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January 2027 biotech catalysts

registry pull 2026-08-24

101 trial readouts estimated for January 2027.

Primary-completion dates that listed drug and biotech companies filed with ClinicalTrials.gov. They are the sponsor's own estimated windows, revised as a study runs — not announcement or FDA approval dates. A month-only filing counts to the last day it can mean, which is what the “≤” on a countdown says. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-24

Readouts filed for January 2027

soonest first
ReadoutStudySponsorPhaseConditionStatus
2027-01-01in 129 dFirst-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)4568.TDaiichi Sankyo Co., Ltd.Phase 1Breast CancerActive, not recruiting
2027-01-01in 129 dCONVERGE Post-Approval Study (PAS)ATRCAtriCure, Inc.Not applicableChronic Atrial FibrillationActive, not recruiting
2027-01-01in 129 dA Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D MutationINCYIncyte CorporationPhase 1Solid TumorsRecruiting
2027-01-01in 129 dStudy to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOSSIGASIGA TechnologiesPhase 2SmallpoxActive, not recruiting
2027-01-04in 132 dA Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With HeFHAZNAstraZenecaPhase 3Heterozygous Familial HypercholesterolaemiaActive, not recruiting
2027-01-04in 132 dA Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal DiseaseINCYIncyte CorporationPhase 1Renal ImpairmentRecruiting
2027-01-06in 134 dA Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye DiseaseAMGNAmgenPhase 1/2Thyroid Eye DiseaseActive, not recruiting
2027-01-06in 134 dDetermine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)AZNAstraZenecaPhase 3Systemic SclerosisActive, not recruiting
2027-01-06in 134 dA Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell DiseaseBMYBristol-Myers SquibbPhase 1/2Sickle Cell DiseaseRecruiting
2027-01-06in 134 dA Ph1b/2 Study of Axatilimab Monotherapy in Chinese Participants With Recurrent or Refractory cGVHDINCYIncyte CorporationPhase 1/2Graft-Versus-Host DiseaseActive, not recruiting
2027-01-06in 134 dA Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With CemiplimabREGNRegeneron PharmaceuticalsPhase 1Solid TumorsRecruiting
2027-01-07in 135 dStudy of IDE397 in Participants With Solid Tumors Harboring MTAP DeletionIDYAIDEAYA BiosciencesPhase 1Solid TumorsActive, not recruiting
2027-01-07in 135 dStudy of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell DiseaseSNYSanofiPhase 3Sickle Cell DiseaseRecruiting
2027-01-08in 136 dStudy to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular DegenerationOCULOcular Therapeutix, Inc.Phase 3Age-Related Macular DegenerationActive, not recruiting
2027-01-08in 136 dA Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple MyelomaSNYSanofiPhase 2Plasma Cell Myeloma RefractoryRecruiting
2027-01-11in 139 dA Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD EventAZNAstraZenecaPhase 3Cardiovascular DiseaseActive, not recruiting
2027-01-13in 141 dA Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With TezepelumabAZNAstraZenecaPhase 3Chronic RhinosinusitisActive, not recruiting
2027-01-13in 141 dA Study to Learn How the Study Medicine Called PF-08653945 is Taken up Into the Blood in Adults With Overweight or ObesityPFEPfizerPhase 1OverweightNot yet recruiting
2027-01-14in 142 dA Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or ObesityNVONovo Nordisk A/SPhase 2OverweightRecruiting
2027-01-15in 143 dA Study to Evaluate Topical ATR04-484 for EGFRi-Associated Dermal ToxicityAZTRAzitra Inc.Phase 1/2EGFR Inhibitor-associated RashRecruiting
2027-01-15in 143 dIDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal MelanomaIDYAIDEAYA BiosciencesPhase 2/3Metastatic Uveal MelanomaActive, not recruiting
2027-01-15in 143 dEvaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate ResponseMLTXMoonLake Immunotherapeutics AGPhase 3Psoriatic ArthritisRecruiting
2027-01-15in 143 dA Research Study on the Effects of NNC0537-1482 in Participants With Heart FailureNVONovo Nordisk A/SPhase 1Heart FailureRecruiting
2027-01-15in 143 dNatrunix in Combination With Methotrexate for Rheumatoid Arthritis TreatmentXBITXBiotech, Inc.Phase 2Rheumatoid ArthritisNot yet recruiting
2027-01-16in 144 dA Phase 1/2 Study to Investigate CRB-701 in Solid TumorsCRBPCorbus Pharmaceuticals Inc.Phase 1/2Solid TumorsRecruiting
2027-01-18in 146 dSavolitinib Combine With Durvalumab in EGFR Wild-type Locally Advanced or Metastatic NSCLCAZNAstraZenecaPhase 2Lung CancerActive, not recruiting
2027-01-18in 146 dStudy to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.PFEPfizerPhase 3Lower Respiratory Tract IllnessActive, not recruiting
2027-01-19in 147 dA Study to Assess Safety, Tolerability and Drug Levels of Navlimetostat (BMS-986504) in Participants With Advanced Solid TumorsBMYBristol-Myers SquibbPhase 1Solid TumorsRecruiting
2027-01-19in 147 dA First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid TumorsSNYSanofiPhase 1/2Solid TumorsRecruiting
2027-01-20in 148 dA Study to Describe the Persistence With Ozanimod Treatment in Relapsing-Remitting Multiple Sclerosis (RRMS) ParticipantsBMYBristol-Myers SquibbMultiple SclerosisActive, not recruiting
2027-01-20in 148 dSafety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back PainCELZCreative Medical Technology Holdings IncPhase 1/2Chronic Low-back Pain, Degenerative Disc DiseaseActive, not recruiting
2027-01-20in 148 dA Research Study to See How Insulin Icodec Helps People With Type 1 Diabetes Control Their Blood SugarNVONovo Nordisk A/SType 1 DiabetesActive, not recruiting
2027-01-21in 149 dEvaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are OverweightAMGNAmgenPhase 3ObesityActive, not recruiting
2027-01-21in 149 dEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are OverweightAMGNAmgenPhase 3Type 2 Diabetes Mellitus (T2DM), Obesity, OverweightActive, not recruiting
2027-01-21in 149 dA Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or ObesityNVONovo Nordisk A/SPhase 1OverweightRecruiting
2027-01-21in 149 dAn Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis (AD)REGNRegeneron PharmaceuticalsAtopic DermatitisRecruiting
2027-01-21in 149 dStudy to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of UblituximabTGTXTG Therapeutics, Inc.Phase 3Multiple SclerosisRecruiting
2027-01-22in 150 dATGAM General InvestigationPFEPfizerAplastic AnemiaActive, not recruiting
2027-01-23in 151 dEvaluation of Efficacy and Safety of Prolia in Subjects of Male Osteoporosis in Mainland ChinaAMGNAmgenPhase 4OsteoporosisActive, not recruiting
2027-01-24in 152 dKorea Comirnaty Post-marketing SurveillancePFEPfizerCOVID-19Active, not recruiting
2027-01-25in 153 dA Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 DiabetesNVONovo Nordisk A/SPhase 3Type 1 DiabetesRecruiting
2027-01-25in 153 dA Phase 3 Study in India to Describe the Safety and Immunogenicity of RSVpreFPFEPfizerPhase 3Respiratory Syncytial VirusRecruiting
2027-01-25in 153 dEvaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)VRTXVertex Pharmaceuticals IncorporatedPhase 3Diabetic Peripheral Neuropathic PainActive, not recruiting
2027-01-26in 154 dA Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or ObeseNVONovo Nordisk A/SPhase 1OverweightRecruiting
2027-01-27in 155 dA Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or ObesityPFEPfizerPhase 1ObesityActive, not recruiting
2027-01-27in 155 dPacritinib Effectiveness in Real-world SettingsSOBI.STSwedish Orphan BiovitrumMyelofibrosisNot yet recruiting
2027-01-28in 156 dA Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy AdultsMRNAModernaTX, Inc.Phase 3InfluenzaActive, not recruiting
2027-01-29in 157 dA Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and OverweightAZNAstraZenecaPhase 1/2ObesityActive, not recruiting
2027-01-29in 157 dA Study to Investigate the Efficacy and Safety of Volrustomig ± Casdatifan vs Nivolumab + Ipilimumab as 1L Treatment for Advanced ccRCCAZNAstraZenecaPhase 1Renal Cell CarcinomaActive, not recruiting
2027-01-29in 157 dStudy of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC FusionsIDYAIDEAYA BiosciencesPhase 1/2MelanomaRecruiting
2027-01-29in 157 dDisitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2PFESeagen, a wholly owned subsidiary of PfizerPhase 3Urothelial CarcinomaActive, not recruiting
2027-01-30in 158 dA Study to Assess the Safety, Tolerability, Efficacy, and Drug Levels of BMS-986369 (Golcadomide) in Participants With Relapsed or Refractory T-cell Lymphomas in Japan (GOLSEEK-3)BMYBristol-Myers SquibbPhase 1/2Relapsed or Refractory T-cell LymphomasActive, not recruiting
2027-01-30in 158 dA Retrospective Review: Outcomes of the REFLECT™ System for Idiopathic ScoliosisGMEDGlobus Medical IncIdiopathic ScoliosisNot yet recruiting
2027-01-30in 158 dEnhancing Heart Allograft Function With the OCS Heart System TrialTMDXTransMedicsNot applicableHeart TransplantRecruiting
2027-01-30in 158 dEvaluation of Pain Treatment After Total Knee ArthroplastyVRTXVertex Pharmaceuticals IncorporatedPhase 4PainRecruiting
2027-01-31in 159 dLong-term, Extension Study of DS-5141b in Patients With Duchenne Muscular Dystrophy4568.TDaiichi Sankyo Co., Ltd.Phase 2Duchenne Muscular DystrophyActive, not recruiting
Jan 2027≤ 159 dSafety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With MyelofibrosisABBVAbbViePhase 1MyelofibrosisActive, not recruiting
Jan 2027≤ 159 dAn Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's DiseaseABBVAbbVieParkinson's DiseaseActive, not recruiting
Jan 2027≤ 159 dSafety and Efficacy of Upadacitinib in Combination With Topical Corticosteroids in Children From 2 to Less Than 12 Years of Age in Japan With Moderate to Severe Atopic DermatitisABBVAbbViePhase 3Atopic DermatitisActive, not recruiting
Jan 2027≤ 159 dA Study to Assess Change in Sleep Disturbances of Adult Participants With Advanced Parkinson's Disease Receiving Subcutaneous Foslevodopa/FoscarbidopaABBVAbbVieParkinson's DiseaseRecruiting
Jan 2027≤ 159 dA Study to Assess How Intravenous and Subcutaneous Administrations of Risankizumab Moves Through the Body of Healthy Adult ParticipantsABBVAbbViePhase 1Healthy VolunteerRecruiting
Jan 2027≤ 159 dA Study to Assess Adverse Events, Tolerability, and Pharmacokinetics of Subcutaneous Injections of ABBV-295 in Healthy Adult Japanese Participants With Overweight or Obesity.ABBVAbbViePhase 1Healthy VolunteerActive, not recruiting
2027-01-31in 159 dCryoablation for Monomorphic Ventricular TachycardiaADGMAdagio MedicalNot applicableSustained VTActive, not recruiting
Jan 2027≤ 159 dInappropriate Sinus Tachycardia RegistryATRCAtriCure, Inc.Inappropriate Sinus Tachycardia, Postural Tachycardia SyndromeRecruiting
2027-01-31in 159 dA Multicenter Observational Study to Understand the Clinical Characteristics, Treatment Patterns and Access to Novel Therapies of Patients With Diffuse Large B-Cell Lymphoma in the MEA RegionAZNAstraZenecaHematology, Diffused Large B Cell LymphomaRecruiting
2027-01-31in 159 dLung Cancer Screening Implementation Project in the Brazilian Public Health Care System (LUSIP)AZNAstraZenecaLung CancerNot yet recruiting
Jan 2027≤ 159 dPersonal BP - CAI StudyBDXBecton, Dickinson and CompanyNot applicableBlood PressureRecruiting
Jan 2027≤ 159 dThe Continuity StudyBDXBecton, Dickinson and CompanyNot applicableBlood PressureRecruiting
2027-01-31in 159 dA Study to Evaluate the Safety and Efficacy of the Bausch + Lomb Myopia Control Lens for the Correction of Myopic Ametropia and Slowing the Progression of Myopia in ChildrenBLCOBausch & Lomb IncorporatedNot applicableMyopiaRecruiting
2027-01-31in 159 dA Study on the Safety of Deucravacitinib Exposure in Pregnant Women and Their OffspringBMYBristol-Myers SquibbPsoriasisActive, not recruiting
2027-01-31in 159 dSafety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 DiabetesCELZCreative Medical Technology Holdings IncPhase 1/2Type 1 DiabetesRecruiting
Jan 2027≤ 159 dCLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)CGEMCullinan Therapeutics Inc.Phase 1Acute Myeloid LeukemiaRecruiting
Jan 2027≤ 159 dStudy of COYA 302 for the Treatment of ALSCOYACoya TherapeuticsPhase 2/3Amyotrophic Lateral Sclerosis (ALS)Recruiting
Jan 2027≤ 159 dOral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)CPIXCumberland PharmaceuticalsPhase 2Idiopathic Pulmonary FibrosisRecruiting
Jan 2027≤ 159 dSafety, Pharmacokinetics, and Efficacy of AT 1501 in Patients Undergoing Kidney TransplantELDNEledon PharmaceuticalsPhase 1/2Prevention of Rejection in Kidney TransplantRecruiting
Jan 2027≤ 159 dELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast CancerELVNEnliven TherapeuticsPhase 1Breast CancerActive, not recruiting
Jan 2027≤ 159 dA Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX)EWTXEdgewise Therapeutics, Inc.Phase 2Duchenne Muscular DystrophyActive, not recruiting
2027-01-31in 159 dStudy of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid TumorsEXELExelixisPhase 1Renal Cell CarcinomaRecruiting
Jan 2027≤ 159 dStudy of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative ColitisGILDGilead SciencesPhase 2Ulcerative ColitisRecruiting
Jan 2027≤ 159 dKO-2806 Monotherapy and Combination Therapies in Advanced Solid TumorsKURAKura Oncology, Inc.Phase 1Lung CancerRecruiting
Jan 2027≤ 159 dA Study of [18F]LY4214835 in Healthy Volunteers and Participants With CancerLLYEli Lilly and CompanyPhase 1Neoplasms, HealthyRecruiting
Jan 2027≤ 159 dA Study of LY4355756 in Healthy ParticipantsLLYEli Lilly and CompanyPhase 1HealthyNot yet recruiting
Jan 2027≤ 159 dAn Open-Label Study of CTI-1601 in Subjects With Friedreich's AtaxiaLRMRLarimar Therapeutics, Inc.Phase 2Friedreich AtaxiaRecruiting
Jan 2027≤ 159 dPost-Marketing Surveillance of Dehydrated Human Amnion/Chorion Membrane (DHACM) in Non-Ischemic Chronic WoundsMDXGMiMedx Group, Inc.Not applicableDiabetic Foot Ulcer, Venous Leg UlcerRecruiting
Jan 2027≤ 159 dA Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) InhibitorNBIXNeurocrine BiosciencesPhase 4SchizophreniaRecruiting
Jan 2027≤ 159 dA Study of NX-5948 in Adults With Relapsed/Refractory B-cell MalignanciesNRIXNurix Therapeutics, Inc.Phase 1Chronic Lymphocytic LeukemiaRecruiting
Jan 2027≤ 159 dA Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)NUVLNuvalent Inc.Phase 1Solid TumorsRecruiting
Jan 2027≤ 159 dORKA-002-211 A Phase I Study to Evaluate ORKA-002 in Healthy Volunteers Following A Single DoseORKAOruka Therapeutics, Inc.Phase 1Healthy VolunteersActive, not recruiting
Jan 2027≤ 159 dSafety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49PCVXVaxcyte, Inc.Phase 3Pneumococcal DiseaseActive, not recruiting
2027-01-31in 159 dA Study to Look at the Health Outcomes of Patients With COVID-19 and InfluenzaPFEPfizerCOVID-19Active, not recruiting
Jan 2027≤ 159 dRandomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal SeizuresPRAXPraxis Precision MedicinesPhase 3Epilepsy and Seizure DisordersActive, not recruiting
2027-01-31in 159 dPhase 2/3 Clinical Study of QRX003 Lotion in Subjects With Netherton SyndromeQNRXQuoin PharmaceuticalsPhase 2/3Netherton SyndromeRecruiting
Jan 2027≤ 159 dSetrusumab in Pediatric Japanese Subjects With Osteogenesis ImperfectaRAREUltragenyx Pharmaceutical IncPhase 3Osteogenesis ImperfectaActive, not recruiting
Jan 2027≤ 159 dA Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract MalignanciesRCUSArcus Biosciences, Inc.Phase 2Gastrointestinal Tract MalignanciesActive, not recruiting
2027-01-31in 159 dSAD Study in Patients With Parkinson's Disease and Motor FluctuationsSERSerina TherapeuticsPhase 1Parkinson's DiseaseRecruiting
Jan 2027≤ 159 dPhase 1 Study to Evaluate the Safety, Tolerability, PK, and PD of TVB-3567 in Healthy Participants With or Without AcneSGMTSagimet Biosciences Inc.Phase 1AcneRecruiting
Jan 2027≤ 159 dA Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune DiseaseTCRXTScan Therapeutics, Inc.Ulcerative ColitisRecruiting
Jan 2027≤ 159 dAn Open-Label Study of Azetukalner in Major Depressive DisorderXENEXenon Pharmaceuticals Inc.Phase 3Major Depressive DisorderEnrolling by invitation
Jan 2027≤ 159 dPMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip ArthroplastyZBHZimmer BiometOsteoarthritisActive, not recruiting
Jan 2027≤ 159 dZNN Bactiguard Antegrade Femoral Nails PMCF StudyZBHZimmer BiometFemur Fracture, OsteotomyRecruiting
Jan 2027≤ 159 dROSA Knee Intraoperative Planning Flexibility StudyZBHZimmer BiometRheumatoid ArthritisRecruiting

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