| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,165,0067.2M | $105M | 8.53% | — |
| 2 | BlackRock, Inc. | 6,160,4226.2M | $90M | 7.33% | ADD 22% |
| 3 | STATE STREET CORP | 3,565,9923.6M | $52M | 4.25% | ADD 28% |
| 4 | ADAMS STREET PARTNERS LLC | 3,275,6163.3M | $48M | 3.90% | — |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 3,234,5383.2M | $47M | 3.85% | NEW† |
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,917,3002.9M | $43M | 3.47% | ADD 8454% |
| 7 | Vivo Capital, LLC | 2,805,8162.8M | $41M | 3.34% | ADD 26% |
| 8 | MORGAN STANLEY | 2,498,8252.5M | $37M | 2.98% | TRIM -30% |
| 9 | Deep Track Capital, LP | 2,491,5392.5M | $36M | 2.97% | NEW† |
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 2,318,5172.3M | $34M | 2.76% | ADD 637% |
| 11 | PERCEPTIVE ADVISORS LLC | 2,292,4412.3M | $34M | 2.73% | ADD 231% |
| 12 | Commodore Capital LP | 2,258,7352.3M | $33M | 2.69% | NEW† |
| 13 | Foresite Capital Management VI LLC | 1,831,2331.8M | $27M | 2.18% | ADD 33% |
| 14 | BRAIDWELL LP | 1,752,7981.8M | $26M | 2.09% | NEW† |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 1,712,7411.7M | $25M | 2.04% | ADD 16% |
| 16 | MPM BIOIMPACT LLC | 1,674,8751.7M | $25M | 1.99% | TRIM -39% |
| 17 | GOLDMAN SACHS GROUP INC | 1,540,8091.5M | $23M | 1.83% | ADD 178% |
| 18 | Hood River Capital Management LLC | 1,335,1091.3M | $20M | 1.59% | NEW |
| 19 | Boxer Capital Management, LLC | 1,100,0001.1M | $16M | 1.31% | NEW |
| 20 | Polar Capital Holdings Plc | 1,070,1741.1M | $16M | 1.27% | NEW |
| 21 | Catalio Capital Management, LP | 891,933891,933 | $13M | 1.06% | NEW |
| 22 | MILLENNIUM MANAGEMENT LLC | 866,362866,362 | $13M | 1.03% | ADD 26% |
| 23 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000750,000 | $11M | 0.89% | NEW |
| 24 | EMERALD ADVISERS, LLC | 686,216686,216 | $10M | 0.82% | NEW |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 669,895669,895 | $10M | 0.80% | NEW |
| 26 | DCF Advisers, LLC | 637,500637,500 | $9M | 0.76% | TRIM -13% |
| 27 | EVENTIDE ASSET MANAGEMENT, LLC | 550,000550,000 | $8M | 0.65% | NEW |
| 28 | MARSHALL WACE, LLP | 548,285548,285 | $8M | 0.65% | ADD 154% |
| 29 | Blue Owl Capital Holdings LP | 545,000545,000 | $8M | 0.65% | NEW |
| 30 | TWO SIGMA INVESTMENTS, LP | 539,869539,869 | $8M | 0.64% | ADD 276% |
| 31 | NORTHERN TRUST CORP | 506,104506,104 | $7M | 0.60% | ADD 18% |
| 32 | VANGUARD FIDUCIARY TRUST CO | 504,631504,631 | $7M | 0.60% | NEW |
| 33 | EMERALD MUTUAL FUND ADVISERS TRUST | 459,253459,253 | $7M | 0.55% | NEW |
| 34 | RA CAPITAL MANAGEMENT, L.P. | 450,000450,000 | $7M | 0.54% | NEW |
| 35 | Nextech Invest, Ltd. | 450,000450,000 | $7M | 0.54% | NEW |
| 36 | Logos Global Management LP | 450,000450,000 | $7M | 0.54% | TRIM -10% |
| 37 | CITADEL ADVISORS LLC | 442,522442,522 | $6M | 0.53% | ADD 113% |
| 38 | UBS Group AG | 289,114289,114 | $4M | 0.34% | ADD 36% |
| 39 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 278,007278,007 | $4M | 0.33% | NEW |
| 40 | SPHERA FUNDS MANAGEMENT LTD. | 247,961247,961 | $4M | 0.30% | TRIM -39% |
| 41 | DIADEMA PARTNERS LP | 244,811244,811 | $4M | 0.29% | NEW |
| 42 | BARCLAYS PLC | 243,776243,776 | $4M | 0.29% | TRIM -38% |
| 43 | BANK OF AMERICA CORP /DE/ | 237,004237,004 | $3M | 0.28% | — |
| 44 | Avidity Partners Management LP | 230,000230,000 | $3M | 0.27% | NEW |
| 45 | Spruce Street Capital LP | 231,585231,585 | $3M | 0.28% | NEW |
| 46 | SEB Asset Management AB | 226,837226,837 | $3M | 0.27% | NEW |
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,129188,129 | $3M | 0.22% | ADD 10% |
| 48 | Bank of New York Mellon Corp | 185,347185,347 | $3M | 0.22% | ADD 41% |
| 49 | Polymer Capital Management (HK) LTD | 183,187183,187 | $3M | 0.22% | NEW |
| 50 | Brevan Howard Capital Management LP | 167,971167,971 | $2M | 0.20% | NEW |
| 51 | Nuveen, LLC | 149,126149,126 | $2M | 0.18% | ADD 119% |
| 52 | Jump Financial, LLC | 147,850147,850 | $2M | 0.18% | NEW |
| 53 | Informed Momentum Co LLC | 138,148138,148 | $2M | 0.16% | NEW |
| 54 | JPMORGAN CHASE & CO | 145,157145,157 | $2M | 0.17% | ADD 374% |
| 55 | VICTORY CAPITAL MANAGEMENT INC | 128,352128,352 | $2M | 0.15% | NEW |
| 56 | Squarepoint Ops LLC | 123,896123,896 | $2M | 0.15% | ADD 18% |
| 57 | TD Asset Management Inc | 123,738123,738 | $2M | 0.15% | NEW |
| 58 | Rafferty Asset Management, LLC | 112,608112,608 | $2M | 0.13% | ADD 13% |
| 59 | Tidal Investments LLC | 107,775107,775 | $2M | 0.13% | NEW |
| 60 | Tema ETFs LLC | 107,775107,775 | $2M | 0.13% | ADD 35% |
| 61 | Aquatic Capital Management LLC | 102,364102,364 | $1M | 0.12% | NEW |
| 62 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,779101,779 | $1M | 0.12% | ADD 482% |
| 63 | F/m Investments LLC | 100,029100,029 | $1M | 0.12% | NEW |
| 64 | RAYMOND JAMES FINANCIAL INC | 99,88399,883 | $1M | 0.12% | TRIM -18% |
| 65 | VOYA INVESTMENT MANAGEMENT LLC | 99,63199,631 | $1M | 0.12% | ADD 260% |
| 66 | ADAR1 Capital Management, LLC | 87,90187,901 | $1M | 0.10% | TRIM -81% |
| 67 | Propel Bio Management, LLC | 85,79185,791 | $1M | 0.10% | NEW |
| 68 | Connor, Clark & Lunn Investment Management Ltd. | 83,90783,907 | $1M | 0.10% | ADD 198% |
| 69 | Seven Fleet Capital Management LP | 82,89082,890 | $1M | 0.10% | NEW |
| 70 | RENAISSANCE TECHNOLOGIES LLC | 81,31081,310 | $1M | 0.10% | NEW |
| 71 | RHUMBLINE ADVISERS | 76,51476,514 | $1M | 0.09% | ADD 8% |
| 72 | TOWERVIEW LLC | 70,00070,000 | $1M | 0.08% | TRIM -50% |
| 73 | ACADIAN ASSET MANAGEMENT LLC | 69,15269,152 | $1M | 0.08% | NEW |
| 74 | ALPS ADVISORS INC | 68,19468,194 | $997,678 | 0.08% | ADD 11% |
| 75 | JACKSON SQUARE CAPITAL, LLC | 63,77363,773 | $932,999 | 0.08% | — |
| 76 | Persistent Asset Partners Ltd | 62,05162,051 | $907,806 | 0.07% | NEW |
| 77 | SEI INVESTMENTS CO | 60,84860,848 | $890,206 | 0.07% | NEW |
| 78 | Ancora Advisors LLC | 54,76854,768 | $801,256 | 0.07% | ADD 15% |
| 79 | DEUTSCHE BANK AG\ | 54,47954,479 | $797,028 | 0.06% | TRIM -3% |
| 80 | PROFUND ADVISORS LLC | 50,23550,235 | $734,938 | 0.06% | ADD 36% |
| 81 | SEVEN GRAND MANAGERS, LLC | 50,00050,000 | $731,500 | 0.06% | NEW |
| 82 | Hikari Power Ltd | 49,95949,959 | $731,000 | 0.06% | — |
| 83 | Vanguard Global Advisers, LLC | 47,68847,688 | $697,675 | 0.06% | NEW |
| 84 | JANE STREET GROUP, LLC | 44,47344,473 | $650,640 | 0.05% | TRIM -88% |
| 85 | Creative Planning | 43,03243,032 | $629,558 | 0.05% | ADD 10% |
| 86 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 41,41641,416 | $605,916 | 0.05% | NEW |
| 87 | FRANKLIN RESOURCES INC | 39,08139,081 | $571,755 | 0.05% | NEW |
| 88 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,63638,636 | $565,245 | 0.05% | TRIM -37% |
| 89 | Invesco Ltd. | 38,21238,212 | $559,042 | 0.05% | TRIM -12% |
| 90 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,15238,152 | $548,350 | 0.05% | ADD 18% |
| 91 | SG Americas Securities, LLC | 35,42035,420 | $518,000 | 0.04% | ADD 77% |
| 92 | SIMPLEX TRADING, LLC | 34,72334,723 | $507,997 | 0.04% | NEW |
| 93 | XTX Topco Ltd | 34,30534,305 | $501,882 | 0.04% | NEW |
| 94 | Qube Research & Technologies Ltd | 33,22833,228 | $486,126 | 0.04% | TRIM -71% |
| 95 | AVITY INVESTMENT MANAGEMENT INC. | 33,20033,200 | $485,716 | 0.04% | — |
| 96 | MetLife Investment Management, LLC | 33,10033,100 | $484,253 | 0.04% | ADD 8% |
| 97 | Virtus Investment Advisers, LLC | 32,57932,579 | $476,631 | 0.04% | ADD 3% |
| 98 | ALLIANCEBERNSTEIN L.P. | 61,74061,740 | $475,398 | 0.07% | ADD 261% |
| 99 | Composition Wealth, LLC | 30,00030,000 | $438,900 | 0.04% | NEW |
| 100 | Optimize Financial Inc | 28,06028,060 | $410,518 | 0.03% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6.9M | 6.9M | 7.2M | 7.2M | 7.2M | 7.2M | $105M |
| BlackRock, Inc. | 1.1M | 1.1M | 4.2M | 4.7M | 5.1M | 6.2M | $90M |
| STATE STREET CORP | 206K | 230K | 665K | 1.0M | 2.8M | 3.6M | $52M |
| ADAMS STREET PARTNERS LLC | 3.3M | 3.3M | 3.3M | 3.3M | 3.3M | 3.3M | $48M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 3.2M | $47M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | 26K | 32K | 34K | 2.9M | $43M |
| Vivo Capital, LLC | 2.2M | 2.2M | 2.2M | 2.2M | 2.2M | 2.8M | $41M |
| MORGAN STANLEY | 397K | 674K | 894K | 617K | 3.6M | 2.5M | $37M |
| Deep Track Capital, LP | — | — | — | — | — | 2.5M | $36M |
| WELLINGTON MANAGEMENT GROUP LLP | — | 105K | 102K | 180K | 315K | 2.3M | $34M |
| PERCEPTIVE ADVISORS LLC | — | — | 1.4M | 1.4M | 692K | 2.3M | $34M |
| Commodore Capital LP | — | — | — | — | — | 2.3M | $33M |
| Foresite Capital Management VI LLC | 1.6M | 1.6M | 1.7M | 1.7M | 1.4M | 1.8M | $27M |
| BRAIDWELL LP | — | — | — | — | — | 1.8M | $26M |
| GEODE CAPITAL MANAGEMENT, LLC | 567K | 590K | 1.4M | 1.5M | 1.5M | 1.7M | $25M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| MILLER RICHARD A MD | 7.8% | Exempt |
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +3,234,538 | $47M | OPEN |
| PRICE T ROWE ASSOCIATES INC /MD/ | +2,883,195 | $42M | ADD |
| Deep Track Capital, LP | +2,491,539 | $36M | OPEN |
| Commodore Capital LP | +2,258,735 | $33M | OPEN |
| WELLINGTON MANAGEMENT GROUP LLP | +2,003,834 | $29M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −3,873,482 | $57M | CLOSE |
| Point72 Asset Management, L.P. | −2,875,000 | $42M | CLOSE |
| MORGAN STANLEY | −1,069,083 | $16M | TRIM |
| MPM BIOIMPACT LLC | −1,068,796 | $16M | TRIM |
| RTW INVESTMENTS, LP | −447,607 | $7M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 164 | 70,089,537 | 83.4% | $1.0B |
| 2025-Q4 | 124 | 46,742,073 | 62.6% | $360M |
| 2025-Q3 | 103 | 42,474,476 | 57.0% | $313M |
| 2025-Q2 | 92 | 41,896,453 | 54.3% | $168M |
| 2025-Q1 | 88 | 36,288,523 | 53.3% | $115M |
| 2024-Q4 | 86 | 37,763,478 | 58.8% | $202M |
| 2024-Q3 | 62 | 30,075,821 | 48.1% | $159M |
| 2024-Q2 | 47 | 27,600,861 | 56.3% | $50M |
| 2024-Q1 | 47 | 18,503,313 | 37.7% | $33M |
| 2023-Q4 | 48 | 19,443,771 | 39.6% | $34M |
| 2023-Q3 | 52 | 19,186,336 | 39.2% | $28M |
| 2023-Q2 | 52 | 19,492,020 | 41.9% | $45M |
| 2023-Q1 | 37 | 20,792,622 | 44.6% | $19M |
| 2022-Q4 | 42 | 21,367,259 | 45.9% | $18M |
| 2022-Q3 | 48 | 22,098,447 | 47.5% | $18M |
| 2022-Q2 | 47 | 25,607,647 | 55.0% | $25M |
| 2022-Q1 | 57 | 27,405,572 | 58.9% | $45M |
| 2021-Q4 | 62 | 27,767,542 | 59.7% | $67M |
| 2021-Q3 | 61 | 28,180,871 | 66.4% | $136M |
| 2021-Q2 | 50 | 23,674,142 | 61.8% | $63M |
| 2021-Q1 | 49 | 20,394,632 | 53.2% | $63M |
| 2020-Q4 | 38 | 16,328,330 | 58.2% | $58M |
| 2020-Q3 | 38 | 17,217,242 | 61.4% | $69M |
| 2020-Q2 | 38 | 20,441,409 | 73.1% | $56M |
| 2020-Q1 | 43 | 20,656,950 | 70.4% | $44M |
| 2019-Q4 | 37 | 20,917,452 | 71.1% | $114M |
| 2019-Q3 | 35 | 22,891,762 | 77.9% | $69M |
| 2019-Q2 | 45 | 24,342,711 | 83.0% | $91M |
| 2019-Q1 | 58 | 24,764,985 | 84.4% | $100M |
| 2018-Q4 | 61 | 25,282,325 | 86.3% | $93M |
| 2018-Q3 | 61 | 25,701,558 | 88.0% | $220M |
| 2018-Q2 | 57 | 25,933,339 | 88.8% | $285M |
| 2018-Q1 | 55 | 25,285,647 | — | $288M |
| 2017-Q4 | 54 | 17,418,801 | 82.8% | $180M |
| 2017-Q3 | 54 | 17,544,249 | 83.8% | $280M |
| 2017-Q2 | 52 | 17,504,696 | 83.6% | $212M |
| 2017-Q1 | 52 | 17,339,959 | 82.8% | $360M |
| 2016-Q4 | 53 | 17,494,472 | 83.7% | $250M |
| 2016-Q3 | 45 | 16,266,808 | 77.8% | $268M |
| 2016-Q2 | 45 | 17,333,065 | 84.9% | $237M |
| 2016-Q1 | 31 | 16,395,501 | 80.3% | $228M |
| 2025-12-31 |
| SEC → |
| Sirenia Capital Management LP | 7.5% | QII | 2026-03-31 | SEC → |
| BlackRock, Inc. | 7.5% | QII | 2026-06-30 | SEC → |
| Point72 Asset Management, L.P. | 0% | Passive | 2026-03-31 | SEC → |
| VANGUARD GROUP INC | 0% | QII | 2026-03-13 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
