| 1 | 1BlackRock, Inc. | 13,035,91813.0M | $157M | 17.58% | ADD 9% |
| 2 | 2PRIMECAP MANAGEMENT CO/CA/ | 10,338,02210.3M | $125M | 13.94% | — |
| 3 | 3BVF INC/IL | 7,133,7207.1M | $86M | 9.62% | — |
| 4 | 4RTW INVESTMENTS, LP | 6,777,4616.8M | $82M | 9.14% | — |
| 5 | 5RA CAPITAL MANAGEMENT, L.P. | 4,897,2374.9M | $59M | 6.61% | NEW† |
| 6 | 6STATE STREET CORP | 4,352,0364.4M | $52M | 5.87% | TRIM -3% |
| 7 | 7VANGUARD PORTFOLIO MANAGEMENT LLC | 3,500,3423.5M | $42M | 4.72% | NEW† |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 3,101,6473.1M | $37M | 4.18% | NEW† |
| 9 | 9TCG Crossover Management, LLC | 2,452,1382.5M | $30M | 3.31% | — |
| 10 | 10EcoR1 Capital, LLC | 2,183,0002.2M | $26M | 2.94% | TRIM -33% |
| 11 | 11GEODE CAPITAL MANAGEMENT, LLC | 1,815,5771.8M | $22M | 2.45% | ADD 4% |
| 12 | 12PRICE T ROWE ASSOCIATES INC /MD/ | 1,560,4201.6M | $19M | 2.10% | TRIM -3% |
| 13 | 13MORGAN STANLEY | 1,558,2901.6M | $19M | 2.10% | ADD 3% |
| 14 | 14DIMENSIONAL FUND ADVISORS LP | 1,294,8871.3M | $16M | 1.75% | ADD 4% |
| 15 | 15BAKER BROS. ADVISORS LP | 1,102,1061.1M | $13M | 1.49% | — |
| 16 | 16UBS Group AG | 1,082,4191.1M | $13M | 1.46% | ADD 70% |
| 17 | 17Legal & General Group Plc | 1,066,7801.1M | $13M | 1.44% | TRIM -18% |
| 18 | 18TWO SIGMA INVESTMENTS, LP | 805,421805,421 | $10M | 1.09% | ADD 200% |
| 19 | 19GOLDMAN SACHS GROUP INC | 763,793763,793 | $9M | 1.03% | — |
| 20 | 20JOHNSON & JOHNSON | 748,062748,062 | $9M | 1.01% | — |
| 21 | 21NORTHERN TRUST CORP | 744,519744,519 | $9M | 1.00% | ADD 10% |
| 22 | 22Jefferies Financial Group Inc. | 720,440720,440 | $9M | 0.97% | — |
| 23 | 23CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 696,854696,854 | $8M | 0.94% | — |
| 24 | 24PANAGORA ASSET MANAGEMENT INC | 620,756620,756 | $7M | 0.84% | ADD 6% |
| 25 | 25MILLENNIUM MANAGEMENT LLC | 609,788609,788 | $7M | 0.82% | ADD 3% |
| 26 | 26Lynx1 Capital Management LP | 536,398536,398 | $6M | 0.72% | TRIM -24% |
| 27 | 27TORONTO DOMINION BANK | 491,000491,000 | $6M | 0.66% | — |
| 28 | 28Hudson Bay Capital Management LP | 487,320487,320 | $6M | 0.66% | ADD 15% |
| 29 | 29VANGUARD FIDUCIARY TRUST CO | 471,076471,076 | $6M | 0.64% | NEW |
| 30 | 30Erste Asset Management GmbH | 430,200430,200 | $5M | 0.58% | TRIM -10% |
| 31 | 31Bank of New York Mellon Corp | 395,941395,941 | $5M | 0.53% | TRIM -4% |
| 32 | 32CITADEL ADVISORS LLC | 377,699377,699 | $5M | 0.51% | ADD 17% |
| 33 | 33BANK OF AMERICA CORP /DE/ | 366,093366,093 | $4M | 0.49% | TRIM -42% |
| 34 | 34PRINCIPAL FINANCIAL GROUP INC | 347,078347,078 | $4M | 0.47% | — |
| 35 | 35JACOBS LEVY EQUITY MANAGEMENT, INC | 293,080293,080 | $4M | 0.40% | ADD 13% |
| 36 | 36ACADIAN ASSET MANAGEMENT LLC | 291,624291,624 | $4M | 0.39% | TRIM -29% |
| 37 | 37Nantahala Capital Management, LLC | 264,639264,639 | $3M | 0.36% | ADD 61% |
| 38 | 38Invesco Ltd. | 263,844263,844 | $3M | 0.36% | — |
| 39 | 39Public Sector Pension Investment Board | 255,472255,472 | $3M | 0.34% | ADD 3% |
| 40 | 40Velan Capital Investment Management LP | 250,000250,000 | $3M | 0.34% | NEW |
| 41 | 41DEUTSCHE BANK AG\ | 223,669223,669 | $3M | 0.30% | ADD 3% |
| 42 | 42BARCLAYS PLC | 218,354218,354 | $3M | 0.29% | TRIM -39% |
| 43 | 43NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200,000200,000 | $2M | 0.27% | — |
| 44 | 44JPMORGAN CHASE & CO | 201,890201,890 | $2M | 0.27% | TRIM -34% |
| 45 | 45AMERICAN CENTURY COMPANIES INC | 175,177175,177 | $2M | 0.24% | — |
| 46 | 46RHUMBLINE ADVISERS | 170,461170,461 | $2M | 0.23% | ADD 3% |
| 47 | 47AQR CAPITAL MANAGEMENT LLC | 162,415162,415 | $2M | 0.22% | ADD 45% |
| 48 | 48Susquehanna Portfolio Strategies, LLC | 138,124138,124 | $2M | 0.19% | TRIM -28% |
| 49 | 49Nuveen, LLC | 134,778134,778 | $2M | 0.18% | — |
| 50 | 50AMERIPRISE FINANCIAL INC | 128,558128,558 | $2M | 0.17% | TRIM -5% |
| 51 | 51UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 121,342121,342 | $1M | 0.16% | — |
| 52 | 52FMR LLC | 111,891111,891 | $1M | 0.15% | ADD 20% |
| 53 | 53GSA CAPITAL PARTNERS LLP | 106,699106,699 | $1M | 0.14% | ADD 657% |
| 54 | 54WINTON GROUP Ltd | 104,713104,713 | $1M | 0.14% | ADD 19% |
| 55 | 55CITIGROUP INC | 104,299104,299 | $1M | 0.14% | TRIM -7% |
| 56 | 56DCF Advisers, LLC | 103,736103,736 | $1M | 0.14% | TRIM -33% |
| 57 | 57VOLORIDGE INVESTMENT MANAGEMENT, LLC | 102,987102,987 | $1M | 0.14% | ADD 17% |
| 58 | 58Swiss National Bank | 98,80098,800 | $1M | 0.13% | TRIM -17% |
| 59 | 59Essex LLC | 98,66198,661 | $1M | 0.13% | — |
| 60 | 60Man Group plc | 93,69493,694 | $1M | 0.13% | ADD 391% |
| 61 | 61ADAR1 Capital Management, LLC | 93,66593,665 | $1M | 0.13% | ADD 67% |
| 62 | 62XTX Topco Ltd | 92,09892,098 | $1M | 0.12% | ADD 188% |
| 63 | 63ALLIANCEBERNSTEIN L.P. | 72,09072,090 | $1M | 0.10% | — |
| 64 | 64Russell Investments Group, Ltd. | 82,53482,534 | $995,371 | 0.11% | ADD 75% |
| 65 | 65MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,89980,899 | $975,642 | 0.11% | TRIM -2% |
| 66 | 66ALGERT GLOBAL LLC | 80,49080,490 | $971,000 | 0.11% | TRIM -35% |
| 67 | 67Seven Fleet Capital Management LP | 80,00080,000 | $964,800 | 0.11% | TRIM -27% |
| 68 | 68Rafferty Asset Management, LLC | 75,58075,580 | $911,495 | 0.10% | TRIM -23% |
| 69 | 69PRUDENTIAL FINANCIAL INC | 74,19074,190 | $894,731 | 0.10% | ADD 10% |
| 70 | 70NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 68,18768,187 | $822,000 | 0.09% | TRIM -3% |
| 71 | 71SG Americas Securities, LLC | 67,56667,566 | $815,000 | 0.09% | TRIM -47% |
| 72 | 72TD Asset Management Inc | 62,17462,174 | $749,818 | 0.08% | TRIM -20% |
| 73 | 73Thrivent Financial for Lutherans | 61,27361,273 | $739,000 | 0.08% | TRIM -26% |
| 74 | 74ALPS ADVISORS INC | 59,70259,702 | $720,006 | 0.08% | — |
| 75 | 75HRT FINANCIAL LP | 59,70759,707 | $720,000 | 0.08% | NEW |
| 76 | 76HSBC HOLDINGS PLC | 58,57958,579 | $717,007 | 0.08% | ADD 40% |
| 77 | 77INTECH INVESTMENT MANAGEMENT LLC | 58,76758,767 | $708,730 | 0.08% | TRIM -17% |
| 78 | 78CANADA LIFE ASSURANCE Co | 57,16457,164 | $689,000 | 0.08% | — |
| 79 | 79Quantinno Capital Management LP | 57,07757,077 | $688,349 | 0.08% | ADD 21% |
| 80 | 80OP Asset Management Ltd | 55,08255,082 | $664,289 | 0.07% | NEW |
| 81 | 81HighVista Strategies LLC | 53,04553,045 | $639,723 | 0.07% | NEW |
| 82 | 82DRW Securities, LLC | 48,44248,442 | $584,210 | 0.07% | NEW |
| 83 | 83ExodusPoint Capital Management, LP | 48,07348,073 | $579,760 | 0.06% | NEW |
| 84 | 84Trexquant Investment LP | 44,49144,491 | $536,561 | 0.06% | TRIM -75% |
| 85 | 85TUDOR INVESTMENT CORP ET AL | 43,81843,818 | $528,445 | 0.06% | ADD 26% |
| 86 | 86Campbell & CO Investment Adviser LLC | 43,52643,526 | $524,924 | 0.06% | NEW |
| 87 | 87Brevan Howard Capital Management LP | 42,68442,684 | $514,769 | 0.06% | ADD 85% |
| 88 | 88Inspire Investing, LLC | 42,52942,529 | $512,898 | 0.06% | ADD 39% |
| 89 | 89Linden Thomas Advisory Services, LLC | 42,08442,084 | $507,533 | 0.06% | ADD 3% |
| 90 | 90FRANKLIN RESOURCES INC | 41,18441,184 | $496,679 | 0.06% | — |
| 91 | 91CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,07041,070 | $495,304 | 0.06% | TRIM -30% |
| 92 | 92MetLife Investment Management, LLC | 39,71539,715 | $478,963 | 0.05% | — |
| 93 | 93CIBC Bancorp USA Inc. | 38,63838,638 | $465,974 | 0.05% | NEW |
| 94 | 94MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,28438,284 | $457,972 | 0.05% | — |
| 95 | 95STATE OF WISCONSIN INVESTMENT BOARD | 37,23637,236 | $449,066 | 0.05% | TRIM -4% |
| 96 | 96PROFUND ADVISORS LLC | 36,85536,855 | $444,471 | 0.05% | TRIM -16% |
| 97 | 97State of Alaska, Department of Revenue | 35,25035,250 | $425,000 | 0.05% | TRIM -3% |
| 98 | 98Louisiana State Employees Retirement System | 31,70031,700 | $382,302 | 0.04% | TRIM -3% |
| 99 | 99VANGUARD ASSET MANAGEMENT, Ltd | 31,39331,393 | $378,600 | 0.04% | NEW |
| 100 | 100Cerity Partners LLC | 30,51230,512 | $367,975 | 0.04% | TRIM -3% |
