| 1 | 1RTW INVESTMENTS, LP | 6,576,3066.6M | $35M | 7.48% | — |
| 2 | 2BlackRock, Inc. | 6,194,9256.2M | $33M | 7.05% | ADD 30% |
| 3 | 3Deep Track Capital, LP | 5,740,8505.7M | $30M | 6.53% | — |
| 4 | 4ARMISTICE CAPITAL, LLC | 4,592,0004.6M | $24M | 5.23% | ADD 30% |
| 5 | 5Nantahala Capital Management, LLC | 3,584,8203.6M | $19M | 4.08% | ADD 676% |
| 6 | 6STATE STREET CORP | 3,516,6513.5M | $19M | 4.00% | ADD 9% |
| 7 | 7VANGUARD CAPITAL MANAGEMENT LLC | 3,322,7703.3M | $18M | 3.78% | NEW† |
| 8 | 8Stonepine Capital Management, LLC | 3,302,3003.3M | $18M | 3.76% | ADD 21% |
| 9 | 9Foresite Capital Management VI LLC | 3,146,6313.1M | $17M | 3.58% | — |
| 10 | 10MILLENNIUM MANAGEMENT LLC | 2,411,9652.4M | $13M | 2.74% | ADD 334% |
| 11 | 11CITADEL ADVISORS LLC | 2,308,6692.3M | $12M | 2.63% | — |
| 12 | 12MORGAN STANLEY | 2,247,2732.2M | $12M | 2.56% | ADD 20% |
| 13 | 13Rosalind Advisors, Inc. | 2,138,4752.1M | $11M | 2.43% | ADD 20% |
| 14 | 14Alyeska Investment Group, L.P. | 2,050,0002.0M | $11M | 2.33% | NEW† |
| 15 | 15AIGH Capital Management LLC | 2,000,0002.0M | $11M | 2.28% | NEW† |
| 16 | 16GEODE CAPITAL MANAGEMENT, LLC | 1,717,5571.7M | $9M | 1.95% | ADD 23% |
| 17 | 17J. Goldman & Co LP | 1,680,7521.7M | $9M | 1.91% | ADD 77% |
| 18 | 18GOLDMAN SACHS GROUP INC | 1,484,0031.5M | $8M | 1.69% | — |
| 19 | 19Qube Research & Technologies Ltd | 1,476,0281.5M | $8M | 1.68% | ADD 479% |
| 20 | 20ACORN CAPITAL ADVISORS, LLC | 1,469,1531.5M | $8M | 1.67% | — |
| 21 | 21NEXTBio Capital Management LP | 1,306,8001.3M | $7M | 1.49% | — |
| 22 | 22FRANKLIN RESOURCES INC | 1,105,8851.1M | $6M | 1.26% | ADD 19% |
| 23 | 23Logos Global Management LP | 1,000,0001.0M | $5M | 1.14% | TRIM -41% |
| 24 | 24Ishara Investments LP | 820,000820,000 | $4M | 0.93% | ADD 204% |
| 25 | 25Longaeva Partners L.P. | 807,755807,755 | $4M | 0.92% | NEW |
| 26 | 26VANGUARD PORTFOLIO MANAGEMENT LLC | 756,875756,875 | $4M | 0.86% | NEW |
| 27 | 27TWO SIGMA INVESTMENTS, LP | 667,010667,010 | $4M | 0.76% | ADD 40% |
| 28 | 28Exome Asset Management LLC | 636,700636,700 | $3M | 0.72% | ADD 58% |
| 29 | 29BAKER BROS. ADVISORS LP | 584,757584,757 | $3M | 0.67% | NEW |
| 30 | 30JANE STREET GROUP, LLC | 570,618570,618 | $3M | 0.65% | ADD 78% |
| 31 | 31Jefferies Financial Group Inc. | 556,016556,016 | $3M | 0.63% | — |
| 32 | 32UBS Group AG | 543,689543,689 | $3M | 0.62% | ADD 8% |
| 33 | 33NORTHERN TRUST CORP | 515,786515,786 | $3M | 0.59% | ADD 31% |
| 34 | 34Pinnacle Financial Partners, Inc. | 495,266495,266 | $3M | 0.56% | ADD 27% |
| 35 | 35VANGUARD FIDUCIARY TRUST CO | 494,694494,694 | $3M | 0.56% | NEW |
| 36 | 36FMR LLC | 473,657473,657 | $3M | 0.54% | ADD 19% |
| 37 | 37TORONTO DOMINION BANK | 460,413460,413 | $2M | 0.52% | — |
| 38 | 38BANK OF AMERICA CORP /DE/ | 416,985416,985 | $2M | 0.47% | ADD 32% |
| 39 | 39Balyasny Asset Management L.P. | 409,779409,779 | $2M | 0.47% | TRIM -87% |
| 40 | 40XTX Topco Ltd | 395,834395,834 | $2M | 0.45% | ADD 202% |
| 41 | 41CANTOR FITZGERALD, L. P. | 363,132363,132 | $2M | 0.41% | ADD 759% |
| 42 | 42Y-Intercept (Hong Kong) Ltd | 345,571345,571 | $2M | 0.39% | TRIM -5% |
| 43 | 43SPHERA FUNDS MANAGEMENT LTD. | 343,678343,678 | $2M | 0.39% | — |
| 44 | 44ALGERT GLOBAL LLC | 305,246305,246 | $2M | 0.35% | ADD 2675% |
| 45 | 45Torray Investment Partners LLC | 298,958298,958 | $2M | 0.34% | ADD 38% |
| 46 | 46Squarepoint Ops LLC | 270,553270,553 | $1M | 0.31% | — |
| 47 | 47Palo Alto Investors LP | 246,093246,093 | $1M | 0.28% | NEW |
| 48 | 48PANAGORA ASSET MANAGEMENT INC | 244,103244,103 | $1M | 0.28% | — |
| 49 | 49Hennion & Walsh Asset Management, Inc. | 221,323221,323 | $1M | 0.25% | ADD 27% |
| 50 | 50SG Americas Securities, LLC | 215,004215,004 | $1M | 0.24% | TRIM -45% |
| 51 | 51Ikarian Capital, LLC | 213,865213,865 | $1M | 0.24% | — |
| 52 | 52Nuveen, LLC | 206,096206,096 | $1M | 0.23% | ADD 9% |
| 53 | 53RAYMOND JAMES FINANCIAL INC | 199,003199,003 | $1M | 0.23% | — |
| 54 | 54CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 196,501196,501 | $1M | 0.22% | ADD 22% |
| 55 | 55ExodusPoint Capital Management, LP | 183,976183,976 | $975,073 | 0.21% | ADD 75% |
| 56 | 56Bank of New York Mellon Corp | 161,707161,707 | $857,046 | 0.18% | ADD 32% |
| 57 | 57WELLINGTON MANAGEMENT GROUP LLP | 151,240151,240 | $801,572 | 0.17% | ADD 4% |
| 58 | 58Birchview Capital, LP | 150,000150,000 | $795,000 | 0.17% | — |
| 59 | 59PRELUDE CAPITAL MANAGEMENT, LLC | 144,719144,719 | $767,011 | 0.16% | ADD 95% |
| 60 | 60Seven Fleet Capital Management LP | 123,400123,400 | $654,020 | 0.14% | ADD 715% |
| 61 | 61Jump Financial, LLC | 118,473118,473 | $627,906 | 0.13% | NEW |
| 62 | 62Susquehanna Portfolio Strategies, LLC | 114,891114,891 | $608,922 | 0.13% | NEW |
| 63 | 63ROYAL BANK OF CANADA | 110,729110,729 | $587,000 | 0.13% | ADD 15% |
| 64 | 64Rafferty Asset Management, LLC | 109,123109,123 | $578,352 | 0.12% | TRIM -16% |
| 65 | 65Invesco Ltd. | 104,049104,049 | $551,460 | 0.12% | — |
| 66 | 66Knott David M Jr | 104,000104,000 | $551,200 | 0.12% | NEW |
| 67 | 67Quarry LP | 100,000100,000 | $530,000 | 0.11% | ADD 270% |
| 68 | 68ALLIANCEBERNSTEIN L.P. | 67,27067,270 | $519,324 | 0.08% | — |
| 69 | 69Man Group plc | 96,83396,833 | $513,215 | 0.11% | NEW |
| 70 | 70SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,76091,760 | $486,328 | 0.10% | TRIM -36% |
| 71 | 71BARCLAYS PLC | 90,30090,300 | $478,591 | 0.10% | TRIM -55% |
| 72 | 72Quantinno Capital Management LP | 74,28574,285 | $393,710 | 0.08% | NEW |
| 73 | 73RHUMBLINE ADVISERS | 71,97371,973 | $381,451 | 0.08% | ADD 19% |
| 74 | 74ADAR1 Capital Management, LLC | 71,10071,100 | $376,830 | 0.08% | NEW |
| 75 | 75BOOTHBAY FUND MANAGEMENT, LLC | 68,54168,541 | $363,267 | 0.08% | — |
| 76 | 76Graham Capital Management, L.P. | 67,06567,065 | $355,445 | 0.08% | ADD 186% |
| 77 | 77AQR CAPITAL MANAGEMENT LLC | 66,06566,065 | $350,143 | 0.08% | ADD 35% |
| 78 | 78DEUTSCHE BANK AG\ | 62,80462,804 | $332,862 | 0.07% | ADD 38% |
| 79 | 79Quadrature Capital Ltd | 52,09852,098 | $276,119 | 0.06% | NEW |
| 80 | 80Brevan Howard Capital Management LP | 51,15851,158 | $270,882 | 0.06% | ADD 103% |
| 81 | 81PROFUND ADVISORS LLC | 48,76148,761 | $258,433 | 0.06% | ADD 2% |
| 82 | 82PRICE T ROWE ASSOCIATES INC /MD/ | 46,82746,827 | $249,000 | 0.05% | ADD 72% |
| 83 | 83WINTON GROUP Ltd | 46,20046,200 | $244,860 | 0.05% | NEW |
| 84 | 84Cetera Investment Advisers | 43,34643,346 | $229,734 | 0.05% | — |
| 85 | 85Aquatic Capital Management LLC | 42,88042,880 | $227,264 | 0.05% | ADD 39% |
| 86 | 86Vanguard Global Advisers, LLC | 42,70142,701 | $226,315 | 0.05% | NEW |
| 87 | 87ENVESTNET ASSET MANAGEMENT INC | 42,39242,392 | $224,678 | 0.05% | — |
| 88 | 88HSBC HOLDINGS PLC | 39,39039,390 | $209,752 | 0.04% | NEW |
| 89 | 89STIFEL FINANCIAL CORP | 38,89138,891 | $206,127 | 0.04% | TRIM -2% |
| 90 | 90MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,00739,007 | $203,322 | 0.04% | ADD 21% |
| 91 | 91Dauntless Investment Group, LLC | 36,75036,750 | $194,775 | 0.04% | NEW |
| 92 | 92Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 36,17036,170 | $191,701 | 0.04% | NEW |
| 93 | 93FOX RUN MANAGEMENT, L.L.C. | 39,00439,004 | $189,169 | 0.04% | TRIM -32% |
| 94 | 94MetLife Investment Management, LLC | 32,95832,958 | $174,677 | 0.04% | ADD 14% |
| 95 | 95CANADA PENSION PLAN INVESTMENT BOARD | 32,60032,600 | $172,780 | 0.04% | ADD 161% |
| 96 | 96WELLS FARGO & COMPANY/MN | 30,08630,086 | $159,456 | 0.03% | TRIM -52% |
| 97 | 97MIZUHO SECURITIES USA LLC | 30,00030,000 | $159,000 | 0.03% | NEW |
| 98 | 98LOS ANGELES CAPITAL MANAGEMENT LLC | 29,52029,520 | $156,456 | 0.03% | NEW |
| 99 | 99Virtus Investment Advisers, LLC | 28,37428,374 | $150,382 | 0.03% | ADD 2% |
| 100 | 100D. E. Shaw & Co., Inc. | 26,65926,659 | $141,293 | 0.03% | TRIM -92% |