% of shares outstanding suppressed: the summed institutional 13F holdings (64,316,475) exceed the latest reported shares-outstanding count (54,666,233) by more than securities-lending double counting can explain (FINRA short interest 6,552,520 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 7,767,6867.8M | $652M | — | ADD 21% |
| 2 | Avidity Partners Management LP | 4,208,3684.2M | $361M | — | ADD 100% |
| 3 | BlackRock, Inc. | 3,175,7033.2M | $267M | — | ADD 66% |
| 4 | RA CAPITAL MANAGEMENT, L.P. | 2,611,7332.6M | $219M | — | ADD 62% |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 2,595,7832.6M | $218M | — | ADD 4% |
| 6 | Fairmount Funds Management LLC | 2,537,1912.5M | $213M | — | ADD 19% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 2,031,2492.0M | $170M | — | NEW† |
| 8 | Octagon Capital Advisors LP | 1,946,6671.9M | $163M | — | TRIM -19% |
| 9 | TCG Crossover Management, LLC | 1,676,6241.7M | $141M | — | — |
| 10 | CITADEL ADVISORS LLC | 1,610,4831.6M | $135M | — | ADD 51% |
| 11 | STATE STREET CORP | 1,398,9131.4M | $117M | — | TRIM -7% |
| 12 | T. Rowe Price Investment Management, Inc. | 1,292,1821.3M | $108M | — | NEW† |
| 13 | Venrock Adviser, LLC | 1,180,0001.2M | $99M | — | ADD 18% |
| 14 | FRED ALGER MANAGEMENT, LLC | 1,161,9231.2M | $98M | — | ADD 3373% |
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,146,9481.1M | $96M | — | ADD 86% |
| 16 | Polar Capital Holdings Plc | 1,076,0091.1M | $90M | — | ADD 7% |
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,019,8131.0M | $86M | — | NEW |
| 18 | FRANKLIN RESOURCES INC | 968,182968,182 | $81M | — | ADD 109% |
| 19 | Cormorant Asset Management, LP | 950,000950,000 | $80M | — | NEW |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 916,211916,211 | $77M | — | ADD 35% |
| 21 | BRAIDWELL LP | 899,364899,364 | $75M | — | TRIM -29% |
| 22 | BAKER BROS. ADVISORS LP | 852,164852,164 | $72M | — | ADD 8% |
| 23 | FARALLON CAPITAL MANAGEMENT LLC | 836,000836,000 | $70M | — | NEW |
| 24 | UBS Group AG | 781,282781,282 | $66M | — | ADD 29% |
| 25 | SILVERARC CAPITAL MANAGEMENT, LLC | 654,746654,746 | $55M | — | TRIM -13% |
| 26 | Point72 Asset Management, L.P. | 643,599643,599 | $54M | — | TRIM -45% |
| 27 | Catalio Capital Management, LP | 560,308560,308 | $47M | — | TRIM -14% |
| 28 | GOLDMAN SACHS GROUP INC | 548,010548,010 | $46M | — | TRIM -5% |
| 29 | JENNISON ASSOCIATES LLC | 485,136485,136 | $41M | — | NEW |
| 30 | Balyasny Asset Management L.P. | 474,085474,085 | $40M | — | NEW |
| 31 | ALLIANCEBERNSTEIN L.P. | 926,071926,071 | $38M | — | ADD 11% |
| 32 | Woodline Partners LP | 433,457433,457 | $36M | — | ADD 103% |
| 33 | SAMLYN CAPITAL, LLC | 431,115431,115 | $36M | — | NEW |
| 34 | MPM BIOIMPACT LLC | 423,982423,982 | $36M | — | NEW |
| 35 | Logos Global Management LP | 400,000400,000 | $34M | — | ADD 27% |
| 36 | Artisan Partners Limited Partnership | 382,121382,121 | $32M | — | NEW |
| 37 | BARCLAYS PLC | 379,606379,606 | $32M | — | ADD 115% |
| 38 | Spruce Street Capital LP | 373,274373,274 | $31M | — | ADD 25% |
| 39 | Sio Capital Management, LLC | 370,045370,045 | $31M | — | TRIM -22% |
| 40 | Bain Capital Life Sciences Investors, LLC | 362,470362,470 | $30M | — | TRIM -51% |
| 41 | AMERIPRISE FINANCIAL INC | 358,470358,470 | $30M | — | ADD 131% |
| 42 | Vivo Capital, LLC | 353,998353,998 | $30M | — | — |
| 43 | Affinity Asset Advisors, LLC | 350,000350,000 | $29M | — | ADD 204% |
| 44 | VANGUARD PORTFOLIO MANAGEMENT LLC | 349,381349,381 | $29M | — | NEW |
| 45 | MARSHALL WACE, LLP | 341,929341,929 | $29M | — | TRIM -66% |
| 46 | DIMENSIONAL FUND ADVISORS LP | 325,440325,440 | $27M | — | ADD 54% |
| 47 | Driehaus Capital Management LLC | 317,312317,312 | $27M | — | NEW |
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 305,440305,440 | $26M | — | ADD 22% |
| 49 | NORTHERN TRUST CORP | 303,752303,752 | $25M | — | ADD 47% |
| 50 | LORD, ABBETT & CO. LLC | 299,210299,210 | $25M | — | NEW |
| 51 | TANG CAPITAL MANAGEMENT LLC | 264,692264,692 | $22M | — | — |
| 52 | MILLENNIUM MANAGEMENT LLC | 261,962261,962 | $22M | — | TRIM -61% |
| 53 | VANGUARD FIDUCIARY TRUST CO | 249,679249,679 | $21M | — | NEW |
| 54 | RTW INVESTMENTS, LP | 248,063248,063 | $21M | — | NEW |
| 55 | Freestone Grove Partners LP | 239,943239,943 | $20M | — | NEW |
| 56 | BNP PARIBAS FINANCIAL MARKETS | 235,748235,748 | $20M | — | TRIM -50% |
| 57 | EVENTIDE ASSET MANAGEMENT, LLC | 225,261225,261 | $19M | — | NEW |
| 58 | First Turn Management, LLC | 220,921220,921 | $19M | — | NEW |
| 59 | Nuveen, LLC | 217,482217,482 | $18M | — | ADD 14% |
| 60 | Candriam S.C.A. | 213,522213,522 | $18M | — | TRIM -31% |
| 61 | Ensign Peak Advisors, Inc | 204,336204,336 | $17M | — | ADD 52% |
| 62 | Jefferies Financial Group Inc. | 202,410202,410 | $17M | — | NEW |
| 63 | BANK OF AMERICA CORP /DE/ | 188,779188,779 | $16M | — | TRIM -59% |
| 64 | Bank of New York Mellon Corp | 188,412188,412 | $16M | — | ADD 151% |
| 65 | PFM Health Sciences, LP | 172,137172,137 | $14M | — | ADD 73% |
| 66 | STEMPOINT CAPITAL LP | 171,004171,004 | $14M | — | ADD 116% |
| 67 | Artia Global Partners LP | 162,990162,990 | $14M | — | TRIM -21% |
| 68 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000160,000 | $13M | — | NEW |
| 69 | Walleye Capital LLC | 153,585153,585 | $13M | — | TRIM -25% |
| 70 | Integral Health Asset Management, LLC | 150,000150,000 | $13M | — | TRIM -45% |
| 71 | D. E. Shaw & Co., Inc. | 149,609149,609 | $13M | — | TRIM -3% |
| 72 | Tri Locum Partners LP | 145,543145,543 | $12M | — | TRIM -77% |
| 73 | Invesco Ltd. | 130,747130,747 | $11M | — | ADD 29% |
| 74 | Russell Investments Group, Ltd. | 129,065129,065 | $11M | — | ADD 46% |
| 75 | Atika Capital Management LLC | 128,800128,800 | $11M | — | TRIM -4% |
| 76 | TD Asset Management Inc | 116,576116,576 | $10M | — | ADD 267% |
| 77 | LMR Partners LLP | 116,444116,444 | $10M | — | NEW |
| 78 | Hudson Bay Capital Management LP | 109,238109,238 | $9M | — | NEW |
| 79 | Atom Investors LP | 107,753107,753 | $9M | — | TRIM -41% |
| 80 | SummitTX Capital, L.P. | 100,044100,044 | $8M | — | ADD 14% |
| 81 | SEVEN GRAND MANAGERS, LLC | 100,000100,000 | $8M | — | NEW |
| 82 | MORGAN STANLEY | 97,45597,455 | $8M | — | TRIM -57% |
| 83 | Cinctive Capital Management LP | 94,40894,408 | $8M | — | ADD 106% |
| 84 | Patient Square Capital LP | 93,88293,882 | $8M | — | TRIM -37% |
| 85 | SEI INVESTMENTS CO | 92,22992,229 | $8M | — | ADD 566% |
| 86 | ExodusPoint Capital Management, LP | 85,53085,530 | $7M | — | TRIM -65% |
| 87 | Moody Aldrich Partners LLC | 82,12982,129 | $7M | — | ADD 99% |
| 88 | Rhenman & Partners Asset Management AB | 81,62781,627 | $7M | — | TRIM -17% |
| 89 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,00180,001 | $7M | — | ADD 55% |
| 90 | AMERICAN CENTURY COMPANIES INC | 79,09679,096 | $7M | — | ADD 9% |
| 91 | Informed Momentum Co LLC | 76,64076,640 | $6M | — | TRIM -9% |
| 92 | Schonfeld Strategic Advisors LLC | 73,46873,468 | $6M | — | TRIM -60% |
| 93 | Swiss National Bank | 69,00069,000 | $6M | — | ADD 120% |
| 94 | Nantahala Capital Management, LLC | 67,28267,282 | $6M | — | TRIM -82% |
| 95 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,23865,238 | $5M | — | ADD 155% |
| 96 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 60,43560,435 | $5M | — | ADD 401% |
| 97 | Trexquant Investment LP | 59,07759,077 | $5M | — | ADD 1033% |
| 98 | NEUBERGER BERMAN GROUP LLC | 59,07659,076 | $5M | — | TRIM -33% |
| 99 | ADAR1 Capital Management, LLC | 55,00055,000 | $5M | — | NEW |
| 100 | Seven Fleet Capital Management LP | 54,25854,258 | $5M | — | ADD 270% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4.4M | 4.5M | 4.5M | 6.0M | 6.4M | 7.8M | $652M |
| Avidity Partners Management LP | 2.9M | 1.7M | 1.7M | 3.2M | 2.1M | 4.2M | $361M |
| BlackRock, Inc. | 1.7M | 1.6M | 1.4M | 1.3M | 1.9M | 3.2M | $267M |
| RA CAPITAL MANAGEMENT, L.P. | 1.9M | 2.9M | 2.9M | 2.9M | 1.6M | 2.6M | $219M |
| WELLINGTON MANAGEMENT GROUP LLP | 60K | 68K | 74K | 2.6M | 2.5M | 2.6M | $218M |
| Fairmount Funds Management LLC | 2.7M | 2.7M | 2.7M | 3.3M | 2.1M | 2.5M | $213M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.0M | $170M |
| Octagon Capital Advisors LP | 2.1M | 2.3M | 2.3M | 2.4M | 2.4M | 1.9M | $163M |
| TCG Crossover Management, LLC | 1.5M | 1.5M | 1.5M | 1.7M | 1.7M | 1.7M | $141M |
| CITADEL ADVISORS LLC | 422K | 471K | 665K | 1.0M | 1.1M | 1.6M | $135M |
| STATE STREET CORP | 819K | 760K | 820K | 671K | 1.5M | 1.4M | $117M |
| T. Rowe Price Investment Management, Inc. | — | — | — | — | — | 1.3M | $108M |
| Venrock Adviser, LLC | 1.7M | 1.7M | 1.0M | 961K | 1.0M | 1.2M | $99M |
| FRED ALGER MANAGEMENT, LLC | — | — | — | 45K | 33K | 1.2M | $98M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9K | 10K | 11K | 216K | 616K | 1.1M | $96M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 241 | 64,316,475 | — | $5.4B |
| 2025-Q4 | 166 | 49,125,602 | 89.9% | $2.0B |
| 2025-Q3 | 140 | 46,896,911 | 85.8% | $1.8B |
| 2025-Q2 | 103 | 39,110,813 | 71.5% | $729M |
| 2025-Q1 | 99 | 37,715,367 | 69.0% | $685M |
| 2024-Q4 | 96 | 35,126,698 | 64.3% | $766M |
| 2024-Q3 | 91 | 31,375,452 | 57.4% | $859M |
| 2024-Q2 | 74 | 29,712,762 | 54.4% | $769M |
| 2024-Q1 | 76 | 26,135,034 | 47.8% | $784M |
| 2023-Q4 | 39 | 10,619,651 | 19.4% | $110M |
| 2023-Q3 | 30 | 10,072,644 | 18.4% | $136M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Item 4 of the Statement is hereby amended and supplemented as follows: On November 24, 2025, Fund II provided notice to the Company to decrease the Maximum Percentage of the Pre-Funded Warrants from 9.99% to 4.99%, such that the Reporting Persons may only exercise the Pre-Funded Warrants to the extent that after giving effect to such exercise the holders thereof and their affiliates and any persons who are members of a Section 13(d) group with the holders would beneficially own in the aggregate ”
“The Reporting Persons are filing this Amendment No. 3 to report a greater than 1.00% decrease in the percentage of shares of Common Stock beneficially owned by the Reporting Persons due to the sale of shares of Common Stock by private investment funds managed by Avidity Partners Management LP, including Avidity Private Master Fund I LP. Although the Reporting Persons do not have any specific plan or proposal to acquire, transfer or dispose of Common Stock at the time of this filing, consistent w”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
