STOK US Equity

Stoke Therapeutics, Inc.

Nasdaq+ Compare Tear sheet →

Health Care · Pharmaceutical Preparations · CIK 1623526 · FYE 1231

$29.48

+0.09 (+0.31%)

USD · as of 2026-07-29 · marketstack

Switch Ticker

Institutional ownership· 13F filers holding STOK · 2026-Q1 methodology → sources →

197 holders

% of shares outstanding held

114.2%

Shares held (13F)

71,107,856

Reporting holders

197

Institutional 13F holdings sum to 114.2% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 13,026,590 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 197 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RTW INVESTMENTS, LP	5,623,5255.6M	$183M	9.03%	—
2	BlackRock, Inc.	5,385,7145.4M	$175M	8.65%	ADD 3%
3	FMR LLC	5,383,6665.4M	$175M	8.64%	TRIM -4%
4	Lynx1 Capital Management LP	4,763,6734.8M	$155M	7.65%	TRIM -12%
5	Redmile Group, LLC	4,164,1204.2M	$136M	6.69%	ADD 3%
6	MORGAN STANLEY	3,423,2803.4M	$111M	5.50%	TRIM -3%
7	BAKER BROS. ADVISORS LP	3,336,6973.3M	$109M	5.36%	—
8	TORONTO DOMINION BANK	3,173,2583.2M	$103M	5.10%	—
9	WELLINGTON MANAGEMENT GROUP LLP	3,095,7003.1M	$101M	4.97%	ADD 321%
10	BVF INC/IL	2,547,5572.5M	$83M	4.09%	ADD 12%
11	VANGUARD CAPITAL MANAGEMENT LLC	2,355,6032.4M	$77M	3.78%	NEW†
12	STATE STREET CORP	2,276,5122.3M	$74M	3.66%	TRIM -9%
13	Siren, L.L.C.	1,995,3472.0M	$65M	3.20%	TRIM -11%
14	PRICE T ROWE ASSOCIATES INC /MD/	1,934,1711.9M	$63M	3.11%	ADD 419%
15	DEERFIELD MANAGEMENT COMPANY, L.P.	1,823,5001.8M	$59M	2.93%	—
16	JANUS HENDERSON GROUP PLC	1,612,7811.6M	$52M	2.59%	ADD 11%
17	GEODE CAPITAL MANAGEMENT, LLC	1,322,2601.3M	$43M	2.12%	ADD 13%
18	Polar Capital Holdings Plc	1,132,5111.1M	$37M	1.82%	TRIM -11%
19	DIMENSIONAL FUND ADVISORS LP	989,936989,936	$32M	1.59%	ADD 20%
20	Assenagon Asset Management S.A.	907,015907,015	$30M	1.46%	TRIM -26%
21	GOLDMAN SACHS GROUP INC	830,702830,702	$27M	1.33%	TRIM -27%
22	MPM BIOIMPACT LLC	767,038767,038	$25M	1.23%	—
23	Opaleye Management Inc.	700,000700,000	$23M	1.12%	—
24	Troluce Capital Advisors LLC	652,800652,800	$21M	1.05%	NEW
25	BAILLIE GIFFORD & CO	575,182575,182	$19M	0.92%	ADD 133%
26	BANK OF AMERICA CORP /DE/	543,095543,095	$18M	0.87%	ADD 163%
27	Candriam S.C.A.	502,020502,020	$16M	0.81%	ADD 12%
28	TANG CAPITAL MANAGEMENT LLC	500,000500,000	$16M	0.80%	—
29	MILLENNIUM MANAGEMENT LLC	472,141472,141	$15M	0.76%	NEW
30	VANGUARD PORTFOLIO MANAGEMENT LLC	462,682462,682	$15M	0.74%	NEW
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	437,175437,175	$14M	0.70%	ADD 6%
32	Erste Asset Management GmbH	446,000446,000	$14M	0.72%	ADD 13%
33	NORTHERN TRUST CORP	431,630431,630	$14M	0.69%	ADD 7%
34	VANGUARD FIDUCIARY TRUST CO	356,947356,947	$12M	0.57%	NEW
35	Parkman Healthcare Partners LLC	336,519336,519	$11M	0.54%	TRIM -22%
36	Granahan Investment Management, LLC	335,586335,586	$11M	0.54%	ADD 75%
37	Artisan Partners Limited Partnership	315,492315,492	$10M	0.51%	NEW
38	JPMORGAN CHASE & CO	265,473265,473	$8M	0.43%	TRIM -4%
39	T. Rowe Price Investment Management, Inc.	250,913250,913	$8M	0.40%	NEW
40	Birchview Capital, LP	210,000210,000	$7M	0.34%	TRIM -19%
41	FIRST TRUST ADVISORS LP	163,459163,459	$5M	0.26%	—
42	UBS Group AG	158,304158,304	$5M	0.25%	TRIM -7%
43	Invesco Ltd.	150,045150,045	$5M	0.24%	TRIM -42%
44	Bank of New York Mellon Corp	143,407143,407	$5M	0.23%	—
45	FRANKLIN RESOURCES INC	142,793142,793	$5M	0.23%	ADD 8%
46	DAFNA Capital Management LLC	130,875130,875	$4M	0.21%	ADD 20%
47	CITADEL ADVISORS LLC	123,022123,022	$4M	0.20%	ADD 676%
48	Susquehanna Portfolio Strategies, LLC	119,226119,226	$4M	0.19%	TRIM -6%
49	GILDER GAGNON HOWE & CO LLC	112,627112,627	$4M	0.18%	TRIM -8%
50	Nuveen, LLC	108,617108,617	$4M	0.17%	ADD 4%
51	EcoR1 Capital, LLC	100,000100,000	$3M	0.16%	NEW
52	Palo Alto Investors LP	84,63184,631	$3M	0.14%	ADD 18%
53	HUSSMAN STRATEGIC ADVISORS, INC.	84,00084,000	$3M	0.13%	ADD 33%
54	Rhenman & Partners Asset Management AB	83,00083,000	$3M	0.13%	TRIM -62%
55	Swiss National Bank	79,10079,100	$3M	0.13%	ADD 4%
56	Quantedge Capital Pte Ltd	78,60078,600	$3M	0.13%	TRIM -10%
57	TD Asset Management Inc	74,40074,400	$2M	0.12%	NEW
58	MANUFACTURERS LIFE INSURANCE COMPANY, THE	69,22269,222	$2M	0.11%	ADD 411%
59	RHUMBLINE ADVISERS	67,31567,315	$2M	0.11%	ADD 8%
60	JANE STREET GROUP, LLC	64,34964,349	$2M	0.10%	TRIM -4%
61	PRINCIPAL FINANCIAL GROUP INC	63,93363,933	$2M	0.10%	TRIM -9%
62	Harvest Investment Services, LLC	62,83862,838	$2M	0.10%	ADD 64%
63	HighVista Strategies LLC	62,61762,617	$2M	0.10%	TRIM -46%
64	Rafferty Asset Management, LLC	59,89859,898	$2M	0.10%	TRIM -34%
65	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	58,18558,185	$2M	0.09%	—
66	SUSQUEHANNA INTERNATIONAL GROUP, LLP	57,29157,291	$2M	0.09%	ADD 24%
67	BNP PARIBAS FINANCIAL MARKETS	56,12856,128	$2M	0.09%	ADD 1218%
68	Informed Momentum Co LLC	52,00052,000	$2M	0.08%	TRIM -56%
69	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	51,60651,606	$2M	0.08%	ADD 39%
70	Woodline Partners LP	50,12050,120	$2M	0.08%	—
71	Privium Fund Management B.V.	50,00050,000	$2M	0.08%	TRIM -9%
72	D. E. Shaw & Co., Inc.	49,97249,972	$2M	0.08%	—
73	Schonfeld Strategic Advisors LLC	49,30249,302	$2M	0.08%	TRIM -22%
74	Creative Planning	48,10848,108	$2M	0.08%	ADD 15%
75	STATE OF WISCONSIN INVESTMENT BOARD	47,85947,859	$2M	0.08%	ADD 223%
76	BOOTHBAY FUND MANAGEMENT, LLC	47,30747,307	$2M	0.08%	NEW
77	ALPS ADVISORS INC	46,49846,498	$2M	0.07%	TRIM -30%
78	AQR CAPITAL MANAGEMENT LLC	46,45946,459	$2M	0.07%	ADD 58%
79	OMERS ADMINISTRATION Corp	41,50041,500	$1M	0.07%	NEW
80	PLATINUM INVESTMENT MANAGEMENT LTD	40,81540,815	$1M	0.07%	—
81	ALLIANCEBERNSTEIN L.P.	41,83041,830	$1M	0.07%	ADD 3%
82	DEUTSCHE BANK AG\	40,59640,596	$1M	0.07%	ADD 22%
83	Moran Wealth Management, LLC	40,55240,552	$1M	0.07%	NEW
84	NEW YORK STATE COMMON RETIREMENT FUND	39,15839,158	$1M	0.06%	ADD 160%
85	LPL Financial LLC	36,04736,047	$1M	0.06%	ADD 388%
86	Caption Management, LLC	35,17435,174	$1M	0.06%	NEW
87	SG Americas Securities, LLC	33,99633,996	$1M	0.05%	ADD 32%
88	VICTORY CAPITAL MANAGEMENT INC	33,89033,890	$1M	0.05%	TRIM -18%
89	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	33,87333,873	$1M	0.05%	ADD 4%
90	SCHRODER INVESTMENT MANAGEMENT GROUP	34,10234,102	$1M	0.05%	NEW
91	Legal & General Group Plc	32,04832,048	$1M	0.05%	TRIM -12%
92	Blackstone Inc.	30,57930,579	$995,652	0.05%	NEW
93	LOS ANGELES CAPITAL MANAGEMENT LLC	30,47930,479	$992,396	0.05%	ADD 231%
94	PROFUND ADVISORS LLC	26,98526,985	$878,632	0.04%	TRIM -19%
95	NOMURA HOLDINGS INC	26,89126,891	$875,571	0.04%	TRIM -39%
96	Vanguard Global Advisers, LLC	26,63926,639	$867,366	0.04%	NEW
97	CANADA PENSION PLAN INVESTMENT BOARD	26,20026,200	$853,072	0.04%	TRIM -26%
98	MetLife Investment Management, LLC	26,10626,106	$850,011	0.04%	ADD 3%
99	VANGUARD ASSET MANAGEMENT, Ltd	25,11425,114	$817,712	0.04%	NEW
100	Cresset Asset Management, LLC	24,49424,494	$797,525	0.04%	TRIM -7%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RTW INVESTMENTS, LP

5.1M

5.5M

5.6M

$183M

BlackRock, Inc.

5.9M

6.0M

5.2M

5.4M

$175M

FMR LLC

165K

2.5M

7.4M

6.9M

5.6M

5.4M

$175M

Lynx1 Capital Management LP

5.2M

5.3M

5.4M

4.8M

$155M

Redmile Group, LLC

4.6M

4.5M

4.4M

4.2M

4.0M

4.2M

$136M

MORGAN STANLEY

3.4M

3.6M

3.5M

3.4M

$111M

BAKER BROS. ADVISORS LP

4.6M

3.3M

$109M

TORONTO DOMINION BANK

3.2M

$103M

WELLINGTON MANAGEMENT GROUP LLP

135K

136K

137K

738K

736K

3.1M

$101M

BVF INC/IL

—

1.7M

2.3M

2.5M

$83M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.4M

$77M

STATE STREET CORP

1.6M

1.5M

1.4M

2.5M

2.3M

$74M

Siren, L.L.C.

2.0M

2.2M

2.0M

$65M

PRICE T ROWE ASSOCIATES INC /MD/

37K

39K

44K

51K

372K

1.9M

$63M

DEERFIELD MANAGEMENT COMPANY, L.P.

—

1.8M

$59M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	197	71,107,856	114.2%	$2.3B
2025-Q4	183	66,984,195	107.6%	$2.1B
2025-Q3	151	67,715,815	108.7%	$1.6B
2025-Q2	134	65,692,237	105.5%	$746M
2025-Q1	126	63,384,386	101.8%	$422M
2024-Q4	130	58,272,313	93.6%	$643M
2024-Q3	118	58,616,643	94.1%	$720M
2024-Q2	114	62,576,431	100.5%	$845M

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · STOK

Activists — 13D, active intent

Skorpios Trust4.1%▼ -1.9ppSCHEDULE 13D/A · Amd 6 · event 2025-08-22SEC →

2,256,181 shares · 4 reporting persons

“Item 4 is hereby amended and supplemented by adding the following: On August 22, 2025, Blue Horizon sold 1,000,000 Shares of the Issuer in an open market transaction at a price of $18.50 per share.”

Large holders — 13G, passive (top 5 of 12 by % of class)

Holder

% of class

Type

As of

RTW INVESTMENTS, LP

9.9%

QII

2026-03-31

SEC →

FMR LLC

9.8%

QII

2025-12-31

SEC →

Lynx1 Capital Management LP

8.1%

Passive

Institutional ownership· 13F filers holding STOK · 2026-Q1 methodology → sources →

197 holders

% of shares outstanding held

114.2%

Shares held (13F)

71,107,856

Reporting holders

197

Top holders

largest 100 of 197 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RTW INVESTMENTS, LP	5,623,5255.6M	$183M	9.03%	—
2	BlackRock, Inc.	5,385,7145.4M	$175M	8.65%	ADD 3%
3	FMR LLC	5,383,6665.4M	$175M	8.64%	TRIM -4%
4	Lynx1 Capital Management LP	4,763,6734.8M	$155M	7.65%	TRIM -12%
5	Redmile Group, LLC	4,164,1204.2M	$136M	6.69%	ADD 3%
6	MORGAN STANLEY	3,423,2803.4M	$111M	5.50%	TRIM -3%
7	BAKER BROS. ADVISORS LP	3,336,6973.3M	$109M	5.36%	—
8	TORONTO DOMINION BANK	3,173,2583.2M	$103M	5.10%	—
9	WELLINGTON MANAGEMENT GROUP LLP	3,095,7003.1M	$101M	4.97%	ADD 321%
10	BVF INC/IL	2,547,5572.5M	$83M	4.09%	ADD 12%
11	VANGUARD CAPITAL MANAGEMENT LLC	2,355,6032.4M	$77M	3.78%	NEW†
12	STATE STREET CORP	2,276,5122.3M	$74M	3.66%	TRIM -9%
13	Siren, L.L.C.	1,995,3472.0M	$65M	3.20%	TRIM -11%
14	PRICE T ROWE ASSOCIATES INC /MD/	1,934,1711.9M	$63M	3.11%	ADD 419%
15	DEERFIELD MANAGEMENT COMPANY, L.P.	1,823,5001.8M	$59M	2.93%	—
16	JANUS HENDERSON GROUP PLC	1,612,7811.6M	$52M	2.59%	ADD 11%
17	GEODE CAPITAL MANAGEMENT, LLC	1,322,2601.3M	$43M	2.12%	ADD 13%
18	Polar Capital Holdings Plc	1,132,5111.1M	$37M	1.82%	TRIM -11%
19	DIMENSIONAL FUND ADVISORS LP	989,936989,936	$32M	1.59%	ADD 20%
20	Assenagon Asset Management S.A.	907,015907,015	$30M	1.46%	TRIM -26%
21	GOLDMAN SACHS GROUP INC	830,702830,702	$27M	1.33%	TRIM -27%
22	MPM BIOIMPACT LLC	767,038767,038	$25M	1.23%	—
23	Opaleye Management Inc.	700,000700,000	$23M	1.12%	—
24	Troluce Capital Advisors LLC	652,800652,800	$21M	1.05%	NEW
25	BAILLIE GIFFORD & CO	575,182575,182	$19M	0.92%	ADD 133%
26	BANK OF AMERICA CORP /DE/	543,095543,095	$18M	0.87%	ADD 163%
27	Candriam S.C.A.	502,020502,020	$16M	0.81%	ADD 12%
28	TANG CAPITAL MANAGEMENT LLC	500,000500,000	$16M	0.80%	—
29	MILLENNIUM MANAGEMENT LLC	472,141472,141	$15M	0.76%	NEW
30	VANGUARD PORTFOLIO MANAGEMENT LLC	462,682462,682	$15M	0.74%	NEW
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	437,175437,175	$14M	0.70%	ADD 6%
32	Erste Asset Management GmbH	446,000446,000	$14M	0.72%	ADD 13%
33	NORTHERN TRUST CORP	431,630431,630	$14M	0.69%	ADD 7%
34	VANGUARD FIDUCIARY TRUST CO	356,947356,947	$12M	0.57%	NEW
35	Parkman Healthcare Partners LLC	336,519336,519	$11M	0.54%	TRIM -22%
36	Granahan Investment Management, LLC	335,586335,586	$11M	0.54%	ADD 75%
37	Artisan Partners Limited Partnership	315,492315,492	$10M	0.51%	NEW
38	JPMORGAN CHASE & CO	265,473265,473	$8M	0.43%	TRIM -4%
39	T. Rowe Price Investment Management, Inc.	250,913250,913	$8M	0.40%	NEW
40	Birchview Capital, LP	210,000210,000	$7M	0.34%	TRIM -19%
41	FIRST TRUST ADVISORS LP	163,459163,459	$5M	0.26%	—
42	UBS Group AG	158,304158,304	$5M	0.25%	TRIM -7%
43	Invesco Ltd.	150,045150,045	$5M	0.24%	TRIM -42%
44	Bank of New York Mellon Corp	143,407143,407	$5M	0.23%	—
45	FRANKLIN RESOURCES INC	142,793142,793	$5M	0.23%	ADD 8%
46	DAFNA Capital Management LLC	130,875130,875	$4M	0.21%	ADD 20%
47	CITADEL ADVISORS LLC	123,022123,022	$4M	0.20%	ADD 676%
48	Susquehanna Portfolio Strategies, LLC	119,226119,226	$4M	0.19%	TRIM -6%
49	GILDER GAGNON HOWE & CO LLC	112,627112,627	$4M	0.18%	TRIM -8%
50	Nuveen, LLC	108,617108,617	$4M	0.17%	ADD 4%
51	EcoR1 Capital, LLC	100,000100,000	$3M	0.16%	NEW
52	Palo Alto Investors LP	84,63184,631	$3M	0.14%	ADD 18%
53	HUSSMAN STRATEGIC ADVISORS, INC.	84,00084,000	$3M	0.13%	ADD 33%
54	Rhenman & Partners Asset Management AB	83,00083,000	$3M	0.13%	TRIM -62%
55	Swiss National Bank	79,10079,100	$3M	0.13%	ADD 4%
56	Quantedge Capital Pte Ltd	78,60078,600	$3M	0.13%	TRIM -10%
57	TD Asset Management Inc	74,40074,400	$2M	0.12%	NEW
58	MANUFACTURERS LIFE INSURANCE COMPANY, THE	69,22269,222	$2M	0.11%	ADD 411%
59	RHUMBLINE ADVISERS	67,31567,315	$2M	0.11%	ADD 8%
60	JANE STREET GROUP, LLC	64,34964,349	$2M	0.10%	TRIM -4%
61	PRINCIPAL FINANCIAL GROUP INC	63,93363,933	$2M	0.10%	TRIM -9%
62	Harvest Investment Services, LLC	62,83862,838	$2M	0.10%	ADD 64%
63	HighVista Strategies LLC	62,61762,617	$2M	0.10%	TRIM -46%
64	Rafferty Asset Management, LLC	59,89859,898	$2M	0.10%	TRIM -34%
65	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	58,18558,185	$2M	0.09%	—
66	SUSQUEHANNA INTERNATIONAL GROUP, LLP	57,29157,291	$2M	0.09%	ADD 24%
67	BNP PARIBAS FINANCIAL MARKETS	56,12856,128	$2M	0.09%	ADD 1218%
68	Informed Momentum Co LLC	52,00052,000	$2M	0.08%	TRIM -56%
69	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	51,60651,606	$2M	0.08%	ADD 39%
70	Woodline Partners LP	50,12050,120	$2M	0.08%	—
71	Privium Fund Management B.V.	50,00050,000	$2M	0.08%	TRIM -9%
72	D. E. Shaw & Co., Inc.	49,97249,972	$2M	0.08%	—
73	Schonfeld Strategic Advisors LLC	49,30249,302	$2M	0.08%	TRIM -22%
74	Creative Planning	48,10848,108	$2M	0.08%	ADD 15%
75	STATE OF WISCONSIN INVESTMENT BOARD	47,85947,859	$2M	0.08%	ADD 223%
76	BOOTHBAY FUND MANAGEMENT, LLC	47,30747,307	$2M	0.08%	NEW
77	ALPS ADVISORS INC	46,49846,498	$2M	0.07%	TRIM -30%
78	AQR CAPITAL MANAGEMENT LLC	46,45946,459	$2M	0.07%	ADD 58%
79	OMERS ADMINISTRATION Corp	41,50041,500	$1M	0.07%	NEW
80	PLATINUM INVESTMENT MANAGEMENT LTD	40,81540,815	$1M	0.07%	—
81	ALLIANCEBERNSTEIN L.P.	41,83041,830	$1M	0.07%	ADD 3%
82	DEUTSCHE BANK AG\	40,59640,596	$1M	0.07%	ADD 22%
83	Moran Wealth Management, LLC	40,55240,552	$1M	0.07%	NEW
84	NEW YORK STATE COMMON RETIREMENT FUND	39,15839,158	$1M	0.06%	ADD 160%
85	LPL Financial LLC	36,04736,047	$1M	0.06%	ADD 388%
86	Caption Management, LLC	35,17435,174	$1M	0.06%	NEW
87	SG Americas Securities, LLC	33,99633,996	$1M	0.05%	ADD 32%
88	VICTORY CAPITAL MANAGEMENT INC	33,89033,890	$1M	0.05%	TRIM -18%
89	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	33,87333,873	$1M	0.05%	ADD 4%
90	SCHRODER INVESTMENT MANAGEMENT GROUP	34,10234,102	$1M	0.05%	NEW
91	Legal & General Group Plc	32,04832,048	$1M	0.05%	TRIM -12%
92	Blackstone Inc.	30,57930,579	$995,652	0.05%	NEW
93	LOS ANGELES CAPITAL MANAGEMENT LLC	30,47930,479	$992,396	0.05%	ADD 231%
94	PROFUND ADVISORS LLC	26,98526,985	$878,632	0.04%	TRIM -19%
95	NOMURA HOLDINGS INC	26,89126,891	$875,571	0.04%	TRIM -39%
96	Vanguard Global Advisers, LLC	26,63926,639	$867,366	0.04%	NEW
97	CANADA PENSION PLAN INVESTMENT BOARD	26,20026,200	$853,072	0.04%	TRIM -26%
98	MetLife Investment Management, LLC	26,10626,106	$850,011	0.04%	ADD 3%
99	VANGUARD ASSET MANAGEMENT, Ltd	25,11425,114	$817,712	0.04%	NEW
100	Cresset Asset Management, LLC	24,49424,494	$797,525	0.04%	TRIM -7%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RTW INVESTMENTS, LP

5.1M

5.5M

5.6M

$183M

BlackRock, Inc.

5.9M

6.0M

5.2M

5.4M

$175M

FMR LLC

165K

2.5M

7.4M

6.9M

5.6M

5.4M

$175M

Lynx1 Capital Management LP

5.2M

5.3M

5.4M

4.8M

$155M

Redmile Group, LLC

4.6M

4.5M

4.4M

4.2M

4.0M

4.2M

$136M

MORGAN STANLEY

3.4M

3.6M

3.5M

3.4M

$111M

BAKER BROS. ADVISORS LP

4.6M

3.3M

$109M

TORONTO DOMINION BANK

3.2M

$103M

WELLINGTON MANAGEMENT GROUP LLP

135K

136K

137K

738K

736K

3.1M

$101M

BVF INC/IL

—

1.7M

2.3M

2.5M

$83M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.4M

$77M

STATE STREET CORP

1.6M

1.5M

1.4M

2.5M

2.3M

$74M

Siren, L.L.C.

2.0M

2.2M

2.0M

$65M

PRICE T ROWE ASSOCIATES INC /MD/

37K

39K

44K

51K

372K

1.9M

$63M

DEERFIELD MANAGEMENT COMPANY, L.P.

—

1.8M

$59M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	197	71,107,856	114.2%	$2.3B
2025-Q4	183	66,984,195	107.6%	$2.1B
2025-Q3	151	67,715,815	108.7%	$1.6B
2025-Q2	134	65,692,237	105.5%	$746M
2025-Q1	126	63,384,386	101.8%	$422M
2024-Q4	130	58,272,313	93.6%	$643M
2024-Q3	118	58,616,643	94.1%	$720M
2024-Q2	114	62,576,431	100.5%	$845M

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · STOK

Activists — 13D, active intent

Skorpios Trust4.1%▼ -1.9ppSCHEDULE 13D/A · Amd 6 · event 2025-08-22SEC →

2,256,181 shares · 4 reporting persons

Large holders — 13G, passive (top 5 of 12 by % of class)

Holder

% of class

Type

As of

RTW INVESTMENTS, LP

9.9%

QII

2026-03-31

SEC →

FMR LLC

9.8%

QII

2025-12-31

SEC →

Lynx1 Capital Management LP

8.1%

Passive

STOK US Equity☆

Institutional ownership· 13F filers holding STOK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · STOK

Institutional ownership· 13F filers holding STOK · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · STOK

STOK US Equity