutsche Girozentrale	80,00080,000	$3M	0.07%	—
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	73,41973,419	$2M	0.07%	ADD 46%
81	PRICE T ROWE ASSOCIATES INC /MD/	69,42769,427	$2M	0.06%	ADD 21%
82	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	67,40867,408	$2M	0.06%	NEW
83	Artia Global Partners LP	65,50065,500	$2M	0.06%	NEW
84	J. Goldman & Co LP	61,42161,421	$2M	0.06%	NEW
85	FEDERATED HERMES, INC.	56,77856,778	$2M	0.05%	TRIM -31%
86	HighMark Wealth Management LLC	53,17953,179	$2M	0.05%	—
87	TWO SIGMA INVESTMENTS, LP	50,84850,848	$2M	0.05%	—
88	Ishara Investments LP	49,20049,200	$2M	0.05%	TRIM -15%
89	SEI INVESTMENTS CO	49,08249,082	$2M	0.05%	ADD 57%
90	Jain Global LLC	46,40146,401	$1M	0.04%	TRIM -59%
91	SILVERARC CAPITAL MANAGEMENT, LLC	42,61542,615	$1M	0.04%	—
92	Legal & General Group Plc	42,53742,537	$1M	0.04%	TRIM -19%
93	FRANKLIN RESOURCES INC	41,72641,726	$1M	0.04%	TRIM -3%
94	VOYA INVESTMENT MANAGEMENT LLC	39,15339,153	$1M	0.04%	—
95	Caption Management, LLC	38,67538,675	$1M	0.04%	NEW
96	Knights of Columbus Asset Advisors LLC	38,41438,414	$1M	0.04%	—
97	MetLife Investment Management, LLC	38,08438,084	$1M	0.04%	—
98	Longaeva Partners L.P.	36,93136,931	$1M	0.03%	NEW
99	VANGUARD ASSET MANAGEMENT, Ltd	35,74435,744	$1M	0.03%	NEW
100	JANE STREET GROUP, LLC	35,57835,578	$1M	0.03%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

ORBIMED ADVISORS LLC

15.0M

15.5M

$489M

RA CAPITAL MANAGEMENT, L.P.

8.9M

9.9M

10.4M

$328M

Paradigm Biocapital Advisors LP

4.5M

4.4M

6.1M

6.2M

6.5M

7.4M

$232M

BAKER BROS. ADVISORS LP

6.2M

7.3M

6.6M

$207M

BlackRock, Inc.

6.5M

6.8M

6.4M

6.6M

6.5M

$204M

JANUS HENDERSON GROUP PLC

5.0M

5.3M

5.5M

5.0M

4.6M

5.9M

$186M

NOVO HOLDINGS A/S

5.0M

5.3M

$169M

Driehaus Capital Management LLC

1.5M

1.4M

2.1M

2.2M

4.2M

4.5M

$141M

Siren, L.L.C.

734K

1.7M

3.2M

3.9M

4.5M

4.4M

$140M

PERCEPTIVE ADVISORS LLC

2.7M

6.5M

4.6M

3.8M

4.5M

4.4M

$139M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.8M

$119M

Cormorant Asset Management, LP

3.4M

4.1M

4.3M

4.0M

3.3M

$103M

BRAIDWELL LP

2.3M

2.5M

5.2M

2.3M

$74M

MORGAN STANLEY

436K

409K

728K

870K

2.9M

2.2M

$71M

GEODE CAPITAL MANAGEMENT, LLC

1.6M

1.7M

1.8M

1.7M

1.8M

$56M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	214	118,823,488	110.4%	$3.7B
2025-Q4	199	121,825,111	—	$3.0B
2025-Q3	173	112,032,764	104.1%	$1.8B
2025-Q2	179	118,745,640	—	$1.6B
2025-Q1	193	105,630,364	98.2%	$2.3B
2024-Q4	201	98,998,467	92.0%	$2.6B
2024-Q3	177	101,593,926	94.4%	$2.7B
2024-Q2	140	101,709,448	94.5%	$1.8B
2024-Q1	129	92,425,846	85.9%	$1.7B
2023-Q4	116	79,913,745	74.3%	$874M

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · EWTX

Activists — 13D, active intent

ORBIMED ADVISORS LLC14.5%NEWSCHEDULE 13D/A · Amd 4 · event 2025-05-09SEC →

15,252,867 shares · 4 reporting persons

“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”

Novo Holdings A/S4.9%NEWSCHEDULE 13D/A · Amd 6 · event 2026-04-23SEC →

5,350,000 shares

Large holders — 13G, passive (top 5 of 6 by % of class)

Holder

% of class

Type

As of

RA CAPITAL MANAGEMENT, L.P.

9.9%

Passive

2025-09-30

SEC →

Institutional ownership· 13F filers holding EWTX · 2026-Q1 methodology → sources →

214 holders

% of shares outstanding held

110.4%

Shares held (13F)

118,823,488

Reporting holders

214

Top holders

largest 100 of 214 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	ORBIMED ADVISORS LLC	15,518,49215.5M	$489M	14.42%	—
2	RA CAPITAL MANAGEMENT, L.P.	10,428,43710.4M	$328M	9.69%	—
3	Paradigm Biocapital Advisors LP	7,365,0387.4M	$232M	6.85%	ADD 13%
4	BAKER BROS. ADVISORS LP	6,575,9406.6M	$207M	6.11%	—
5	BlackRock, Inc.	6,472,9916.5M	$204M	6.02%	TRIM -2%
6	JANUS HENDERSON GROUP PLC	5,915,5565.9M	$186M	5.50%	ADD 30%
7	NOVO HOLDINGS A/S	5,350,0005.3M	$169M	4.97%	—
8	Driehaus Capital Management LLC	4,477,9424.5M	$141M	4.16%	ADD 7%
9	Siren, L.L.C.	4,430,2634.4M	$140M	4.12%	TRIM -2%
10	PERCEPTIVE ADVISORS LLC	4,423,9744.4M	$139M	4.11%	—
11	VANGUARD CAPITAL MANAGEMENT LLC	3,788,1613.8M	$119M	3.52%	NEW†
12	Cormorant Asset Management, LP	3,260,0003.3M	$103M	3.03%	—
13	BRAIDWELL LP	2,347,5832.3M	$74M	2.18%	TRIM -55%
14	MORGAN STANLEY	2,246,0282.2M	$71M	2.09%	TRIM -23%
15	GEODE CAPITAL MANAGEMENT, LLC	1,789,8191.8M	$56M	1.66%	ADD 2%
16	STATE STREET CORP	1,716,8231.7M	$54M	1.60%	—
17	MPM BIOIMPACT LLC	1,660,6961.7M	$52M	1.54%	—
18	Integral Health Asset Management, LLC	1,600,0001.6M	$50M	1.49%	ADD 7%
19	Bellevue Group AG	1,528,5181.5M	$48M	1.42%	—
20	Soleus Capital Management, L.P.	1,449,9151.4M	$46M	1.35%	ADD 59%
21	ALLIANCEBERNSTEIN L.P.	1,722,1691.7M	$43M	1.60%	ADD 66%
22	BANK OF AMERICA CORP /DE/	1,327,3601.3M	$42M	1.23%	TRIM -10%
23	UBS Group AG	1,311,1251.3M	$41M	1.22%	TRIM -38%
24	DIMENSIONAL FUND ADVISORS LP	1,219,7171.2M	$38M	1.13%	—
25	AMERICAN CENTURY COMPANIES INC	1,147,1761.1M	$36M	1.07%	TRIM -3%
26	FMR LLC	1,017,0521.0M	$32M	0.95%	ADD 47%
27	First Light Asset Management, LLC	1,001,8461.0M	$32M	0.93%	TRIM -36%
28	Aberdeen Group plc	826,059826,059	$26M	0.77%	—
29	Qube Research & Technologies Ltd	825,910825,910	$26M	0.77%	ADD 179%
30	VICTORY CAPITAL MANAGEMENT INC	789,043789,043	$25M	0.73%	ADD 6%
31	Artisan Partners Limited Partnership	659,067659,067	$21M	0.61%	TRIM -6%
32	MARSHALL WACE, LLP	648,393648,393	$20M	0.60%	TRIM -5%
33	GOLDMAN SACHS GROUP INC	629,820629,820	$20M	0.59%	TRIM -12%
34	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	596,310596,310	$19M	0.55%	TRIM -2%
35	STEMPOINT CAPITAL LP	581,728581,728	$18M	0.54%	ADD 61%
36	NORTHERN TRUST CORP	576,556576,556	$18M	0.54%	ADD 3%
37	VANGUARD PORTFOLIO MANAGEMENT LLC	557,260557,260	$18M	0.52%	NEW
38	VANGUARD FIDUCIARY TRUST CO	521,726521,726	$16M	0.48%	NEW
39	Opaleye Management Inc.	500,000500,000	$16M	0.46%	—
40	Candriam S.C.A.	447,416447,416	$14M	0.42%	TRIM -11%
41	CITADEL ADVISORS LLC	429,032429,032	$14M	0.40%	ADD 249%
42	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	404,200404,200	$13M	0.38%	TRIM -37%
43	Sofinnova Investments, Inc.	386,498386,498	$12M	0.36%	TRIM -12%
44	Squadron Capital Management LLC	350,000350,000	$11M	0.33%	—
45	MILLENNIUM MANAGEMENT LLC	342,867342,867	$11M	0.32%	ADD 171%
46	Nuveen, LLC	335,783335,783	$11M	0.31%	ADD 98%
47	Parkman Healthcare Partners LLC	322,828322,828	$10M	0.30%	TRIM -25%
48	Universal- Beteiligungs- und Servicegesellschaft mbH	283,312283,312	$9M	0.26%	ADD 4%
49	Sio Capital Management, LLC	268,986268,986	$8M	0.25%	ADD 13%
50	KENNEDY CAPITAL MANAGEMENT LLC	264,204264,204	$8M	0.25%	ADD 9%
51	Woodline Partners LP	224,290224,290	$7M	0.21%	—
52	DEUTSCHE BANK AG\	221,868221,868	$7M	0.21%	ADD 3%
53	PEREGRINE CAPITAL MANAGEMENT LLC	208,672208,672	$7M	0.19%	NEW
54	SEB Asset Management AB	206,512206,512	$7M	0.19%	NEW
55	Granahan Investment Management, LLC	200,843200,843	$6M	0.19%	TRIM -14%
56	AMERIPRISE FINANCIAL INC	200,661200,661	$6M	0.19%	—
57	Bank of New York Mellon Corp	192,434192,434	$6M	0.18%	TRIM -3%
58	BARCLAYS PLC	177,244177,244	$6M	0.16%	TRIM -52%
59	NEUBERGER BERMAN GROUP LLC	168,678168,678	$5M	0.16%	ADD 33%
60	Ally Bridge Group (NY) LLC	161,000161,000	$5M	0.15%	TRIM -17%
61	EVENTIDE ASSET MANAGEMENT, LLC	149,863149,863	$5M	0.14%	TRIM -74%
62	Freestone Grove Partners LP	148,426148,426	$5M	0.14%	NEW
63	JPMORGAN CHASE & CO	147,573147,573	$4M	0.14%	—
64	SCHRODER INVESTMENT MANAGEMENT GROUP	145,286145,286	$4M	0.14%	—
65	Invesco Ltd.	138,399138,399	$4M	0.13%	ADD 83%
66	KVP Capital Advisors, LP	133,000133,000	$4M	0.12%	—
67	Quantum Private Wealth, LLC	116,624116,624	$4M	0.11%	ADD 10%
68	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	114,720114,720	$4M	0.11%	ADD 17%
69	Moody Aldrich Partners LLC	114,141114,141	$4M	0.11%	ADD 165%
70	DAFNA Capital Management LLC	112,236112,236	$4M	0.10%	TRIM -30%
71	D. E. Shaw & Co., Inc.	104,863104,863	$3M	0.10%	TRIM -73%
72	Swiss National Bank	103,900103,900	$3M	0.10%	—
73	Schonfeld Strategic Advisors LLC	99,07599,075	$3M	0.09%	ADD 67%
74	HighVista Strategies LLC	91,93191,931	$3M	0.09%	TRIM -46%
75	ADAR1 Capital Management, LLC	90,59990,599	$3M	0.08%	—
76	NEW YORK STATE COMMON RETIREMENT FUND	88,93788,937	$3M	0.08%	—
77	ALPS ADVISORS INC	87,32687,326	$3M	0.08%	—
78	RHUMBLINE ADVISERS	83,54083,540	$3M	0.08%	—
79	DekaBank Deutsche Girozentrale	80,00080,000	$3M	0.07%	—
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	73,41973,419	$2M	0.07%	ADD 46%
81	PRICE T ROWE ASSOCIATES INC /MD/	69,42769,427	$2M	0.06%	ADD 21%
82	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	67,40867,408	$2M	0.06%	NEW
83	Artia Global Partners LP	65,50065,500	$2M	0.06%	NEW
84	J. Goldman & Co LP	61,42161,421	$2M	0.06%	NEW
85	FEDERATED HERMES, INC.	56,77856,778	$2M	0.05%	TRIM -31%
86	HighMark Wealth Management LLC	53,17953,179	$2M	0.05%	—
87	TWO SIGMA INVESTMENTS, LP	50,84850,848	$2M	0.05%	—
88	Ishara Investments LP	49,20049,200	$2M	0.05%	TRIM -15%
89	SEI INVESTMENTS CO	49,08249,082	$2M	0.05%	ADD 57%
90	Jain Global LLC	46,40146,401	$1M	0.04%	TRIM -59%
91	SILVERARC CAPITAL MANAGEMENT, LLC	42,61542,615	$1M	0.04%	—
92	Legal & General Group Plc	42,53742,537	$1M	0.04%	TRIM -19%
93	FRANKLIN RESOURCES INC	41,72641,726	$1M	0.04%	TRIM -3%
94	VOYA INVESTMENT MANAGEMENT LLC	39,15339,153	$1M	0.04%	—
95	Caption Management, LLC	38,67538,675	$1M	0.04%	NEW
96	Knights of Columbus Asset Advisors LLC	38,41438,414	$1M	0.04%	—
97	MetLife Investment Management, LLC	38,08438,084	$1M	0.04%	—
98	Longaeva Partners L.P.	36,93136,931	$1M	0.03%	NEW
99	VANGUARD ASSET MANAGEMENT, Ltd	35,74435,744	$1M	0.03%	NEW
100	JANE STREET GROUP, LLC	35,57835,578	$1M	0.03%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

ORBIMED ADVISORS LLC

15.0M

15.5M

$489M

RA CAPITAL MANAGEMENT, L.P.

8.9M

9.9M

10.4M

$328M

Paradigm Biocapital Advisors LP

4.5M

4.4M

6.1M

6.2M

6.5M

7.4M

$232M

BAKER BROS. ADVISORS LP

6.2M

7.3M

6.6M

$207M

BlackRock, Inc.

6.5M

6.8M

6.4M

6.6M

6.5M

$204M

JANUS HENDERSON GROUP PLC

5.0M

5.3M

5.5M

5.0M

4.6M

5.9M

$186M

NOVO HOLDINGS A/S

5.0M

5.3M

$169M

Driehaus Capital Management LLC

1.5M

1.4M

2.1M

2.2M

4.2M

4.5M

$141M

Siren, L.L.C.

734K

1.7M

3.2M

3.9M

4.5M

4.4M

$140M

PERCEPTIVE ADVISORS LLC

2.7M

6.5M

4.6M

3.8M

4.5M

4.4M

$139M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.8M

$119M

Cormorant Asset Management, LP

3.4M

4.1M

4.3M

4.0M

3.3M

$103M

BRAIDWELL LP

2.3M

2.5M

5.2M

2.3M

$74M

MORGAN STANLEY

436K

409K

728K

870K

2.9M

2.2M

$71M

GEODE CAPITAL MANAGEMENT, LLC

1.6M

1.7M

1.8M

1.7M

1.8M

$56M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	214	118,823,488	110.4%	$3.7B
2025-Q4	199	121,825,111	—	$3.0B
2025-Q3	173	112,032,764	104.1%	$1.8B
2025-Q2	179	118,745,640	—	$1.6B
2025-Q1	193	105,630,364	98.2%	$2.3B
2024-Q4	201	98,998,467	92.0%	$2.6B
2024-Q3	177	101,593,926	94.4%	$2.7B
2024-Q2	140	101,709,448	94.5%	$1.8B
2024-Q1	129	92,425,846	85.9%	$1.7B
2023-Q4	116	79,913,745	74.3%	$874M

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · EWTX

Activists — 13D, active intent

ORBIMED ADVISORS LLC14.5%NEWSCHEDULE 13D/A · Amd 4 · event 2025-05-09SEC →

15,252,867 shares · 4 reporting persons

Novo Holdings A/S4.9%NEWSCHEDULE 13D/A · Amd 6 · event 2026-04-23SEC →

5,350,000 shares

Large holders — 13G, passive (top 5 of 6 by % of class)

Holder

% of class

Type

As of

RA CAPITAL MANAGEMENT, L.P.

9.9%

Passive

2025-09-30

SEC →

EWTX US Equity☆

Institutional ownership· 13F filers holding EWTX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · EWTX

Institutional ownership· 13F filers holding EWTX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · EWTX

EWTX US Equity