| 1 | 1JANUS HENDERSON GROUP PLC | 1,284,3241.3M | $94M | — | ADD 11% |
| 2 | 2Cormorant Asset Management, LP | 1,059,3311.1M | $77M | — | — |
| 3 | 3BlackRock, Inc. | 621,933621,933 | $45M | — | ADD 58% |
| 4 | 4Vivo Capital, LLC | 557,172557,172 | $41M | — | ADD 11% |
| 5 | 5BRAIDWELL LP | 539,708539,708 | $39M | — | ADD 66% |
| 6 | 6ADAGE CAPITAL PARTNERS GP, L.L.C. | 495,743495,743 | $36M | — | ADD 25% |
| 7 | 7Vestal Point Capital, LP | 492,319492,319 | $36M | — | NEW |
| 8 | 8Driehaus Capital Management LLC | 432,515432,515 | $32M | — | ADD 60% |
| 9 | 9PERCEPTIVE ADVISORS LLC | 377,544377,544 | $28M | — | TRIM -16% |
| 10 | 10Balyasny Asset Management L.P. | 297,158297,158 | $22M | — | ADD 32% |
| 11 | 11DEERFIELD MANAGEMENT COMPANY, L.P. | 283,000283,000 | $21M | — | NEW |
| 12 | 12RA CAPITAL MANAGEMENT, L.P. | 265,000265,000 | $19M | — | NEW |
| 13 | 13GREAT POINT PARTNERS LLC | 220,000220,000 | $16M | — | NEW |
| 14 | 14MPM BIOIMPACT LLC | 212,175212,175 | $15M | — | TRIM -8% |
| 15 | 15Ikarian Capital, LLC | 166,647166,647 | $12M | — | ADD 5% |
| 16 | 16WELLINGTON MANAGEMENT GROUP LLP | 136,677136,677 | $10M | — | ADD 899% |
| 17 | 17MORGAN STANLEY | 132,764132,764 | $10M | — | — |
| 18 | 18EVENTIDE ASSET MANAGEMENT, LLC | 130,013130,013 | $9M | — | ADD 26% |
| 19 | 19SEVEN GRAND MANAGERS, LLC | 120,000120,000 | $9M | — | ADD 140% |
| 20 | 20ACUTA CAPITAL PARTNERS, LLC | 111,996111,996 | $8M | — | ADD 33% |
| 21 | 21STATE STREET CORP | 108,239108,239 | $8M | — | ADD 40% |
| 22 | 22GEODE CAPITAL MANAGEMENT, LLC | 88,71688,716 | $6M | — | ADD 40% |
| 23 | 23Sio Capital Management, LLC | 86,08386,083 | $6M | — | ADD 5% |
| 24 | 24GOLDMAN SACHS GROUP INC | 74,36974,369 | $5M | — | ADD 53% |
| 25 | 25B Group, Inc. | 67,50067,500 | $5M | — | NEW |
| 26 | 26VANGUARD PORTFOLIO MANAGEMENT LLC | 60,48260,482 | $4M | — | NEW |
| 27 | 27Walleye Capital LLC | 53,70653,706 | $4M | — | ADD 108% |
| 28 | 28MILLENNIUM MANAGEMENT LLC | 52,83252,832 | $4M | — | TRIM -73% |
| 29 | 29BOOTHBAY FUND MANAGEMENT, LLC | 51,29051,290 | $4M | — | ADD 8% |
| 30 | 30AMERIPRISE FINANCIAL INC | 50,02750,027 | $4M | — | NEW |
| 31 | 31Woodline Partners LP | 45,66845,668 | $3M | — | NEW |
| 32 | 32Parkman Healthcare Partners LLC | 40,09840,098 | $3M | — | NEW |
| 33 | 33ORBIMED ADVISORS LLC | 40,00040,000 | $3M | — | NEW |
| 34 | 34Artia Global Partners LP | 38,40738,407 | $3M | — | ADD 15% |
| 35 | 35NORTHERN TRUST CORP | 37,37837,378 | $3M | — | ADD 46% |
| 36 | 36ADAR1 Capital Management, LLC | 33,90033,900 | $2M | — | ADD 869% |
| 37 | 37KVP Capital Advisors, LP | 31,81331,813 | $2M | — | NEW |
| 38 | 38BANK OF AMERICA CORP /DE/ | 19,42219,422 | $1M | — | ADD 29% |
| 39 | 39PLATINUM INVESTMENT MANAGEMENT LTD | 19,12719,127 | $1M | — | TRIM -12% |
| 40 | 40D. E. Shaw & Co., Inc. | 15,44515,445 | $1M | — | ADD 294% |
| 41 | 41CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,31815,318 | $1M | — | ADD 23% |
| 42 | 42SUPERSTRING CAPITAL MANAGEMENT LP | 13,31113,311 | $971,304 | — | TRIM -72% |
| 43 | 43UBS Group AG | 13,28013,280 | $969,042 | — | TRIM -4% |
| 44 | 44Bank of New York Mellon Corp | 13,25313,253 | $967,045 | — | ADD 33% |
| 45 | 45Schonfeld Strategic Advisors LLC | 13,24413,244 | $966,414 | — | TRIM -56% |
| 46 | 46AdvisorShares Investments LLC | 12,61312,613 | $920,371 | — | ADD 27% |
| 47 | 47SEI INVESTMENTS CO | 11,18811,188 | $816,388 | — | NEW |
| 48 | 48Ghisallo Capital Management LLC | 11,00011,000 | $802,670 | — | NEW |
| 49 | 49Informed Momentum Co LLC | 9,1899,189 | $670,521 | — | NEW |
| 50 | 50Nuveen, LLC | 8,3298,329 | $607,767 | — | ADD 39% |
| 51 | 51RHUMBLINE ADVISERS | 7,7627,762 | $566,385 | — | ADD 31% |
| 52 | 52Trexquant Investment LP | 7,4517,451 | $543,699 | — | NEW |
| 53 | 53Quadrature Capital Ltd | 6,4986,498 | $474,159 | — | NEW |
| 54 | 54LPL Financial LLC | 6,4956,495 | $473,940 | — | ADD 15% |
| 55 | 55JANE STREET GROUP, LLC | 6,4006,400 | $467,008 | — | TRIM -29% |
| 56 | 56Seven Fleet Capital Management LP | 6,3956,395 | $466,644 | — | NEW |
| 57 | 57Invesco Ltd. | 6,2966,296 | $459,420 | — | ADD 50% |
| 58 | 58DEUTSCHE BANK AG\ | 6,2586,258 | $456,646 | — | ADD 47% |
| 59 | 59VANGUARD FIDUCIARY TRUST CO | 6,0626,062 | $442,344 | — | NEW |
| 60 | 60PRICE T ROWE ASSOCIATES INC /MD/ | 4,9474,947 | $361,000 | — | ADD 75% |
| 61 | 61DNB Asset Management AS | 4,4414,441 | $324,060 | — | NEW |
| 62 | 62MetLife Investment Management, LLC | 3,9113,911 | $285,386 | — | ADD 34% |
| 63 | 63STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,7813,781 | $275,900 | — | — |
| 64 | 64JPMORGAN CHASE & CO | 3,8773,877 | $265,381 | — | ADD 54% |
| 65 | 65MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,2603,260 | $237,882 | — | ADD 40% |
| 66 | 66SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3,1413,141 | $229,199 | — | NEW |
| 67 | 67Virtu Financial LLC | 3,1293,129 | $228,000 | — | ADD 8% |
| 68 | 68BARCLAYS PLC | 3,0773,077 | $224,529 | — | TRIM -68% |
| 69 | 69Vanguard Global Advisers, LLC | 3,0583,058 | $223,142 | — | NEW |
| 70 | 70STRS OHIO | 2,7002,700 | $197,019 | — | ADD 200% |
| 71 | 71NEW YORK STATE COMMON RETIREMENT FUND | 2,6002,600 | $189,722 | — | — |
| 72 | 72WELLS FARGO & COMPANY/MN | 2,5322,532 | $184,760 | — | TRIM -54% |
| 73 | 73Persistent Asset Partners Ltd | 2,3102,310 | $168,561 | — | NEW |
| 74 | 74Aquatic Capital Management LLC | 2,0452,045 | $149,224 | — | NEW |
| 75 | 75Police & Firemen's Retirement System of New Jersey | 2,0362,036 | $148,567 | — | ADD 35% |
| 76 | 76BNP PARIBAS FINANCIAL MARKETS | 1,5711,571 | $114,636 | — | TRIM -94% |
| 77 | 77Russell Investments Group, Ltd. | 882882 | $64,359 | — | TRIM -6% |
| 78 | 78FMR LLC | 819819 | $59,776 | — | TRIM -26% |
| 79 | 79Legal & General Group Plc | 616616 | $44,950 | — | ADD 13% |
| 80 | 80Tower Research Capital LLC (TRC) | 597597 | $43,563 | — | TRIM -45% |
| 81 | 81China Universal Asset Management Co., Ltd. | 500500 | $36,485 | — | NEW |
| 82 | 82Ameritas Investment Partners, Inc. | 470470 | $34,296 | — | — |
| 83 | 83ROYAL BANK OF CANADA | 406406 | $30,000 | — | TRIM -23% |
| 84 | 84CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 380380 | $27,729 | — | ADD 23% |
| 85 | 85CITIGROUP INC | 297297 | $21,574 | — | ADD 161% |
| 86 | 86Sterling Capital Management LLC | 4545 | $3,284 | — | ADD 50% |
| 87 | 87GAMMA Investing LLC | 3333 | $2,408 | — | NEW |
| 88 | 88CWM, LLC | 1111 | $803 | — | ADD 10% |
| 89 | 89Bell Investment Advisors, Inc | 66 | $438 | — | NEW |
| 90 | 90SBI Securities Co., Ltd. | 55 | $365 | — | — |
| 91 | 91Allworth Financial LP | 33 | $219 | — | NEW |
| 92 | 92MAI Capital Management | 11 | $73 | — | NEW |
| 93 | 93TWIN PEAKS WEALTH ADVISORS, LLC | 11 | $73 | — | NEW |