| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | JANUS HENDERSON GROUP PLC | 1,317,4101.3M | $72M | 19.69% | — |
| 2 | RA CAPITAL MANAGEMENT, L.P. | 667,207667,207 | $37M | 9.97% | — |
| 3 | Saturn V Capital Management LP | 345,626345,626 | $19M | 5.16% | ADD 6% |
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 323,745323,745 | $18M | 4.84% | ADD 90% |
| 5 | BlackRock, Inc. | 316,567316,567 | $17M | 4.73% | ADD 24% |
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 309,195309,195 | $17M | 4.62% | TRIM -52% |
| 7 | Siren, L.L.C. | 270,118270,118 | $15M | 4.04% | ADD 27% |
| 8 | ADAR1 Capital Management, LLC | 264,278264,278 | $14M | 3.95% | ADD 13% |
| 9 | Polar Capital Holdings Plc | 226,526226,526 | $12M | 3.38% | ADD 114% |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 218,463218,463 | $12M | 3.26% | NEW† |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 174,342174,342 | $10M | 2.61% | TRIM -23% |
| 12 | Sio Capital Management, LLC | 173,506173,506 | $10M | 2.59% | NEW† |
| 13 | Balyasny Asset Management L.P. | 136,443136,443 | $7M | 2.04% | ADD 328% |
| 14 | TCG Crossover Management, LLC | 132,103132,103 | $7M | 1.97% | TRIM -7% |
| 15 | Alyeska Investment Group, L.P. | 100,000100,000 | $5M | 1.49% | ADD 150% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 99,91899,918 | $5M | 1.49% | — |
| 17 | Vivo Capital, LLC | 90,50090,500 | $5M | 1.35% | — |
| 18 | STATE STREET CORP | 88,35588,355 | $5M | 1.32% | ADD 5% |
| 19 | Bank of New York Mellon Corp | 78,61878,618 | $4M | 1.17% | ADD 21% |
| 20 | Vestal Point Capital, LP | 65,41865,418 | $4M | 0.98% | NEW |
| 21 | Walleye Capital LLC | 63,11963,119 | $3M | 0.94% | NEW |
| 22 | BANK OF AMERICA CORP /DE/ | 59,69959,699 | $3M | 0.89% | ADD 838% |
| 23 | CITADEL ADVISORS LLC | 58,43658,436 | $3M | 0.87% | ADD 1052% |
| 24 | MILLENNIUM MANAGEMENT LLC | 52,95152,951 | $3M | 0.79% | TRIM -31% |
| 25 | PRICE T ROWE ASSOCIATES INC /MD/ | 47,70247,702 | $3M | 0.71% | ADD 110% |
| 26 | VANGUARD PORTFOLIO MANAGEMENT LLC | 45,98745,987 | $3M | 0.69% | NEW |
| 27 | SILVERARC CAPITAL MANAGEMENT, LLC | 43,48843,488 | $2M | 0.65% | NEW |
| 28 | NEUBERGER BERMAN GROUP LLC | 42,43442,434 | $2M | 0.63% | ADD 30% |
| 29 | UBS Group AG | 39,43639,436 | $2M | 0.59% | ADD 828% |
| 30 | GOLDMAN SACHS GROUP INC | 34,71034,710 | $2M | 0.52% | ADD 235% |
| 31 | Driehaus Capital Management LLC | 33,15633,156 | $2M | 0.50% | — |
| 32 | NORTHERN TRUST CORP | 31,86231,862 | $2M | 0.48% | ADD 5% |
| 33 | DEUTSCHE BANK AG\ | 28,82228,822 | $2M | 0.43% | ADD 754% |
| 34 | VANGUARD FIDUCIARY TRUST CO | 28,44728,447 | $2M | 0.43% | NEW |
| 35 | BARCLAYS PLC | 24,93524,935 | $1M | 0.37% | ADD 23% |
| 36 | Jump Financial, LLC | 22,80822,808 | $1M | 0.34% | NEW |
| 37 | MORGAN STANLEY | 22,31222,312 | $1M | 0.33% | TRIM -17% |
| 38 | Squarepoint Ops LLC | 21,75421,754 | $1M | 0.33% | ADD 107% |
| 39 | Russell Investments Group, Ltd. | 14,24914,249 | $780,707 | 0.21% | ADD 4079% |
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,55812,558 | $688,053 | 0.19% | TRIM -12% |
| 41 | TWO SIGMA INVESTMENTS, LP | 9,7659,765 | $535,024 | 0.15% | ADD 96% |
| 42 | SEI INVESTMENTS CO | 7,5827,582 | $415,418 | 0.11% | ADD 9% |
| 43 | WINTON GROUP Ltd | 6,8296,829 | $374,161 | 0.10% | NEW |
| 44 | AMERIPRISE FINANCIAL INC | 6,8196,819 | $373,614 | 0.10% | NEW |
| 45 | Informed Momentum Co LLC | 6,2256,225 | $341,068 | 0.09% | TRIM -45% |
| 46 | Creative Planning | 5,9875,987 | $328,028 | 0.09% | NEW |
| 47 | TD Asset Management Inc | 5,8845,884 | $322,384 | 0.09% | ADD 91% |
| 48 | GERBER, LLC | 5,6015,601 | $306,879 | 0.08% | — |
| 49 | Nuveen, LLC | 5,5515,551 | $304,139 | 0.08% | — |
| 50 | RHUMBLINE ADVISERS | 4,9464,946 | $270,981 | 0.07% | — |
| 51 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,5724,572 | $250,500 | 0.07% | NEW |
| 52 | Engineers Gate Manager LP | 4,4344,434 | $242,939 | 0.07% | ADD 2% |
| 53 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4,1374,137 | $226,666 | 0.06% | NEW |
| 54 | Quadrature Capital Ltd | 3,6733,673 | $201,244 | 0.05% | NEW |
| 55 | Virtus Investment Advisers, LLC | 3,6553,655 | $200,257 | 0.05% | ADD 3% |
| 56 | Your Advocates Ltd., LLP | 3,3443,344 | $183,218 | 0.05% | NEW |
| 57 | MetLife Investment Management, LLC | 2,5382,538 | $139,057 | 0.04% | — |
| 58 | JPMORGAN CHASE & CO | 2,4222,422 | $129,068 | 0.04% | ADD 15% |
| 59 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,0562,056 | $112,648 | 0.03% | — |
| 60 | WELLS FARGO & COMPANY/MN | 1,7281,728 | $94,678 | 0.03% | TRIM -66% |
| 61 | DIADEMA PARTNERS LP | 1,6301,630 | $89,308 | 0.02% | NEW |
| 62 | Vanguard Global Advisers, LLC | 1,5531,553 | $85,089 | 0.02% | NEW |
| 63 | NEW YORK STATE COMMON RETIREMENT FUND | 1,2001,200 | $65,748 | 0.02% | — |
| 64 | BNP PARIBAS FINANCIAL MARKETS | 979979 | $53,639 | 0.01% | TRIM -4% |
| 65 | Police & Firemen's Retirement System of New Jersey | 964964 | $52,818 | 0.01% | — |
| 66 | Persistent Asset Partners Ltd | 783783 | $42,900 | 0.01% | NEW |
| 67 | Tower Research Capital LLC (TRC) | 761761 | $41,695 | 0.01% | ADD 119% |
| 68 | MEEDER ASSET MANAGEMENT INC | 637637 | $34,901 | 0.01% | TRIM -36% |
| 69 | FMR LLC | 409409 | $22,409 | 0.01% | ADD 14% |
| 70 | Legal & General Group Plc | 408408 | $22,354 | 0.01% | TRIM -15% |
| 71 | Ameritas Investment Partners, Inc. | 300300 | $16,437 | 0.00% | — |
| 72 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 247247 | $13,533 | 0.00% | TRIM -12% |
| 73 | CITIGROUP INC | 232232 | $12,711 | 0.00% | TRIM -98% |
| 74 | Allworth Financial LP | 111111 | $6,082 | 0.00% | ADD 11% |
| 75 | US BANCORP \DE\ | 7272 | $3,945 | 0.00% | NEW |
| 76 | ROYAL BANK OF CANADA | 4949 | $2,000 | 0.00% | TRIM -85% |
| 77 | Sterling Capital Management LLC | 2929 | $1,589 | 0.00% | — |
| 78 | GAMMA Investing LLC | 2929 | $1,589 | 0.00% | ADD 107% |
| 79 | Caitong International Asset Management Co., Ltd | 2525 | $1,370 | 0.00% | TRIM -99% |
| 80 | CWM, LLC | 1515 | $822 | 0.00% | ADD 200% |
| 81 | Kilter Group LLC | 11 | $55 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1.0M | 1.1M | 1.2M | 1.3M | 1.3M | 1.3M | $72M |
| RA CAPITAL MANAGEMENT, L.P. | 511K | 511K | 511K | 511K | 667K | 667K | $37M |
| Saturn V Capital Management LP | — | — | — | 155K | 326K | 346K | $19M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | — | — | 160K | 171K | 324K | $18M |
| BlackRock, Inc. | 8K | 14K | 205K | 204K | 255K | 317K | $17M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 599K | 599K | 599K | 659K | 639K | 309K | $17M |
| Siren, L.L.C. | — | — | — | — | 212K | 270K | $15M |
| ADAR1 Capital Management, LLC | 130K | 101K | 101K | 130K | 234K | 264K | $14M |
| Polar Capital Holdings Plc | — | — | — | — | 106K | 227K | $12M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 218K | $12M |
| WELLINGTON MANAGEMENT GROUP LLP | — | — | — | 231K | 226K | 174K | $10M |
| Sio Capital Management, LLC | — | — | — | — | — | 174K | $10M |
| Balyasny Asset Management L.P. | — | 6K | — | — | 32K | 136K | $7M |
| TCG Crossover Management, LLC | — | — | — | 153K | 142K | 132K | $7M |
| Alyeska Investment Group, L.P. | — | — | — | 12K | 40K | 100K | $5M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +218,463 | $12M | OPEN |
| Sio Capital Management, LLC | +173,506 | $10M | OPEN |
| DEERFIELD MANAGEMENT COMPANY, L.P. | +153,187 | $8M | ADD |
| Polar Capital Holdings Plc | +120,776 | $7M | ADD |
| Balyasny Asset Management L.P. | +104,536 | $6M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | −330,272 | $18M | TRIM |
| VANGUARD GROUP INC | −293,816 | $16M | CLOSE |
| Deep Track Capital, LP | −95,408 | $5M | CLOSE |
| WELLINGTON MANAGEMENT GROUP LLP | −51,726 | $3M | TRIM |
| MILLENNIUM MANAGEMENT LLC | −23,723 | $1M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 81 | 6,235,385 | 93.2% | $342M |
| 2025-Q4 | 74 | 5,527,030 | 82.7% | $361M |
| 2025-Q3 | 56 | 4,337,522 | 70.3% | $354M |
| 2025-Q2 | 43 | 3,176,516 | 51.9% | $113M |
| 2025-Q1 | 35 | 2,886,031 | 47.2% | $109M |
| 2024-Q4 | 18 | 2,578,295 | 48.9% | $57M |
| 2024-Q3 | 6 | 15,707 | 0.4% | $105,865 |
| 2024-Q2 | 12 | 418,162 | 2.4% | $310,094 |
| 2024-Q1 | 16 | 396,928 | 2.3% | $269,144 |
| 2023-Q4 | 14 | 272,192 | 1.8% | $91,978 |
| 2023-Q3 | 14 | 301,390 | 2.1% | $182,200 |
| 2023-Q2 | 8 | 192,440 | 1.5% | $164,536 |
| 2023-Q1 | 11 | 231,615 | 1.8% | $322,922 |
| 2022-Q4 | 10 | 198,728 | 1.5% | $470,991 |
| 2022-Q3 | 10 | 199,126 | 1.6% | $314,000 |
| 2022-Q2 | 13 | 208,038 | 1.6% | $483,610 |
| 2022-Q1 | 13 | 204,486 | 1.6% | $532,785 |
| 2021-Q4 | 13 | 204,233 | 1.6% | $657,247 |
| 2021-Q3 | 9 | 198,366 | 1.6% | $964,409 |
| 2021-Q2 | 10 | 187,460 | 1.5% | $1M |
| 2021-Q1 | 13 | 194,828 | 1.6% | $1M |
| 2020-Q4 | 7 | 69,929 | 0.6% | $429,000 |
| 2020-Q3 | 6 | 75,376 | 0.7% | $403,000 |
| 2020-Q2 | 5 | 56,765 | 0.5% | $424,000 |
| 2020-Q1 | 7 | 18,290 | 0.2% | $132,000 |
| 2019-Q4 | 4 | 26,432 | 0.3% | $439,000 |
