Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
← catalyst calendarNCT06858878 · readout in 154 d
Sponsored by Amgen (industry) · AMGN — their whole pipeline →.
Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
1,105actual
Sites
187
Countries
Argentina, Bulgaria, Canada +10
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-03-17 | actual | When the study began enrolling |
| Primary completion | 2027-01-21 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-04-16 | estimated | The whole study's end, after follow-up |
| First posted | 2025-03-05 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-12-31 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Interventions
- Drug: Maridebart cafraglutide — also filed as AMG 133, MariTide
- Drug: Placebo
Primary outcome
what the primary-completion date above is the date OFPercent Change from Baseline in Body Weight at Week 72
measured Baseline and Week 72
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