BCRX US Equity

BIOCRYST PHARMACEUTICALS INC

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Health Care · Biological Products, (No Diagnostic Substances) · CIK 882796 · FYE 1231

$9.53

-0.21 (-2.16%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding BCRX · 2026-Q1 methodology → sources →

299 holders

% of shares outstanding held

97.4%

Shares held (13F)

247,494,789

Reporting holders

299

Top holders

largest 100 of 299 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BlackRock, Inc.	22,650,98822.7M	$216M	8.91%	ADD 7%
2	RA CAPITAL MANAGEMENT, L.P.	15,827,18615.8M	$151M	6.23%	—
3	DEERFIELD MANAGEMENT COMPANY, L.P.	15,038,00015.0M	$143M	5.92%	ADD 5%
4	STATE STREET CORP	12,208,36012.2M	$116M	4.80%	ADD 10%
5	VANGUARD PORTFOLIO MANAGEMENT LLC	11,244,62511.2M	$107M	4.42%	NEW†
6	VANGUARD CAPITAL MANAGEMENT LLC	11,135,76211.1M	$106M	4.38%	NEW†
7	TCG Crossover Management, LLC	11,020,96811.0M	$105M	4.34%	NEW†
8	JANUS HENDERSON GROUP PLC	8,908,5068.9M	$85M	3.51%	ADD 20%
9	PERCEPTIVE ADVISORS LLC	7,434,0337.4M	$71M	2.92%	ADD 135%
10	Vestal Point Capital, LP	7,025,0007.0M	$67M	2.76%	ADD 212%
11	TWO SIGMA INVESTMENTS, LP	6,392,6286.4M	$61M	2.52%	ADD 42%
12	GEODE CAPITAL MANAGEMENT, LLC	5,782,7765.8M	$55M	2.28%	ADD 14%
13	Kynam Capital Management, LP	5,680,7955.7M	$54M	2.24%	TRIM -39%
14	BANK OF AMERICA CORP /DE/	5,091,7655.1M	$48M	2.00%	ADD 232%
15	Aberdeen Group plc	5,040,6705.0M	$48M	1.98%	ADD 452%
16	UBS Group AG	4,943,9944.9M	$47M	1.95%	TRIM -6%
17	Frazier Life Sciences Management, L.P.	4,009,2404.0M	$38M	1.58%	NEW
18	Royalty Pharma Sub-Manager, LLC	3,846,1543.8M	$37M	1.51%	—
19	Nuveen, LLC	3,819,2633.8M	$36M	1.50%	ADD 6%
20	GW&K Investment Management, LLC	3,240,4623.2M	$31M	1.27%	ADD 3%
21	Eversept Partners, LP	3,039,8203.0M	$29M	1.20%	—
22	RFG Advisory, LLC	2,870,7002.9M	$27M	1.13%	NEW
23	SUSQUEHANNA INTERNATIONAL GROUP, LLP	2,815,3042.8M	$27M	1.11%	ADD 319%
24	Fisher Asset Management, LLC	2,733,2532.7M	$26M	1.08%	ADD 11%
25	DIMENSIONAL FUND ADVISORS LP	2,690,6512.7M	$26M	1.06%	ADD 119%
26	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	2,350,4052.4M	$22M	0.92%	ADD 17%
27	GOLDMAN SACHS GROUP INC	2,347,4432.3M	$22M	0.92%	TRIM -27%
28	Candriam S.C.A.	2,286,8412.3M	$22M	0.90%	NEW
29	RICE HALL JAMES & ASSOCIATES, LLC	2,230,1052.2M	$21M	0.88%	ADD 17%
30	NORTHERN TRUST CORP	2,104,7252.1M	$20M	0.83%	ADD 13%
31	MORGAN STANLEY	2,022,9882.0M	$19M	0.80%	ADD 16%
32	Nantahala Capital Management, LLC	1,987,3972.0M	$19M	0.78%	ADD 47%
33	STIFEL FINANCIAL CORP	1,825,1841.8M	$17M	0.72%	—
34	Parkman Healthcare Partners LLC	1,708,0991.7M	$16M	0.67%	ADD 90%
35	VANGUARD FIDUCIARY TRUST CO	1,664,2971.7M	$16M	0.65%	NEW
36	JPMORGAN CHASE & CO	1,541,9781.5M	$15M	0.61%	ADD 83%
37	ORBIMED ADVISORS LLC	1,425,2001.4M	$14M	0.56%	TRIM -18%
38	Legal & General Group Plc	1,411,1991.4M	$13M	0.56%	ADD 569%
39	Schonfeld Strategic Advisors LLC	1,337,6931.3M	$13M	0.53%	ADD 846%
40	Invesco Ltd.	1,308,8131.3M	$12M	0.51%	TRIM -3%
41	BNP PARIBAS FINANCIAL MARKETS	1,302,2571.3M	$12M	0.51%	TRIM -49%
42	Man Group plc	1,293,3001.3M	$12M	0.51%	ADD 217%
43	OP Asset Management Ltd	1,252,8631.3M	$12M	0.49%	ADD 800%
44	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1,227,0401.2M	$12M	0.48%	NEW
45	JUPITER ASSET MANAGEMENT LTD	1,196,3711.2M	$11M	0.47%	—
46	CITADEL ADVISORS LLC	1,018,7431.0M	$10M	0.40%	TRIM -22%
47	JACOBS LEVY EQUITY MANAGEMENT, INC	1,004,3731.0M	$10M	0.40%	TRIM -3%
48	Elmind Capital, LP	1,000,0001.0M	$10M	0.39%	TRIM -53%
49	Rosalind Advisors, Inc.	923,057923,057	$9M	0.36%	NEW
50	SPHERA FUNDS MANAGEMENT LTD.	866,464866,464	$8M	0.34%	ADD 3%
51	DEUTSCHE BANK AG\	821,367821,367	$8M	0.32%	ADD 67%
52	FIRST TRUST ADVISORS LP	800,900800,900	$8M	0.32%	ADD 114%
53	RENAISSANCE TECHNOLOGIES LLC	776,990776,990	$7M	0.31%	TRIM -64%
54	Hillsdale Investment Management Inc.	639,100639,100	$6M	0.25%	ADD 14%
55	Bridgewater Associates, LP	638,054638,054	$6M	0.25%	ADD 171%
56	Bank of New York Mellon Corp	637,658637,658	$6M	0.25%	ADD 5%
57	FMR LLC	633,132633,132	$6M	0.25%	ADD 13%
58	IMC-Chicago, LLC	631,290631,290	$6M	0.25%	NEW
59	JANE STREET GROUP, LLC	622,607622,607	$6M	0.24%	TRIM -4%
60	PDT Partners, LLC	563,440563,440	$5M	0.22%	TRIM -18%
61	VOYA INVESTMENT MANAGEMENT LLC	536,304536,304	$5M	0.21%	TRIM -14%
62	FRANKLIN RESOURCES INC	523,281523,281	$5M	0.21%	TRIM -8%
63	Hudson Bay Capital Management LP	490,369490,369	$5M	0.19%	TRIM -52%
64	Pictet Asset Management Holding SA	471,573471,573	$4M	0.19%	TRIM -36%
65	AQR CAPITAL MANAGEMENT LLC	440,141440,141	$4M	0.17%	TRIM -38%
66	PRINCIPAL FINANCIAL GROUP INC	430,558430,558	$4M	0.17%	ADD 14%
67	DAFNA Capital Management LLC	430,248430,248	$4M	0.17%	ADD 3%
68	Swiss National Bank	408,668408,668	$4M	0.16%	ADD 4%
69	DOLIVER ADVISORS, LP	374,328374,328	$4M	0.15%	ADD 36%
70	Susquehanna Portfolio Strategies, LLC	374,016374,016	$4M	0.15%	TRIM -52%
71	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	368,978368,978	$4M	0.15%	TRIM -3%
72	Rafferty Asset Management, LLC	354,260354,260	$3M	0.14%	TRIM -7%
73	Gotham Asset Management, LLC	312,961312,961	$3M	0.12%	ADD 44%
74	FEDERATED HERMES, INC.	306,464306,464	$3M	0.12%	ADD 5%
75	D. E. Shaw & Co., Inc.	302,101302,101	$3M	0.12%	TRIM -76%
76	STATE OF WISCONSIN INVESTMENT BOARD	279,064279,064	$3M	0.11%	TRIM -20%
77	Russell Investments Group, Ltd.	271,668271,668	$3M	0.11%	ADD 19%
78	RHUMBLINE ADVISERS	266,137266,137	$3M	0.10%	—
79	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	258,345258,345	$2M	0.10%	ADD 35%
80	MARSHALL WACE, LLP	246,477246,477	$2M	0.10%	NEW
81	MACKENZIE FINANCIAL CORP	243,416243,416	$2M	0.10%	ADD 61%
82	WELLS FARGO & COMPANY/MN	236,941236,941	$2M	0.09%	—
83	Assenagon Asset Management S.A.	232,947232,947	$2M	0.09%	TRIM -35%
84	PRICE T ROWE ASSOCIATES INC /MD/	230,996230,996	$2M	0.09%	ADD 30%
85	ALLIANCEBERNSTEIN L.P.	263,669263,669	$2M	0.10%	TRIM -5%
86	Zurcher Kantonalbank (Zurich Cantonalbank)	208,903208,903	$2M	0.08%	ADD 264%
87	Capricorn Fund Managers Ltd	202,900202,900	$2M	0.08%	NEW
88	VANGUARD ASSET MANAGEMENT, Ltd	196,280196,280	$2M	0.08%	NEW
89	Phocas Financial Corp.	195,540195,540	$2M	0.08%	TRIM -22%
90	Engineers Gate Manager LP	194,475194,475	$2M	0.08%	TRIM -13%
91	ExodusPoint Capital Management, LP	190,058190,058	$2M	0.07%	NEW
92	MILLENNIUM MANAGEMENT LLC	187,721187,721	$2M	0.07%	ADD 36%
93	Balyasny Asset Management L.P.	186,125186,125	$2M	0.07%	NEW
94	ACADIAN ASSET MANAGEMENT LLC	180,010180,010	$2M	0.07%	ADD 111%
95	Janney Montgomery Scott LLC	163,266163,266	$2M	0.06%	ADD 525%
96	RAYMOND JAMES FINANCIAL INC	160,531160,531	$2M	0.06%	ADD 22%
97	QTR Family Wealth, LLC	157,062157,062	$2M	0.06%	—
98	PROFUND ADVISORS LLC	158,462158,462	$2M	0.06%	ADD 12%
99	SEI INVESTMENTS CO	150,264150,264	$1M	0.06%	ADD 46%
100	GROUP ONE TRADING LLC	136,282136,282	$1M	0.05%	ADD 125%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BlackRock, Inc.

22.1M

22.8M

21.4M

21.2M

21.1M

22.7M

$216M

RA CAPITAL MANAGEMENT, L.P.

—

15.8M

$151M

DEERFIELD MANAGEMENT COMPANY, L.P.

8.1M

5.2M

4.7M

12.2M

14.3M

15.0M

$143M

STATE STREET CORP

7.5M

7.8M

8.5M

9.8M

11.1M

12.2M

$116M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

11.2M

$107M

VANGUARD CAPITAL MANAGEMENT LLC

—

11.1M

$106M

TCG Crossover Management, LLC

—

11.0M

$105M

JANUS HENDERSON GROUP PLC

79K

94K

7.4M

8.9M

$85M

PERCEPTIVE ADVISORS LLC

—

3.2M

7.4M

$71M

Vestal Point Capital, LP

—

2.3M

7.0M

$67M

TWO SIGMA INVESTMENTS, LP

1.8M

2.0M

4.3M

4.4M

4.5M

6.4M

$61M

GEODE CAPITAL MANAGEMENT, LLC

4.8M

5.0M

5.1M

5.8M

$55M

Kynam Capital Management, LP

9.1M

8.9M

8.5M

9.4M

5.7M

$54M

BANK OF AMERICA CORP /DE/

900K

1.4M

2.8M

1.9M

1.5M

5.1M

$48M

Aberdeen Group plc

—

914K

5.0M

$48M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	299	247,494,789	97.4%	$2.4B
2025-Q4

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · BCRX

Large holders — 13G, passive (top 5 of 7 by % of class)

Holder

% of class

Type

As of

BlackRock, Inc.

8.4%

QII

2025-03-31

SEC →

RA CAPITAL MANAGEMENT, L.P.

7.3%

Passive

2025-11-04

SEC →

Flynn James E

6.81%

Passive

2025-12-31

SEC →

VANGUARD CAPITAL MANAGEMENT LLC

5.16%

QII

2026-03-31

SEC →

STATE STREET CORP

4.9%

QII

Institutional ownership· 13F filers holding BCRX · 2026-Q1 methodology → sources →

299 holders

% of shares outstanding held

97.4%

Shares held (13F)

247,494,789

Reporting holders

299

Top holders

largest 100 of 299 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BlackRock, Inc.	22,650,98822.7M	$216M	8.91%	ADD 7%
2	RA CAPITAL MANAGEMENT, L.P.	15,827,18615.8M	$151M	6.23%	—
3	DEERFIELD MANAGEMENT COMPANY, L.P.	15,038,00015.0M	$143M	5.92%	ADD 5%
4	STATE STREET CORP	12,208,36012.2M	$116M	4.80%	ADD 10%
5	VANGUARD PORTFOLIO MANAGEMENT LLC	11,244,62511.2M	$107M	4.42%	NEW†
6	VANGUARD CAPITAL MANAGEMENT LLC	11,135,76211.1M	$106M	4.38%	NEW†
7	TCG Crossover Management, LLC	11,020,96811.0M	$105M	4.34%	NEW†
8	JANUS HENDERSON GROUP PLC	8,908,5068.9M	$85M	3.51%	ADD 20%
9	PERCEPTIVE ADVISORS LLC	7,434,0337.4M	$71M	2.92%	ADD 135%
10	Vestal Point Capital, LP	7,025,0007.0M	$67M	2.76%	ADD 212%
11	TWO SIGMA INVESTMENTS, LP	6,392,6286.4M	$61M	2.52%	ADD 42%
12	GEODE CAPITAL MANAGEMENT, LLC	5,782,7765.8M	$55M	2.28%	ADD 14%
13	Kynam Capital Management, LP	5,680,7955.7M	$54M	2.24%	TRIM -39%
14	BANK OF AMERICA CORP /DE/	5,091,7655.1M	$48M	2.00%	ADD 232%
15	Aberdeen Group plc	5,040,6705.0M	$48M	1.98%	ADD 452%
16	UBS Group AG	4,943,9944.9M	$47M	1.95%	TRIM -6%
17	Frazier Life Sciences Management, L.P.	4,009,2404.0M	$38M	1.58%	NEW
18	Royalty Pharma Sub-Manager, LLC	3,846,1543.8M	$37M	1.51%	—
19	Nuveen, LLC	3,819,2633.8M	$36M	1.50%	ADD 6%
20	GW&K Investment Management, LLC	3,240,4623.2M	$31M	1.27%	ADD 3%
21	Eversept Partners, LP	3,039,8203.0M	$29M	1.20%	—
22	RFG Advisory, LLC	2,870,7002.9M	$27M	1.13%	NEW
23	SUSQUEHANNA INTERNATIONAL GROUP, LLP	2,815,3042.8M	$27M	1.11%	ADD 319%
24	Fisher Asset Management, LLC	2,733,2532.7M	$26M	1.08%	ADD 11%
25	DIMENSIONAL FUND ADVISORS LP	2,690,6512.7M	$26M	1.06%	ADD 119%
26	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	2,350,4052.4M	$22M	0.92%	ADD 17%
27	GOLDMAN SACHS GROUP INC	2,347,4432.3M	$22M	0.92%	TRIM -27%
28	Candriam S.C.A.	2,286,8412.3M	$22M	0.90%	NEW
29	RICE HALL JAMES & ASSOCIATES, LLC	2,230,1052.2M	$21M	0.88%	ADD 17%
30	NORTHERN TRUST CORP	2,104,7252.1M	$20M	0.83%	ADD 13%
31	MORGAN STANLEY	2,022,9882.0M	$19M	0.80%	ADD 16%
32	Nantahala Capital Management, LLC	1,987,3972.0M	$19M	0.78%	ADD 47%
33	STIFEL FINANCIAL CORP	1,825,1841.8M	$17M	0.72%	—
34	Parkman Healthcare Partners LLC	1,708,0991.7M	$16M	0.67%	ADD 90%
35	VANGUARD FIDUCIARY TRUST CO	1,664,2971.7M	$16M	0.65%	NEW
36	JPMORGAN CHASE & CO	1,541,9781.5M	$15M	0.61%	ADD 83%
37	ORBIMED ADVISORS LLC	1,425,2001.4M	$14M	0.56%	TRIM -18%
38	Legal & General Group Plc	1,411,1991.4M	$13M	0.56%	ADD 569%
39	Schonfeld Strategic Advisors LLC	1,337,6931.3M	$13M	0.53%	ADD 846%
40	Invesco Ltd.	1,308,8131.3M	$12M	0.51%	TRIM -3%
41	BNP PARIBAS FINANCIAL MARKETS	1,302,2571.3M	$12M	0.51%	TRIM -49%
42	Man Group plc	1,293,3001.3M	$12M	0.51%	ADD 217%
43	OP Asset Management Ltd	1,252,8631.3M	$12M	0.49%	ADD 800%
44	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1,227,0401.2M	$12M	0.48%	NEW
45	JUPITER ASSET MANAGEMENT LTD	1,196,3711.2M	$11M	0.47%	—
46	CITADEL ADVISORS LLC	1,018,7431.0M	$10M	0.40%	TRIM -22%
47	JACOBS LEVY EQUITY MANAGEMENT, INC	1,004,3731.0M	$10M	0.40%	TRIM -3%
48	Elmind Capital, LP	1,000,0001.0M	$10M	0.39%	TRIM -53%
49	Rosalind Advisors, Inc.	923,057923,057	$9M	0.36%	NEW
50	SPHERA FUNDS MANAGEMENT LTD.	866,464866,464	$8M	0.34%	ADD 3%
51	DEUTSCHE BANK AG\	821,367821,367	$8M	0.32%	ADD 67%
52	FIRST TRUST ADVISORS LP	800,900800,900	$8M	0.32%	ADD 114%
53	RENAISSANCE TECHNOLOGIES LLC	776,990776,990	$7M	0.31%	TRIM -64%
54	Hillsdale Investment Management Inc.	639,100639,100	$6M	0.25%	ADD 14%
55	Bridgewater Associates, LP	638,054638,054	$6M	0.25%	ADD 171%
56	Bank of New York Mellon Corp	637,658637,658	$6M	0.25%	ADD 5%
57	FMR LLC	633,132633,132	$6M	0.25%	ADD 13%
58	IMC-Chicago, LLC	631,290631,290	$6M	0.25%	NEW
59	JANE STREET GROUP, LLC	622,607622,607	$6M	0.24%	TRIM -4%
60	PDT Partners, LLC	563,440563,440	$5M	0.22%	TRIM -18%
61	VOYA INVESTMENT MANAGEMENT LLC	536,304536,304	$5M	0.21%	TRIM -14%
62	FRANKLIN RESOURCES INC	523,281523,281	$5M	0.21%	TRIM -8%
63	Hudson Bay Capital Management LP	490,369490,369	$5M	0.19%	TRIM -52%
64	Pictet Asset Management Holding SA	471,573471,573	$4M	0.19%	TRIM -36%
65	AQR CAPITAL MANAGEMENT LLC	440,141440,141	$4M	0.17%	TRIM -38%
66	PRINCIPAL FINANCIAL GROUP INC	430,558430,558	$4M	0.17%	ADD 14%
67	DAFNA Capital Management LLC	430,248430,248	$4M	0.17%	ADD 3%
68	Swiss National Bank	408,668408,668	$4M	0.16%	ADD 4%
69	DOLIVER ADVISORS, LP	374,328374,328	$4M	0.15%	ADD 36%
70	Susquehanna Portfolio Strategies, LLC	374,016374,016	$4M	0.15%	TRIM -52%
71	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	368,978368,978	$4M	0.15%	TRIM -3%
72	Rafferty Asset Management, LLC	354,260354,260	$3M	0.14%	TRIM -7%
73	Gotham Asset Management, LLC	312,961312,961	$3M	0.12%	ADD 44%
74	FEDERATED HERMES, INC.	306,464306,464	$3M	0.12%	ADD 5%
75	D. E. Shaw & Co., Inc.	302,101302,101	$3M	0.12%	TRIM -76%
76	STATE OF WISCONSIN INVESTMENT BOARD	279,064279,064	$3M	0.11%	TRIM -20%
77	Russell Investments Group, Ltd.	271,668271,668	$3M	0.11%	ADD 19%
78	RHUMBLINE ADVISERS	266,137266,137	$3M	0.10%	—
79	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	258,345258,345	$2M	0.10%	ADD 35%
80	MARSHALL WACE, LLP	246,477246,477	$2M	0.10%	NEW
81	MACKENZIE FINANCIAL CORP	243,416243,416	$2M	0.10%	ADD 61%
82	WELLS FARGO & COMPANY/MN	236,941236,941	$2M	0.09%	—
83	Assenagon Asset Management S.A.	232,947232,947	$2M	0.09%	TRIM -35%
84	PRICE T ROWE ASSOCIATES INC /MD/	230,996230,996	$2M	0.09%	ADD 30%
85	ALLIANCEBERNSTEIN L.P.	263,669263,669	$2M	0.10%	TRIM -5%
86	Zurcher Kantonalbank (Zurich Cantonalbank)	208,903208,903	$2M	0.08%	ADD 264%
87	Capricorn Fund Managers Ltd	202,900202,900	$2M	0.08%	NEW
88	VANGUARD ASSET MANAGEMENT, Ltd	196,280196,280	$2M	0.08%	NEW
89	Phocas Financial Corp.	195,540195,540	$2M	0.08%	TRIM -22%
90	Engineers Gate Manager LP	194,475194,475	$2M	0.08%	TRIM -13%
91	ExodusPoint Capital Management, LP	190,058190,058	$2M	0.07%	NEW
92	MILLENNIUM MANAGEMENT LLC	187,721187,721	$2M	0.07%	ADD 36%
93	Balyasny Asset Management L.P.	186,125186,125	$2M	0.07%	NEW
94	ACADIAN ASSET MANAGEMENT LLC	180,010180,010	$2M	0.07%	ADD 111%
95	Janney Montgomery Scott LLC	163,266163,266	$2M	0.06%	ADD 525%
96	RAYMOND JAMES FINANCIAL INC	160,531160,531	$2M	0.06%	ADD 22%
97	QTR Family Wealth, LLC	157,062157,062	$2M	0.06%	—
98	PROFUND ADVISORS LLC	158,462158,462	$2M	0.06%	ADD 12%
99	SEI INVESTMENTS CO	150,264150,264	$1M	0.06%	ADD 46%
100	GROUP ONE TRADING LLC	136,282136,282	$1M	0.05%	ADD 125%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BlackRock, Inc.

22.1M

22.8M

21.4M

21.2M

21.1M

22.7M

$216M

RA CAPITAL MANAGEMENT, L.P.

—

15.8M

$151M

DEERFIELD MANAGEMENT COMPANY, L.P.

8.1M

5.2M

4.7M

12.2M

14.3M

15.0M

$143M

STATE STREET CORP

7.5M

7.8M

8.5M

9.8M

11.1M

12.2M

$116M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

11.2M

$107M

VANGUARD CAPITAL MANAGEMENT LLC

—

11.1M

$106M

TCG Crossover Management, LLC

—

11.0M

$105M

JANUS HENDERSON GROUP PLC

79K

94K

7.4M

8.9M

$85M

PERCEPTIVE ADVISORS LLC

—

3.2M

7.4M

$71M

Vestal Point Capital, LP

—

2.3M

7.0M

$67M

TWO SIGMA INVESTMENTS, LP

1.8M

2.0M

4.3M

4.4M

4.5M

6.4M

$61M

GEODE CAPITAL MANAGEMENT, LLC

4.8M

5.0M

5.1M

5.8M

$55M

Kynam Capital Management, LP

9.1M

8.9M

8.5M

9.4M

5.7M

$54M

BANK OF AMERICA CORP /DE/

900K

1.4M

2.8M

1.9M

1.5M

5.1M

$48M

Aberdeen Group plc

—

914K

5.0M

$48M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	299	247,494,789	97.4%	$2.4B
2025-Q4

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · BCRX

Large holders — 13G, passive (top 5 of 7 by % of class)

Holder

% of class

Type

As of

BlackRock, Inc.

8.4%

QII

2025-03-31

SEC →

RA CAPITAL MANAGEMENT, L.P.

7.3%

Passive

2025-11-04

SEC →

Flynn James E

6.81%

Passive

2025-12-31

SEC →

VANGUARD CAPITAL MANAGEMENT LLC

5.16%

QII

2026-03-31

SEC →

STATE STREET CORP

4.9%

QII

BCRX US Equity☆

Institutional ownership· 13F filers holding BCRX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · BCRX

Institutional ownership· 13F filers holding BCRX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · BCRX

BCRX US Equity