% of shares outstanding suppressed: the summed institutional 13F holdings (31,599,256) exceed the cover-page shares-outstanding count for this quarter (22,788,452, as of 2026-03-18) by more than securities-lending double counting can explain (FINRA short interest 5,733,586 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 2,879,4812.9M | $43M | — | ADD 1207% |
| 2 | T. Rowe Price Investment Management, Inc. | 2,162,6842.2M | $32M | — | NEW† |
| 3 | Caligan Partners LP | 1,635,0231.6M | $24M | — | ADD 85% |
| 4 | BVF INC/IL | 1,632,8451.6M | $24M | — | ADD 20% |
| 5 | Avoro Capital Advisors LLC | 1,410,0001.4M | $21M | — | NEW† |
| 6 | Affinity Asset Advisors, LLC | 1,340,8401.3M | $20M | — | ADD 28% |
| 7 | Nantahala Capital Management, LLC | 1,235,0001.2M | $18M | — | — |
| 8 | UBS Group AG | 1,141,9801.1M | $17M | — | ADD 139% |
| 9 | Point72 Asset Management, L.P. | 916,142916,142 | $14M | — | ADD 46% |
| 10 | FARALLON CAPITAL MANAGEMENT LLC | 916,000916,000 | $14M | — | NEW |
| 11 | RTW INVESTMENTS, LP | 856,962856,962 | $13M | — | NEW |
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 854,000854,000 | $13M | — | ADD 55% |
| 13 | MILLENNIUM MANAGEMENT LLC | 835,484835,484 | $12M | — | ADD 27% |
| 14 | TCG Crossover Management, LLC | 738,383738,383 | $11M | — | ADD 53% |
| 15 | Balyasny Asset Management L.P. | 731,586731,586 | $11M | — | ADD 67% |
| 16 | VANGUARD CAPITAL MANAGEMENT LLC | 719,694719,694 | $11M | — | NEW |
| 17 | RA CAPITAL MANAGEMENT, L.P. | 662,968662,968 | $10M | — | — |
| 18 | BANK OF AMERICA CORP /DE/ | 643,000643,000 | $10M | — | ADD 3% |
| 19 | Seven Fleet Capital Management LP | 573,883573,883 | $9M | — | ADD 806% |
| 20 | Commodore Capital LP | 483,000483,000 | $7M | — | — |
| 21 | ORBIMED ADVISORS LLC | 475,165475,165 | $7M | — | TRIM -60% |
| 22 | JENNISON ASSOCIATES LLC | 470,775470,775 | $7M | — | — |
| 23 | Caption Management, LLC | 455,000455,000 | $7M | — | ADD 764% |
| 24 | Soleus Capital Management, L.P. | 441,978441,978 | $7M | — | — |
| 25 | BNP PARIBAS FINANCIAL MARKETS | 422,781422,781 | $6M | — | ADD 114% |
| 26 | KENNEDY CAPITAL MANAGEMENT LLC | 387,982387,982 | $6M | — | NEW |
| 27 | DV Trading LLC | 360,064360,064 | $5M | — | NEW |
| 28 | BlackRock, Inc. | 327,082327,082 | $5M | — | ADD 13% |
| 29 | BOOTHBAY FUND MANAGEMENT, LLC | 324,258324,258 | $5M | — | ADD 60% |
| 30 | Logos Global Management LP | 300,000300,000 | $4M | — | NEW |
| 31 | Boxer Capital Management, LLC | 300,000300,000 | $4M | — | ADD 9% |
| 32 | Pivotal bioVenture Partners Investment Advisor LLC | 295,933295,933 | $4M | — | NEW |
| 33 | STEMPOINT CAPITAL LP | 269,484269,484 | $4M | — | ADD 99% |
| 34 | CITADEL ADVISORS LLC | 193,735193,735 | $3M | — | TRIM -54% |
| 35 | NAN FUNG TRINITY (HK) LTD | 189,000189,000 | $3M | — | — |
| 36 | Velan Capital Investment Management LP | 185,122185,122 | $3M | — | TRIM -30% |
| 37 | JPMORGAN CHASE & CO | 194,391194,391 | $3M | — | ADD 338% |
| 38 | Qube Research & Technologies Ltd | 174,506174,506 | $3M | — | ADD 171% |
| 39 | JANE STREET GROUP, LLC | 173,320173,320 | $3M | — | TRIM -3% |
| 40 | AMERIPRISE FINANCIAL INC | 172,149172,149 | $3M | — | TRIM -21% |
| 41 | Aberdeen Group plc | 171,679171,679 | $3M | — | ADD 80% |
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 169,889169,889 | $3M | — | ADD 2% |
| 43 | MORGAN STANLEY | 161,392161,392 | $2M | — | TRIM -39% |
| 44 | Hudson Bay Capital Management LP | 161,087161,087 | $2M | — | ADD 861% |
| 45 | Exome Asset Management LLC | 159,341159,341 | $2M | — | NEW |
| 46 | Moody Aldrich Partners LLC | 159,324159,324 | $2M | — | ADD 20% |
| 47 | DEUTSCHE BANK AG\ | 150,000150,000 | $2M | — | — |
| 48 | PERCEPTIVE ADVISORS LLC | 139,667139,667 | $2M | — | — |
| 49 | MARSHALL WACE, LLP | 129,136129,136 | $2M | — | TRIM -75% |
| 50 | XTX Topco Ltd | 126,732126,732 | $2M | — | ADD 213% |
| 51 | Quadrature Capital Ltd | 125,195125,195 | $2M | — | ADD 136% |
| 52 | GREAT POINT PARTNERS LLC | 124,666124,666 | $2M | — | — |
| 53 | RENAISSANCE TECHNOLOGIES LLC | 120,114120,114 | $2M | — | ADD 556% |
| 54 | VANGUARD FIDUCIARY TRUST CO | 86,43486,434 | $1M | — | NEW |
| 55 | Squarepoint Ops LLC | 81,28581,285 | $1M | — | ADD 99% |
| 56 | Rosalind Advisors, Inc. | 75,00075,000 | $1M | — | NEW |
| 57 | STATE STREET CORP | 71,65471,654 | $1M | — | TRIM -10% |
| 58 | TWO SIGMA INVESTMENTS, LP | 64,42564,425 | $961,865 | — | TRIM -57% |
| 59 | ACUTA CAPITAL PARTNERS, LLC | 60,80860,808 | $907,863 | — | NEW |
| 60 | GOLDMAN SACHS GROUP INC | 60,10660,106 | $897,383 | — | TRIM -8% |
| 61 | HighVista Strategies LLC | 58,62258,622 | $875,226 | — | TRIM -39% |
| 62 | SEI INVESTMENTS CO | 56,85456,854 | $848,830 | — | NEW |
| 63 | 683 Capital Management, LLC | 56,85056,850 | $848,771 | — | — |
| 64 | TD Asset Management Inc | 51,40851,408 | $767,521 | — | NEW |
| 65 | HRT FINANCIAL LP | 48,10548,105 | $718,000 | — | NEW |
| 66 | Man Group plc | 46,55346,553 | $695,036 | — | NEW |
| 67 | DIMENSIONAL FUND ADVISORS LP | 40,82140,821 | $607,287 | — | NEW |
| 68 | PRELUDE CAPITAL MANAGEMENT, LLC | 35,09635,096 | $523,983 | — | NEW |
| 69 | NORTHERN TRUST CORP | 30,55630,556 | $456,201 | — | TRIM -5% |
| 70 | EntryPoint Capital, LLC | 30,04130,041 | $448,512 | — | NEW |
| 71 | Aquatic Capital Management LLC | 29,71229,712 | $443,600 | — | NEW |
| 72 | Artia Global Partners LP | 28,97028,970 | $432,522 | — | TRIM -30% |
| 73 | GLENMEDE TRUST CO NA | 25,73025,730 | $384,148 | — | ADD 26% |
| 74 | ENVESTNET ASSET MANAGEMENT INC | 19,99619,996 | $298,540 | — | ADD 25% |
| 75 | Brevan Howard Capital Management LP | 19,32119,321 | $288,463 | — | NEW |
| 76 | ExodusPoint Capital Management, LP | 17,75117,751 | $265,022 | — | TRIM -45% |
| 77 | Susquehanna Portfolio Strategies, LLC | 17,22717,227 | $257,199 | — | NEW |
| 78 | WESTFIELD CAPITAL MANAGEMENT CO LP | 15,63915,639 | $233,490 | — | NEW |
| 79 | BARCLAYS PLC | 14,64214,642 | $218,605 | — | TRIM -86% |
| 80 | Jump Financial, LLC | 12,81012,810 | $191,253 | — | TRIM -2% |
| 81 | OMERS ADMINISTRATION Corp | 11,80011,800 | $176,174 | — | TRIM -40% |
| 82 | AlphaCentric Advisors LLC | 11,66811,668 | $174,203 | — | NEW |
| 83 | Shay Capital LLC | 10,16610,166 | $151,778 | — | NEW |
| 84 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,00010,000 | $149,300 | — | NEW |
| 85 | Persistent Asset Partners Ltd | 7,9187,918 | $118,216 | — | TRIM -48% |
| 86 | Vanguard Global Advisers, LLC | 5,6055,605 | $83,683 | — | NEW |
| 87 | US BANCORP \DE\ | 3,3873,387 | $50,568 | — | ADD 24% |
| 88 | PFS Partners, LLC | 2,0002,000 | $29,860 | — | — |
| 89 | ROYAL BANK OF CANADA | 216216 | $2,000 | — | NEW |
| 90 | Farther Finance Advisors, LLC | 7575 | $1,253 | — | NEW |
| 91 | Fortitude Family Office, LLC | 6363 | $941 | — | NEW |
| 92 | EverSource Wealth Advisors, LLC | 3535 | $523 | — | NEW |
| 93 | Parallel Advisors, LLC | 11 | $15 | — | — |
| 94 | Key Financial Inc | 11 | $15 | — | — |
| 95 | Activest Wealth Management | 11 | $15 | — | — |
| 96 | Silver Grove Financial Group, Inc. | 11 | $15 | — | NEW |
| 97 | OSAIC HOLDINGS, INC. | 11 | $14 | — | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | — | — | — | — | 220K | 2.9M | $43M |
| T. Rowe Price Investment Management, Inc. | — | — | — | — | — | 2.2M | $32M |
| Caligan Partners LP | — | — | — | 833K | 882K | 1.6M | $24M |
| BVF INC/IL | 1.0M | 1.0M | 1.0M | 1.4M | 1.4M | 1.6M | $24M |
| Avoro Capital Advisors LLC | — | — | — | — | — | 1.4M | $21M |
| Affinity Asset Advisors, LLC | 551K | 657K | 608K | 1.0M | 1.1M | 1.3M | $20M |
| Nantahala Capital Management, LLC | — | 900K | 995K | 1.2M | 1.2M | 1.2M | $18M |
| UBS Group AG | 99K | 99K | 84K | 45K | 478K | 1.1M | $17M |
| Point72 Asset Management, L.P. | — | — | — | 1.1M | 628K | 916K | $14M |
| FARALLON CAPITAL MANAGEMENT LLC | — | — | — | — | — | 916K | $14M |
| RTW INVESTMENTS, LP | — | — | — | — | — | 857K | $13M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | 259K | 550K | 854K | $13M |
| MILLENNIUM MANAGEMENT LLC | — | — | — | 137K | 660K | 835K | $12M |
| TCG Crossover Management, LLC | 483K | 483K | 483K | 483K | 483K | 738K | $11M |
| Balyasny Asset Management L.P. | — | — | — | 817K | 439K | 732K | $11M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 97 | 31,599,256 | — | $472M |
| 2025-Q4 | 84 | 19,885,517 | 109.7% | $361M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| FMR LLC | +2,659,181 | $40M | ADD |
| T. Rowe Price Investment Management, Inc. | +2,162,684 | $32M | OPEN |
| Avoro Capital Advisors LLC | +1,410,000 | $21M | OPEN |
| FARALLON CAPITAL MANAGEMENT LLC | +916,000 | $14M | OPEN |
| RTW INVESTMENTS, LP | +856,962 | $13M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −804,084 | $12M | CLOSE |
| ORBIMED ADVISORS LLC | −712,135 | $11M | TRIM |
| SILVERARC CAPITAL MANAGEMENT, LLC | −524,436 | $8M | CLOSE |
| MARSHALL WACE, LLP | −378,414 | $6M | TRIM |
| Patient Square Capital LP | −311,966 | $5M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| 2025-Q3 | 66 | 15,319,263 | — | $195M |
| 2025-Q2 | 36 | 7,843,045 | 72.4% | $39M |
| 2025-Q1 | 34 | 8,255,062 | 77.4% | $66M |
| 2024-Q4 | 33 | 7,530,521 | 72.5% | $56M |
| 2024-Q3 | 29 | 6,656,940 | 64.0% | $63M |
| 2024-Q2 | 21 | 771,104 | 74.6% | $10M |
| 2024-Q1 | 18 | 87,587 | 8.5% | $2M |
| 2023-Q4 | 12 | 23,012 | 0.0% | $209,784 |
| 2023-Q3 | 28 | 1,340,139 | 6.6% | $158,939 |
| 2023-Q2 | 26 | 2,427,693 | 18.4% | $862,717 |
| 2023-Q1 | 32 | 9,131,084 | 69.2% | $16M |
| 2022-Q4 | 28 | 5,551,066 | 59.0% | $28M |
| 2022-Q3 | 27 | 5,550,139 | 59.0% | $18M |
| 2022-Q2 | 54 | 69,415,201 | 61.5% | $35M |
| 2022-Q1 | 70 | 77,720,174 | 68.9% | $56M |
| 2021-Q4 | 75 | 80,056,986 | 71.3% | $136M |
| 2021-Q3 | 77 | 80,497,431 | 83.8% | $176M |
