| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,251,7881.3M | $31M | 7.56% | NEW† |
| 2 | Affinity Asset Advisors, LLC | 1,069,5191.1M | $27M | 6.46% | ADD 43% |
| 3 | SAMSARA BIOCAPITAL, LLC | 1,062,8721.1M | $26M | 6.42% | ADD 420% |
| 4 | Kynam Capital Management, LP | 872,558872,558 | $22M | 5.27% | ADD 82% |
| 5 | ORBIMED ADVISORS LLC | 801,144801,144 | $20M | 4.84% | NEW† |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 720,442720,442 | $18M | 4.35% | NEW† |
| 7 | PERCEPTIVE ADVISORS LLC | 715,307715,307 | $18M | 4.32% | NEW† |
| 8 | RA CAPITAL MANAGEMENT, L.P. | 715,307715,307 | $18M | 4.32% | NEW† |
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 715,307715,307 | $18M | 4.32% | NEW† |
| 10 | Point72 Asset Management, L.P. | 692,111692,111 | $17M | 4.18% | ADD 286% |
| 11 | ADAR1 Capital Management, LLC | 524,441524,441 | $13M | 3.17% | ADD 682% |
| 12 | Velan Capital Investment Management LP | 512,160512,160 | $13M | 3.09% | ADD 64% |
| 13 | Balyasny Asset Management L.P. | 465,792465,792 | $12M | 2.81% | ADD 102% |
| 14 | Woodline Partners LP | 457,441457,441 | $11M | 2.76% | NEW† |
| 15 | UBS Group AG | 392,871392,871 | $10M | 2.37% | ADD 4892% |
| 16 | ACADIAN ASSET MANAGEMENT LLC | 335,813335,813 | $8M | 2.03% | — |
| 17 | Merck & Co., Inc. | 272,351272,351 | $7M | 1.64% | — |
| 18 | ACUTA CAPITAL PARTNERS, LLC | 269,425269,425 | $7M | 1.63% | ADD 299% |
| 19 | BlackRock, Inc. | 232,684232,684 | $6M | 1.40% | ADD 98% |
| 20 | KVP Capital Advisors, LP | 226,575226,575 | $6M | 1.37% | NEW |
| 21 | MARSHALL WACE, LLP | 222,634222,634 | $6M | 1.34% | ADD 160% |
| 22 | MILLENNIUM MANAGEMENT LLC | 210,378210,378 | $5M | 1.27% | TRIM -50% |
| 23 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000200,000 | $5M | 1.21% | — |
| 24 | Opaleye Management Inc. | 190,671190,671 | $5M | 1.15% | — |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 171,386171,386 | $4M | 1.03% | ADD 104% |
| 26 | CITADEL ADVISORS LLC | 117,537117,537 | $3M | 0.71% | ADD 266% |
| 27 | RENAISSANCE TECHNOLOGIES LLC | 97,82497,824 | $2M | 0.59% | TRIM -20% |
| 28 | VANGUARD FIDUCIARY TRUST CO | 94,83894,838 | $2M | 0.57% | NEW |
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,90284,902 | $2M | 0.51% | NEW |
| 30 | Eversept Partners, LP | 73,16173,161 | $2M | 0.44% | TRIM -62% |
| 31 | Burkehill Global Management, LP | 71,53071,530 | $2M | 0.43% | NEW |
| 32 | TWO SIGMA INVESTMENTS, LP | 65,17665,176 | $2M | 0.39% | ADD 40% |
| 33 | STATE STREET CORP | 52,11852,118 | $1M | 0.31% | ADD 52% |
| 34 | STEMPOINT CAPITAL LP | 46,59046,590 | $1M | 0.28% | NEW |
| 35 | Fisher Asset Management, LLC | 35,29535,295 | $879,198 | 0.21% | — |
| 36 | Trexquant Investment LP | 34,34334,343 | $855,484 | 0.21% | NEW |
| 37 | NORTHERN TRUST CORP | 33,16633,166 | $826,165 | 0.20% | ADD 131% |
| 38 | JANE STREET GROUP, LLC | 27,76027,760 | $691,502 | 0.17% | ADD 21% |
| 39 | GOLDMAN SACHS GROUP INC | 27,18727,187 | $677,228 | 0.16% | ADD 74% |
| 40 | GSA CAPITAL PARTNERS LLP | 25,82225,822 | $643,000 | 0.16% | TRIM -71% |
| 41 | BANK OF AMERICA CORP /DE/ | 18,87318,873 | $470,126 | 0.11% | ADD 348% |
| 42 | CITIGROUP INC | 18,84518,845 | $469,429 | 0.11% | ADD 1707% |
| 43 | Brevan Howard Capital Management LP | 18,79118,791 | $468,084 | 0.11% | NEW |
| 44 | AJU IB Investment Co., Ltd. | 17,50017,500 | $435,925 | 0.11% | — |
| 45 | Invesco Ltd. | 17,16517,165 | $427,580 | 0.10% | — |
| 46 | RBF Capital, LLC | 15,27215,272 | $380,426 | 0.09% | TRIM -50% |
| 47 | Hudson Bay Capital Management LP | 14,76814,768 | $367,871 | 0.09% | NEW |
| 48 | Sigma Planning Corp | 12,52012,520 | $311,873 | 0.08% | NEW |
| 49 | Jump Financial, LLC | 12,38512,385 | $308,510 | 0.07% | NEW |
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,57710,577 | $263,473 | 0.06% | NEW |
| 51 | MORGAN STANLEY | 10,52910,529 | $262,277 | 0.06% | TRIM -34% |
| 52 | OMERS ADMINISTRATION Corp | 8,7008,700 | $216,717 | 0.05% | TRIM -21% |
| 53 | AQR CAPITAL MANAGEMENT LLC | 8,6058,605 | $214,351 | 0.05% | TRIM -52% |
| 54 | XTX Topco Ltd | 8,2038,203 | $204,337 | 0.05% | NEW |
| 55 | Persistent Asset Partners Ltd | 7,4117,411 | $184,608 | 0.04% | NEW |
| 56 | State of Tennessee, Department of Treasury | 7,4007,400 | $184,334 | 0.04% | — |
| 57 | Vanguard Global Advisers, LLC | 7,1827,182 | $178,904 | 0.04% | NEW |
| 58 | OSAIC HOLDINGS, INC. | 1,2801,280 | $31,884 | 0.01% | TRIM -4% |
| 59 | FMR LLC | 1,0501,050 | $26,156 | 0.01% | TRIM -5% |
| 60 | CWM, LLC | 983983 | $24,487 | 0.01% | TRIM -34% |
| 61 | FNY Investment Advisers, LLC | 1,0001,000 | $24,000 | 0.01% | — |
| 62 | Owl Creek Wealth Partners LLC | 491491 | $12,231 | 0.00% | NEW |
| 63 | Physician Wealth Advisors, Inc. | 182182 | $4,534 | 0.00% | — |
| 64 | BARCLAYS PLC | 139139 | $3,462 | 0.00% | NEW |
| 65 | BNP PARIBAS FINANCIAL MARKETS | 111111 | $2,765 | 0.00% | — |
| 66 | PNC FINANCIAL SERVICES GROUP, INC. | 6262 | $1,544 | 0.00% | — |
| 67 | SIMPLEX TRADING, LLC | 6262 | $1,544 | 0.00% | NEW |
| 68 | Fortitude Family Office, LLC | 5656 | $1,395 | 0.00% | — |
| 69 | Bogart Wealth, LLC | 5050 | $1,246 | 0.00% | — |
| 70 | Parallel Advisors, LLC | 4747 | $1,171 | 0.00% | — |
| 71 | NISA INVESTMENT ADVISORS, LLC | 4444 | $1,096 | 0.00% | — |
| 72 | Avion Wealth | 7272 | $1,000 | 0.00% | — |
| 73 | HighMark Wealth Management LLC | 2323 | $572 | 0.00% | — |
| 74 | EverSource Wealth Advisors, LLC | 1919 | $473 | 0.00% | TRIM -39% |
| 75 | Advisory Services Network, LLC | 1515 | $374 | 0.00% | NEW |
| 76 | Arax Advisory Partners | 4141 | $75 | 0.00% | ADD 1267% |
| 77 | FIFTH THIRD BANCORP | 22 | $50 | 0.00% | NEW |
| 78 | ROYAL BANK OF CANADA | 1212 | $0 | 0.00% | ADD 9% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | — | — | — | — | — | 1.3M | $31M |
| Affinity Asset Advisors, LLC | — | 753K | 753K | 753K | 748K | 1.1M | $27M |
| SAMSARA BIOCAPITAL, LLC | 2.2M | 2.2M | 2.2M | 2.2M | 205K | 1.1M | $26M |
| Kynam Capital Management, LP | 3.6M | 5.4M | 5.1M | 5.1M | 480K | 873K | $22M |
| ORBIMED ADVISORS LLC | — | — | — | — | — | 801K | $20M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 720K | $18M |
| EVENTIDE ASSET MANAGEMENT, LLC | — | — | — | — | — | 715K | $18M |
| RA CAPITAL MANAGEMENT, L.P. | — | 4.4M | — | — | — | 715K | $18M |
| PERCEPTIVE ADVISORS LLC | — | — | — | — | — | 715K | $18M |
| Point72 Asset Management, L.P. | 2.2M | — | — | — | 179K | 692K | $17M |
| ADAR1 Capital Management, LLC | — | — | — | — | 67K | 524K | $13M |
| Velan Capital Investment Management LP | 30K | 1.0M | 3.1M | 3.1M | 312K | 512K | $13M |
| Balyasny Asset Management L.P. | — | — | — | — | 230K | 466K | $12M |
| Woodline Partners LP | — | — | — | — | — | 457K | $11M |
| UBS Group AG | 184K | 76K | 1.6M | 1.8M | 8K | 393K | $10M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| BlackRock, Inc. | 6.4% | QII | 2026-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| BVF INC/IL | +1,251,788 | $31M | OPEN |
| SAMSARA BIOCAPITAL, LLC | +858,369 | $21M | ADD |
| ORBIMED ADVISORS LLC | +801,144 | $20M | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +720,442 | $18M | OPEN |
| EVENTIDE ASSET MANAGEMENT, LLC | +715,307 | $18M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −375,786 | $9M | CLOSE |
| Vestal Point Capital, LP | −243,000 | $6M | CLOSE |
| MILLENNIUM MANAGEMENT LLC | −207,818 | $5M | TRIM |
| TANG CAPITAL MANAGEMENT LLC | −139,617 | $3M | CLOSE |
| Eversept Partners, LP | −120,410 | $3M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 78 | 14,408,693 | 87.0% | $359M |
| 2025-Q4 | 63 | 5,613,823 | 65.9% | $65M |
| 2025-Q3 | 88 | 53,466,223 | 63.1% | $46M |
| 2025-Q2 | 101 | 55,778,070 | 66.0% | $40M |
| 2025-Q1 | 113 | 61,494,764 | 73.4% | $40M |
| 2024-Q4 | 123 | 63,896,169 | 77.5% | $118M |
| 2024-Q3 | 130 | 62,575,596 | 76.3% | $217M |
| 2024-Q2 | 119 | 63,225,636 | 77.3% | $185M |
| 2024-Q1 | 117 | 54,559,799 | 87.4% | $308M |
| 2023-Q4 | 114 | 55,938,500 | 91.8% | $240M |
| 2023-Q3 | 108 | 55,894,809 | 92.3% | $194M |
| 2023-Q2 | 120 | 54,105,236 | 89.6% | $252M |
| 2023-Q1 | 115 | 53,579,202 | 89.1% | $247M |
| 2022-Q4 | 119 | 49,964,447 | 86.9% | $398M |
| 2022-Q3 | 113 | 51,631,598 | 99.0% | $287M |
| 2022-Q2 | 114 | 46,077,559 | 98.2% | $240M |
| 2022-Q1 | 114 | 41,642,550 | 89.8% | $342M |
| 2021-Q4 | 117 | 40,257,765 | 87.0% | $599M |
| 2021-Q3 | 120 | 39,838,089 | 86.3% | $753M |
| 2021-Q2 | 124 | 41,241,344 | 89.4% | $767M |
| 2021-Q1 | 138 | 44,385,119 | 96.7% | $1.0B |
| 2020-Q4 | 134 | 39,392,924 | 102.0% | $855M |
| 2020-Q3 | 86 | 30,551,767 | 85.2% | $307M |
| 2020-Q2 | 80 | 24,363,944 | 104.9% | $189M |
| 2020-Q1 | 60 | 11,928,178 | 51.6% | $122M |
| 2019-Q4 | 64 | 11,712,679 | 50.7% | $129M |
| 2019-Q3 | 59 | 11,076,328 | 48.3% | $101M |
| 2019-Q2 | 58 | 11,817,506 | 51.5% | $134M |
| 2019-Q1 | 50 | 11,231,815 | 49.0% | $128M |
| 2018-Q4 | 43 | 10,900,292 | 47.7% | $98M |
| 2018-Q3 | 32 | 9,128,528 | 40.0% | $136M |
