| 1 | 1FMR LLC | 11,781,02411.8M | $594M | 15.00% | — |
| 2 | 2BlackRock, Inc. | 5,521,2215.5M | $278M | 7.03% | — |
| 3 | 3RTW INVESTMENTS, LP | 4,171,9964.2M | $210M | 5.31% | — |
| 4 | 4Fairmount Funds Management LLC | 4,018,1014.0M | $203M | 5.12% | — |
| 5 | 5PERCEPTIVE ADVISORS LLC | 3,783,2253.8M | $191M | 4.82% | ADD 23% |
| 6 | 6Venrock Adviser, LLC | 3,685,4483.7M | $186M | 4.69% | — |
| 7 | 7VANGUARD CAPITAL MANAGEMENT LLC | 3,057,4013.1M | $154M | 3.89% | NEW† |
| 8 | 8Driehaus Capital Management LLC | 2,790,7852.8M | $141M | 3.55% | TRIM -3% |
| 9 | 9STATE STREET CORP | 2,607,0312.6M | $131M | 3.32% | ADD 15% |
| 10 | 10Paradigm Biocapital Advisors LP | 1,957,2662.0M | $99M | 2.49% | ADD 33% |
| 11 | 11Commodore Capital LP | 1,912,3801.9M | $96M | 2.43% | TRIM -20% |
| 12 | 12TCG Crossover Management, LLC | 1,900,5821.9M | $96M | 2.42% | — |
| 13 | 13TANG CAPITAL MANAGEMENT LLC | 1,892,2001.9M | $95M | 2.41% | — |
| 14 | 14WELLINGTON MANAGEMENT GROUP LLP | 1,824,8111.8M | $92M | 2.32% | ADD 18% |
| 15 | 15Capital International Investors | 1,746,1291.7M | $88M | 2.22% | TRIM -50% |
| 16 | 16GEODE CAPITAL MANAGEMENT, LLC | 1,720,9121.7M | $87M | 2.19% | ADD 4% |
| 17 | 17JANUS HENDERSON GROUP PLC | 1,656,1641.7M | $84M | 2.11% | TRIM -9% |
| 18 | 18RA CAPITAL MANAGEMENT, L.P. | 1,621,6201.6M | $82M | 2.06% | — |
| 19 | 19PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,7301.6M | $81M | 2.04% | — |
| 20 | 20Remedium Capital Partners, LLC | 1,456,2311.5M | $73M | 1.85% | — |
| 21 | 21Affinity Asset Advisors, LLC | 1,279,1341.3M | $65M | 1.63% | TRIM -11% |
| 22 | 22BANK OF AMERICA CORP /DE/ | 1,228,0931.2M | $62M | 1.56% | ADD 193% |
| 23 | 23BAKER BROS. ADVISORS LP | 1,000,0001.0M | $50M | 1.27% | — |
| 24 | 24BRAIDWELL LP | 932,823932,823 | $47M | 1.19% | TRIM -43% |
| 25 | 25FRANKLIN RESOURCES INC | 882,833882,833 | $45M | 1.12% | TRIM -20% |
| 26 | 26JPMORGAN CHASE & CO | 979,299979,299 | $44M | 1.25% | ADD 1456% |
| 27 | 27Caligan Partners LP | 878,127878,127 | $44M | 1.12% | NEW |
| 28 | 28Siren, L.L.C. | 818,598818,598 | $41M | 1.04% | — |
| 29 | 29Polar Capital Holdings Plc | 792,847792,847 | $40M | 1.01% | ADD 7% |
| 30 | 30UBS Group AG | 671,235671,235 | $34M | 0.85% | — |
| 31 | 31Capital World Investors | 666,564666,564 | $34M | 0.85% | ADD 233% |
| 32 | 32EMERALD ADVISERS, LLC | 613,365613,365 | $31M | 0.78% | TRIM -4% |
| 33 | 33Candriam S.C.A. | 610,282610,282 | $31M | 0.78% | ADD 43% |
| 34 | 34VANGUARD PORTFOLIO MANAGEMENT LLC | 585,130585,130 | $30M | 0.75% | NEW |
| 35 | 35NORTHERN TRUST CORP | 578,907578,907 | $29M | 0.74% | ADD 3% |
| 36 | 36CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 562,653562,653 | $28M | 0.72% | TRIM -2% |
| 37 | 37Pictet Asset Management Holding SA | 491,649491,649 | $25M | 0.63% | TRIM -46% |
| 38 | 38VANGUARD FIDUCIARY TRUST CO | 464,651464,651 | $23M | 0.59% | NEW |
| 39 | 39EMERALD MUTUAL FUND ADVISERS TRUST | 408,113408,113 | $21M | 0.52% | — |
| 40 | 40SAMLYN CAPITAL, LLC | 396,661396,661 | $20M | 0.51% | NEW |
| 41 | 41ADAR1 Capital Management, LLC | 338,323338,323 | $17M | 0.43% | ADD 894% |
| 42 | 42STEMPOINT CAPITAL LP | 335,212335,212 | $17M | 0.43% | ADD 935% |
| 43 | 43Blackstone Inc. | 292,847292,847 | $15M | 0.37% | TRIM -42% |
| 44 | 44VICTORY CAPITAL MANAGEMENT INC | 292,126292,126 | $15M | 0.37% | ADD 100% |
| 45 | 45GOLDMAN SACHS GROUP INC | 269,938269,938 | $14M | 0.34% | — |
| 46 | 46Woodline Partners LP | 265,892265,892 | $13M | 0.34% | — |
| 47 | 47MORGAN STANLEY | 246,719246,719 | $12M | 0.31% | ADD 35% |
| 48 | 48UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,314207,314 | $10M | 0.26% | ADD 233% |
| 49 | 49BOOTHBAY FUND MANAGEMENT, LLC | 193,031193,031 | $10M | 0.25% | NEW |
| 50 | 50Bank of New York Mellon Corp | 191,395191,395 | $10M | 0.24% | — |
| 51 | 51SILVERARC CAPITAL MANAGEMENT, LLC | 186,618186,618 | $9M | 0.24% | — |
| 52 | 52FIRST TRUST ADVISORS LP | 178,389178,389 | $9M | 0.23% | NEW |
| 53 | 53Universal- Beteiligungs- und Servicegesellschaft mbH | 170,381170,381 | $9M | 0.22% | — |
| 54 | 54AMERIPRISE FINANCIAL INC | 159,217159,217 | $8M | 0.20% | ADD 316% |
| 55 | 55Nuveen, LLC | 153,899153,899 | $8M | 0.20% | — |
| 56 | 56Ensign Peak Advisors, Inc | 148,537148,537 | $7M | 0.19% | NEW |
| 57 | 57MILLENNIUM MANAGEMENT LLC | 146,639146,639 | $7M | 0.19% | ADD 92% |
| 58 | 58HighVista Strategies LLC | 146,264146,264 | $7M | 0.19% | TRIM -22% |
| 59 | 59MARSHALL WACE, LLP | 139,259139,259 | $7M | 0.18% | NEW |
| 60 | 60TD Asset Management Inc | 137,390137,390 | $7M | 0.17% | TRIM -8% |
| 61 | 61Invesco Ltd. | 132,390132,390 | $7M | 0.17% | TRIM -12% |
| 62 | 62DEUTSCHE BANK AG\ | 129,242129,242 | $7M | 0.16% | ADD 6% |
| 63 | 63ARMISTICE CAPITAL, LLC | 120,931120,931 | $6M | 0.15% | TRIM -38% |
| 64 | 64MANUFACTURERS LIFE INSURANCE COMPANY, THE | 112,841112,841 | $6M | 0.14% | TRIM -13% |
| 65 | 65CITADEL ADVISORS LLC | 108,135108,135 | $5M | 0.14% | ADD 69% |
| 66 | 66SEVEN GRAND MANAGERS, LLC | 100,000100,000 | $5M | 0.13% | — |
| 67 | 67B Group, Inc. | 100,000100,000 | $5M | 0.13% | — |
| 68 | 68F/m Investments LLC | 99,46099,460 | $5M | 0.13% | TRIM -4% |
| 69 | 69Swiss National Bank | 96,50096,500 | $5M | 0.12% | — |
| 70 | 70ExodusPoint Capital Management, LP | 87,06587,065 | $4M | 0.11% | ADD 130% |
| 71 | 71RHUMBLINE ADVISERS | 85,12185,121 | $4M | 0.11% | ADD 3% |
| 72 | 72MERCER GLOBAL ADVISORS INC /ADV | 71,09171,091 | $4M | 0.09% | TRIM -33% |
| 73 | 73Atle Fund Management AB | 62,73562,735 | $3M | 0.08% | NEW |
| 74 | 74Rockefeller Capital Management L.P. | 64,00264,002 | $3M | 0.08% | ADD 11558% |
| 75 | 75ALPS ADVISORS INC | 63,93963,939 | $3M | 0.08% | — |
| 76 | 76PRUDENTIAL FINANCIAL INC | 59,55559,555 | $3M | 0.08% | NEW |
| 77 | 77FRED ALGER MANAGEMENT, LLC | 59,45359,453 | $3M | 0.08% | NEW |
| 78 | 78CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,24259,242 | $3M | 0.08% | ADD 23% |
| 79 | 79SCHRODER INVESTMENT MANAGEMENT GROUP | 63,68463,684 | $3M | 0.08% | ADD 3% |
| 80 | 80Rafferty Asset Management, LLC | 56,92056,920 | $3M | 0.07% | ADD 7% |
| 81 | 81Balyasny Asset Management L.P. | 55,47755,477 | $3M | 0.07% | TRIM -24% |
| 82 | 82VOYA INVESTMENT MANAGEMENT LLC | 53,97053,970 | $3M | 0.07% | ADD 98% |
| 83 | 83Susquehanna Portfolio Strategies, LLC | 53,10153,101 | $3M | 0.07% | — |
| 84 | 84DIMENSIONAL FUND ADVISORS LP | 47,69747,697 | $2M | 0.06% | TRIM -38% |
| 85 | 85ALLIANCEBERNSTEIN L.P. | 70,90070,900 | $2M | 0.09% | ADD 5% |
| 86 | 86BARCLAYS PLC | 45,78645,786 | $2M | 0.06% | TRIM -75% |
| 87 | 87Legal & General Group Plc | 44,79244,792 | $2M | 0.06% | TRIM -21% |
| 88 | 88MetLife Investment Management, LLC | 38,40738,407 | $2M | 0.05% | — |
| 89 | 89MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,32336,323 | $2M | 0.05% | ADD 3% |
| 90 | 90VANGUARD ASSET MANAGEMENT, Ltd | 33,23233,232 | $2M | 0.04% | NEW |
| 91 | 91WELLS FARGO & COMPANY/MN | 33,20833,208 | $2M | 0.04% | TRIM -60% |
| 92 | 92Vanguard Global Advisers, LLC | 31,14131,141 | $2M | 0.04% | NEW |
| 93 | 93SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,96228,962 | $1M | 0.04% | ADD 374% |
| 94 | 94Cinctive Capital Management LP | 27,43027,430 | $1M | 0.03% | TRIM -24% |
| 95 | 95STATE OF WISCONSIN INVESTMENT BOARD | 26,52326,523 | $1M | 0.03% | TRIM -3% |
| 96 | 96PROFUND ADVISORS LLC | 26,04326,043 | $1M | 0.03% | ADD 26% |
| 97 | 97Waverly Advisors, LLC | 25,96625,966 | $1M | 0.03% | — |
| 98 | 98TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,79925,799 | $1M | 0.03% | — |
| 99 | 99XTX Topco Ltd | 24,43524,435 | $1M | 0.03% | NEW |
| 100 | 100NEW YORK STATE COMMON RETIREMENT FUND | 22,26522,265 | $1M | 0.03% | ADD 16% |