Institutional 13F holdings sum to 103.7% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 27,631,844 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 24,471,26424.5M | $134M | 11.96% | — |
| 2 | Bain Capital Life Sciences Investors, LLC | 17,600,62117.6M | $96M | 8.60% | — |
| 3 | Venrock Adviser, LLC | 13,740,37513.7M | $75M | 6.71% | — |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,00013.6M | $74M | 6.63% | — |
| 5 | TCG Crossover Management, LLC | 12,362,20512.4M | $67M | 6.04% | — |
| 6 | BlackRock, Inc. | 11,291,18511.3M | $62M | 5.52% | — |
| 7 | Frazier Life Sciences Management, L.P. | 9,720,8529.7M | $53M | 4.75% | — |
| 8 | Polar Capital Holdings Plc | 9,541,7869.5M | $52M | 4.66% | ADD 15% |
| 9 | VANGUARD CAPITAL MANAGEMENT LLC | 7,783,9137.8M | $43M | 3.80% | NEW† |
| 10 | Nantahala Capital Management, LLC | 7,344,7837.3M | $40M | 3.59% | — |
| 11 | STATE STREET CORP | 6,707,6846.7M | $37M | 3.28% | ADD 55% |
| 12 | RTW INVESTMENTS, LP | 5,952,3806.0M | $32M | 2.91% | — |
| 13 | MARSHALL WACE, LLP | 4,514,3484.5M | $25M | 2.21% | — |
| 14 | Woodline Partners LP | 4,245,1194.2M | $23M | 2.07% | — |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 3,594,4803.6M | $20M | 1.76% | ADD 5% |
| 16 | Spruce Street Capital LP | 3,383,1753.4M | $18M | 1.65% | ADD 40% |
| 17 | EMERALD ADVISERS, LLC | 3,371,2853.4M | $18M | 1.65% | TRIM -4% |
| 18 | Rosalind Advisors, Inc. | 3,203,7213.2M | $17M | 1.57% | TRIM -6% |
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 2,710,7232.7M | $15M | 1.32% | — |
| 20 | Vestal Point Capital, LP | 2,600,0522.6M | $14M | 1.27% | ADD 62% |
| 21 | Affinity Asset Advisors, LLC | 2,512,1532.5M | $14M | 1.23% | TRIM -10% |
| 22 | EMERALD MUTUAL FUND ADVISERS TRUST | 2,368,6692.4M | $13M | 1.16% | — |
| 23 | Pictet Asset Management Holding SA | 2,275,3812.3M | $12M | 1.11% | NEW |
| 24 | D. E. Shaw & Co., Inc. | 2,111,8822.1M | $12M | 1.03% | ADD 27% |
| 25 | NAN FUNG TRINITY (HK) LTD | 1,842,3501.8M | $10M | 0.90% | ADD 9% |
| 26 | MORGAN STANLEY | 1,786,2931.8M | $10M | 0.87% | TRIM -24% |
| 27 | SUPERSTRING CAPITAL MANAGEMENT LP | 1,585,9771.6M | $9M | 0.77% | ADD 59% |
| 28 | ADAR1 Capital Management, LLC | 1,464,5351.5M | $8M | 0.72% | ADD 4% |
| 29 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,430,9821.4M | $8M | 0.70% | NEW |
| 30 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,375,4771.4M | $8M | 0.67% | NEW |
| 31 | Longaeva Partners L.P. | 1,275,0001.3M | $7M | 0.62% | ADD 2% |
| 32 | NORTHERN TRUST CORP | 1,189,9941.2M | $6M | 0.58% | ADD 10% |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,140,2441.1M | $6M | 0.56% | — |
| 34 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,052,8931.1M | $6M | 0.51% | — |
| 35 | VANGUARD FIDUCIARY TRUST CO | 1,004,7471.0M | $5M | 0.49% | NEW |
| 36 | ALGERT GLOBAL LLC | 864,614864,614 | $5M | 0.42% | NEW |
| 37 | DEUTSCHE BANK AG\ | 848,391848,391 | $5M | 0.41% | ADD 3% |
| 38 | CITADEL ADVISORS LLC | 798,735798,735 | $4M | 0.39% | ADD 3% |
| 39 | VOYA INVESTMENT MANAGEMENT LLC | 756,774756,774 | $4M | 0.37% | — |
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 739,164739,164 | $4M | 0.36% | TRIM -37% |
| 41 | Swedbank AB | 700,000700,000 | $4M | 0.34% | TRIM -18% |
| 42 | RENAISSANCE TECHNOLOGIES LLC | 652,672652,672 | $4M | 0.32% | ADD 97% |
| 43 | F/m Investments LLC | 651,024651,024 | $4M | 0.32% | TRIM -4% |
| 44 | ORBIMED ADVISORS LLC | 635,000635,000 | $3M | 0.31% | NEW |
| 45 | Moody Aldrich Partners LLC | 614,279614,279 | $3M | 0.30% | NEW |
| 46 | Sio Capital Management, LLC | 613,888613,888 | $3M | 0.30% | — |
| 47 | KVP Capital Advisors, LP | 605,280605,280 | $3M | 0.30% | — |
| 48 | Integral Health Asset Management, LLC | 600,000600,000 | $3M | 0.29% | NEW |
| 49 | UBS Group AG | 596,715596,715 | $3M | 0.29% | ADD 194% |
| 50 | BANK OF AMERICA CORP /DE/ | 588,199588,199 | $3M | 0.29% | ADD 39% |
| 51 | GOLDMAN SACHS GROUP INC | 580,059580,059 | $3M | 0.28% | ADD 12% |
| 52 | Point72 Asset Management, L.P. | 463,002463,002 | $3M | 0.23% | NEW |
| 53 | JANE STREET GROUP, LLC | 430,967430,967 | $2M | 0.21% | TRIM -26% |
| 54 | Eversept Partners, LP | 384,264384,264 | $2M | 0.19% | ADD 126% |
| 55 | XTX Topco Ltd | 379,402379,402 | $2M | 0.19% | ADD 1437% |
| 56 | Sofinnova Investments, Inc. | 364,763364,763 | $2M | 0.18% | ADD 20% |
| 57 | Nuveen, LLC | 343,553343,553 | $2M | 0.17% | ADD 26% |
| 58 | Bank of New York Mellon Corp | 309,695309,695 | $2M | 0.15% | — |
| 59 | WEDGE CAPITAL MANAGEMENT L L P/NC | 307,998307,998 | $2M | 0.15% | NEW |
| 60 | Seven Fleet Capital Management LP | 295,688295,688 | $2M | 0.14% | ADD 371% |
| 61 | HighVista Strategies LLC | 250,999250,999 | $1M | 0.12% | NEW |
| 62 | BNP PARIBAS FINANCIAL MARKETS | 240,600240,600 | $1M | 0.12% | ADD 671% |
| 63 | Invesco Ltd. | 223,010223,010 | $1M | 0.11% | TRIM -68% |
| 64 | Walleye Capital LLC | 195,077195,077 | $1M | 0.10% | ADD 30% |
| 65 | SCHRODER INVESTMENT MANAGEMENT GROUP | 205,090205,090 | $1M | 0.10% | NEW |
| 66 | Rafferty Asset Management, LLC | 188,954188,954 | $1M | 0.09% | ADD 110% |
| 67 | Squarepoint Ops LLC | 170,819170,819 | $932,672 | 0.08% | NEW |
| 68 | RHUMBLINE ADVISERS | 157,142157,142 | $857,986 | 0.08% | ADD 3% |
| 69 | Aquatic Capital Management LLC | 153,147153,147 | $836,183 | 0.07% | ADD 84% |
| 70 | ALLIANCEBERNSTEIN L.P. | 127,040127,040 | $766,051 | 0.06% | — |
| 71 | Swiss National Bank | 136,800136,800 | $746,928 | 0.07% | NEW |
| 72 | Verdad Advisers, LP | 128,376128,376 | $700,933 | 0.06% | NEW |
| 73 | Connor, Clark & Lunn Investment Management Ltd. | 122,862122,862 | $670,827 | 0.06% | ADD 64% |
| 74 | Trexquant Investment LP | 114,198114,198 | $623,521 | 0.06% | NEW |
| 75 | GLENMEDE TRUST CO NA | 105,273105,273 | $574,790 | 0.05% | NEW |
| 76 | PRICE T ROWE ASSOCIATES INC /MD/ | 101,472101,472 | $555,000 | 0.05% | ADD 46% |
| 77 | GSA CAPITAL PARTNERS LLP | 93,72693,726 | $512,000 | 0.05% | TRIM -33% |
| 78 | Vanguard Global Advisers, LLC | 91,71091,710 | $500,737 | 0.04% | NEW |
| 79 | Universal- Beteiligungs- und Servicegesellschaft mbH | 90,00090,000 | $491,400 | 0.04% | — |
| 80 | ENVESTNET ASSET MANAGEMENT INC | 88,72088,720 | $484,411 | 0.04% | NEW |
| 81 | Qube Research & Technologies Ltd | 87,57587,575 | $478,160 | 0.04% | NEW |
| 82 | WELLS FARGO & COMPANY/MN | 86,92986,929 | $474,633 | 0.04% | TRIM -48% |
| 83 | PROFUND ADVISORS LLC | 84,98184,981 | $463,996 | 0.04% | ADD 142% |
| 84 | Optimize Financial Inc | 84,10384,103 | $459,202 | 0.04% | NEW |
| 85 | Cresset Asset Management, LLC | 83,48483,484 | $455,823 | 0.04% | — |
| 86 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 81,28681,286 | $438,432 | 0.04% | ADD 14% |
| 87 | JPMORGAN CHASE & CO | 80,70980,709 | $407,581 | 0.04% | ADD 10% |
| 88 | EntryPoint Capital, LLC | 73,88173,881 | $403,390 | 0.04% | ADD 81% |
| 89 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,59971,599 | $390,931 | 0.03% | TRIM -87% |
| 90 | MetLife Investment Management, LLC | 69,44969,449 | $379,192 | 0.03% | TRIM -12% |
| 91 | FMR LLC | 69,03169,031 | $376,909 | 0.03% | ADD 148% |
| 92 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,17568,175 | $372,236 | 0.03% | ADD 57% |
| 93 | FIFTH THIRD BANCORP | 66,42866,428 | $362,697 | 0.03% | NEW |
| 94 | Susquehanna Portfolio Strategies, LLC | 59,97459,974 | $327,458 | 0.03% | — |
| 95 | Creative Planning | 59,82959,829 | $326,666 | 0.03% | ADD 7% |
| 96 | SG Americas Securities, LLC | 57,40057,400 | $313,000 | 0.03% | ADD 26% |
| 97 | AQR CAPITAL MANAGEMENT LLC | 55,17755,177 | $301,266 | 0.03% | NEW |
| 98 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,71852,718 | $287,841 | 0.03% | NEW |
| 99 | Sivia Capital Partners, LLC | 48,50048,500 | $264,810 | 0.02% | — |
| 100 | VARCOV Co. | 48,33548,335 | $263,909 | 0.02% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24.5M | 24.5M | 24.5M | 24.5M | 24.5M | 24.5M | $134M |
| Bain Capital Life Sciences Investors, LLC | 14.6M | 17.6M | 17.6M | 17.6M | 17.6M | 17.6M | $96M |
| Venrock Adviser, LLC | — | 3.3M | 8.9M | 12.7M | 13.7M | 13.7M | $75M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8.0M | 8.0M | 8.0M | 8.0M | 13.6M | 13.6M | $74M |
| TCG Crossover Management, LLC | 12.4M | 12.4M | 12.4M | 12.4M | 12.4M | 12.4M | $67M |
| BlackRock, Inc. | 9.6M | 9.9M | 9.8M | 8.4M | 11.1M | 11.3M | $62M |
| Frazier Life Sciences Management, L.P. | 8.7M | 11.5M | 11.5M | 11.5M | 9.9M | 9.7M | $53M |
| Polar Capital Holdings Plc | — | — | — | — | 8.3M | 9.5M | $52M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 7.8M | $43M |
| Nantahala Capital Management, LLC | 7.5M | 8.1M | 8.3M | 8.8M | 7.3M | 7.3M | $40M |
| STATE STREET CORP | 4.2M | 2.4M | 2.5M | 2.4M | 4.3M | 6.7M | $37M |
| RTW INVESTMENTS, LP | — | — | — | — | 6.0M | 6.0M | $32M |
| MARSHALL WACE, LLP | 361K | — | — | — | 4.6M | 4.5M | $25M |
| Woodline Partners LP | 2.7M | 252K | 156K | 237K | 4.2M | 4.2M | $23M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.8M | 2.8M | 3.0M | 2.8M | 3.4M | 3.6M | $20M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“GEO acquired the GEO Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, GEO and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Is”
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | Passive |
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +7,783,913 | $43M | OPEN |
| STATE STREET CORP | +2,374,662 | $13M | ADD |
| Pictet Asset Management Holding SA | +2,275,381 | $12M | OPEN |
| SILVERARC CAPITAL MANAGEMENT, LLC | +1,430,982 | $8M | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,375,477 | $8M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −10,041,647 | $55M | CLOSE |
| PERCEPTIVE ADVISORS LLC | −2,400,000 | $13M | CLOSE |
| Siren, L.L.C. | −1,000,000 | $5M | CLOSE |
| MORGAN STANLEY | −551,603 | $3M | TRIM |
| MILLENNIUM MANAGEMENT LLC | −534,968 | $3M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 185 | 212,257,690 | 103.7% | $1.2B |
| 2025-Q4 | 147 | 201,146,785 | 98.9% | $1.2B |
| 2025-Q3 | 125 | 163,102,361 | 94.4% | $582M |
| 2025-Q2 | 123 | 167,703,770 | 97.0% | $382M |
| 2025-Q1 | 136 | 165,177,413 | 95.7% | $458M |
| 2024-Q4 | 135 | 162,840,086 | 94.9% | $500M |
| 2024-Q3 | 125 | 160,559,487 | 97.5% | $681M |
| 2024-Q2 | 131 | 154,457,002 | — | $622M |
| 2024-Q1 | 119 | 121,701,861 | 88.1% | $606M |
| 2023-Q4 | 97 | 122,016,522 | 90.2% | $573M |
| 2023-Q3 | 83 | 116,727,670 | 86.4% | $441M |
| 2023-Q2 | 77 | 89,100,782 | 78.1% | $285M |
| 2023-Q1 | 68 | 83,460,606 | 73.2% | $163M |
| 2022-Q4 | 55 | 80,000,207 | 70.1% | $124M |
| 2022-Q3 | 56 | 83,368,135 | 73.1% | $129M |
| 2022-Q2 | 54 | 80,618,573 | 70.7% | $123M |
| 2022-Q1 | 53 | 79,331,265 | 69.6% | $104M |
| 2021-Q4 | 54 | 74,697,849 | 65.6% | $93M |
| 2021-Q3 | 59 | 75,033,692 | 65.9% | $104M |
| 2021-Q2 | 75 | 79,174,266 | 69.7% | $135M |
| 2021-Q1 | 83 | 75,361,159 | — | $158M |
| 2020-Q4 | 66 | 21,673,587 | 40.0% | $25M |
| 2020-Q3 | 70 | 22,217,261 | 41.0% | $42M |
| 2020-Q2 | 73 | 26,128,443 | 50.1% | $75M |
| 2020-Q1 | 74 | 25,334,591 | 49.8% | $66M |
| 2019-Q4 | 78 | 21,203,771 | 51.5% | $95M |
| 2019-Q3 | 75 | 15,184,542 | 36.9% | $40M |
| 2019-Q2 | 79 | 17,377,825 | 46.1% | $41M |
| 2019-Q1 | 82 | 16,393,464 | 46.4% | $121M |
| 2018-Q4 | 79 | 17,416,895 | 49.6% | $132M |
| 2018-Q3 | 83 | 18,148,217 | 51.7% | $203M |
| 2018-Q2 | 76 | 14,783,348 | 48.3% | $167M |
| 2018-Q1 | 61 | 12,953,343 | 42.3% | $119M |
| 2017-Q4 | 49 | 11,673,310 | 38.3% | $173M |
| 2017-Q3 | 20 | 4,418,076 | 18.3% | $42M |
| 2017-Q2 | 21 | 3,979,301 | 26.3% | $23M |
| 2016-Q1 | 1 | 142 | 0.0% | $1,000 |
| 2025-12-31 |
| SEC → |
| Farallon Capital Partners, L.P. | 6.9% | Passive | 2025-12-31 | SEC → |
| Flynn James E | 6.74% | Passive | 2025-10-30 | SEC → |
| TCG Crossover GP I, LLC | 6.1% | Passive | 2025-12-31 | SEC → |
| BlackRock, Inc. | 5.4% | QII | 2025-12-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
