| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 10,909,25610.9M | $37M | 13.70% | — |
| 2 | BAKER BROS. ADVISORS LP | 10,123,82410.1M | $35M | 12.71% | — |
| 3 | Kynam Capital Management, LP | 1,592,5511.6M | $5M | 2.00% | ADD 102% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 1,230,4061.2M | $4M | 1.54% | NEW |
| 5 | EcoR1 Capital, LLC | 947,049947,049 | $3M | 1.19% | NEW |
| 6 | TWO SIGMA INVESTMENTS, LP | 923,626923,626 | $3M | 1.16% | ADD 17% |
| 7 | SPHERA FUNDS MANAGEMENT LTD. | 558,339558,339 | $2M | 0.70% | ADD 355% |
| 8 | ACADIAN ASSET MANAGEMENT LLC | 511,519511,519 | $2M | 0.64% | TRIM -5% |
| 9 | MILLENNIUM MANAGEMENT LLC | 382,737382,737 | $1M | 0.48% | ADD 153% |
| 10 | MARSHALL WACE, LLP | 358,906358,906 | $1M | 0.45% | ADD 31% |
| 11 | MORGAN STANLEY | 322,161322,161 | $1M | 0.40% | TRIM -4% |
| 12 | BlackRock, Inc. | 321,886321,886 | $1M | 0.40% | ADD 21% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 302,458302,458 | $1M | 0.38% | ADD 11% |
| 14 | RENAISSANCE TECHNOLOGIES LLC | 275,200275,200 | $941,184 | 0.35% | — |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,788267,788 | $915,835 | 0.34% | ADD 97% |
| 16 | GOLDMAN SACHS GROUP INC | 236,469236,469 | $808,724 | 0.30% | ADD 101% |
| 17 | JANE STREET GROUP, LLC | 192,963192,963 | $659,933 | 0.24% | ADD 74% |
| 18 | VANGUARD FIDUCIARY TRUST CO | 157,380157,380 | $538,240 | 0.20% | NEW |
| 19 | ADAR1 Capital Management, LLC | 152,825152,825 | $522,662 | 0.19% | NEW |
| 20 | STATE STREET CORP | 138,231138,231 | $472,750 | 0.17% | ADD 9% |
| 21 | CITADEL ADVISORS LLC | 124,378124,378 | $425,373 | 0.16% | NEW |
| 22 | Connor, Clark & Lunn Investment Management Ltd. | 109,085109,085 | $373,071 | 0.14% | ADD 137% |
| 23 | UBS Group AG | 64,50564,505 | $220,607 | 0.08% | ADD 3374% |
| 24 | HRT FINANCIAL LP | 58,69958,699 | $200,000 | 0.07% | NEW |
| 25 | XTX Topco Ltd | 57,19057,190 | $195,590 | 0.07% | ADD 14% |
| 26 | BANK OF AMERICA CORP /DE/ | 56,52556,525 | $193,316 | 0.07% | ADD 476% |
| 27 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 53,50053,500 | $182,970 | 0.07% | — |
| 28 | NORTHERN TRUST CORP | 50,12050,120 | $171,410 | 0.06% | — |
| 29 | Focus Partners Wealth | 50,00750,007 | $171,024 | 0.06% | — |
| 30 | DIMENSIONAL FUND ADVISORS LP | 35,21035,210 | $119,690 | 0.04% | NEW |
| 31 | Cerity Partners LLC | 32,87532,875 | $112,433 | 0.04% | — |
| 32 | OMERS ADMINISTRATION Corp | 32,70032,700 | $111,834 | 0.04% | TRIM -55% |
| 33 | PRUDENTIAL FINANCIAL INC | 17,42017,420 | $59,576 | 0.02% | ADD 12% |
| 34 | Qube Research & Technologies Ltd | 16,41716,417 | $56,146 | 0.02% | TRIM -24% |
| 35 | Point72 Asset Management, L.P. | 16,32916,329 | $55,845 | 0.02% | TRIM -72% |
| 36 | HSBC HOLDINGS PLC | 13,65213,652 | $47,919 | 0.02% | TRIM -50% |
| 37 | Diametric Capital, LP | 11,98011,980 | $40,971 | 0.02% | NEW |
| 38 | NINE MASTS CAPITAL Ltd | 11,69911,699 | $40,011 | 0.01% | NEW |
| 39 | Graham Capital Management, L.P. | 11,34311,343 | $38,793 | 0.01% | NEW |
| 40 | AMERICAN CENTURY COMPANIES INC | 10,29410,294 | $35,205 | 0.01% | NEW |
| 41 | BARCLAYS PLC | 8,6008,600 | $29,412 | 0.01% | — |
| 42 | FMR LLC | 6,0096,009 | $20,551 | 0.01% | TRIM -2% |
| 43 | Vanguard Global Advisers, LLC | 4,6364,636 | $15,855 | 0.01% | NEW |
| 44 | GROUP ONE TRADING LLC | 3,9073,907 | $13,362 | 0.00% | ADD 681% |
| 45 | SBI Securities Co., Ltd. | 2,6412,641 | $9,032 | 0.00% | TRIM -4% |
| 46 | ROYAL BANK OF CANADA | 2,3312,331 | $8,000 | 0.00% | ADD 34% |
| 47 | NISA INVESTMENT ADVISORS, LLC | 1,6341,634 | $5,588 | 0.00% | — |
| 48 | PNC FINANCIAL SERVICES GROUP, INC. | 1,1711,171 | $4,005 | 0.00% | — |
| 49 | CALDWELL SUTTER CAPITAL, INC. | 1,0001,000 | $3,420 | 0.00% | TRIM -50% |
| 50 | CWM, LLC | 573573 | $1,960 | 0.00% | TRIM -17% |
| 51 | Fortitude Family Office, LLC | 230230 | $787 | 0.00% | NEW |
| 52 | BNP PARIBAS FINANCIAL MARKETS | 9595 | $325 | 0.00% | — |
| 53 | JPMORGAN CHASE & CO | 6262 | $190 | 0.00% | — |
| 54 | Optiver Holding B.V. | 2020 | $68 | 0.00% | — |
| 55 | CITIGROUP INC | 55 | $17 | 0.00% | ADD 400% |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 10.9M | 10.9M | 10.9M | 10.9M | 10.9M | 10.9M | $37M |
| BAKER BROS. ADVISORS LP | 10.1M | 10.1M | 10.1M | 10.1M | 10.1M | 10.1M | $35M |
| Kynam Capital Management, LP | — | — | — | — | 789K | 1.6M | $5M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $4M |
| EcoR1 Capital, LLC | — | — | — | — | — | 947K | $3M |
| TWO SIGMA INVESTMENTS, LP | 232K | 184K | 155K | 152K | 789K | 924K | $3M |
| SPHERA FUNDS MANAGEMENT LTD. | — | — | — | — | 123K | 558K | $2M |
| ACADIAN ASSET MANAGEMENT LLC | 485K | 529K | 541K | 541K | 536K | 512K | $2M |
| MILLENNIUM MANAGEMENT LLC | 463K | 147K | 248K | 1.1M | 151K | 383K | $1M |
| MARSHALL WACE, LLP | 392K | — | 42K | — | 274K | 359K | $1M |
| MORGAN STANLEY | 365K | 303K | 284K | 284K | 335K | 322K | $1M |
| BlackRock, Inc. | 1.1M | 1.0M | 433K | 265K | 266K | 322K | $1M |
| GEODE CAPITAL MANAGEMENT, LLC | 402K | 405K | 218K | 218K | 273K | 302K | $1M |
| RENAISSANCE TECHNOLOGIES LLC | 635K | 657K | 582K | 544K | 271K | 275K | $941,184 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73K | 78K | 40K | — | 136K | 268K | $915,835 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 55 | 30,772,416 | 38.6% | $105M |
| 2025-Q4 | 48 | 28,485,967 | 35.8% | $83M |
| 2025-Q3 | 47 | 27,166,015 | 34.1% | $39M |
| 2025-Q2 | 50 | 27,190,915 | 34.1% | $22M |
| 2025-Q1 | 59 | 30,535,164 | 38.3% | $27M |
| 2024-Q4 | 62 | 32,170,360 | 40.4% | $41M |
| 2024-Q3 | 70 | 35,760,658 | 44.9% | $74M |
| 2024-Q2 | 61 | 33,923,377 | 42.6% | $129M |
| 2024-Q1 | 58 | 34,810,815 | 43.7% | $165M |
| 2023-Q4 | 56 | 35,033,480 | 44.0% |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| Soleus Private Equity Fund III, L.P. | 5.2% | Passive | 2026-04-21 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| $150M |
| 2023-Q3 | 60 | 36,614,487 | 46.0% | $113M |
| 2023-Q2 | 55 | 38,547,817 | 48.4% | $176M |
| 2023-Q1 | 54 | 36,034,376 | 45.2% | $205M |
| 2022-Q4 | 60 | 31,178,734 | 39.1% | $188M |
| 2022-Q3 | 53 | 31,822,065 | 40.0% | $210M |
| 2022-Q2 | 62 | 32,737,487 | 41.1% | $171M |
| 2022-Q1 | 68 | 34,110,201 | 42.8% | $235M |
| 2021-Q4 | 75 | 35,181,245 | 44.2% | $438M |
| 2021-Q3 | 61 | 35,967,400 | 45.2% | $1.1B |
| 2021-Q2 | 57 | 34,458,579 | 43.3% | $987M |
| 2021-Q1 | 60 | 32,543,662 | 40.9% | $1.4B |
| 2020-Q4 | 51 | 34,651,491 | 43.5% | $2.5B |
| 2020-Q3 | 39 | 33,322,071 | 41.8% | $1000M |
