| 1 | 1RA CAPITAL MANAGEMENT, L.P. | 23,555,64823.6M | $105M | 8.20% | — |
| 2 | 2GOLDMAN SACHS GROUP INC | 22,369,64522.4M | $100M | 7.78% | ADD 63% |
| 3 | 3Avoro Capital Advisors LLC | 21,700,00021.7M | $97M | 7.55% | — |
| 4 | 4BlackRock, Inc. | 18,365,60818.4M | $82M | 6.39% | — |
| 5 | 5Vestal Point Capital, LP | 18,000,00018.0M | $80M | 6.26% | ADD 31% |
| 6 | 6MORGAN STANLEY | 17,965,37118.0M | $80M | 6.25% | — |
| 7 | 7FMR LLC | 14,321,25514.3M | $64M | 4.98% | ADD 6% |
| 8 | 8RTW INVESTMENTS, LP | 13,680,24813.7M | $61M | 4.76% | TRIM -17% |
| 9 | 9STATE STREET CORP | 11,209,07811.2M | $50M | 3.90% | ADD 4% |
| 10 | 10VANGUARD CAPITAL MANAGEMENT LLC | 10,231,50210.2M | $46M | 3.56% | NEW† |
| 11 | 11Octagon Capital Advisors LP | 8,859,9118.9M | $40M | 3.08% | — |
| 12 | 12Siren, L.L.C. | 8,829,9138.8M | $39M | 3.07% | TRIM -13% |
| 13 | 13Polar Capital Holdings Plc | 5,654,3405.7M | $25M | 1.97% | TRIM -29% |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 5,531,9555.5M | $25M | 1.93% | ADD 3% |
| 15 | 15GordonMD Global Investments LP | 737,550737,550 | $22M | 0.26% | TRIM -45% |
| 16 | 16D. E. Shaw & Co., Inc. | 4,427,3014.4M | $20M | 1.54% | ADD 10% |
| 17 | 17BAKER BROS. ADVISORS LP | 4,004,7564.0M | $18M | 1.39% | — |
| 18 | 18MILLENNIUM MANAGEMENT LLC | 3,281,8203.3M | $15M | 1.14% | ADD 3% |
| 19 | 19Casdin Capital, LLC | 3,250,0003.3M | $15M | 1.13% | ADD 117% |
| 20 | 20ADAR1 Capital Management, LLC | 2,979,4293.0M | $13M | 1.04% | ADD 19% |
| 21 | 21HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 2,883,3012.9M | $13M | 1.00% | TRIM -23% |
| 22 | 22DEERFIELD MANAGEMENT COMPANY, L.P. | 2,722,1652.7M | $12M | 0.95% | — |
| 23 | 23BARCLAYS PLC | 2,812,0102.8M | $11M | 0.98% | TRIM -49% |
| 24 | 24SG Americas Securities, LLC | 2,176,7422.2M | $10M | 0.76% | ADD 179% |
| 25 | 25VANGUARD PORTFOLIO MANAGEMENT LLC | 2,022,4982.0M | $9M | 0.70% | NEW |
| 26 | 26RICE HALL JAMES & ASSOCIATES, LLC | 1,944,6711.9M | $9M | 0.68% | ADD 53% |
| 27 | 27NORTHERN TRUST CORP | 1,814,3181.8M | $8M | 0.63% | ADD 47% |
| 28 | 28CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,808,5991.8M | $8M | 0.63% | TRIM -5% |
| 29 | 29B Group, Inc. | 1,800,5561.8M | $8M | 0.63% | — |
| 30 | 30BANK OF AMERICA CORP /DE/ | 1,677,0461.7M | $7M | 0.58% | ADD 45% |
| 31 | 31VANGUARD FIDUCIARY TRUST CO | 1,530,4611.5M | $7M | 0.53% | NEW |
| 32 | 32Palo Alto Investors LP | 1,391,3821.4M | $6M | 0.48% | ADD 18% |
| 33 | 33Aberdeen Group plc | 1,021,0631.0M | $5M | 0.36% | — |
| 34 | 34Affinity Asset Advisors, LLC | 1,000,0001.0M | $4M | 0.35% | TRIM -70% |
| 35 | 35Granahan Investment Management, LLC | 883,241883,241 | $4M | 0.31% | ADD 25% |
| 36 | 36Quantum Private Wealth, LLC | 849,212849,212 | $4M | 0.30% | ADD 4% |
| 37 | 37TWO SIGMA INVESTMENTS, LP | 742,081742,081 | $3M | 0.26% | ADD 111% |
| 38 | 38Sands Capital Alternatives, LLC | 724,873724,873 | $3M | 0.25% | — |
| 39 | 39JPMORGAN CHASE & CO | 754,782754,782 | $3M | 0.26% | TRIM -3% |
| 40 | 40WELLINGTON MANAGEMENT GROUP LLP | 626,361626,361 | $3M | 0.22% | TRIM -12% |
| 41 | 41Seven Fleet Capital Management LP | 625,708625,708 | $3M | 0.22% | ADD 274% |
| 42 | 42Bank of New York Mellon Corp | 608,123608,123 | $3M | 0.21% | TRIM -3% |
| 43 | 43Nuveen, LLC | 549,153549,153 | $2M | 0.19% | — |
| 44 | 44UBS Group AG | 517,698517,698 | $2M | 0.18% | ADD 35% |
| 45 | 45Woodline Partners LP | 513,828513,828 | $2M | 0.18% | ADD 3% |
| 46 | 46VOYA INVESTMENT MANAGEMENT LLC | 511,983511,983 | $2M | 0.18% | ADD 135% |
| 47 | 47DIMENSIONAL FUND ADVISORS LP | 490,472490,472 | $2M | 0.17% | — |
| 48 | 48Jefferies Financial Group Inc. | 479,000479,000 | $2M | 0.17% | ADD 1816% |
| 49 | 49Point72 Asset Management, L.P. | 461,856461,856 | $2M | 0.16% | TRIM -88% |
| 50 | 50ACUTA CAPITAL PARTNERS, LLC | 439,464439,464 | $2M | 0.15% | TRIM -3% |
| 51 | 51RENAISSANCE TECHNOLOGIES LLC | 413,203413,203 | $2M | 0.14% | ADD 141% |
| 52 | 52CITADEL ADVISORS LLC | 411,135411,135 | $2M | 0.14% | TRIM -78% |
| 53 | 53Squarepoint Ops LLC | 410,282410,282 | $2M | 0.14% | TRIM -13% |
| 54 | 54Hennion & Walsh Asset Management, Inc. | 391,476391,476 | $2M | 0.14% | ADD 27% |
| 55 | 55Invesco Ltd. | 368,021368,021 | $2M | 0.13% | TRIM -72% |
| 56 | 56MOORE CAPITAL MANAGEMENT, LP | 328,831328,831 | $1M | 0.11% | NEW |
| 57 | 57POLEN CAPITAL MANAGEMENT LLCtracked | 319,748319,748 | $1M | 0.11% | ADD 104% |
| 58 | 58Rafferty Asset Management, LLC | 299,903299,903 | $1M | 0.10% | TRIM -13% |
| 59 | 59Ensign Peak Advisors, Inc | 275,111275,111 | $1M | 0.10% | — |
| 60 | 60Swiss National Bank | 268,800268,800 | $1M | 0.09% | — |
| 61 | 61UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 265,795265,795 | $1M | 0.09% | ADD 59% |
| 62 | 62STATE OF WISCONSIN INVESTMENT BOARD | 263,332263,332 | $1M | 0.09% | ADD 133% |
| 63 | 63RHUMBLINE ADVISERS | 258,530258,530 | $1M | 0.09% | — |
| 64 | 64SUPERSTRING CAPITAL MANAGEMENT LP | 258,269258,269 | $1M | 0.09% | TRIM -74% |
| 65 | 65Chicago Partners Investment Group LLC | 170,751170,751 | $1M | 0.06% | ADD 3% |
| 66 | 66ALLIANCEBERNSTEIN L.P. | 189,240189,240 | $1M | 0.07% | ADD 5% |
| 67 | 67ALPS ADVISORS INC | 222,986222,986 | $996,747 | 0.08% | — |
| 68 | 68VICTORY CAPITAL MANAGEMENT INC | 195,745195,745 | $874,980 | 0.07% | — |
| 69 | 69WELLS FARGO & COMPANY/MN | 183,334183,334 | $819,503 | 0.06% | TRIM -40% |
| 70 | 70PANAGORA ASSET MANAGEMENT INC | 182,164182,164 | $814,273 | 0.06% | ADD 1474% |
| 71 | 71Privium Fund Management B.V. | 181,900181,900 | $813,093 | 0.06% | ADD 10% |
| 72 | 72DEUTSCHE BANK AG\ | 181,769181,769 | $812,507 | 0.06% | ADD 13% |
| 73 | 73AQR CAPITAL MANAGEMENT LLC | 177,309177,309 | $792,571 | 0.06% | ADD 5% |
| 74 | 74WEXFORD CAPITAL LP | 160,654160,654 | $718,123 | 0.06% | TRIM -11% |
| 75 | 75PRICE T ROWE ASSOCIATES INC /MD/ | 158,954158,954 | $711,000 | 0.06% | ADD 30% |
| 76 | 76Palumbo Wealth Management LLC | 146,709146,709 | $655,790 | 0.05% | TRIM -18% |
| 77 | 77TUDOR INVESTMENT CORP ET AL | 143,575143,575 | $641,780 | 0.05% | NEW |
| 78 | 78CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,933136,933 | $612,091 | 0.05% | — |
| 79 | 79PROFUND ADVISORS LLC | 134,671134,671 | $601,979 | 0.05% | ADD 5% |
| 80 | 80MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 124,730124,730 | $549,044 | 0.04% | — |
| 81 | 81BNP PARIBAS FINANCIAL MARKETS | 120,200120,200 | $537,294 | 0.04% | TRIM -30% |
| 82 | 82MetLife Investment Management, LLC | 120,116120,116 | $536,919 | 0.04% | ADD 6% |
| 83 | 83Vanguard Global Advisers, LLC | 116,691116,691 | $521,609 | 0.04% | NEW |
| 84 | 84SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,297116,297 | $519,848 | 0.04% | TRIM -7% |
| 85 | 85FRANKLIN RESOURCES INC | 108,399108,399 | $484,544 | 0.04% | — |
| 86 | 86Legal & General Group Plc | 104,308104,308 | $466,258 | 0.04% | TRIM -22% |
| 87 | 87MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,37199,371 | $444,188 | 0.03% | ADD 48% |
| 88 | 88VANGUARD ASSET MANAGEMENT, Ltd | 90,47490,474 | $404,419 | 0.03% | NEW |
| 89 | 89Balyasny Asset Management L.P. | 83,01983,019 | $371,095 | 0.03% | ADD 97% |
| 90 | 90Zurcher Kantonalbank (Zurich Cantonalbank) | 80,77980,779 | $361,082 | 0.03% | ADD 20% |
| 91 | 91JANUS HENDERSON GROUP PLC | 69,00069,000 | $308,085 | 0.02% | — |
| 92 | 92NEW YORK STATE COMMON RETIREMENT FUND | 67,50067,500 | $301,725 | 0.02% | — |
| 93 | 93RED REEF ADVISORS LLC | 65,95065,950 | $294,797 | 0.02% | — |
| 94 | 94Creative Planning | 59,80159,801 | $267,310 | 0.02% | TRIM -5% |
| 95 | 95VARCOV Co. | 58,51158,511 | $261,544 | 0.02% | NEW |
| 96 | 96COMMONWEALTH EQUITY SERVICES, LLC | 58,44258,442 | $261,236 | 0.02% | ADD 5% |
| 97 | 97Abacus Wealth Partners, LLC | 58,24158,241 | $260,337 | 0.02% | ADD 6% |
| 98 | 98Police & Firemen's Retirement System of New Jersey | 57,16857,168 | $255,541 | 0.02% | — |
| 99 | 99CITIGROUP INC | 57,08057,080 | $255,148 | 0.02% | TRIM -9% |
| 100 | 100Mitsubishi UFJ Asset Management Co., Ltd. | 56,57756,577 | $252,899 | 0.02% | TRIM -2% |
