| 1 | 1T. Rowe Price Investment Management, Inc. | 30,785,80130.8M | $558M | — | ADD 51% |
| 2 | 2JANUS HENDERSON GROUP PLC | 13,647,37613.6M | $247M | — | — |
| 3 | 3BlackRock, Inc. | 11,699,87011.7M | $212M | — | ADD 5% |
| 4 | 4Atlas Venture Life Science Advisors, LLC | 9,130,4659.1M | $166M | — | — |
| 5 | 5FMR LLC | 8,908,9808.9M | $162M | — | ADD 36% |
| 6 | 6Orbis Allan Gray Ltd | 6,762,2316.8M | $123M | — | ADD 41% |
| 7 | 7STATE STREET CORP | 6,653,7466.7M | $121M | — | — |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 6,405,0696.4M | $116M | — | NEW† |
| 9 | 9PERCEPTIVE ADVISORS LLC | 4,668,8394.7M | $85M | — | ADD 34% |
| 10 | 10FCPM III SERVICES B.V. | 4,644,3864.6M | $84M | — | TRIM -15% |
| 11 | 11TCG Crossover Management, LLC | 4,615,1444.6M | $84M | — | — |
| 12 | 12VANGUARD PORTFOLIO MANAGEMENT LLC | 4,162,0414.2M | $75M | — | NEW† |
| 13 | 13Vestal Point Capital, LP | 4,000,0004.0M | $73M | — | ADD 3233% |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 3,504,1143.5M | $64M | — | ADD 7% |
| 15 | 15ARMISTICE CAPITAL, LLC | 3,175,1103.2M | $58M | — | TRIM -2% |
| 16 | 16Frazier Life Sciences Management, L.P. | 3,153,0823.2M | $57M | — | — |
| 17 | 17JPMORGAN CHASE & CO | 3,253,4733.3M | $56M | — | TRIM -8% |
| 18 | 18ORBIMED ADVISORS LLC | 2,917,8842.9M | $53M | — | ADD 32% |
| 19 | 19PRICE T ROWE ASSOCIATES INC /MD/ | 2,328,3732.3M | $42M | — | — |
| 20 | 20Siren, L.L.C. | 2,229,1252.2M | $40M | — | TRIM -36% |
| 21 | 21Venrock Adviser, LLC | 2,173,9132.2M | $39M | — | — |
| 22 | 22FRANKLIN RESOURCES INC | 2,009,0822.0M | $36M | — | — |
| 23 | 23Deep Track Capital, LP | 2,000,0002.0M | $36M | — | TRIM -25% |
| 24 | 24SAMLYN CAPITAL, LLC | 1,922,5431.9M | $35M | — | ADD 29% |
| 25 | 25GOLDMAN SACHS GROUP INC | 1,723,1161.7M | $31M | — | TRIM -25% |
| 26 | 26BRAIDWELL LP | 1,681,9981.7M | $30M | — | ADD 14% |
| 27 | 27Palo Alto Investors LP | 1,652,9721.7M | $30M | — | ADD 12% |
| 28 | 28Sofinnova Investments, Inc. | 1,633,8971.6M | $30M | — | TRIM -28% |
| 29 | 29Vivo Capital, LLC | 1,557,4661.6M | $28M | — | TRIM -40% |
| 30 | 30BANK OF AMERICA CORP /DE/ | 1,443,3131.4M | $26M | — | ADD 63% |
| 31 | 31Aberdeen Group plc | 1,430,3841.4M | $26M | — | ADD 29% |
| 32 | 32MPM BIOIMPACT LLC | 1,408,1521.4M | $26M | — | — |
| 33 | 33Logos Global Management LP | 1,400,0001.4M | $25M | — | ADD 12% |
| 34 | 34Fiera Capital Corp | 1,380,6201.4M | $25M | — | NEW |
| 35 | 35Polar Capital Holdings Plc | 1,359,1691.4M | $25M | — | ADD 7% |
| 36 | 36NORTHERN TRUST CORP | 1,198,8381.2M | $22M | — | ADD 10% |
| 37 | 37CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,158,3901.2M | $21M | — | — |
| 38 | 38STEMPOINT CAPITAL LP | 1,012,1501.0M | $18M | — | ADD 21% |
| 39 | 39ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,0001.0M | $18M | — | TRIM -81% |
| 40 | 40Rock Springs Capital Management LP | 972,198972,198 | $18M | — | ADD 6% |
| 41 | 41Saturn V Capital Management LP | 966,609966,609 | $18M | — | TRIM -46% |
| 42 | 42DIMENSIONAL FUND ADVISORS LP | 951,589951,589 | $17M | — | ADD 870% |
| 43 | 43VANGUARD FIDUCIARY TRUST CO | 947,438947,438 | $17M | — | NEW |
| 44 | 44MORGAN STANLEY | 929,003929,003 | $17M | — | TRIM -23% |
| 45 | 45Squarepoint Ops LLC | 834,176834,176 | $15M | — | ADD 227% |
| 46 | 46FRONTIER CAPITAL MANAGEMENT CO LLC | 821,849821,849 | $15M | — | TRIM -28% |
| 47 | 47BAKER BROS. ADVISORS LP | 813,449813,449 | $15M | — | — |
| 48 | 48Nuveen, LLC | 718,333718,333 | $13M | — | ADD 16% |
| 49 | 49ArrowMark Colorado Holdings LLC | 673,949673,949 | $12M | — | TRIM -4% |
| 50 | 50Artisan Partners Limited Partnership | 619,457619,457 | $11M | — | TRIM -5% |
| 51 | 51RENAISSANCE TECHNOLOGIES LLC | 533,600533,600 | $10M | — | ADD 13% |
| 52 | 52TD Asset Management Inc | 529,312529,312 | $10M | — | ADD 26% |
| 53 | 53Ensign Peak Advisors, Inc | 496,590496,590 | $9M | — | — |
| 54 | 54University of Wisconsin Foundation | 484,745484,745 | $9M | — | ADD 16% |
| 55 | 55ALGERT GLOBAL LLC | 454,463454,463 | $8M | — | ADD 68% |
| 56 | 56RAYMOND JAMES FINANCIAL INC | 451,644451,644 | $8M | — | TRIM -15% |
| 57 | 57WASATCH ADVISORS LP | 443,668443,668 | $8M | — | ADD 9% |
| 58 | 58Clearbridge Investments, LLC | 403,225403,225 | $7M | — | — |
| 59 | 59Bank of New York Mellon Corp | 401,616401,616 | $7M | — | ADD 14% |
| 60 | 60UBS Group AG | 380,561380,561 | $7M | — | — |
| 61 | 61NEW YORK STATE COMMON RETIREMENT FUND | 333,497333,497 | $6M | — | ADD 321% |
| 62 | 62Fisher Asset Management, LLC | 323,051323,051 | $6M | — | ADD 29% |
| 63 | 63Catalio Capital Management, LP | 282,954282,954 | $5M | — | TRIM -46% |
| 64 | 64Tetragon Partners GP Ltd | 258,132258,132 | $5M | — | ADD 4% |
| 65 | 65Qube Research & Technologies Ltd | 253,153253,153 | $5M | — | TRIM -39% |
| 66 | 66Invesco Ltd. | 248,941248,941 | $5M | — | ADD 81% |
| 67 | 67UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 239,285239,285 | $4M | — | ADD 12% |
| 68 | 68Swiss National Bank | 228,100228,100 | $4M | — | ADD 3% |
| 69 | 69DEUTSCHE BANK AG\ | 221,123221,123 | $4M | — | ADD 13% |
| 70 | 70CITADEL ADVISORS LLC | 201,144201,144 | $4M | — | TRIM -83% |
| 71 | 71SummitTX Capital, L.P. | 196,188196,188 | $4M | — | TRIM -19% |
| 72 | 72RHUMBLINE ADVISERS | 187,223187,223 | $3M | — | ADD 7% |
| 73 | 73PDT Partners, LLC | 182,986182,986 | $3M | — | — |
| 74 | 74Rafferty Asset Management, LLC | 182,977182,977 | $3M | — | TRIM -22% |
| 75 | 75HighVista Strategies LLC | 182,929182,929 | $3M | — | ADD 207% |
| 76 | 76Neo Ivy Capital Management | 168,753168,753 | $3M | — | TRIM -29% |
| 77 | 77BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 164,887164,887 | $3M | — | — |
| 78 | 78AMERIPRISE FINANCIAL INC | 162,972162,972 | $3M | — | TRIM -18% |
| 79 | 79SPHERA FUNDS MANAGEMENT LTD. | 160,594160,594 | $3M | — | TRIM -59% |
| 80 | 80MILLENNIUM MANAGEMENT LLC | 158,548158,548 | $3M | — | TRIM -82% |
| 81 | 81Burkehill Global Management, LP | 155,000155,000 | $3M | — | — |
| 82 | 82Darwin Wealth Management, LLC | 154,862154,862 | $3M | — | ADD 34% |
| 83 | 83Woodline Partners LP | 149,388149,388 | $3M | — | ADD 24% |
| 84 | 84ALLIANCEBERNSTEIN L.P. | 135,940135,940 | $3M | — | — |
| 85 | 85WELLS FARGO & COMPANY/MN | 145,509145,509 | $3M | — | — |
| 86 | 86CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 139,663139,663 | $3M | — | ADD 16% |
| 87 | 87Aegis Wealth Management LLC | 135,030135,030 | $2M | — | ADD 78% |
| 88 | 88SG Americas Securities, LLC | 112,626112,626 | $2M | — | TRIM -58% |
| 89 | 89SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,724108,724 | $2M | — | ADD 11% |
| 90 | 90Legal & General Group Plc | 96,46296,462 | $2M | — | TRIM -18% |
| 91 | 91Man Group plc | 95,68295,682 | $2M | — | NEW |
| 92 | 92VOYA INVESTMENT MANAGEMENT LLC | 86,60986,609 | $2M | — | — |
| 93 | 93AQR CAPITAL MANAGEMENT LLC | 84,23884,238 | $2M | — | ADD 19% |
| 94 | 94MARSHALL WACE, LLP | 83,14783,147 | $2M | — | TRIM -88% |
| 95 | 95PROFUND ADVISORS LLC | 82,13882,138 | $1M | — | TRIM -5% |
| 96 | 96MOORE CAPITAL MANAGEMENT, LP | 78,76578,765 | $1M | — | NEW |
| 97 | 97TUDOR INVESTMENT CORP ET AL | 77,03177,031 | $1M | — | TRIM -48% |
| 98 | 98MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 75,46975,469 | $1M | — | ADD 6% |
| 99 | 99VANGUARD ASSET MANAGEMENT, Ltd | 73,30873,308 | $1M | — | NEW |
| 100 | 100MetLife Investment Management, LLC | 72,84172,841 | $1M | — | ADD 5% |
