% of shares outstanding suppressed: the summed institutional 13F holdings (100,364,715) exceed the cover-page shares-outstanding count for this quarter (83,190,316, as of 2026-02-23) by more than securities-lending double counting can explain (FINRA short interest 4,149,067 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 10,818,49110.8M | $629M | — | ADD 21% |
| 2 | Avoro Capital Advisors LLC | 5,777,7775.8M | $336M | — | ADD 7% |
| 3 | BlackRock, Inc. | 5,640,1185.6M | $328M | — | ADD 11% |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 4,829,6414.8M | $281M | — | — |
| 5 | Driehaus Capital Management LLC | 4,491,6534.5M | $261M | — | — |
| 6 | Polar Capital Holdings Plc | 4,405,3124.4M | $256M | — | ADD 79% |
| 7 | JANUS HENDERSON GROUP PLC | 4,175,9824.2M | $243M | — | ADD 2% |
| 8 | Capital International Investors | 2,674,7272.7M | $156M | — | TRIM -22% |
| 9 | CITADEL ADVISORS LLC | 2,652,9902.7M | $154M | — | ADD 101% |
| 10 | JPMORGAN CHASE & CO | 1,923,6101.9M | $107M | — | ADD 29% |
| 11 | STATE STREET CORP | 1,720,5331.7M | $100M | — | ADD 15% |
| 12 | Affinity Asset Advisors, LLC | 1,675,0001.7M | $97M | — | ADD 34% |
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,615,6961.6M | $94M | — | ADD 198% |
| 14 | Holocene Advisors, LP | 1,518,6861.5M | $88M | — | ADD 18% |
| 15 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,401,4831.4M | $81M | — | ADD 14% |
| 16 | Caligan Partners LP | 1,393,0271.4M | $81M | — | ADD 153% |
| 17 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,342,0281.3M | $78M | — | ADD 27% |
| 18 | BRAIDWELL LP | 1,338,4521.3M | $78M | — | TRIM -27% |
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,329,5911.3M | $77M | — | ADD 54% |
| 20 | JENNISON ASSOCIATES LLC | 1,318,8141.3M | $77M | — | ADD 2% |
| 21 | Siren, L.L.C. | 1,318,5641.3M | $77M | — | ADD 62% |
| 22 | Alyeska Investment Group, L.P. | 1,299,4691.3M | $76M | — | NEW |
| 23 | FRANKLIN RESOURCES INC | 1,280,5771.3M | $74M | — | ADD 69% |
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 1,092,9321.1M | $64M | — | ADD 15% |
| 25 | ALLIANCEBERNSTEIN L.P. | 1,403,2971.4M | $63M | — | TRIM -12% |
| 26 | ORBIMED ADVISORS LLC | 1,059,9711.1M | $62M | — | ADD 137% |
| 27 | FEDERATED HERMES, INC. | 972,237972,237 | $57M | — | ADD 45% |
| 28 | T. Rowe Price Investment Management, Inc. | 951,955951,955 | $55M | — | ADD 49% |
| 29 | Capital World Investors | 840,072840,072 | $49M | — | ADD 28% |
| 30 | Commodore Capital LP | 825,000825,000 | $48M | — | TRIM -54% |
| 31 | First Turn Management, LLC | 786,844786,844 | $46M | — | — |
| 32 | GOLDMAN SACHS GROUP INC | 769,875769,875 | $45M | — | ADD 11% |
| 33 | Rock Springs Capital Management LP | 763,020763,020 | $44M | — | TRIM -3% |
| 34 | Fiera Capital Corp | 709,529709,529 | $41M | — | ADD 3% |
| 35 | AMERICAN CENTURY COMPANIES INC | 679,314679,314 | $40M | — | — |
| 36 | Pictet Asset Management Holding SA | 679,709679,709 | $39M | — | ADD 9% |
| 37 | Vestal Point Capital, LP | 639,900639,900 | $37M | — | ADD 7% |
| 38 | Aberdeen Group plc | 609,929609,929 | $35M | — | TRIM -19% |
| 39 | TWO SIGMA INVESTMENTS, LP | 606,085606,085 | $35M | — | ADD 39% |
| 40 | MPM BIOIMPACT LLC | 588,706588,706 | $34M | — | ADD 21% |
| 41 | LOOMIS SAYLES & CO L P | 564,897564,897 | $33M | — | TRIM -8% |
| 42 | VANGUARD PORTFOLIO MANAGEMENT LLC | 543,062543,062 | $32M | — | NEW |
| 43 | NORTHERN TRUST CORP | 527,783527,783 | $31M | — | ADD 20% |
| 44 | Parkman Healthcare Partners LLC | 497,035497,035 | $29M | — | ADD 222% |
| 45 | TUDOR INVESTMENT CORP ET AL | 495,591495,591 | $29M | — | ADD 95% |
| 46 | Octagon Capital Advisors LP | 490,000490,000 | $28M | — | NEW |
| 47 | NOVO HOLDINGS A/S | 485,438485,438 | $28M | — | NEW |
| 48 | Candriam S.C.A. | 476,494476,494 | $28M | — | ADD 14% |
| 49 | MORGAN STANLEY | 473,759473,759 | $28M | — | ADD 61% |
| 50 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 470,000470,000 | $27M | — | TRIM -31% |
| 51 | Logos Global Management LP | 450,000450,000 | $26M | — | NEW |
| 52 | Trails Edge Capital Partners, LP | 440,000440,000 | $26M | — | TRIM -26% |
| 53 | Bank of New York Mellon Corp | 396,138396,138 | $23M | — | ADD 2% |
| 54 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 375,166375,166 | $22M | — | ADD 158869% |
| 55 | BAKER BROS. ADVISORS LP | 370,208370,208 | $22M | — | — |
| 56 | TimesSquare Capital Management, LLC | 359,293359,293 | $21M | — | TRIM -33% |
| 57 | Schonfeld Strategic Advisors LLC | 324,722324,722 | $19M | — | NEW |
| 58 | Sofinnova Investments, Inc. | 305,216305,216 | $18M | — | ADD 410% |
| 59 | RENAISSANCE TECHNOLOGIES LLC | 300,500300,500 | $17M | — | NEW |
| 60 | Soleus Capital Management, L.P. | 292,000292,000 | $17M | — | NEW |
| 61 | STEMPOINT CAPITAL LP | 281,510281,510 | $16M | — | TRIM -19% |
| 62 | BOOTHBAY FUND MANAGEMENT, LLC | 270,412270,412 | $16M | — | ADD 658% |
| 63 | BANK OF AMERICA CORP /DE/ | 265,267265,267 | $15M | — | ADD 20% |
| 64 | ALGERT GLOBAL LLC | 264,200264,200 | $15M | — | ADD 114% |
| 65 | Redmile Group, LLC | 262,674262,674 | $15M | — | ADD 96% |
| 66 | STATE OF WISCONSIN INVESTMENT BOARD | 254,483254,483 | $15M | — | ADD 24% |
| 67 | DAFNA Capital Management LLC | 250,772250,772 | $15M | — | TRIM -13% |
| 68 | Nuveen, LLC | 250,036250,036 | $15M | — | ADD 16% |
| 69 | NAN FUNG TRINITY (HK) LTD | 247,765247,765 | $14M | — | ADD 9% |
| 70 | Nicholas Investment Partners, LP | 247,101247,101 | $14M | — | — |
| 71 | Allspring Global Investments Holdings, LLC | 246,306246,306 | $14M | — | NEW |
| 72 | Duquesne Family Office LLC | 238,600238,600 | $14M | — | NEW |
| 73 | BARCLAYS PLC | 238,209238,209 | $14M | — | TRIM -60% |
| 74 | Balyasny Asset Management L.P. | 233,905233,905 | $14M | — | ADD 177% |
| 75 | ADAR1 Capital Management, LLC | 228,899228,899 | $13M | — | ADD 12% |
| 76 | Patient Square Capital LP | 227,000227,000 | $13M | — | ADD 66% |
| 77 | MILLENNIUM MANAGEMENT LLC | 201,785201,785 | $12M | — | TRIM -68% |
| 78 | Integral Health Asset Management, LLC | 200,000200,000 | $12M | — | NEW |
| 79 | SILVERARC CAPITAL MANAGEMENT, LLC | 197,759197,759 | $11M | — | NEW |
| 80 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,080189,080 | $11M | — | — |
| 81 | NEW YORK STATE COMMON RETIREMENT FUND | 188,505188,505 | $11M | — | — |
| 82 | NEXTBio Capital Management LP | 183,225183,225 | $11M | — | — |
| 83 | DNB Asset Management AS | 181,085181,085 | $11M | — | TRIM -34% |
| 84 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 177,137177,137 | $10M | — | ADD 2029% |
| 85 | ExodusPoint Capital Management, LP | 173,425173,425 | $10M | — | NEW |
| 86 | DEUTSCHE BANK AG\ | 162,682162,682 | $9M | — | TRIM -14% |
| 87 | Foresite Capital Management IV, LLC | 160,000160,000 | $9M | — | — |
| 88 | Swiss National Bank | 157,700157,700 | $9M | — | ADD 38% |
| 89 | Jump Financial, LLC | 155,776155,776 | $9M | — | ADD 403% |
| 90 | Woodline Partners LP | 150,302150,302 | $9M | — | NEW |
| 91 | PEREGRINE CAPITAL MANAGEMENT LLC | 143,136143,136 | $8M | — | TRIM -18% |
| 92 | NEUBERGER BERMAN GROUP LLC | 130,438130,438 | $8M | — | TRIM -27% |
| 93 | Eversept Partners, LP | 129,574129,574 | $8M | — | TRIM -44% |
| 94 | Russell Investments Group, Ltd. | 129,399129,399 | $8M | — | ADD 50% |
| 95 | KBC Group NV | 129,010129,010 | $8M | — | ADD 4541% |
| 96 | SPHERA FUNDS MANAGEMENT LTD. | 127,000127,000 | $7M | — | NEW |
| 97 | HSBC HOLDINGS PLC | 121,558121,558 | $7M | — | NEW |
| 98 | WELLS FARGO & COMPANY/MN | 115,652115,652 | $7M | — | TRIM -24% |
| 99 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 115,594115,594 | $7M | — | — |
| 100 | SEI INVESTMENTS CO | 114,381114,381 | $7M | — | ADD 161% |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7.5M | 8.3M | 8.9M | 8.9M | 8.9M | 10.8M | $629M |
| Avoro Capital Advisors LLC | 5.7M | 5.7M | 5.4M | 5.4M | 5.4M | 5.8M | $336M |
| BlackRock, Inc. | 2.1M | 2.0M | 5.4M | 4.8M | 5.1M | 5.6M | $328M |
| WELLINGTON MANAGEMENT GROUP LLP | 3.8M | 3.8M | 2.2M | 3.6M | 4.8M | 4.8M | $281M |
| Driehaus Capital Management LLC | 4.5M | 4.6M | 4.3M | 4.2M | 4.5M | 4.5M | $261M |
| Polar Capital Holdings Plc | 2.7M | 2.6M | 2.7M | 2.5M | 2.5M | 4.4M | $256M |
| JANUS HENDERSON GROUP PLC | 2.9M | 3.3M | 3.6M | 3.9M | 4.1M | 4.2M | $243M |
| Capital International Investors | 2.5M | 3.1M | 3.2M | 3.2M | 3.4M | 2.7M | $156M |
| CITADEL ADVISORS LLC | 327K | 687K | 120K | 959K | 1.3M | 2.7M | $154M |
| JPMORGAN CHASE & CO | 1.4M | 1.4M | 1.3M | 2.8M | 1.5M | 1.9M | $107M |
| STATE STREET CORP | 289K | 306K | 1.4M | 1.5M | 1.5M | 1.7M | $100M |
| Affinity Asset Advisors, LLC | 1.2M | 1.3M | 1.1M | 1.4M | 1.3M | 1.7M | $97M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | — | 542K | 542K | 542K | 1.6M | $94M |
| Holocene Advisors, LP | — | — | 1.8M | 2.0M | 1.3M | 1.5M | $88M |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.2M | 1.4M | 1.2M | 1.2M | 1.2M | 1.4M | $81M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Polar Capital Holdings Plc | +1,939,618 | $113M | ADD |
| FMR LLC | +1,898,241 | $110M | ADD |
| CITADEL ADVISORS LLC | +1,331,777 | $77M | ADD |
| Alyeska Investment Group, L.P. | +1,299,469 | $76M | OPEN |
| DEERFIELD MANAGEMENT COMPANY, L.P. | +1,073,676 | $62M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| Commodore Capital LP | −975,000 | $57M | TRIM |
| Capital International Investors | −740,232 | $43M | TRIM |
| VANGUARD GROUP INC | −664,641 | $39M | CLOSE |
| BRAIDWELL LP | −486,624 | $28M | TRIM |
| DIMENSIONAL FUND ADVISORS LP | −452,147 | $26M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 289 | 100,364,715 | — | $5.8B |
| 2025-Q4 | 246 | 84,548,768 | 109.4% | $3.8B |
| 2025-Q3 | 219 | 85,719,863 | — | $3.4B |
| 2025-Q2 | 206 | 83,293,331 | 108.5% | $2.6B |
| 2025-Q1 | 206 | 76,774,061 | 100.3% | $2.6B |
| 2024-Q4 | 209 | 76,311,942 | 100.1% | $3.0B |
| 2024-Q3 | 203 | 75,876,277 | 100.1% | $3.0B |
| 2024-Q2 | 213 | 75,008,281 | 99.4% | $2.9B |
| 2024-Q1 | 220 | 75,202,311 | 99.7% | $3.2B |
| 2023-Q4 | 204 | 73,252,342 | — | $3.4B |
| 2023-Q3 | 180 | 62,507,305 | 97.4% | $2.1B |
| 2023-Q2 | 175 | 63,281,186 | 99.6% | $2.4B |
| 2023-Q1 | 163 | 67,656,858 | 107.3% | $2.4B |
| 2022-Q4 | 159 | 62,525,274 | 100.0% | $2.5B |
| 2022-Q3 | 154 | 58,315,783 | 93.7% | $2.1B |
| 2022-Q2 | 151 | 57,200,652 | 107.7% | $1.7B |
| 2022-Q1 | 133 | 49,368,193 | 95.1% | $1.5B |
| 2021-Q4 | 130 | 50,101,339 | 97.1% | $1.6B |
| 2021-Q3 | 118 | 34,109,982 | 82.9% | $522M |
| 2021-Q2 | 103 | 35,251,629 | 86.0% | $703M |
| 2021-Q1 | 91 | 32,964,357 | 92.1% | $590M |
| 2020-Q4 | 81 | 28,020,842 | 80.0% | $431M |
| 2020-Q3 | 80 | 27,925,216 | 79.8% | $309M |
| 2020-Q2 | 79 | 27,992,558 | 80.0% | $351M |
| 2020-Q1 | 70 | 27,710,944 | 79.3% | $314M |
| 2019-Q4 | 66 | 18,724,038 | 72.4% | $245M |
| 2019-Q3 | 54 | 16,095,757 | 62.4% | $145M |
| 2019-Q2 | 60 | 17,563,373 | 68.1% | $173M |
| 2019-Q1 | 63 | 17,737,001 | 68.9% | $180M |
| 2018-Q4 | 58 | 17,466,358 | 69.2% | $110M |
| 2018-Q3 | 59 | 17,651,195 | 91.6% | $234M |
| 2018-Q2 | 42 | 9,243,057 | 65.2% | $85M |
| 2018-Q1 | 35 | 6,350,539 | 35.3% | $31M |
| 2017-Q4 | 32 | 9,156,673 | 50.9% | $26M |
| 2017-Q3 | 32 | 9,825,582 | 54.6% | $29M |
| 2017-Q2 | 39 | 9,948,582 | 55.3% | $31M |
| 2017-Q1 | 38 | 10,077,549 | 56.2% | $40M |
| 2016-Q4 | 31 | 10,494,092 | 58.6% | $81M |
| 2016-Q3 | 30 | 9,918,729 | 68.8% | $80M |
| 2016-Q2 | 21 | 5,377,516 | 37.3% | $32M |
| 2016-Q1 | 25 | 5,708,042 | 39.6% | $40M |
| 2015-Q4 | 25 | 5,841,167 | 40.6% | $47M |
| 2015-Q3 | 25 | 5,682,732 | 39.8% | $47M |
| 2015-Q2 | 26 | 4,806,647 | 33.8% | $55M |
| 2015-Q1 | 23 | 4,449,844 | 31.3% | $75M |
| 2014-Q4 | 17 | 4,275,095 | 30.1% | $83M |
| 2025-12-31 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
