| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | EQT Fund Management S.a r.l. | 4,929,6334.9M | $113M | 13.69% | — |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3,494,6383.5M | $80M | 9.70% | — |
| 3 | Pivotal bioVenture Partners Investment Advisor LLC | 1,926,9431.9M | $44M | 5.35% | — |
| 4 | ANDERA PARTNERS | 1,897,3621.9M | $44M | 5.27% | — |
| 5 | RTW INVESTMENTS, LP | 1,502,2351.5M | $35M | 4.17% | ADD 17% |
| 6 | MPM BIOIMPACT LLC | 1,455,8631.5M | $33M | 4.04% | ADD 1188% |
| 7 | Nan Fung Group Holdings Ltd | 1,441,0321.4M | $33M | 4.00% | — |
| 8 | JPMORGAN CHASE & CO | 1,459,4201.5M | $32M | 4.05% | ADD 11% |
| 9 | SymBiosis Capital Partners, LLC | 1,280,7781.3M | $29M | 3.56% | — |
| 10 | EVENTIDE ASSET MANAGEMENT, LLC | 1,209,1291.2M | $28M | 3.36% | ADD 26% |
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,119,0211.1M | $26M | 3.11% | ADD 43% |
| 12 | JANUS HENDERSON GROUP PLC | 896,700896,700 | $21M | 2.49% | NEW† |
| 13 | MARSHALL WACE, LLP | 879,728879,728 | $20M | 2.44% | TRIM -11% |
| 14 | BAKER BROS. ADVISORS LP | 847,390847,390 | $19M | 2.35% | NEW† |
| 15 | Alyeska Investment Group, L.P. | 726,362726,362 | $17M | 2.02% | NEW† |
| 16 | Defilade Capital Management, L.P. | 678,589678,589 | $16M | 1.88% | ADD 215% |
| 17 | BlackRock, Inc. | 673,571673,571 | $15M | 1.87% | ADD 373% |
| 18 | Kynam Capital Management, LP | 625,496625,496 | $14M | 1.74% | ADD 237% |
| 19 | SECTORAL ASSET MANAGEMENT INC | 589,005589,005 | $14M | 1.64% | — |
| 20 | Verition Fund Management LLC | 549,991549,991 | $13M | 1.53% | TRIM -3% |
| 21 | AMERICAN CENTURY COMPANIES INC | 492,938492,938 | $11M | 1.37% | ADD 18% |
| 22 | VANGUARD CAPITAL MANAGEMENT LLC | 455,051455,051 | $10M | 1.26% | NEW |
| 23 | PERCEPTIVE ADVISORS LLC | 448,350448,350 | $10M | 1.24% | NEW |
| 24 | Velan Capital Investment Management LP | 446,255446,255 | $10M | 1.24% | TRIM -12% |
| 25 | STEMPOINT CAPITAL LP | 387,554387,554 | $9M | 1.08% | ADD 468% |
| 26 | Freestone Grove Partners LP | 337,291337,291 | $8M | 0.94% | NEW |
| 27 | FEDERATED HERMES, INC. | 325,000325,000 | $7M | 0.90% | — |
| 28 | GREAT POINT PARTNERS LLC | 325,000325,000 | $7M | 0.90% | — |
| 29 | UBS Group AG | 298,375298,375 | $7M | 0.83% | ADD 8640% |
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 248,611248,611 | $6M | 0.69% | ADD 126% |
| 31 | E Fund Management Co., Ltd. | 243,700243,700 | $6M | 0.68% | NEW |
| 32 | Integral Health Asset Management, LLC | 225,000225,000 | $5M | 0.62% | ADD 80% |
| 33 | NEXTBio Capital Management LP | 184,063184,063 | $4M | 0.51% | TRIM -19% |
| 34 | ADAR1 Capital Management, LLC | 184,062184,062 | $4M | 0.51% | — |
| 35 | STATE STREET CORP | 179,511179,511 | $4M | 0.50% | ADD 470% |
| 36 | Monashee Investment Management LLC | 179,340179,340 | $4M | 0.50% | TRIM -2% |
| 37 | SEVEN GRAND MANAGERS, LLC | 164,670164,670 | $4M | 0.46% | ADD 120% |
| 38 | GOLDMAN SACHS GROUP INC | 154,323154,323 | $4M | 0.43% | ADD 150% |
| 39 | Octagon Capital Advisors LP | 143,472143,472 | $3M | 0.40% | TRIM -71% |
| 40 | Blue Owl Capital Holdings LP | 100,000100,000 | $2M | 0.28% | NEW |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 94,94894,948 | $2M | 0.26% | ADD 51% |
| 42 | ExodusPoint Capital Management, LP | 93,91393,913 | $2M | 0.26% | NEW |
| 43 | AMERIPRISE FINANCIAL INC | 91,42991,429 | $2M | 0.25% | TRIM -13% |
| 44 | NORTHERN TRUST CORP | 79,75579,755 | $2M | 0.22% | ADD 252% |
| 45 | SPHERA FUNDS MANAGEMENT LTD. | 78,23478,234 | $2M | 0.22% | TRIM -53% |
| 46 | VANGUARD FIDUCIARY TRUST CO | 72,58272,582 | $2M | 0.20% | NEW |
| 47 | VANGUARD PORTFOLIO MANAGEMENT LLC | 60,99360,993 | $1M | 0.17% | NEW |
| 48 | Propel Bio Management, LLC | 55,66455,664 | $1M | 0.15% | NEW |
| 49 | Eversept Partners, LP | 54,68054,680 | $1M | 0.15% | NEW |
| 50 | Hudson Bay Capital Management LP | 51,36451,364 | $1M | 0.14% | NEW |
| 51 | Burkehill Global Management, LP | 50,00050,000 | $1M | 0.14% | — |
| 52 | TD Asset Management Inc | 40,21040,210 | $924,428 | 0.11% | TRIM -10% |
| 53 | Point72 Asset Management, L.P. | 36,57736,577 | $840,905 | 0.10% | ADD 6% |
| 54 | BANK OF AMERICA CORP /DE/ | 30,20130,201 | $694,321 | 0.08% | ADD 928% |
| 55 | Palumbo Wealth Management LLC | 29,93129,931 | $688,114 | 0.08% | NEW |
| 56 | MORGAN STANLEY | 25,07025,070 | $576,360 | 0.07% | ADD 200% |
| 57 | Bank of New York Mellon Corp | 22,09122,091 | $507,872 | 0.06% | NEW |
| 58 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,81212,812 | $294,548 | 0.04% | ADD 25% |
| 59 | Nuveen, LLC | 12,45212,452 | $286,271 | 0.03% | NEW |
| 60 | XTX Topco Ltd | 12,04012,040 | $276,800 | 0.03% | TRIM -36% |
| 61 | RHUMBLINE ADVISERS | 11,82111,821 | $271,758 | 0.03% | NEW |
| 62 | MetLife Investment Management, LLC | 6,0316,031 | $138,653 | 0.02% | NEW |
| 63 | China Universal Asset Management Co., Ltd. | 5,0005,000 | $114,950 | 0.01% | ADD 150% |
| 64 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,8814,881 | $112,214 | 0.01% | NEW |
| 65 | NEW YORK STATE COMMON RETIREMENT FUND | 4,3004,300 | $98,857 | 0.01% | NEW |
| 66 | WELLS FARGO & COMPANY/MN | 3,8673,867 | $88,902 | 0.01% | NEW |
| 67 | Vanguard Global Advisers, LLC | 3,7603,760 | $86,442 | 0.01% | NEW |
| 68 | Police & Firemen's Retirement System of New Jersey | 3,0063,006 | $69,108 | 0.01% | NEW |
| 69 | NATIONAL BANK OF CANADA /FI/ | 2,4002,400 | $55,008 | 0.01% | ADD 9% |
| 70 | Tower Research Capital LLC (TRC) | 2,2492,249 | $51,705 | 0.01% | TRIM -18% |
| 71 | BNP PARIBAS FINANCIAL MARKETS | 2,2002,200 | $50,578 | 0.01% | NEW |
| 72 | BARCLAYS PLC | 1,9781,978 | $45,475 | 0.01% | NEW |
| 73 | STRS OHIO | 1,8001,800 | $41,382 | 0.00% | NEW |
| 74 | FMR LLC | 1,7191,719 | $39,520 | 0.00% | NEW |
| 75 | Plante Moran Financial Advisors, LLC | 1,1471,147 | $26,370 | 0.00% | NEW |
| 76 | Legal & General Group Plc | 919919 | $21,128 | 0.00% | ADD 130% |
| 77 | Ameritas Investment Partners, Inc. | 855855 | $19,656 | 0.00% | NEW |
| 78 | Russell Investments Group, Ltd. | 788788 | $18,116 | 0.00% | NEW |
| 79 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 571571 | $13,127 | 0.00% | NEW |
| 80 | CITIGROUP INC | 518518 | $11,909 | 0.00% | NEW |
| 81 | Sterling Capital Management LLC | 200200 | $4,598 | 0.00% | NEW |
| 82 | OSAIC HOLDINGS, INC. | 8080 | $1,839 | 0.00% | NEW |
| 83 | FIFTH THIRD BANCORP | 2121 | $472 | 0.00% | NEW |
| 84 | CWM, LLC | 77 | $161 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| EQT Fund Management S.a r.l. | — | — | — | — | 4.9M | 4.9M | $113M |
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | — | 3.5M | 3.5M | $80M |
| Pivotal bioVenture Partners Investment Advisor LLC | — | — | — | — | 1.9M | 1.9M | $44M |
| ANDERA PARTNERS | — | — | — | — | 1.9M | 1.9M | $44M |
| RTW INVESTMENTS, LP | — | — | — | — | 1.3M | 1.5M | $35M |
| MPM BIOIMPACT LLC | — | — | — | — | 113K | 1.5M | $33M |
| Nan Fung Group Holdings Ltd | — | — | — | — | 1.4M | 1.4M | $33M |
| JPMORGAN CHASE & CO | — | — | — | — | 1.3M | 1.5M | $32M |
| SymBiosis Capital Partners, LLC | — | — | — | — | 1.3M | 1.3M | $29M |
| EVENTIDE ASSET MANAGEMENT, LLC | — | — | — | — | 962K | 1.2M | $28M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | — | — | 782K | 1.1M | $26M |
| JANUS HENDERSON GROUP PLC | — | — | — | — | — | 897K | $21M |
| MARSHALL WACE, LLP | — | — | — | — | 988K | 880K | $20M |
| BAKER BROS. ADVISORS LP | — | — | — | — | — | 847K | $19M |
| Alyeska Investment Group, L.P. | — | — | — | — | — | 726K | $17M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 84 | 34,770,516 | 96.5% | $798M |
| 2025-Q4 | 59 | 27,200,904 | 86.3% | $466M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| Point72 Asset Management, L.P. | 5.3% | Passive | 2026-07-15 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| MPM BIOIMPACT LLC | +1,342,841 | $31M | ADD |
| JANUS HENDERSON GROUP PLC | +896,700 | $21M | OPEN |
| BAKER BROS. ADVISORS LP | +847,390 | $19M | OPEN |
| Alyeska Investment Group, L.P. | +726,362 | $17M | OPEN |
| BlackRock, Inc. | +531,131 | $12M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| Aberdeen Group plc | −525,376 | $12M | CLOSE |
| VANGUARD GROUP INC | −502,574 | $12M | CLOSE |
| Octagon Capital Advisors LP | −356,528 | $8M | TRIM |
| Sofinnova Investments, Inc. | −153,320 | $4M | CLOSE |
| MARSHALL WACE, LLP | −108,472 | $2M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
