% of shares outstanding suppressed: the summed institutional 13F holdings (52,482,931) exceed the latest reported shares-outstanding count (47,826,929) by more than securities-lending double counting can explain (FINRA short interest 3,048,448 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 7,168,9397.2M | $224M | — | — |
| 2 | TRV GP V, LLC | 7,135,2337.1M | $223M | — | — |
| 3 | ARCH Venture Management, LLC | 3,728,7383.7M | $117M | — | — |
| 4 | Capital International Investors | 3,097,9733.1M | $97M | — | TRIM -9% |
| 5 | Cormorant Asset Management, LP | 2,957,5213.0M | $93M | — | TRIM -2% |
| 6 | GOLDMAN SACHS GROUP INC | 2,942,2512.9M | $92M | — | — |
| 7 | BlackRock, Inc. | 2,505,9552.5M | $78M | — | ADD 3% |
| 8 | Sofinnova Investments, Inc. | 1,904,4081.9M | $60M | — | — |
| 9 | JOHNSON & JOHNSON | 1,784,5171.8M | $56M | — | — |
| 10 | Polar Capital Holdings Plc | 1,642,4611.6M | $51M | — | ADD 63% |
| 11 | BAKER BROS. ADVISORS LP | 1,547,0901.5M | $48M | — | — |
| 12 | Vestal Point Capital, LP | 1,436,2291.4M | $45M | — | ADD 29% |
| 13 | VANGUARD CAPITAL MANAGEMENT LLC | 1,325,0821.3M | $41M | — | NEW† |
| 14 | TRV GP VI, LLC | 969,218969,218 | $30M | — | — |
| 15 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 918,866918,866 | $29M | — | TRIM -4% |
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 866,456866,456 | $27M | — | — |
| 17 | STATE STREET CORP | 759,552759,552 | $24M | — | ADD 6% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 721,622721,622 | $23M | — | ADD 4% |
| 19 | ALLIANCEBERNSTEIN L.P. | 727,843727,843 | $22M | — | TRIM -8% |
| 20 | PERCEPTIVE ADVISORS LLC | 673,923673,923 | $21M | — | — |
| 21 | Siren, L.L.C. | 641,469641,469 | $20M | — | TRIM -9% |
| 22 | T. Rowe Price Investment Management, Inc. | 620,600620,600 | $19M | — | TRIM -27% |
| 23 | Capital World Investors | 536,607536,607 | $17M | — | NEW |
| 24 | Sio Capital Management, LLC | 366,809366,809 | $11M | — | ADD 98% |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 320,909320,909 | $10M | — | NEW |
| 26 | MILLENNIUM MANAGEMENT LLC | 319,552319,552 | $10M | — | ADD 58% |
| 27 | KENNEDY CAPITAL MANAGEMENT LLC | 257,431257,431 | $8M | — | ADD 44% |
| 28 | Burkehill Global Management, LP | 250,000250,000 | $8M | — | — |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 239,917239,917 | $8M | — | — |
| 30 | NORTHERN TRUST CORP | 237,992237,992 | $7M | — | ADD 8% |
| 31 | DIMENSIONAL FUND ADVISORS LP | 224,498224,498 | $7M | — | ADD 169% |
| 32 | Ensign Peak Advisors, Inc | 194,200194,200 | $6M | — | — |
| 33 | VANGUARD FIDUCIARY TRUST CO | 189,253189,253 | $6M | — | NEW |
| 34 | Candriam S.C.A. | 185,925185,925 | $6M | — | NEW |
| 35 | D. E. Shaw & Co., Inc. | 175,449175,449 | $5M | — | TRIM -29% |
| 36 | Invesco Ltd. | 171,757171,757 | $5M | — | TRIM -36% |
| 37 | MORGAN STANLEY | 165,954165,954 | $5M | — | TRIM -21% |
| 38 | UBS Group AG | 151,758151,758 | $5M | — | TRIM -33% |
| 39 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000150,000 | $5M | — | — |
| 40 | Artia Global Partners LP | 138,508138,508 | $4M | — | — |
| 41 | Freestone Grove Partners LP | 127,783127,783 | $4M | — | NEW |
| 42 | PRUDENTIAL FINANCIAL INC | 114,815114,815 | $4M | — | TRIM -55% |
| 43 | Swedbank AB | 113,200113,200 | $4M | — | — |
| 44 | BANK OF AMERICA CORP /DE/ | 110,826110,826 | $3M | — | ADD 221% |
| 45 | TD Asset Management Inc | 99,07899,078 | $3M | — | TRIM -14% |
| 46 | CITIGROUP INC | 78,79978,799 | $2M | — | ADD 40% |
| 47 | WELLINGTON MANAGEMENT GROUP LLP | 78,23178,231 | $2M | — | ADD 39% |
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,35975,359 | $2M | — | TRIM -4% |
| 49 | DAFNA Capital Management LLC | 75,00075,000 | $2M | — | — |
| 50 | VOYA INVESTMENT MANAGEMENT LLC | 72,94872,948 | $2M | — | ADD 10% |
| 51 | Bank of New York Mellon Corp | 72,31972,319 | $2M | — | TRIM -2% |
| 52 | Nuveen, LLC | 71,50871,508 | $2M | — | — |
| 53 | Swiss National Bank | 56,50056,500 | $2M | — | ADD 3% |
| 54 | AMERICAN CENTURY COMPANIES INC | 56,29256,292 | $2M | — | ADD 20% |
| 55 | XTX Topco Ltd | 47,90347,903 | $1M | — | ADD 267% |
| 56 | ALPS ADVISORS INC | 38,90738,907 | $1M | — | — |
| 57 | BNP PARIBAS FINANCIAL MARKETS | 35,95235,952 | $1M | — | ADD 191% |
| 58 | Y-Intercept (Hong Kong) Ltd | 35,82535,825 | $1M | — | NEW |
| 59 | RHUMBLINE ADVISERS | 34,53334,533 | $1M | — | ADD 12% |
| 60 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,42633,426 | $1M | — | ADD 25% |
| 61 | Russell Investments Group, Ltd. | 32,91832,918 | $1M | — | ADD 1343% |
| 62 | SEI INVESTMENTS CO | 30,81930,819 | $964,327 | — | ADD 69% |
| 63 | TWO SIGMA INVESTMENTS, LP | 28,10328,103 | $879,343 | — | TRIM -44% |
| 64 | SECTORAL ASSET MANAGEMENT INC | 25,42125,421 | $835,005 | — | TRIM -35% |
| 65 | AQR CAPITAL MANAGEMENT LLC | 25,51025,510 | $798,208 | — | ADD 22% |
| 66 | DEUTSCHE BANK AG\ | 24,16924,169 | $756,248 | — | ADD 12% |
| 67 | STATE OF WISCONSIN INVESTMENT BOARD | 23,91423,914 | $748,269 | — | ADD 188% |
| 68 | Susquehanna Portfolio Strategies, LLC | 22,78422,784 | $712,911 | — | ADD 224% |
| 69 | Trexquant Investment LP | 20,98420,984 | $656,589 | — | TRIM -67% |
| 70 | VANGUARD ASSET MANAGEMENT, Ltd | 18,53218,532 | $579,866 | — | NEW |
| 71 | Vanguard Global Advisers, LLC | 17,24017,240 | $539,440 | — | NEW |
| 72 | Legal & General Group Plc | 17,15417,154 | $536,749 | — | TRIM -23% |
| 73 | MetLife Investment Management, LLC | 15,99615,996 | $500,515 | — | — |
| 74 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,67215,672 | $490,377 | — | ADD 54% |
| 75 | Creative Planning | 15,51915,519 | $485,590 | — | ADD 27% |
| 76 | VARCOV Co. | 15,47315,473 | $484,150 | — | NEW |
| 77 | Optimize Financial Inc | 14,65614,656 | $458,586 | — | NEW |
| 78 | AMERIPRISE FINANCIAL INC | 14,58514,585 | $456,365 | — | — |
| 79 | JPMORGAN CHASE & CO | 15,84615,846 | $438,776 | — | ADD 5% |
| 80 | PSP Research LLC | 14,00014,000 | $438,060 | — | TRIM -20% |
| 81 | JANUS HENDERSON GROUP PLC | 13,80013,800 | $432,768 | — | — |
| 82 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,61813,618 | $426,107 | — | ADD 3% |
| 83 | Allianz Asset Management GmbH | 13,20013,200 | $413,028 | — | — |
| 84 | China Universal Asset Management Co., Ltd. | 12,05812,058 | $377,295 | — | ADD 12% |
| 85 | ACADIAN ASSET MANAGEMENT LLC | 11,78911,789 | $367,000 | — | TRIM -73% |
| 86 | Walleye Capital LLC | 11,14811,148 | $348,821 | — | NEW |
| 87 | WELLS FARGO & COMPANY/MN | 11,11611,116 | $347,820 | — | TRIM -65% |
| 88 | NEW YORK STATE COMMON RETIREMENT FUND | 11,00011,000 | $344,190 | — | ADD 51% |
| 89 | Soleus Capital Management, L.P. | 10,00010,000 | $312,900 | — | NEW |
| 90 | CATALYST PRIVATE WEALTH, LLC | 10,00010,000 | $312,900 | — | — |
| 91 | GSA CAPITAL PARTNERS LLP | 9,9289,928 | $311,000 | — | TRIM -22% |
| 92 | State of New Jersey Common Pension Fund D | 9,7739,773 | $305,797 | — | NEW |
| 93 | RENAISSANCE TECHNOLOGIES LLC | 9,7009,700 | $303,513 | — | TRIM -92% |
| 94 | BARCLAYS PLC | 9,6119,611 | $300,728 | — | TRIM -82% |
| 95 | CLEAR WAVE WEALTH MANAGEMENT LLC | 9,5009,500 | $297,255 | — | NEW |
| 96 | STIFEL FINANCIAL CORP | 9,0239,023 | $282,329 | — | ADD 32% |
| 97 | Virtus Investment Advisers, LLC | 9,0079,007 | $281,829 | — | ADD 2% |
| 98 | ARIZONA STATE RETIREMENT SYSTEM | 7,8547,854 | $245,752 | — | — |
| 99 | Verition Fund Management LLC | 7,5317,531 | $235,645 | — | NEW |
| 100 | Police & Firemen's Retirement System of New Jersey | 7,4717,471 | $233,768 | — | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5.5M | 5.5M | 5.5M | 6.9M | 7.1M | 7.2M | $224M |
| TRV GP V, LLC | 7.1M | 7.1M | 7.1M | 7.1M | 7.1M | 7.1M | $223M |
| ARCH Venture Management, LLC | 3.7M | 3.7M | 3.7M | 3.7M | 3.7M | 3.7M | $117M |
| Capital International Investors | 2.6M | 2.6M | 2.6M | 3.4M | 3.4M | 3.1M | $97M |
| Cormorant Asset Management, LP | 2.9M | 2.9M | 2.9M | 3.2M | 3.0M | 3.0M | $93M |
| GOLDMAN SACHS GROUP INC | 1.3M | 1.2M | 1.2M | 2.4M | 3.0M | 2.9M | $92M |
| BlackRock, Inc. | 757K | 1.2M | 1.2M | 1.6M | 2.4M | 2.5M | $78M |
| Sofinnova Investments, Inc. | 2.0M | 2.0M | 2.0M | 1.9M | 1.9M | 1.9M | $60M |
| JOHNSON & JOHNSON | 2.5M | 2.5M | 2.5M | 1.8M | 1.8M | 1.8M | $56M |
| Polar Capital Holdings Plc | — | — | — | 939K | 1.0M | 1.6M | $51M |
| BAKER BROS. ADVISORS LP | — | — | 550K | 1.5M | 1.5M | 1.5M | $48M |
| Vestal Point Capital, LP | — | — | — | 950K | 1.1M | 1.4M | $45M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.3M | $41M |
| TRV GP VI, LLC | 969K | 969K | 969K | 969K | 969K | 969K | $30M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | — | 203K | 244K | 892K | 952K | 919K | $29M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 147 | 52,482,931 | — | $1.6B |
| 2025-Q4 | 144 | 51,319,040 | 107.3% | $1.6B |
| 2025-Q3 | 124 | 49,286,721 | 103.1% | $1.5B |
| 2025-Q2 | 82 | 38,496,415 | 80.5% | $438M |
| 2025-Q1 | 77 | 38,102,588 | 79.7% | $382M |
| 2024-Q4 | 70 | 36,577,550 | 76.5% | $649M |
| 2024-Q3 | 55 | 28,448,075 | 59.5% | $582M |
| 2024-Q2 | 35 | 25,558,517 | 53.4% | $593M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Reporting Persons hold their securities of the Issuer for investment purposes. Depending on the factors discussed herein, the Reporting Persons may, from time to time, acquire additional Common Stock and/or retain and/or sell all or a portion of the Common Stock held by the Reporting Persons in the open market or in privately negotiated transactions, and/or may distribute the Common Stock held by the Reporting Persons to their respective members or limited partners. Any actions the Reporting”
| BlackRock, Inc. | 5.03% | QII | 2025-12-31 | SEC → |
| JOHNSON & JOHNSON | 4.9% | Exempt | 2025-09-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
