Institutional 13F holdings sum to 113.1% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 8,413,814 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 7,679,6847.7M | $709M | 12.73% | ADD 13% |
| 2 | JANUS HENDERSON GROUP PLC | 6,945,8136.9M | $642M | 11.51% | ADD 15% |
| 3 | BlackRock, Inc. | 3,846,5303.8M | $355M | 6.37% | ADD 6% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 2,414,7762.4M | $223M | 4.00% | NEW† |
| 5 | FMR LLC | 1,965,3752.0M | $182M | 3.26% | ADD 204% |
| 6 | STATE STREET CORP | 1,944,2811.9M | $180M | 3.22% | TRIM -9% |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,717,4211.7M | $159M | 2.85% | ADD 21% |
| 8 | BVF INC/IL | 1,584,7271.6M | $146M | 2.63% | ADD 6% |
| 9 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,432,0831.4M | $132M | 2.37% | NEW† |
| 10 | EVENTIDE ASSET MANAGEMENT, LLC | 1,408,8711.4M | $130M | 2.33% | TRIM -33% |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 1,334,8091.3M | $123M | 2.21% | ADD 8% |
| 12 | NOVO HOLDINGS A/S | 1,325,0001.3M | $122M | 2.20% | ADD 5% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1,260,0031.3M | $116M | 2.09% | ADD 19% |
| 14 | TANG CAPITAL MANAGEMENT LLC | 1,236,0271.2M | $114M | 2.05% | — |
| 15 | TCG Crossover Management, LLC | 1,062,0491.1M | $98M | 1.76% | ADD 1612% |
| 16 | CITADEL ADVISORS LLC | 1,052,0481.1M | $97M | 1.74% | ADD 25% |
| 17 | BNP PARIBAS FINANCIAL MARKETS | 911,419911,419 | $84M | 1.51% | ADD 39% |
| 18 | Rock Springs Capital Management LP | 811,294811,294 | $75M | 1.34% | ADD 6% |
| 19 | TWO SIGMA INVESTMENTS, LP | 774,841774,841 | $72M | 1.28% | ADD 99% |
| 20 | Capital World Investors | 724,415724,415 | $67M | 1.20% | NEW |
| 21 | BANK OF AMERICA CORP /DE/ | 722,177722,177 | $67M | 1.20% | — |
| 22 | FRANKLIN RESOURCES INC | 714,804714,804 | $66M | 1.18% | ADD 10% |
| 23 | Clearbridge Investments, LLC | 671,870671,870 | $62M | 1.11% | TRIM -22% |
| 24 | GOLDMAN SACHS GROUP INC | 662,306662,306 | $61M | 1.10% | TRIM -9% |
| 25 | Paradigm Biocapital Advisors LP | 625,000625,000 | $58M | 1.04% | NEW |
| 26 | LORD, ABBETT & CO. LLC | 617,064617,064 | $57M | 1.02% | ADD 6% |
| 27 | Bank of New York Mellon Corp | 584,523584,523 | $54M | 0.97% | ADD 3% |
| 28 | RENAISSANCE TECHNOLOGIES LLC | 582,085582,085 | $54M | 0.96% | ADD 33% |
| 29 | Woodline Partners LP | 567,894567,894 | $52M | 0.94% | — |
| 30 | Balyasny Asset Management L.P. | 539,031539,031 | $50M | 0.89% | ADD 89% |
| 31 | MORGAN STANLEY | 524,566524,566 | $48M | 0.87% | ADD 23% |
| 32 | FEDERATED HERMES, INC. | 506,211506,211 | $47M | 0.84% | ADD 5% |
| 33 | UBS Group AG | 494,994494,994 | $46M | 0.82% | ADD 54% |
| 34 | Connor, Clark & Lunn Investment Management Ltd. | 479,476479,476 | $44M | 0.79% | TRIM -8% |
| 35 | LOOMIS SAYLES & CO L P | 475,324475,324 | $44M | 0.79% | TRIM -8% |
| 36 | Nuveen, LLC | 474,227474,227 | $44M | 0.79% | TRIM -6% |
| 37 | Candriam S.C.A. | 464,216464,216 | $43M | 0.77% | TRIM -18% |
| 38 | BAKER BROS. ADVISORS LP | 445,975445,975 | $41M | 0.74% | NEW |
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,090427,090 | $39M | 0.71% | ADD 4% |
| 40 | Pictet Asset Management Holding SA | 423,511423,511 | $39M | 0.70% | TRIM -27% |
| 41 | BOONE CAPITAL MANAGEMENT LLC | 421,236421,236 | $39M | 0.70% | — |
| 42 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 405,321405,321 | $37M | 0.67% | TRIM -4% |
| 43 | First Turn Management, LLC | 400,464400,464 | $37M | 0.66% | TRIM -17% |
| 44 | Soleus Capital Management, L.P. | 400,306400,306 | $37M | 0.66% | TRIM -30% |
| 45 | EMERALD ADVISERS, LLC | 397,263397,263 | $37M | 0.66% | ADD 8% |
| 46 | NORTHERN TRUST CORP | 394,920394,920 | $36M | 0.65% | ADD 5% |
| 47 | NEXT CENTURY GROWTH INVESTORS LLC | 385,539385,539 | $36M | 0.64% | ADD 5% |
| 48 | TimesSquare Capital Management, LLC | 376,473376,473 | $35M | 0.62% | TRIM -5% |
| 49 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000375,000 | $35M | 0.62% | TRIM -20% |
| 50 | MILLENNIUM MANAGEMENT LLC | 368,575368,575 | $34M | 0.61% | ADD 51% |
| 51 | Point72 Asset Management, L.P. | 346,991346,991 | $32M | 0.58% | ADD 82% |
| 52 | Octagon Capital Advisors LP | 338,900338,900 | $31M | 0.56% | NEW |
| 53 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 335,669335,669 | $31M | 0.56% | — |
| 54 | VANGUARD FIDUCIARY TRUST CO | 333,327333,327 | $31M | 0.55% | NEW |
| 55 | Trails Edge Capital Partners, LP | 333,312333,312 | $31M | 0.55% | ADD 946% |
| 56 | Palo Alto Investors LP | 325,175325,175 | $30M | 0.54% | ADD 108% |
| 57 | RA CAPITAL MANAGEMENT, L.P. | 318,554318,554 | $29M | 0.53% | NEW |
| 58 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 286,406286,406 | $26M | 0.47% | NEW |
| 59 | Hood River Capital Management LLC | 285,384285,384 | $26M | 0.47% | — |
| 60 | Invesco Ltd. | 285,236285,236 | $26M | 0.47% | ADD 339% |
| 61 | Polar Capital Holdings Plc | 283,484283,484 | $26M | 0.47% | TRIM -64% |
| 62 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 265,631265,631 | $25M | 0.44% | ADD 3% |
| 63 | Penn Capital Management Company, LLC | 256,767256,767 | $24M | 0.43% | TRIM -9% |
| 64 | EMERALD MUTUAL FUND ADVISERS TRUST | 250,399250,399 | $23M | 0.41% | ADD 3% |
| 65 | NAN FUNG TRINITY (HK) LTD | 232,679232,679 | $21M | 0.39% | ADD 2% |
| 66 | Patient Square Capital LP | 230,000230,000 | $21M | 0.38% | TRIM -23% |
| 67 | RAYMOND JAMES FINANCIAL INC | 228,174228,174 | $21M | 0.38% | TRIM -7% |
| 68 | AMERIPRISE FINANCIAL INC | 219,255219,255 | $20M | 0.36% | TRIM -19% |
| 69 | Ensign Peak Advisors, Inc | 202,473202,473 | $19M | 0.34% | ADD 51% |
| 70 | NEW YORK STATE COMMON RETIREMENT FUND | 201,145201,145 | $19M | 0.33% | TRIM -8% |
| 71 | Logos Global Management LP | 200,000200,000 | $18M | 0.33% | TRIM -11% |
| 72 | Erste Asset Management GmbH | 210,000210,000 | $18M | 0.35% | TRIM -16% |
| 73 | Russell Investments Group, Ltd. | 197,093197,093 | $18M | 0.33% | TRIM -6% |
| 74 | Handelsbanken Fonder AB | 194,000194,000 | $18M | 0.32% | TRIM -9% |
| 75 | SEGALL BRYANT & HAMILL, LLC | 175,898175,898 | $16M | 0.29% | TRIM -5% |
| 76 | D. E. Shaw & Co., Inc. | 167,489167,489 | $15M | 0.28% | TRIM -82% |
| 77 | Legal & General Group Plc | 153,870153,870 | $14M | 0.25% | TRIM -9% |
| 78 | CITIGROUP INC | 153,470153,470 | $14M | 0.25% | ADD 5% |
| 79 | FIRST TRUST ADVISORS LP | 151,272151,272 | $14M | 0.25% | ADD 10% |
| 80 | Voleon Capital Management LP | 150,513150,513 | $14M | 0.25% | TRIM -13% |
| 81 | RICE HALL JAMES & ASSOCIATES, LLC | 147,037147,037 | $14M | 0.24% | TRIM -11% |
| 82 | PDT Partners, LLC | 145,379145,379 | $13M | 0.24% | — |
| 83 | Nicholas Investment Partners, LP | 131,303131,303 | $12M | 0.22% | TRIM -38% |
| 84 | PANAGORA ASSET MANAGEMENT INC | 129,114129,114 | $12M | 0.21% | NEW |
| 85 | Highlander Partners, L.P. | 122,980122,980 | $11M | 0.20% | — |
| 86 | ESSEX INVESTMENT MANAGEMENT CO LLC | 108,338108,338 | $10M | 0.18% | TRIM -3% |
| 87 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 104,099104,099 | $10M | 0.17% | TRIM -65% |
| 88 | Atle Fund Management AB | 195,768195,768 | $9M | 0.32% | ADD 118% |
| 89 | VICTORY CAPITAL MANAGEMENT INC | 95,55595,555 | $9M | 0.16% | ADD 32% |
| 90 | Hennion & Walsh Asset Management, Inc. | 93,59293,592 | $9M | 0.16% | TRIM -5% |
| 91 | Fisher Asset Management, LLC | 93,10993,109 | $9M | 0.15% | ADD 561% |
| 92 | Rhenman & Partners Asset Management AB | 92,60592,605 | $9M | 0.15% | TRIM -13% |
| 93 | ExodusPoint Capital Management, LP | 87,37387,373 | $8M | 0.14% | NEW |
| 94 | JPMORGAN CHASE & CO | 90,66490,664 | $8M | 0.15% | TRIM -7% |
| 95 | SEI INVESTMENTS CO | 81,10981,109 | $7M | 0.13% | ADD 76% |
| 96 | SILVERCREST ASSET MANAGEMENT GROUP LLC | 80,99180,991 | $7M | 0.13% | TRIM -10% |
| 97 | NEUBERGER BERMAN GROUP LLC | 80,54980,549 | $7M | 0.13% | NEW |
| 98 | Swiss National Bank | 74,30074,300 | $7M | 0.12% | — |
| 99 | PICTON MAHONEY ASSET MANAGEMENT | 74,11874,118 | $7M | 0.12% | ADD 5120% |
| 100 | VOYA INVESTMENT MANAGEMENT LLC | 68,81568,815 | $6M | 0.11% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6.6M | 6.8M | 6.8M | 6.8M | 6.8M | 7.7M | $709M |
| JANUS HENDERSON GROUP PLC | 4.6M | 4.8M | 5.2M | 5.0M | 6.1M | 6.9M | $642M |
| BlackRock, Inc. | 3.4M | 3.3M | 3.6M | 3.6M | 3.6M | 3.8M | $355M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.4M | $223M |
| FMR LLC | 5K | 54K | 59K | 640K | 646K | 2.0M | $182M |
| STATE STREET CORP | 1.4M | 1.5M | 1.4M | 1.3M | 2.1M | 1.9M | $180M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.4M | 1.4M | 1.4M | 1.3M | 1.4M | 1.7M | $159M |
| BVF INC/IL | 2.8M | 2.8M | 2.8M | 1.5M | 1.5M | 1.6M | $146M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 1.4M | $132M |
| EVENTIDE ASSET MANAGEMENT, LLC | 2.6M | 2.5M | 2.6M | 2.5M | 2.1M | 1.4M | $130M |
| WELLINGTON MANAGEMENT GROUP LLP | 118K | 113K | 119K | 791K | 1.2M | 1.3M | $123M |
| NOVO HOLDINGS A/S | 1.5M | 1.5M | 1.5M | 1.3M | 1.3M | 1.3M | $122M |
| GEODE CAPITAL MANAGEMENT, LLC | 943K | 964K | 1.0M | 1.0M | 1.1M | 1.3M | $116M |
| TANG CAPITAL MANAGEMENT LLC | 1.2M | 1.2M | 1.2M | 1.2M | 1.2M | 1.2M | $114M |
| TCG Crossover Management, LLC | — | — | — | — | 62K | 1.1M | $98M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 is hereby amended and restated in its entirety to read as follows: Each of FLS IX, FLS X, FLSPF, FLS XI and FLS XII acquired the FLS IX Shares, the FLS X Shares, the FLSPF Shares, the FLS XI Shares and the FLS XII Shares, as the case may be, for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, FLS IX, FLS X, FLSPF, FLS XI and FLS XII and the other Reporting Persons may dispose of or acquire additi”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +2,414,776 | $223M | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,432,083 | $132M | OPEN |
| FMR LLC | +1,318,909 | $122M | ADD |
| TCG Crossover Management, LLC | +1,000,000 | $92M | ADD |
| Frazier Life Sciences Management, L.P. | +884,563 | $82M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −2,596,089 | $240M | CLOSE |
| D. E. Shaw & Co., Inc. | −780,672 | $72M | TRIM |
| EVENTIDE ASSET MANAGEMENT, LLC | −684,711 | $63M | TRIM |
| Polar Capital Holdings Plc | −510,158 | $47M | TRIM |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | −304,626 | $28M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 310 | 68,248,847 | 113.1% | $6.3B |
| 2025-Q4 | 282 | 61,030,296 | — | $4.8B |
| 2025-Q3 | 272 | 57,446,093 | — | $4.2B |
| 2025-Q2 | 214 | 55,400,034 | — | $2.8B |
| 2025-Q1 | 214 | 54,162,566 | — | $2.4B |
| 2024-Q4 | 205 | 52,986,154 | — | $2.2B |
| 2024-Q3 | 178 | 53,353,765 | — | $2.1B |
| 2024-Q2 | 160 | 53,820,039 | — | $1.8B |
| 2024-Q1 | 172 | 54,103,274 | — | $1.4B |
| 2023-Q4 | 187 | 51,307,872 | — | $1.5B |
| 2023-Q3 | 159 | 48,935,342 | — | $1.5B |
| 2023-Q2 | 146 | 36,942,648 | 97.1% | $956M |
| 2023-Q1 | 117 | 34,675,455 | 91.4% | $833M |
| 2022-Q4 | 104 | 33,337,030 | 90.4% | $650M |
| 2022-Q3 | 112 | 34,607,183 | 105.7% | $727M |
| 2022-Q2 | 109 | 30,213,225 | 94.9% | $587M |
| 2022-Q1 | 99 | 27,797,184 | 87.6% | $612M |
| 2021-Q4 | 86 | 24,836,512 | 81.1% | $396M |
| 2021-Q3 | 72 | 23,336,158 | 76.5% | $465M |
| 2021-Q2 | 67 | 24,064,844 | 79.0% | $416M |
| 2021-Q1 | 61 | 23,373,102 | 76.8% | $463M |
| 2020-Q4 | 72 | 23,931,741 | 93.1% | $418M |
| 2020-Q3 | 51 | 18,743,149 | 73.8% | $361M |
| 2020-Q2 | 58 | 18,975,571 | 74.7% | $369M |
| 2020-Q1 | 43 | 18,761,973 | 73.9% | $263M |
| 2019-Q4 | 39 | 16,307,495 | 70.9% | $400M |
| 2019-Q3 | 39 | 16,487,773 | 71.7% | $166M |
| EVENTIDE ASSET MANAGEMENT, LLC | 4.1% | QII | 2025-12-31 | SEC → |
| BIOTECHNOLOGY VALUE FUND L P | 3% | Passive | 2025-09-30 | SEC → |
| VANGUARD GROUP INC | 0% | QII | 2026-03-13 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
