RYTM US Equity

RHYTHM PHARMACEUTICALS, INC.

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Health Care · Pharmaceutical Preparations · CIK 1649904 · FYE 1231

$108.04

+1.91 (+1.80%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding RYTM · 2026-Q1 methodology → sources →

284 holders

% of shares outstanding held

107.4%

Shares held (13F)

73,573,337

Reporting holders

284

Institutional 13F holdings sum to 107.4% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 8,057,652 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 284 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RA CAPITAL MANAGEMENT, L.P.	6,666,8376.7M	$580M	9.73%	—
2	BlackRock, Inc.	6,237,1516.2M	$542M	9.10%	—
3	BAKER BROS. ADVISORS LP	5,604,4835.6M	$487M	8.18%	—
4	PRIMECAP MANAGEMENT CO/CA/	3,417,5093.4M	$297M	4.99%	—
5	VANGUARD PORTFOLIO MANAGEMENT LLC	3,040,7183.0M	$264M	4.44%	NEW†
6	VANGUARD CAPITAL MANAGEMENT LLC	2,967,8253.0M	$258M	4.33%	NEW†
7	PERCEPTIVE ADVISORS LLC	2,373,7952.4M	$206M	3.46%	TRIM -7%
8	STATE STREET CORP	2,271,8512.3M	$198M	3.31%	ADD 3%
9	GOLDMAN SACHS GROUP INC	1,965,4322.0M	$171M	2.87%	ADD 7%
10	WESTFIELD CAPITAL MANAGEMENT CO LP	1,929,1231.9M	$168M	2.81%	ADD 52%
11	FMR LLC	1,689,6711.7M	$147M	2.47%	—
12	PRICE T ROWE ASSOCIATES INC /MD/	1,654,8761.7M	$144M	2.41%	ADD 6%
13	Polar Capital Holdings Plc	1,615,5861.6M	$141M	2.36%	ADD 36%
14	CITADEL ADVISORS LLC	1,418,6191.4M	$123M	2.07%	ADD 825%
15	GEODE CAPITAL MANAGEMENT, LLC	1,416,2691.4M	$123M	2.07%	ADD 3%
16	JPMORGAN CHASE & CO	1,553,6441.6M	$120M	2.27%	ADD 9%
17	FEDERATED HERMES, INC.	1,286,3031.3M	$112M	1.88%	TRIM -21%
18	Checkpoint Capital L.P.	1,227,2001.2M	$107M	1.79%	ADD 24%
19	ALLIANCEBERNSTEIN L.P.	910,413910,413	$97M	1.33%	TRIM -2%
20	Capital Research Global Investors	1,115,4601.1M	$97M	1.63%	ADD 13%
21	JANUS HENDERSON GROUP PLC	918,153918,153	$80M	1.34%	TRIM -18%
22	Point72 Asset Management, L.P.	846,801846,801	$74M	1.24%	ADD 97%
23	Woodline Partners LP	758,891758,891	$66M	1.11%	ADD 10%
24	ADAGE CAPITAL PARTNERS GP, L.L.C.	725,744725,744	$63M	1.06%	ADD 17%
25	Siren, L.L.C.	725,511725,511	$63M	1.06%	ADD 45%
26	MORGAN STANLEY	703,978703,978	$61M	1.03%	ADD 8%
27	Rock Springs Capital Management LP	689,748689,748	$60M	1.01%	—
28	Pictet Asset Management Holding SA	667,046667,046	$57M	0.97%	ADD 9%
29	BANK OF AMERICA CORP /DE/	628,667628,667	$55M	0.92%	ADD 180%
30	FRANKLIN RESOURCES INC	626,845626,845	$55M	0.91%	TRIM -10%
31	Clearbridge Investments, LLC	609,437609,437	$53M	0.89%	ADD 20%
32	Integral Health Asset Management, LLC	600,000600,000	$52M	0.88%	ADD 26%
33	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	541,450541,450	$47M	0.79%	—
34	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	526,459526,459	$46M	0.77%	—
35	NORTHERN TRUST CORP	498,514498,514	$43M	0.73%	ADD 2%
36	LOOMIS SAYLES & CO L P	465,102465,102	$40M	0.68%	TRIM -8%
37	Candriam S.C.A.	464,340464,340	$40M	0.68%	ADD 61%
38	MILLENNIUM MANAGEMENT LLC	451,825451,825	$39M	0.66%	ADD 142%
39	Sofinnova Investments, Inc.	450,096450,096	$39M	0.66%	ADD 66%
40	Logos Global Management LP	450,000450,000	$39M	0.66%	ADD 137%
41	Driehaus Capital Management LLC	436,546436,546	$38M	0.64%	TRIM -66%
42	VANGUARD FIDUCIARY TRUST CO	421,911421,911	$37M	0.62%	NEW
43	Opaleye Management Inc.	123,000123,000	$35M	0.18%	TRIM -63%
44	Artisan Partners Limited Partnership	390,669390,669	$34M	0.57%	ADD 48%
45	AMERIPRISE FINANCIAL INC	383,957383,957	$33M	0.56%	ADD 47%
46	Invesco Ltd.	364,306364,306	$32M	0.53%	ADD 25%
47	LORD, ABBETT & CO. LLC	348,953348,953	$30M	0.51%	TRIM -44%
48	ORBIMED ADVISORS LLC	314,100314,100	$27M	0.46%	ADD 31%
49	BRAIDWELL LP	310,628310,628	$27M	0.45%	NEW
50	SILVERARC CAPITAL MANAGEMENT, LLC	306,000306,000	$27M	0.45%	ADD 125%
51	Bank of New York Mellon Corp	293,298293,298	$26M	0.43%	TRIM -3%
52	Qube Research & Technologies Ltd	277,943277,943	$24M	0.41%	TRIM -11%
53	WELLINGTON MANAGEMENT GROUP LLP	273,757273,757	$24M	0.40%	ADD 9%
54	Squarepoint Ops LLC	262,968262,968	$23M	0.38%	ADD 701%
55	RENAISSANCE TECHNOLOGIES LLC	258,011258,011	$22M	0.38%	TRIM -24%
56	BNP PARIBAS FINANCIAL MARKETS	247,876247,876	$22M	0.36%	ADD 51%
57	Hood River Capital Management LLC	239,912239,912	$21M	0.35%	—
58	VOYA INVESTMENT MANAGEMENT LLC	233,810233,810	$20M	0.34%	TRIM -6%
59	UBS Group AG	231,650231,650	$20M	0.34%	TRIM -46%
60	ADAR1 Capital Management, LLC	211,450211,450	$18M	0.31%	ADD 312%
61	SummitTX Capital, L.P.	165,599165,599	$14M	0.24%	ADD 105%
62	Connor, Clark & Lunn Investment Management Ltd.	151,842151,842	$13M	0.22%	—
63	DEUTSCHE BANK AG\	141,601141,601	$12M	0.21%	ADD 10%
64	M&G PLC	138,567138,567	$12M	0.20%	—
65	PFM Health Sciences, LP	136,621136,621	$12M	0.20%	ADD 240%
66	NEXTBio Capital Management LP	126,078126,078	$11M	0.18%	ADD 87%
67	NEW YORK STATE COMMON RETIREMENT FUND	125,207125,207	$11M	0.18%	ADD 34%
68	Nuveen, LLC	117,376117,376	$10M	0.17%	—
69	SCHRODER INVESTMENT MANAGEMENT GROUP	131,674131,674	$10M	0.19%	NEW
70	Russell Investments Group, Ltd.	115,712115,712	$10M	0.17%	TRIM -14%
71	Capital World Investors	115,693115,693	$10M	0.17%	—
72	Swiss National Bank	112,200112,200	$10M	0.16%	—
73	AXIOM INVESTORS LLC /DE	91,74991,749	$8M	0.13%	ADD 10%
74	First Light Asset Management, LLC	87,18187,181	$8M	0.13%	TRIM -71%
75	FIRST TRUST ADVISORS LP	85,50685,506	$7M	0.12%	TRIM -3%
76	Aberdeen Group plc	79,35779,357	$7M	0.12%	NEW
77	Granahan Investment Management, LLC	77,70977,709	$7M	0.11%	ADD 45%
78	NEUBERGER BERMAN GROUP LLC	73,43473,434	$6M	0.11%	—
79	WCM INVESTMENT MANAGEMENT, LLC	80,62080,620	$6M	0.12%	ADD 80%
80	RHUMBLINE ADVISERS	69,85869,858	$6M	0.10%	—
81	KENNEDY CAPITAL MANAGEMENT LLC	65,81865,818	$6M	0.10%	ADD 65%
82	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	65,80665,806	$6M	0.10%	ADD 23%
83	Universal- Beteiligungs- und Servicegesellschaft mbH	62,93662,936	$5M	0.09%	TRIM -49%
84	Blue Owl Capital Holdings LP	61,45561,455	$5M	0.09%	NEW
85	XTX Topco Ltd	59,50259,502	$5M	0.09%	ADD 470%
86	AQR CAPITAL MANAGEMENT LLC	59,27959,279	$5M	0.09%	TRIM -15%
87	ALGERT GLOBAL LLC	58,51358,513	$5M	0.09%	TRIM -34%
88	Atom Investors LP	57,00057,000	$5M	0.08%	ADD 149%
89	Balyasny Asset Management L.P.	52,96752,967	$5M	0.08%	TRIM -27%
90	CASTLEARK MANAGEMENT LLC	52,27952,279	$5M	0.08%	TRIM -19%
91	SUSQUEHANNA INTERNATIONAL GROUP, LLP	50,78450,784	$4M	0.07%	ADD 1140%
92	MANUFACTURERS LIFE INSURANCE COMPANY, THE	50,76950,769	$4M	0.07%	TRIM -15%
93	PICTON MAHONEY ASSET MANAGEMENT	50,37250,372	$4M	0.07%	NEW
94	Rafferty Asset Management, LLC	50,10550,105	$4M	0.07%	TRIM -10%
95	RAYMOND JAMES FINANCIAL INC	49,92049,920	$4M	0.07%	ADD 21%
96	VANGUARD ASSET MANAGEMENT, Ltd	49,68949,689	$4M	0.07%	NEW
97	Nan Fung Group Holdings Ltd	49,12049,120	$4M	0.07%	—
98	Harvest Investment Services, LLC	48,46848,468	$4M	0.07%	ADD 10%
99	Legal & General Group Plc	47,03247,032	$4M	0.07%	TRIM -15%
100	SILVERCREST ASSET MANAGEMENT GROUP LLC	46,88746,887	$4M	0.07%	ADD 37%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RA CAPITAL MANAGEMENT, L.P.

6.1M

5.6M

5.7M

6.7M

$580M

BlackRock, Inc.

7.0M

6.9M

6.3M

6.2M

$542M

BAKER BROS. ADVISORS LP

6.1M

5.6M

$487M

PRIMECAP MANAGEMENT CO/CA/

6.6M

5.8M

4.9M

4.3M

3.5M

3.4M

$297M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

3.0M

$264M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.0M

$258M

PERCEPTIVE ADVISORS LLC

3.7M

2.5M

2.4M

2.5M

2.4M

$206M

STATE STREET CORP

1.8M

2.0M

1.9M

2.0M

2.2M

2.3M

$198M

GOLDMAN SACHS GROUP INC

1.8M

1.6M

1.7M

1.9M

1.8M

2.0M

$171M

WESTFIELD CAPITAL MANAGEMENT CO LP

—

1.3M

1.6M

1.1M

1.3M

1.9M

$168M

FMR LLC

113K

1.7M

2.0M

2.1M

1.7M

$147M

PRICE T ROWE ASSOCIATES INC /MD/

685K

1.2M

1.3M

1.4M

1.6M

1.7M

$144M

Polar Capital Holdings Plc

1.5M

500K

1.3M

1.2M

1.6M

$141M

CITADEL ADVISORS LLC

40K

70K

—

133K

153K

1.4M

$123M

GEODE CAPITAL MANAGEMENT, LLC

1.3M

1.4M

$123M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	284	73,573,337	107.4%	$6.4B
2025-Q4	279	72,869,652	106.3%	$7.8B
2025-Q3	264	72,075,251	105.2%	$7.3B
2025-Q2	227	66,735,492	97.4%	$4.2B
2025-Q1	228	64,904,723	94.7%	$3.4B
2024-Q4	203	64,921,853	94.7%	$3.6B
2024-Q3	176	67,781,631

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · RYTM

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

RA CAPITAL MANAGEMENT, L.P.

9.9%

Passive

2025-12-31

SEC →

BAKER BROS. ADVISORS LP

8.9%

QII

2025-03-31

SEC →

BlackRock, Inc.

6.9%

QII

2025-03-31

SEC →

PRIMECAP MANAGEMENT CO/CA/

5.21%

QII

2025-12-31

SEC →

PERCEPTIVE ADVISORS LLC

5.1%

Passive

Institutional ownership· 13F filers holding RYTM · 2026-Q1 methodology → sources →

284 holders

% of shares outstanding held

107.4%

Shares held (13F)

73,573,337

Reporting holders

284

Top holders

largest 100 of 284 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RA CAPITAL MANAGEMENT, L.P.	6,666,8376.7M	$580M	9.73%	—
2	BlackRock, Inc.	6,237,1516.2M	$542M	9.10%	—
3	BAKER BROS. ADVISORS LP	5,604,4835.6M	$487M	8.18%	—
4	PRIMECAP MANAGEMENT CO/CA/	3,417,5093.4M	$297M	4.99%	—
5	VANGUARD PORTFOLIO MANAGEMENT LLC	3,040,7183.0M	$264M	4.44%	NEW†
6	VANGUARD CAPITAL MANAGEMENT LLC	2,967,8253.0M	$258M	4.33%	NEW†
7	PERCEPTIVE ADVISORS LLC	2,373,7952.4M	$206M	3.46%	TRIM -7%
8	STATE STREET CORP	2,271,8512.3M	$198M	3.31%	ADD 3%
9	GOLDMAN SACHS GROUP INC	1,965,4322.0M	$171M	2.87%	ADD 7%
10	WESTFIELD CAPITAL MANAGEMENT CO LP	1,929,1231.9M	$168M	2.81%	ADD 52%
11	FMR LLC	1,689,6711.7M	$147M	2.47%	—
12	PRICE T ROWE ASSOCIATES INC /MD/	1,654,8761.7M	$144M	2.41%	ADD 6%
13	Polar Capital Holdings Plc	1,615,5861.6M	$141M	2.36%	ADD 36%
14	CITADEL ADVISORS LLC	1,418,6191.4M	$123M	2.07%	ADD 825%
15	GEODE CAPITAL MANAGEMENT, LLC	1,416,2691.4M	$123M	2.07%	ADD 3%
16	JPMORGAN CHASE & CO	1,553,6441.6M	$120M	2.27%	ADD 9%
17	FEDERATED HERMES, INC.	1,286,3031.3M	$112M	1.88%	TRIM -21%
18	Checkpoint Capital L.P.	1,227,2001.2M	$107M	1.79%	ADD 24%
19	ALLIANCEBERNSTEIN L.P.	910,413910,413	$97M	1.33%	TRIM -2%
20	Capital Research Global Investors	1,115,4601.1M	$97M	1.63%	ADD 13%
21	JANUS HENDERSON GROUP PLC	918,153918,153	$80M	1.34%	TRIM -18%
22	Point72 Asset Management, L.P.	846,801846,801	$74M	1.24%	ADD 97%
23	Woodline Partners LP	758,891758,891	$66M	1.11%	ADD 10%
24	ADAGE CAPITAL PARTNERS GP, L.L.C.	725,744725,744	$63M	1.06%	ADD 17%
25	Siren, L.L.C.	725,511725,511	$63M	1.06%	ADD 45%
26	MORGAN STANLEY	703,978703,978	$61M	1.03%	ADD 8%
27	Rock Springs Capital Management LP	689,748689,748	$60M	1.01%	—
28	Pictet Asset Management Holding SA	667,046667,046	$57M	0.97%	ADD 9%
29	BANK OF AMERICA CORP /DE/	628,667628,667	$55M	0.92%	ADD 180%
30	FRANKLIN RESOURCES INC	626,845626,845	$55M	0.91%	TRIM -10%
31	Clearbridge Investments, LLC	609,437609,437	$53M	0.89%	ADD 20%
32	Integral Health Asset Management, LLC	600,000600,000	$52M	0.88%	ADD 26%
33	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	541,450541,450	$47M	0.79%	—
34	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	526,459526,459	$46M	0.77%	—
35	NORTHERN TRUST CORP	498,514498,514	$43M	0.73%	ADD 2%
36	LOOMIS SAYLES & CO L P	465,102465,102	$40M	0.68%	TRIM -8%
37	Candriam S.C.A.	464,340464,340	$40M	0.68%	ADD 61%
38	MILLENNIUM MANAGEMENT LLC	451,825451,825	$39M	0.66%	ADD 142%
39	Sofinnova Investments, Inc.	450,096450,096	$39M	0.66%	ADD 66%
40	Logos Global Management LP	450,000450,000	$39M	0.66%	ADD 137%
41	Driehaus Capital Management LLC	436,546436,546	$38M	0.64%	TRIM -66%
42	VANGUARD FIDUCIARY TRUST CO	421,911421,911	$37M	0.62%	NEW
43	Opaleye Management Inc.	123,000123,000	$35M	0.18%	TRIM -63%
44	Artisan Partners Limited Partnership	390,669390,669	$34M	0.57%	ADD 48%
45	AMERIPRISE FINANCIAL INC	383,957383,957	$33M	0.56%	ADD 47%
46	Invesco Ltd.	364,306364,306	$32M	0.53%	ADD 25%
47	LORD, ABBETT & CO. LLC	348,953348,953	$30M	0.51%	TRIM -44%
48	ORBIMED ADVISORS LLC	314,100314,100	$27M	0.46%	ADD 31%
49	BRAIDWELL LP	310,628310,628	$27M	0.45%	NEW
50	SILVERARC CAPITAL MANAGEMENT, LLC	306,000306,000	$27M	0.45%	ADD 125%
51	Bank of New York Mellon Corp	293,298293,298	$26M	0.43%	TRIM -3%
52	Qube Research & Technologies Ltd	277,943277,943	$24M	0.41%	TRIM -11%
53	WELLINGTON MANAGEMENT GROUP LLP	273,757273,757	$24M	0.40%	ADD 9%
54	Squarepoint Ops LLC	262,968262,968	$23M	0.38%	ADD 701%
55	RENAISSANCE TECHNOLOGIES LLC	258,011258,011	$22M	0.38%	TRIM -24%
56	BNP PARIBAS FINANCIAL MARKETS	247,876247,876	$22M	0.36%	ADD 51%
57	Hood River Capital Management LLC	239,912239,912	$21M	0.35%	—
58	VOYA INVESTMENT MANAGEMENT LLC	233,810233,810	$20M	0.34%	TRIM -6%
59	UBS Group AG	231,650231,650	$20M	0.34%	TRIM -46%
60	ADAR1 Capital Management, LLC	211,450211,450	$18M	0.31%	ADD 312%
61	SummitTX Capital, L.P.	165,599165,599	$14M	0.24%	ADD 105%
62	Connor, Clark & Lunn Investment Management Ltd.	151,842151,842	$13M	0.22%	—
63	DEUTSCHE BANK AG\	141,601141,601	$12M	0.21%	ADD 10%
64	M&G PLC	138,567138,567	$12M	0.20%	—
65	PFM Health Sciences, LP	136,621136,621	$12M	0.20%	ADD 240%
66	NEXTBio Capital Management LP	126,078126,078	$11M	0.18%	ADD 87%
67	NEW YORK STATE COMMON RETIREMENT FUND	125,207125,207	$11M	0.18%	ADD 34%
68	Nuveen, LLC	117,376117,376	$10M	0.17%	—
69	SCHRODER INVESTMENT MANAGEMENT GROUP	131,674131,674	$10M	0.19%	NEW
70	Russell Investments Group, Ltd.	115,712115,712	$10M	0.17%	TRIM -14%
71	Capital World Investors	115,693115,693	$10M	0.17%	—
72	Swiss National Bank	112,200112,200	$10M	0.16%	—
73	AXIOM INVESTORS LLC /DE	91,74991,749	$8M	0.13%	ADD 10%
74	First Light Asset Management, LLC	87,18187,181	$8M	0.13%	TRIM -71%
75	FIRST TRUST ADVISORS LP	85,50685,506	$7M	0.12%	TRIM -3%
76	Aberdeen Group plc	79,35779,357	$7M	0.12%	NEW
77	Granahan Investment Management, LLC	77,70977,709	$7M	0.11%	ADD 45%
78	NEUBERGER BERMAN GROUP LLC	73,43473,434	$6M	0.11%	—
79	WCM INVESTMENT MANAGEMENT, LLC	80,62080,620	$6M	0.12%	ADD 80%
80	RHUMBLINE ADVISERS	69,85869,858	$6M	0.10%	—
81	KENNEDY CAPITAL MANAGEMENT LLC	65,81865,818	$6M	0.10%	ADD 65%
82	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	65,80665,806	$6M	0.10%	ADD 23%
83	Universal- Beteiligungs- und Servicegesellschaft mbH	62,93662,936	$5M	0.09%	TRIM -49%
84	Blue Owl Capital Holdings LP	61,45561,455	$5M	0.09%	NEW
85	XTX Topco Ltd	59,50259,502	$5M	0.09%	ADD 470%
86	AQR CAPITAL MANAGEMENT LLC	59,27959,279	$5M	0.09%	TRIM -15%
87	ALGERT GLOBAL LLC	58,51358,513	$5M	0.09%	TRIM -34%
88	Atom Investors LP	57,00057,000	$5M	0.08%	ADD 149%
89	Balyasny Asset Management L.P.	52,96752,967	$5M	0.08%	TRIM -27%
90	CASTLEARK MANAGEMENT LLC	52,27952,279	$5M	0.08%	TRIM -19%
91	SUSQUEHANNA INTERNATIONAL GROUP, LLP	50,78450,784	$4M	0.07%	ADD 1140%
92	MANUFACTURERS LIFE INSURANCE COMPANY, THE	50,76950,769	$4M	0.07%	TRIM -15%
93	PICTON MAHONEY ASSET MANAGEMENT	50,37250,372	$4M	0.07%	NEW
94	Rafferty Asset Management, LLC	50,10550,105	$4M	0.07%	TRIM -10%
95	RAYMOND JAMES FINANCIAL INC	49,92049,920	$4M	0.07%	ADD 21%
96	VANGUARD ASSET MANAGEMENT, Ltd	49,68949,689	$4M	0.07%	NEW
97	Nan Fung Group Holdings Ltd	49,12049,120	$4M	0.07%	—
98	Harvest Investment Services, LLC	48,46848,468	$4M	0.07%	ADD 10%
99	Legal & General Group Plc	47,03247,032	$4M	0.07%	TRIM -15%
100	SILVERCREST ASSET MANAGEMENT GROUP LLC	46,88746,887	$4M	0.07%	ADD 37%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RA CAPITAL MANAGEMENT, L.P.

6.1M

5.6M

5.7M

6.7M

$580M

BlackRock, Inc.

7.0M

6.9M

6.3M

6.2M

$542M

BAKER BROS. ADVISORS LP

6.1M

5.6M

$487M

PRIMECAP MANAGEMENT CO/CA/

6.6M

5.8M

4.9M

4.3M

3.5M

3.4M

$297M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

3.0M

$264M

VANGUARD CAPITAL MANAGEMENT LLC

—

3.0M

$258M

PERCEPTIVE ADVISORS LLC

3.7M

2.5M

2.4M

2.5M

2.4M

$206M

STATE STREET CORP

1.8M

2.0M

1.9M

2.0M

2.2M

2.3M

$198M

GOLDMAN SACHS GROUP INC

1.8M

1.6M

1.7M

1.9M

1.8M

2.0M

$171M

WESTFIELD CAPITAL MANAGEMENT CO LP

—

1.3M

1.6M

1.1M

1.3M

1.9M

$168M

FMR LLC

113K

1.7M

2.0M

2.1M

1.7M

$147M

PRICE T ROWE ASSOCIATES INC /MD/

685K

1.2M

1.3M

1.4M

1.6M

1.7M

$144M

Polar Capital Holdings Plc

1.5M

500K

1.3M

1.2M

1.6M

$141M

CITADEL ADVISORS LLC

40K

70K

—

133K

153K

1.4M

$123M

GEODE CAPITAL MANAGEMENT, LLC

1.3M

1.4M

$123M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	284	73,573,337	107.4%	$6.4B
2025-Q4	279	72,869,652	106.3%	$7.8B
2025-Q3	264	72,075,251	105.2%	$7.3B
2025-Q2	227	66,735,492	97.4%	$4.2B
2025-Q1	228	64,904,723	94.7%	$3.4B
2024-Q4	203	64,921,853	94.7%	$3.6B
2024-Q3	176	67,781,631

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · RYTM

Large holders — 13G, passive (top 5 of 8 by % of class)

Holder

% of class

Type

As of

RA CAPITAL MANAGEMENT, L.P.

9.9%

Passive

2025-12-31

SEC →

BAKER BROS. ADVISORS LP

8.9%

QII

2025-03-31

SEC →

BlackRock, Inc.

6.9%

QII

2025-03-31

SEC →

PRIMECAP MANAGEMENT CO/CA/

5.21%

QII

2025-12-31

SEC →

PERCEPTIVE ADVISORS LLC

5.1%

Passive

RYTM US Equity☆

Institutional ownership· 13F filers holding RYTM · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · RYTM

Institutional ownership· 13F filers holding RYTM · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · RYTM

RYTM US Equity