| 1 | 1RA CAPITAL MANAGEMENT, L.P. | 10,281,49610.3M | $2.4B | 16.59% | — |
| 2 | 2T. Rowe Price Investment Management, Inc. | 6,162,0426.2M | $1.4B | 9.94% | ADD 124% |
| 3 | 3Avoro Capital Advisors LLC | 5,062,5005.1M | $1.2B | 8.17% | — |
| 4 | 4WESTFIELD CAPITAL MANAGEMENT CO LP | 4,813,4404.8M | $1.1B | 7.77% | TRIM -7% |
| 5 | 5FMR LLC | 3,876,6013.9M | $887M | 6.25% | TRIM -7% |
| 6 | 6Artisan Partners Limited Partnership | 3,230,1883.2M | $739M | 5.21% | — |
| 7 | 7FRANKLIN RESOURCES INC | 2,051,9482.1M | $469M | 3.31% | ADD 7% |
| 8 | 8Capital International Investors | 1,958,8432.0M | $448M | 3.16% | TRIM -36% |
| 9 | 9MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,860,6691.9M | $426M | 3.00% | — |
| 10 | 10WELLINGTON MANAGEMENT GROUP LLP | 1,757,6331.8M | $402M | 2.84% | — |
| 11 | 11PERCEPTIVE ADVISORS LLC | 1,531,4211.5M | $350M | 2.47% | ADD 42% |
| 12 | 12PRICE T ROWE ASSOCIATES INC /MD/ | 1,530,3451.5M | $350M | 2.47% | TRIM -3% |
| 13 | 13AMERICAN CENTURY COMPANIES INC | 1,397,1191.4M | $320M | 2.25% | TRIM -3% |
| 14 | 14Capital World Investors | 900,517900,517 | $206M | 1.45% | NEW |
| 15 | 15PRINCIPAL FINANCIAL GROUP INC | 896,397896,397 | $205M | 1.45% | TRIM -13% |
| 16 | 16BlackRock, Inc. | 661,054661,054 | $151M | 1.07% | ADD 5% |
| 17 | 17Polar Capital Holdings Plc | 651,712651,712 | $149M | 1.05% | ADD 76% |
| 18 | 18MORGAN STANLEY | 606,348606,348 | $139M | 0.98% | — |
| 19 | 19GOLDMAN SACHS GROUP INC | 566,192566,192 | $130M | 0.91% | TRIM -5% |
| 20 | 20NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 556,427556,427 | $127M | 0.90% | ADD 12% |
| 21 | 21JPMORGAN CHASE & CO | 539,434539,434 | $118M | 0.87% | ADD 6% |
| 22 | 22AMERIPRISE FINANCIAL INC | 476,466476,466 | $109M | 0.77% | TRIM -13% |
| 23 | 23FIL Ltd | 447,421447,421 | $102M | 0.72% | TRIM -7% |
| 24 | 24Vestal Point Capital, LP | 375,000375,000 | $86M | 0.61% | ADD 114% |
| 25 | 25Spyglass Capital Management LLC | 367,972367,972 | $84M | 0.59% | TRIM -11% |
| 26 | 26Invesco Ltd. | 362,109362,109 | $83M | 0.58% | TRIM -38% |
| 27 | 27SEI INVESTMENTS CO | 351,146351,146 | $80M | 0.57% | ADD 25% |
| 28 | 28BNP PARIBAS FINANCIAL MARKETS | 309,173309,173 | $71M | 0.50% | — |
| 29 | 29FRED ALGER MANAGEMENT, LLC | 304,896304,896 | $70M | 0.49% | TRIM -13% |
| 30 | 30ALLIANCEBERNSTEIN L.P. | 278,203278,203 | $59M | 0.45% | TRIM -4% |
| 31 | 31Tri Locum Partners LP | 255,332255,332 | $58M | 0.41% | TRIM -4% |
| 32 | 32Pictet Asset Management Holding SA | 251,833251,833 | $57M | 0.41% | ADD 243% |
| 33 | 33Candriam S.C.A. | 230,278230,278 | $53M | 0.37% | ADD 23% |
| 34 | 34Bank of New York Mellon Corp | 228,675228,675 | $52M | 0.37% | ADD 18% |
| 35 | 35TWO SIGMA INVESTMENTS, LP | 220,341220,341 | $50M | 0.36% | TRIM -11% |
| 36 | 36TD Asset Management Inc | 217,992217,992 | $50M | 0.35% | TRIM -7% |
| 37 | 37Aberdeen Group plc | 210,154210,154 | $48M | 0.34% | TRIM -5% |
| 38 | 38ARS Investment Partners, LLC | 209,456209,456 | $48M | 0.34% | ADD 20% |
| 39 | 39UBS Group AG | 207,339207,339 | $47M | 0.33% | TRIM -33% |
| 40 | 40BANK OF AMERICA CORP /DE/ | 198,505198,505 | $45M | 0.32% | ADD 22% |
| 41 | 41Rock Springs Capital Management LP | 194,000194,000 | $44M | 0.31% | TRIM -5% |
| 42 | 42MILLENNIUM MANAGEMENT LLC | 189,027189,027 | $43M | 0.30% | TRIM -28% |
| 43 | 43Allspring Global Investments Holdings, LLC | 184,224184,224 | $42M | 0.30% | — |
| 44 | 44ORBIMED ADVISORS LLC | 181,977181,977 | $42M | 0.29% | ADD 6% |
| 45 | 45NEW YORK STATE COMMON RETIREMENT FUND | 171,112171,112 | $39M | 0.28% | TRIM -6% |
| 46 | 46WELLS FARGO & COMPANY/MN | 154,199154,199 | $35M | 0.25% | ADD 356% |
| 47 | 47PFM Health Sciences, LP | 152,034152,034 | $35M | 0.25% | TRIM -14% |
| 48 | 48RICE HALL JAMES & ASSOCIATES, LLC | 148,386148,386 | $34M | 0.24% | ADD 2% |
| 49 | 49LORD, ABBETT & CO. LLC | 145,317145,317 | $33M | 0.23% | ADD 21% |
| 50 | 50DEUTSCHE BANK AG\ | 135,187135,187 | $31M | 0.22% | TRIM -54% |
| 51 | 51Frazier Life Sciences Management, L.P. | 133,333133,333 | $30M | 0.22% | — |
| 52 | 52BRAUN STACEY ASSOCIATES INC | 130,992130,992 | $30M | 0.21% | ADD 10% |
| 53 | 53Catalio Capital Management, LP | 129,111129,111 | $30M | 0.21% | ADD 8% |
| 54 | 54ODDO BHF ASSET MANAGEMENT SAS | 128,657128,657 | $29M | 0.21% | — |
| 55 | 55Driehaus Capital Management LLC | 127,562127,562 | $29M | 0.21% | TRIM -18% |
| 56 | 56SILVERARC CAPITAL MANAGEMENT, LLC | 124,658124,658 | $29M | 0.20% | ADD 153% |
| 57 | 57Chevy Chase Trust Holdings, LLC | 123,467123,467 | $28M | 0.20% | ADD 118% |
| 58 | 58SG Americas Securities, LLC | 120,790120,790 | $28M | 0.19% | ADD 977% |
| 59 | 59RENAISSANCE TECHNOLOGIES LLC | 117,332117,332 | $27M | 0.19% | NEW |
| 60 | 60Integral Health Asset Management, LLC | 115,000115,000 | $26M | 0.19% | ADD 28% |
| 61 | 61VOLORIDGE INVESTMENT MANAGEMENT, LLC | 114,275114,275 | $26M | 0.18% | TRIM -47% |
| 62 | 62Woodline Partners LP | 102,469102,469 | $23M | 0.17% | — |
| 63 | 63Perpetual Ltd | 100,638100,638 | $23M | 0.16% | NEW |
| 64 | 64Q Global Advisors, LLC | 100,000100,000 | $23M | 0.16% | TRIM -47% |
| 65 | 65Troluce Capital Advisors LLC | 99,60099,600 | $23M | 0.16% | NEW |
| 66 | 66Resolute Capital Asset Partners LLC | 98,62798,627 | $23M | 0.16% | ADD 11% |
| 67 | 67Cormorant Asset Management, LP | 95,00095,000 | $22M | 0.15% | TRIM -5% |
| 68 | 68Affinity Asset Advisors, LLC | 95,00095,000 | $22M | 0.15% | ADD 217% |
| 69 | 69ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 91,47091,470 | $21M | 0.15% | NEW |
| 70 | 70STATE STREET CORP | 87,33487,334 | $20M | 0.14% | ADD 29% |
| 71 | 71Eagle Health Investments LP | 86,65086,650 | $20M | 0.14% | NEW |
| 72 | 72LOOMIS SAYLES & CO L P | 80,40580,405 | $18M | 0.13% | TRIM -28% |
| 73 | 73NATIONAL BANK OF CANADA /FI/ | 80,01780,017 | $18M | 0.13% | NEW |
| 74 | 74First Turn Management, LLC | 76,30076,300 | $17M | 0.12% | TRIM -42% |
| 75 | 75GEODE CAPITAL MANAGEMENT, LLC | 72,94172,941 | $17M | 0.12% | ADD 6% |
| 76 | 76Synergy Asset Management, LLC | 70,45670,456 | $16M | 0.11% | NEW |
| 77 | 77Voleon Capital Management LP | 67,83967,839 | $16M | 0.11% | TRIM -2% |
| 78 | 78CASTLEARK MANAGEMENT LLC | 67,61667,616 | $15M | 0.11% | — |
| 79 | 79Trexquant Investment LP | 65,51765,517 | $15M | 0.11% | ADD 11% |
| 80 | 80SCHRODER INVESTMENT MANAGEMENT GROUP | 67,90267,902 | $15M | 0.11% | TRIM -7% |
| 81 | 81MANUFACTURERS LIFE INSURANCE COMPANY, THE | 58,85958,859 | $13M | 0.09% | TRIM -3% |
| 82 | 82Qube Research & Technologies Ltd | 52,75352,753 | $12M | 0.09% | TRIM -73% |
| 83 | 83Defilade Capital Management, L.P. | 51,89551,895 | $12M | 0.08% | TRIM -39% |
| 84 | 84Empowered Funds, LLC | 51,13551,135 | $12M | 0.08% | ADD 39% |
| 85 | 85VOYA INVESTMENT MANAGEMENT LLC | 45,59045,590 | $10M | 0.07% | TRIM -20% |
| 86 | 86NORTHERN TRUST CORP | 44,97144,971 | $10M | 0.07% | ADD 37% |
| 87 | 87NOMURA ASSET MANAGEMENT CO LTD | 43,48443,484 | $10M | 0.07% | — |
| 88 | 88Russell Investments Group, Ltd. | 40,26640,266 | $9M | 0.06% | ADD 15% |
| 89 | 89SEB Asset Management AB | 38,66538,665 | $9M | 0.06% | NEW |
| 90 | 90Diversified Trust Co | 37,16137,161 | $8M | 0.06% | TRIM -12% |
| 91 | 91BARCLAYS PLC | 35,45335,453 | $8M | 0.06% | ADD 215% |
| 92 | 92FIRST TRUST ADVISORS LP | 31,13531,135 | $7M | 0.05% | ADD 155% |
| 93 | 93VICTORY CAPITAL MANAGEMENT INC | 30,77030,770 | $7M | 0.05% | TRIM -29% |
| 94 | 94CANADA PENSION PLAN INVESTMENT BOARD | 30,66330,663 | $7M | 0.05% | TRIM -57% |
| 95 | 95CITIGROUP INC | 29,70129,701 | $7M | 0.05% | TRIM -4% |
| 96 | 96SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,06228,062 | $6M | 0.05% | TRIM -94% |
| 97 | 97Nicholas Investment Partners, LP | 26,86726,867 | $6M | 0.04% | ADD 329% |
| 98 | 98Brevan Howard Capital Management LP | 26,20026,200 | $6M | 0.04% | TRIM -46% |
| 99 | 99Matisse Capital | 26,07726,077 | $6M | 0.04% | TRIM -4% |
| 100 | 100ADAR1 Capital Management, LLC | 25,01425,014 | $6M | 0.04% | — |