| 1 | 1MORGAN STANLEY | 9,466,9929.5M | $39M | 10.04% | ADD 15% |
| 2 | 2Empery Asset Management, LP | 8,944,1188.9M | $37M | 9.48% | — |
| 3 | 3FMR LLC | 8,103,4008.1M | $33M | 8.59% | TRIM -5% |
| 4 | 4Bain Capital Life Sciences Investors, LLC | 7,967,4548.0M | $33M | 8.45% | — |
| 5 | 5Kalehua Capital Management LLC | 7,445,6807.4M | $31M | 7.89% | ADD 100% |
| 6 | 6PERCEPTIVE ADVISORS LLC | 6,737,6486.7M | $28M | 7.14% | ADD 7% |
| 7 | 7Saturn V Capital Management LP | 6,456,6466.5M | $27M | 6.85% | ADD 11% |
| 8 | 8Deep Track Capital, LP | 6,339,5356.3M | $26M | 6.72% | ADD 26% |
| 9 | 9VANGUARD CAPITAL MANAGEMENT LLC | 3,497,6123.5M | $14M | 3.71% | NEW† |
| 10 | 10BRAIDWELL LP | 3,272,9543.3M | $14M | 3.47% | TRIM -3% |
| 11 | 11NEA Management Company, LLC | 3,233,7433.2M | $13M | 3.43% | — |
| 12 | 12Rosalind Advisors, Inc. | 3,214,7663.2M | $13M | 3.41% | ADD 23% |
| 13 | 13Blackstone Inc. | 2,681,9222.7M | $11M | 2.84% | — |
| 14 | 14Trails Edge Capital Partners, LP | 2,571,4782.6M | $11M | 2.73% | — |
| 15 | 15Nantahala Capital Management, LLC | 2,449,4682.4M | $10M | 2.60% | — |
| 16 | 16BVF INC/IL | 2,233,7422.2M | $9M | 2.37% | — |
| 17 | 17SAMSARA BIOCAPITAL, LLC | 1,832,5661.8M | $8M | 1.94% | TRIM -7% |
| 18 | 18STEMPOINT CAPITAL LP | 1,701,4841.7M | $7M | 1.80% | ADD 89% |
| 19 | 19BlackRock, Inc. | 1,211,7941.2M | $5M | 1.28% | — |
| 20 | 20MILLENNIUM MANAGEMENT LLC | 1,210,5141.2M | $5M | 1.28% | ADD 2062% |
| 21 | 21Woodline Partners LP | 1,001,0951.0M | $4M | 1.06% | — |
| 22 | 22GEODE CAPITAL MANAGEMENT, LLC | 939,726939,726 | $4M | 1.00% | — |
| 23 | 23GOLDMAN SACHS GROUP INC | 882,134882,134 | $4M | 0.94% | ADD 6% |
| 24 | 24SUSQUEHANNA INTERNATIONAL GROUP, LLP | 856,222856,222 | $4M | 0.91% | ADD 3768% |
| 25 | 25VANGUARD FIDUCIARY TRUST CO | 480,733480,733 | $2M | 0.51% | NEW |
| 26 | 26STATE STREET CORP | 403,534403,534 | $2M | 0.43% | ADD 104% |
| 27 | 27MARSHALL WACE, LLP | 336,834336,834 | $1M | 0.36% | ADD 319% |
| 28 | 28Stonepine Capital Management, LLC | 335,309335,309 | $1M | 0.36% | TRIM -44% |
| 29 | 29Venrock Adviser, LLC | 330,525330,525 | $1M | 0.35% | NEW |
| 30 | 30UBS Group AG | 267,340267,340 | $1M | 0.28% | ADD 6375% |
| 31 | 31ACORN CAPITAL ADVISORS, LLC | 234,039234,039 | $966,583 | 0.25% | TRIM -14% |
| 32 | 32Qube Research & Technologies Ltd | 218,954218,954 | $904,280 | 0.23% | ADD 223% |
| 33 | 33NORTHERN TRUST CORP | 178,235178,235 | $736,111 | 0.19% | — |
| 34 | 34Pale Fire Capital SE | 167,590167,590 | $692,147 | 0.18% | — |
| 35 | 35BANK OF AMERICA CORP /DE/ | 150,676150,676 | $622,292 | 0.16% | ADD 321% |
| 36 | 36Affinity Asset Advisors, LLC | 145,000145,000 | $598,850 | 0.15% | — |
| 37 | 37Palumbo Wealth Management LLC | 131,014131,014 | $541,088 | 0.14% | ADD 16% |
| 38 | 38Brevan Howard Capital Management LP | 127,321127,321 | $525,836 | 0.13% | NEW |
| 39 | 39Susquehanna Portfolio Strategies, LLC | 102,599102,599 | $423,734 | 0.11% | ADD 137% |
| 40 | 40Dynamic Technology Lab Private Ltd | 36,22136,221 | $384,667 | 0.04% | NEW |
| 41 | 41CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,74966,749 | $275,673 | 0.07% | — |
| 42 | 42OMERS ADMINISTRATION Corp | 57,30057,300 | $236,649 | 0.06% | TRIM -48% |
| 43 | 43Hudson Bay Capital Management LP | 50,28750,287 | $207,685 | 0.05% | ADD 56% |
| 44 | 44Catalyst Funds Management Pty Ltd | 47,38347,383 | $195,692 | 0.05% | NEW |
| 45 | 45JANE STREET GROUP, LLC | 37,14337,143 | $153,401 | 0.04% | TRIM -59% |
| 46 | 46CITIGROUP INC | 35,76535,765 | $147,709 | 0.04% | ADD 11% |
| 47 | 47Vanguard Global Advisers, LLC | 32,97732,977 | $136,195 | 0.03% | NEW |
| 48 | 48Diametric Capital, LP | 28,97328,973 | $119,658 | 0.03% | NEW |
| 49 | 49STIFEL FINANCIAL CORP | 21,78921,789 | $89,989 | 0.02% | ADD 6% |
| 50 | 50Invesco Ltd. | 19,96819,968 | $82,468 | 0.02% | NEW |
| 51 | 51Schonfeld Strategic Advisors LLC | 19,51419,514 | $80,592 | 0.02% | NEW |
| 52 | 52Jefferies Financial Group Inc. | 19,47419,474 | $80,428 | 0.02% | TRIM -25% |
| 53 | 53CAXTON CORP | 15,55715,557 | $64,249 | 0.02% | — |
| 54 | 54ExodusPoint Capital Management, LP | 14,70314,703 | $60,723 | 0.02% | TRIM -81% |
| 55 | 55TWO SIGMA INVESTMENTS, LP | 13,86813,868 | $57,275 | 0.01% | TRIM -20% |
| 56 | 56Creative Planning | 13,81913,819 | $57,072 | 0.01% | TRIM -16% |
| 57 | 57Virtu Financial LLC | 12,73012,730 | $53,000 | 0.01% | TRIM -43% |
| 58 | 58Jump Financial, LLC | 12,31712,317 | $50,869 | 0.01% | NEW |
| 59 | 59Vanguard Personalized Indexing Management, LLC | 11,52511,525 | $47,598 | 0.01% | NEW |
| 60 | 60SummitTX Capital, L.P. | 11,20011,200 | $46,256 | 0.01% | NEW |
| 61 | 61WINTON GROUP Ltd | 10,60010,600 | $43,778 | 0.01% | NEW |
| 62 | 62Indivisible Partners | 10,00010,000 | $37,000 | 0.01% | — |
| 63 | 63BNP PARIBAS FINANCIAL MARKETS | 4,7564,756 | $19,642 | 0.01% | ADD 831% |
| 64 | 64BARCLAYS PLC | 2,8142,814 | $11,622 | 0.00% | TRIM -95% |
| 65 | 65SIGNATUREFD, LLC | 1,9961,996 | $8,243 | 0.00% | TRIM -28% |
| 66 | 66PNC FINANCIAL SERVICES GROUP, INC. | 1,7591,759 | $7,265 | 0.00% | — |
| 67 | 67State of Wyoming | 1,0651,065 | $4,398 | 0.00% | NEW |
| 68 | 68Russell Investments Group, Ltd. | 729729 | $3,011 | 0.00% | — |
| 69 | 69ACADIAN ASSET MANAGEMENT LLC | 802802 | $3,000 | 0.00% | NEW |
| 70 | 70GROUP ONE TRADING LLC | 712712 | $2,941 | 0.00% | TRIM -82% |
| 71 | 71Bleichroeder LP | 595595 | $2,457 | 0.00% | — |
| 72 | 72Farther Finance Advisors, LLC | 331331 | $1,440 | 0.00% | — |
| 73 | 73Allworth Financial LP | 310310 | $1,281 | 0.00% | TRIM -57% |
| 74 | 74Blue Trust, Inc. | 284284 | $1,173 | 0.00% | — |
| 75 | 75Tower Research Capital LLC (TRC) | 180180 | $743 | 0.00% | TRIM -98% |
| 76 | 76QUADRANT CAPITAL GROUP LLC | 128128 | $529 | 0.00% | NEW |
| 77 | 77Parallel Advisors, LLC | 116116 | $479 | 0.00% | NEW |
| 78 | 78SBI Securities Co., Ltd. | 5454 | $223 | 0.00% | ADD 8% |
| 79 | 79JONES FINANCIAL COMPANIES LLLP | 3838 | $154 | 0.00% | — |
| 80 | 80Rockefeller Capital Management L.P. | 3333 | $136 | 0.00% | — |
| 81 | 81JPMORGAN CHASE & CO | 3333 | $132 | 0.00% | TRIM -99% |
| 82 | 82HighMark Wealth Management LLC | 66 | $24 | 0.00% | — |
| 83 | 83NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 55 | $21 | 0.00% | — |
| 84 | 84ROYAL BANK OF CANADA | 115115 | $0 | 0.00% | ADD 11% |