| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 4,543,8954.5M | $82M | 9.33% | — |
| 2 | BlackRock, Inc. | 2,845,5672.8M | $51M | 5.85% | ADD 9% |
| 3 | TORONTO DOMINION BANK | 2,616,7142.6M | $47M | 5.38% | NEW† |
| 4 | MORGAN STANLEY | 2,560,0382.6M | $46M | 5.26% | — |
| 5 | Kynam Capital Management, LP | 2,247,3932.2M | $40M | 4.62% | NEW† |
| 6 | Jefferies Financial Group Inc. | 2,199,6522.2M | $40M | 4.52% | — |
| 7 | Paradigm Biocapital Advisors LP | 1,703,9491.7M | $31M | 3.50% | TRIM -62% |
| 8 | ACORN CAPITAL ADVISORS, LLC | 1,673,4201.7M | $30M | 3.44% | ADD 16% |
| 9 | SG Americas Securities, LLC | 1,657,8461.7M | $30M | 3.41% | ADD 20% |
| 10 | AMERICAN CENTURY COMPANIES INC | 1,637,5701.6M | $29M | 3.36% | ADD 21% |
| 11 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,503,0451.5M | $27M | 3.09% | TRIM -14% |
| 12 | Opaleye Management Inc. | 1,430,0001.4M | $26M | 2.94% | ADD 433% |
| 13 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,314,1121.3M | $24M | 2.70% | ADD 68% |
| 14 | MENORA MIVTACHIM HOLDINGS LTD. | 1,152,5311.2M | $21M | 2.37% | — |
| 15 | D. E. Shaw & Co., Inc. | 1,023,1591.0M | $18M | 2.10% | ADD 6% |
| 16 | MPM BIOIMPACT LLC | 943,803943,803 | $17M | 1.94% | — |
| 17 | J. Goldman & Co LP | 938,870938,870 | $17M | 1.93% | ADD 83% |
| 18 | ORBIMED ADVISORS LLC | 875,487875,487 | $16M | 1.80% | — |
| 19 | STATE STREET CORP | 874,176874,176 | $16M | 1.80% | ADD 8% |
| 20 | Migdal Insurance & Financial Holdings Ltd. | 770,909770,909 | $14M | 1.58% | — |
| 21 | Soleus Capital Management, L.P. | 727,000727,000 | $13M | 1.49% | ADD 385% |
| 22 | GOLDMAN SACHS GROUP INC | 598,528598,528 | $11M | 1.23% | ADD 30% |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 523,831523,831 | $9M | 1.08% | ADD 10% |
| 24 | Woodline Partners LP | 500,726500,726 | $9M | 1.03% | — |
| 25 | Boxer Capital Management, LLC | 500,000500,000 | $9M | 1.03% | — |
| 26 | VANGUARD PORTFOLIO MANAGEMENT LLC | 409,557409,557 | $7M | 0.84% | NEW |
| 27 | TCG Crossover Management, LLC | 405,365405,365 | $7M | 0.83% | TRIM -43% |
| 28 | ADAR1 Capital Management, LLC | 395,459395,459 | $7M | 0.81% | ADD 215% |
| 29 | SUPERSTRING CAPITAL MANAGEMENT LP | 387,371387,371 | $7M | 0.80% | TRIM -46% |
| 30 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 387,074387,074 | $7M | 0.80% | TRIM -66% |
| 31 | MILLENNIUM MANAGEMENT LLC | 370,898370,898 | $7M | 0.76% | TRIM -40% |
| 32 | TANG CAPITAL MANAGEMENT LLC | 350,000350,000 | $6M | 0.72% | — |
| 33 | RICE HALL JAMES & ASSOCIATES, LLC | 285,834285,834 | $5M | 0.59% | — |
| 34 | NORTHERN TRUST CORP | 275,938275,938 | $5M | 0.57% | ADD 16% |
| 35 | Parkman Healthcare Partners LLC | 275,000275,000 | $5M | 0.56% | ADD 63% |
| 36 | CITADEL ADVISORS LLC | 267,996267,996 | $5M | 0.55% | TRIM -64% |
| 37 | Privium Fund Management B.V. | 238,122238,122 | $4M | 0.49% | ADD 11% |
| 38 | DEUTSCHE BANK AG\ | 236,192236,192 | $4M | 0.49% | TRIM -36% |
| 39 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 230,630230,630 | $4M | 0.47% | TRIM -47% |
| 40 | Elmind Capital, LP | 220,000220,000 | $4M | 0.45% | ADD 120% |
| 41 | Ally Bridge Group (NY) LLC | 202,124202,124 | $4M | 0.42% | NEW |
| 42 | Hennion & Walsh Asset Management, Inc. | 183,504183,504 | $3M | 0.38% | ADD 13% |
| 43 | TWO SIGMA INVESTMENTS, LP | 177,901177,901 | $3M | 0.37% | TRIM -26% |
| 44 | UBS Group AG | 159,658159,658 | $3M | 0.33% | TRIM -32% |
| 45 | Schonfeld Strategic Advisors LLC | 158,111158,111 | $3M | 0.32% | NEW |
| 46 | Atom Investors LP | 145,342145,342 | $3M | 0.30% | TRIM -38% |
| 47 | FMR LLC | 144,961144,961 | $3M | 0.30% | ADD 17% |
| 48 | AQR CAPITAL MANAGEMENT LLC | 144,060144,060 | $3M | 0.30% | TRIM -6% |
| 49 | Vestal Point Capital, LP | 139,079139,079 | $3M | 0.29% | NEW |
| 50 | BANK OF AMERICA CORP /DE/ | 126,783126,783 | $2M | 0.26% | — |
| 51 | ARK Investment Management LLC | 115,545115,545 | $2M | 0.24% | TRIM -5% |
| 52 | Aisling Capital Management LP | 108,000108,000 | $2M | 0.22% | — |
| 53 | Tidal Investments LLC | 102,949102,949 | $2M | 0.21% | ADD 282% |
| 54 | WELLINGTON MANAGEMENT GROUP LLP | 100,215100,215 | $2M | 0.21% | TRIM -20% |
| 55 | Bank of New York Mellon Corp | 98,94298,942 | $2M | 0.20% | — |
| 56 | PANAGORA ASSET MANAGEMENT INC | 98,05598,055 | $2M | 0.20% | ADD 32% |
| 57 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 88,46688,466 | $2M | 0.18% | TRIM -3% |
| 58 | Nuveen, LLC | 87,52287,522 | $2M | 0.18% | TRIM -71% |
| 59 | OAK RIDGE INVESTMENTS LLC | 86,40386,403 | $2M | 0.18% | — |
| 60 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 83,62383,623 | $2M | 0.17% | TRIM -49% |
| 61 | Swiss National Bank | 77,80077,800 | $1M | 0.16% | NEW |
| 62 | Trexquant Investment LP | 73,90573,905 | $1M | 0.15% | NEW |
| 63 | TRUIST FINANCIAL CORP | 72,28672,286 | $1M | 0.15% | — |
| 64 | ExodusPoint Capital Management, LP | 70,24070,240 | $1M | 0.14% | ADD 98% |
| 65 | Russell Investments Group, Ltd. | 63,24663,246 | $1M | 0.13% | ADD 34% |
| 66 | Annandale Capital, LLC | 58,55258,552 | $1M | 0.12% | TRIM -3% |
| 67 | WELLS FARGO & COMPANY/MN | 55,75755,757 | $1M | 0.11% | TRIM -34% |
| 68 | RHUMBLINE ADVISERS | 49,40749,407 | $888,326 | 0.10% | ADD 8% |
| 69 | HRT FINANCIAL LP | 49,36349,363 | $887,000 | 0.10% | TRIM -62% |
| 70 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,41947,419 | $852,594 | 0.10% | ADD 11667% |
| 71 | ALLIANCEBERNSTEIN L.P. | 35,04035,040 | $820,637 | 0.07% | — |
| 72 | VOYA INVESTMENT MANAGEMENT LLC | 43,49843,498 | $782,094 | 0.09% | TRIM -43% |
| 73 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,75038,750 | $696,725 | 0.08% | ADD 1606% |
| 74 | Coastal Bridge Advisors, LLC | 37,00037,000 | $665,260 | 0.08% | — |
| 75 | BENDER ROBERT & ASSOCIATES | 34,70134,701 | $623,924 | 0.07% | NEW |
| 76 | Focus Partners Wealth | 34,03834,038 | $612,004 | 0.07% | TRIM -4% |
| 77 | JACOBS LEVY EQUITY MANAGEMENT, INC | 32,50932,509 | $584,512 | 0.07% | TRIM -17% |
| 78 | STATE OF WISCONSIN INVESTMENT BOARD | 32,11632,116 | $577,446 | 0.07% | NEW |
| 79 | VANGUARD FIDUCIARY TRUST CO | 31,55931,559 | $567,431 | 0.06% | NEW |
| 80 | AMERIPRISE FINANCIAL INC | 30,16630,166 | $542,385 | 0.06% | TRIM -78% |
| 81 | Cetera Investment Advisers | 29,09629,096 | $523,146 | 0.06% | TRIM -3% |
| 82 | PRICE T ROWE ASSOCIATES INC /MD/ | 28,45428,454 | $512,000 | 0.06% | TRIM -95% |
| 83 | Invesco Ltd. | 28,08028,080 | $504,878 | 0.06% | ADD 4% |
| 84 | HighVista Strategies LLC | 26,51026,510 | $476,650 | 0.05% | TRIM -5% |
| 85 | VANGUARD ASSET MANAGEMENT, Ltd | 26,00426,004 | $467,552 | 0.05% | NEW |
| 86 | Man Group plc | 25,39525,395 | $456,602 | 0.05% | NEW |
| 87 | Legal & General Group Plc | 25,17225,172 | $452,593 | 0.05% | ADD 591% |
| 88 | Palo Alto Investors LP | 24,50024,500 | $440,510 | 0.05% | — |
| 89 | FOX RUN MANAGEMENT, L.L.C. | 25,67125,671 | $436,407 | 0.05% | NEW |
| 90 | MetLife Investment Management, LLC | 23,32623,326 | $419,401 | 0.05% | ADD 4% |
| 91 | DIADEMA PARTNERS LP | 23,15523,155 | $416,327 | 0.05% | ADD 6% |
| 92 | MEITAV INVESTMENT HOUSE LTD | 22,22322,223 | $399,523 | 0.05% | TRIM -37% |
| 93 | Kranot Hishtalmut Le Morim Tichoniim Havera Menahelet LTD | 21,82321,823 | $392,378 | 0.04% | — |
| 94 | MML INVESTORS SERVICES, LLC | 20,80220,802 | $374,020 | 0.04% | TRIM -15% |
| 95 | Quantinno Capital Management LP | 20,17620,176 | $362,764 | 0.04% | TRIM -14% |
| 96 | JPMORGAN CHASE & CO | 21,12221,122 | $359,074 | 0.04% | TRIM -86% |
| 97 | Susquehanna Portfolio Strategies, LLC | 19,40419,404 | $348,884 | 0.04% | TRIM -29% |
| 98 | JANUS HENDERSON GROUP PLC | 19,10019,100 | $343,132 | 0.04% | NEW |
| 99 | ALGERT GLOBAL LLC | 18,99018,990 | $341,000 | 0.04% | TRIM -71% |
| 100 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,86618,866 | $339,211 | 0.04% | ADD 10% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3.8M | 3.8M | 4.5M | 4.5M | 4.5M | 4.5M | $82M |
| BlackRock, Inc. | 2.5M | 2.4M | 2.4M | 2.6M | 2.6M | 2.8M | $51M |
| TORONTO DOMINION BANK | 1.7M | 1.7M | 3.2M | 3.2M | — | 2.6M | $47M |
| MORGAN STANLEY | 767K | 858K | 2.5M | 2.5M | 2.6M | 2.6M | $46M |
| Kynam Capital Management, LP | — | 25K | 657K | 282K | — | 2.2M | $40M |
| Jefferies Financial Group Inc. | 966K | 815K | 2.2M | 2.2M | 2.2M | 2.2M | $40M |
| Paradigm Biocapital Advisors LP | — | — | — | 4.2M | 4.5M | 1.7M | $31M |
| ACORN CAPITAL ADVISORS, LLC | 1.5M | 1.5M | 1.3M | 1.3M | 1.4M | 1.7M | $30M |
| SG Americas Securities, LLC | 20K | 163K | 1.1M | 1.2M | 1.4M | 1.7M | $30M |
| AMERICAN CENTURY COMPANIES INC | — | — | — | — | 1.4M | 1.6M | $29M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.1M | 1.4M | 2.0M | 1.6M | 1.7M | 1.5M | $27M |
| Opaleye Management Inc. | 220K | — | — | — | 268K | 1.4M | $26M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | — | — | — | — | 782K | 1.3M | $24M |
| MENORA MIVTACHIM HOLDINGS LTD. | 2.3M | 2.3M | 1.2M | 1.2M | 1.2M | 1.2M | $21M |
| D. E. Shaw & Co., Inc. | — | — | 27K | 889K | 963K | 1.0M | $18M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| TORONTO DOMINION BANK | +2,616,714 | $47M | OPEN |
| Kynam Capital Management, LP | +2,247,393 | $40M | OPEN |
| Opaleye Management Inc. | +1,161,577 | $21M | ADD |
| Soleus Capital Management, L.P. | +577,000 | $10M | ADD |
| FRONTIER CAPITAL MANAGEMENT CO LLC | +532,492 | $10M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| Paradigm Biocapital Advisors LP | −2,769,699 | $50M | TRIM |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | −738,026 | $13M | TRIM |
| PRICE T ROWE ASSOCIATES INC /MD/ | −588,152 | $11M | TRIM |
| CITADEL ADVISORS LLC | −469,761 | $8M | TRIM |
| VANGUARD GROUP INC | −439,751 | $8M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 171 | 46,421,120 | 95.4% | $835M |
| 2025-Q4 | 167 | 43,721,890 | 93.4% | $1.0B |
| 2025-Q3 | 161 | 44,509,979 | 96.2% | $888M |
| 2025-Q2 | 150 | 40,662,883 | 88.2% | $557M |
| 2025-Q1 | 140 | 41,654,130 | 90.4% | $461M |
| 2024-Q4 | 138 | 36,274,940 | 86.0% | $386M |
| 2024-Q3 | 128 | 35,196,496 | 83.6% | $447M |
| 2024-Q2 | 115 | 38,244,295 | 105.9% | $642M |
| 2024-Q1 | 112 | 27,960,842 | 81.9% | $419M |
| 2023-Q4 | 105 | 21,885,868 | 70.9% | $328M |
| 2023-Q3 | 101 | 17,724,172 | 58.5% | $248M |
| 2023-Q2 | 85 | 13,315,233 | 56.8% | $138M |
| 2023-Q1 | 65 | 12,520,533 | 53.4% | $116M |
| 2022-Q4 | 64 | 13,022,110 | 56.4% | $115M |
| 2022-Q3 | 60 | 13,320,251 | 58.6% | $111M |
| 2022-Q2 | 65 | 13,445,827 | 59.3% | $109M |
| 2022-Q1 | 83 | 14,224,381 | 62.8% | $124M |
| 2021-Q4 | 77 | 14,753,166 | 65.8% | $141M |
| 2021-Q3 | 92 | 14,085,757 | 63.0% | $237M |
| 2021-Q2 | 82 | 14,093,941 | 63.3% | $215M |
| 2021-Q1 | 89 | 14,300,273 | 64.2% | $279M |
| 2020-Q4 | 81 | 14,565,073 | 65.9% | $262M |
| 2020-Q3 | 80 | 15,024,786 | 68.2% | $289M |
| 2020-Q2 | 84 | 14,678,728 | 66.9% | $382M |
| 2020-Q1 | 79 | 14,022,384 | 66.3% | $250M |
| 2019-Q4 | 86 | 14,305,477 | 68.2% | $477M |
| 2019-Q3 | 84 | 14,565,748 | 69.7% | $347M |
| 2019-Q2 | 84 | 14,688,907 | 70.6% | $527M |
| 2019-Q1 | 74 | 13,462,358 | 65.7% | $497M |
| 2018-Q4 | 63 | 9,593,842 | 46.9% | $413M |
| 2018-Q3 | 71 | 9,952,274 | — | $470M |
| 2018-Q2 | 60 | 9,614,454 | — | $483M |
| 2018-Q1 | 43 | 9,137,603 | 66.4% | $454M |
| 2017-Q4 | 41 | 6,837,229 | 49.7% | $254M |
| 2017-Q3 | 31 | 4,572,251 | 33.2% | $144M |
| 2017-Q2 | 21 | 4,717,389 | — | $85M |
| MENORA MIVTACHIM HOLDINGS LTD. | 4.99% | Passive | 2025-03-11 | SEC → |
| Soleus Capital Master Fund, L.P. | 4.7% | Passive | 2025-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
