SPRY US Equity

ARS Pharmaceuticals, Inc.

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Health Care · Pharmaceutical Preparations · CIK 1671858 · FYE 1231

$5.83

+0.16 (+2.82%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding SPRY · 2026-Q1 methodology → sources →

201 holders

% of shares outstanding held

94.0%

Shares held (13F)

93,325,304

Reporting holders

201

Top holders

largest 100 of 201 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RA CAPITAL MANAGEMENT, L.P.	10,860,97710.9M	$87M	10.94%	—
2	ORBIMED ADVISORS LLC	8,288,5108.3M	$67M	8.35%	—
3	Rubric Capital Management LP	8,000,0008.0M	$64M	8.06%	ADD 29%
4	DEERFIELD MANAGEMENT COMPANY, L.P.	7,503,8127.5M	$60M	7.56%	—
5	MILLENNIUM MANAGEMENT LLC	5,982,9196.0M	$48M	6.02%	ADD 89%
6	BlackRock, Inc.	5,012,2545.0M	$40M	5.05%	—
7	Aberdeen Group plc	4,113,6174.1M	$33M	4.14%	ADD 16%
8	SR One Capital Management, LP	4,012,9034.0M	$32M	4.04%	—
9	STATE STREET CORP	3,644,9663.6M	$29M	3.67%	ADD 13%
10	FRANKLIN RESOURCES INC	3,278,5493.3M	$26M	3.30%	ADD 29%
11	Tyro Capital Management LLC	2,968,5993.0M	$24M	2.99%	ADD 49%
12	VANGUARD CAPITAL MANAGEMENT LLC	2,542,5042.5M	$20M	2.56%	NEW†
13	UBS Group AG	2,260,3252.3M	$18M	2.28%	ADD 2%
14	Janney Montgomery Scott LLC	2,016,4642.0M	$16M	2.03%	ADD 57%
15	CITADEL ADVISORS LLC	1,773,1881.8M	$14M	1.79%	TRIM -9%
16	GEODE CAPITAL MANAGEMENT, LLC	1,526,8241.5M	$12M	1.54%	—
17	ADAR1 Capital Management, LLC	1,361,5361.4M	$11M	1.37%	ADD 268%
18	BAMCO INC /NY/	1,273,3411.3M	$10M	1.28%	—
19	Third Point LLCtracked	1,000,0001.0M	$8M	1.01%	ADD 80%
20	GENERAL AMERICAN INVESTORS CO INC	727,154727,154	$6M	0.73%	ADD 30%
21	GOLDMAN SACHS GROUP INC	724,219724,219	$6M	0.73%	TRIM -11%
22	Nextech Invest, Ltd.	610,703610,703	$5M	0.61%	TRIM -8%
23	K2 PRINCIPAL FUND, L.P.	559,697559,697	$4M	0.56%	ADD 5387%
24	LEVIN CAPITAL STRATEGIES, L.P.	552,561552,561	$4M	0.56%	TRIM -26%
25	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	533,394533,394	$4M	0.54%	TRIM -3%
26	NORTHERN TRUST CORP	529,284529,284	$4M	0.53%	—
27	RAYMOND JAMES FINANCIAL INC	525,224525,224	$4M	0.53%	TRIM -7%
28	VANGUARD PORTFOLIO MANAGEMENT LLC	510,551510,551	$4M	0.51%	NEW
29	Empire Life Investments Inc.	499,150499,150	$4M	0.50%	ADD 42%
30	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	464,681464,681	$4M	0.47%	ADD 53%
31	FIL Ltd	455,575455,575	$4M	0.46%	TRIM -44%
32	VANGUARD FIDUCIARY TRUST CO	446,307446,307	$4M	0.45%	NEW
33	AMERICAN CENTURY COMPANIES INC	428,599428,599	$3M	0.43%	TRIM -6%
34	FIRST TRUST ADVISORS LP	422,038422,038	$3M	0.42%	NEW
35	JPMORGAN CHASE & CO	382,801382,801	$3M	0.39%	TRIM -8%
36	INVESTMENT MANAGEMENT ASSOCIATES INC /ADV	359,074359,074	$3M	0.36%	ADD 15%
37	FMR LLC	342,042342,042	$3M	0.34%	TRIM -14%
38	MORGAN STANLEY	316,673316,673	$3M	0.32%	TRIM -43%
39	CenterBook Partners LP	291,179291,179	$2M	0.29%	TRIM -49%
40	BANK OF AMERICA CORP /DE/	285,728285,728	$2M	0.29%	TRIM -41%
41	XTX Topco Ltd	276,108276,108	$2M	0.28%	ADD 642%
42	BOOTHBAY FUND MANAGEMENT, LLC	250,597250,597	$2M	0.25%	ADD 24%
43	AMERICAN ASSETS INC	7,0007,000	$2M	0.01%	TRIM -87%
44	Tejara Capital Ltd	210,400210,400	$2M	0.21%	NEW
45	DIMENSIONAL FUND ADVISORS LP	172,339172,339	$1M	0.17%	TRIM -2%
46	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	168,789168,789	$1M	0.17%	NEW
47	Bank of New York Mellon Corp	164,064164,064	$1M	0.17%	—
48	Quinn Opportunity Partners LLC	155,000155,000	$1M	0.16%	—
49	Nuveen, LLC	150,696150,696	$1M	0.15%	—
50	Steward Partners Investment Advisory, LLC	146,453146,453	$1M	0.15%	TRIM -32%
51	DAFNA Capital Management LLC	139,285139,285	$1M	0.14%	TRIM -27%
52	Eversept Partners, LP	136,235136,235	$1M	0.14%	TRIM -46%
53	WEXFORD CAPITAL LP	130,313130,313	$1M	0.13%	TRIM -21%
54	Knights of Columbus Asset Advisors LLC	130,032130,032	$1M	0.13%	—
55	Rafferty Asset Management, LLC	117,635117,635	$944,609	0.12%	—
56	Squarepoint Ops LLC	114,273114,273	$917,612	0.12%	NEW
57	Swiss National Bank	107,200107,200	$860,816	0.11%	—
58	MARSHALL WACE, LLP	105,006105,006	$843,198	0.11%	ADD 33%
59	Quantinno Capital Management LP	101,412101,412	$814,338	0.10%	ADD 91%
60	ExodusPoint Capital Management, LP	96,09396,093	$771,627	0.10%	NEW
61	SIT INVESTMENT ASSOCIATES INC	92,87592,875	$746,000	0.09%	—
62	Cambridge Investment Research Advisors, Inc.	87,16187,161	$700,000	0.09%	—
63	SECTORAL ASSET MANAGEMENT INC	79,15079,150	$676,672	0.08%	ADD 166%
64	BARCLAYS PLC	84,16984,169	$675,878	0.08%	TRIM -57%
65	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	83,22583,225	$668,297	0.08%	—
66	Corient Private Wealth LLC	80,94380,943	$649,973	0.08%	NEW
67	ALPS ADVISORS INC	80,83080,830	$649,065	0.08%	—
68	AssuredPartners Investment Advisors, LLC	76,21076,210	$639,405	0.08%	—
69	RHUMBLINE ADVISERS	72,25772,257	$580,215	0.07%	—
70	STATE OF WISCONSIN INVESTMENT BOARD	71,62771,627	$575,165	0.07%	NEW
71	Matisse Capital	67,22967,229	$539,849	0.07%	ADD 21%
72	AXQ CAPITAL, LP	64,30464,304	$516,361	0.06%	NEW
73	Balyasny Asset Management L.P.	61,75261,752	$495,869	0.06%	NEW
74	ALLIANCEBERNSTEIN L.P.	41,98041,980	$489,067	0.04%	TRIM -30%
75	SUSQUEHANNA INTERNATIONAL GROUP, LLP	60,53760,537	$486,112	0.06%	NEW
76	VOYA INVESTMENT MANAGEMENT LLC	58,37358,373	$468,735	0.06%	ADD 71%
77	Coastal Bridge Advisors, LLC	55,73055,730	$447,512	0.06%	ADD 4%
78	DEUTSCHE BANK AG\	54,49154,491	$437,563	0.05%	ADD 12%
79	ROYCE & ASSOCIATES LP	54,02454,024	$433,813	0.05%	TRIM -74%
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	53,65853,658	$430,874	0.05%	—
81	PROFUND ADVISORS LLC	52,32852,328	$420,194	0.05%	ADD 22%
82	SCHULHOFF & CO INC	51,15051,150	$410,734	0.05%	—
83	Headlands Technologies LLC	48,20648,206	$387,094	0.05%	NEW
84	Legal & General Group Plc	47,88547,885	$384,517	0.05%	TRIM -18%
85	Engineers Gate Manager LP	47,25647,256	$379,466	0.05%	NEW
86	Brevan Howard Capital Management LP	46,55846,558	$373,861	0.05%	NEW
87	DRW Securities, LLC	43,66543,665	$350,629	0.04%	NEW
88	Kestra Advisory Services, LLC	40,92040,920	$328,588	0.04%	ADD 1079%
89	PRICE T ROWE ASSOCIATES INC /MD/	40,77940,779	$328,000	0.04%	ADD 21%
90	VANGUARD ASSET MANAGEMENT, Ltd	40,38840,388	$324,316	0.04%	NEW
91	Norman Fields, Gottscho Capital Management, LLC	39,85039,850	$319,996	0.04%	NEW
92	Belpointe Asset Management LLC	38,44538,445	$308,713	0.04%	ADD 51%
93	Invesco Ltd.	38,18638,186	$306,633	0.04%	ADD 3%
94	Permanent Capital Management, LP	35,11535,115	$290,050	0.04%	TRIM -33%
95	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	35,86735,867	$286,253	0.04%	ADD 5%
96	MetLife Investment Management, LLC	34,33834,338	$275,734	0.03%	—
97	DIKER MANAGEMENT LLC	33,50833,508	$269,069	0.03%	—
98	Schonfeld Strategic Advisors LLC	33,03233,032	$265,245	0.03%	NEW
99	VARCOV Co.	32,39332,393	$260,116	0.03%	ADD 45%
100	Empirical Financial Services, LLC d.b.a. Empirical Wealth Management	31,56831,568	$253,492	0.03%	ADD 46%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RA CAPITAL MANAGEMENT, L.P.

10.9M

$87M

ORBIMED ADVISORS LLC

8.3M

$67M

Rubric Capital Management LP

—

1.0M

1.3M

4.5M

6.2M

8.0M

$64M

DEERFIELD MANAGEMENT COMPANY, L.P.

10.5M

9.7M

7.5M

$60M

MILLENNIUM MANAGEMENT LLC

939K

807K

878K

—

3.2M

6.0M

$48M

BlackRock, Inc.

4.6M

4.3M

4.4M

4.8M

5.1M

5.0M

$40M

Aberdeen Group plc

—

1.0M

1.5M

3.1M

3.6M

4.1M

$33M

SR One Capital Management, LP

4.0M

$32M

STATE STREET CORP

2.7M

2.0M

2.2M

2.9M

3.2M

3.6M

$29M

FRANKLIN RESOURCES INC

2.0M

1.9M

1.8M

2.4M

2.5M

3.3M

$26M

Tyro Capital Management LLC

—

2.0M

3.0M

$24M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.5M

$20M

UBS Group AG

1.0M

591K

867K

660K

2.2M

2.3M

$18M

Janney Montgomery Scott LLC

27K

449K

591K

1.2M

1.3M

2.0M

$16M

CITADEL ADVISORS LLC

805K

801K

2.2M

1.6M

2.0M

1.8M

$14M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	201	93,325,304	94.0%	$751M
2025-Q4	190	88,986,236	89.6%	$1.0B
2025-Q3	188	83,667,811	84.3%	$841M
2025-Q2	188	84,624,097	85.2%	$1.5B
2025-Q1	185	76,338,815	76.9%	$960M
2024-Q4	166	71,304,900	71.8%	$752M
2024-Q3	150	64,086,181	64.5%	$929M
2024-Q2	115	62,623,406	63.1%	$533M
2024-Q1	113	60,138,435	60.6%	$615M
2023-Q4	100	67,165,019	67.6%	$368M

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · SPRY

Activists — 13D, active intent

RA CAPITAL MANAGEMENT, L.P.11.1%NEWSCHEDULE 13D/A · Amd 3 · event 2025-09-29SEC →

10,940,977 shares · 4 reporting persons

“Item 4 is hereby amended and supplemented as follows: On September 29, 2025, the Issuer and certain direct and indirect subsidiaries of the Issuer who may become a party thereto from time to time, as guarantors (the "Guarantors"), and ARS Pharmaceuticals Operations, Inc., a wholly owned subsidiary of the Issuer, as the borrower (the "Borrower" and, collectively with the Guarantors, the "Credit Parties"), entered into a credit agreement (the "Credit Agreement") with RA Capital Agency Services, LL”

Flynn James E7.75%▼ -1.04ppSCHEDULE 13D/A · Amd 5 · event 2025-07-30SEC →

7,610,217 shares · 6 reporting persons

Large holders — 13G, passive (top 3 by % of class)

Holder

% of class

Type

As of

Rubric Capital Management LP

8.06%

QII

2026-03-31

Institutional ownership· 13F filers holding SPRY · 2026-Q1 methodology → sources →

201 holders

% of shares outstanding held

94.0%

Shares held (13F)

93,325,304

Reporting holders

201

Top holders

largest 100 of 201 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	RA CAPITAL MANAGEMENT, L.P.	10,860,97710.9M	$87M	10.94%	—
2	ORBIMED ADVISORS LLC	8,288,5108.3M	$67M	8.35%	—
3	Rubric Capital Management LP	8,000,0008.0M	$64M	8.06%	ADD 29%
4	DEERFIELD MANAGEMENT COMPANY, L.P.	7,503,8127.5M	$60M	7.56%	—
5	MILLENNIUM MANAGEMENT LLC	5,982,9196.0M	$48M	6.02%	ADD 89%
6	BlackRock, Inc.	5,012,2545.0M	$40M	5.05%	—
7	Aberdeen Group plc	4,113,6174.1M	$33M	4.14%	ADD 16%
8	SR One Capital Management, LP	4,012,9034.0M	$32M	4.04%	—
9	STATE STREET CORP	3,644,9663.6M	$29M	3.67%	ADD 13%
10	FRANKLIN RESOURCES INC	3,278,5493.3M	$26M	3.30%	ADD 29%
11	Tyro Capital Management LLC	2,968,5993.0M	$24M	2.99%	ADD 49%
12	VANGUARD CAPITAL MANAGEMENT LLC	2,542,5042.5M	$20M	2.56%	NEW†
13	UBS Group AG	2,260,3252.3M	$18M	2.28%	ADD 2%
14	Janney Montgomery Scott LLC	2,016,4642.0M	$16M	2.03%	ADD 57%
15	CITADEL ADVISORS LLC	1,773,1881.8M	$14M	1.79%	TRIM -9%
16	GEODE CAPITAL MANAGEMENT, LLC	1,526,8241.5M	$12M	1.54%	—
17	ADAR1 Capital Management, LLC	1,361,5361.4M	$11M	1.37%	ADD 268%
18	BAMCO INC /NY/	1,273,3411.3M	$10M	1.28%	—
19	Third Point LLCtracked	1,000,0001.0M	$8M	1.01%	ADD 80%
20	GENERAL AMERICAN INVESTORS CO INC	727,154727,154	$6M	0.73%	ADD 30%
21	GOLDMAN SACHS GROUP INC	724,219724,219	$6M	0.73%	TRIM -11%
22	Nextech Invest, Ltd.	610,703610,703	$5M	0.61%	TRIM -8%
23	K2 PRINCIPAL FUND, L.P.	559,697559,697	$4M	0.56%	ADD 5387%
24	LEVIN CAPITAL STRATEGIES, L.P.	552,561552,561	$4M	0.56%	TRIM -26%
25	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	533,394533,394	$4M	0.54%	TRIM -3%
26	NORTHERN TRUST CORP	529,284529,284	$4M	0.53%	—
27	RAYMOND JAMES FINANCIAL INC	525,224525,224	$4M	0.53%	TRIM -7%
28	VANGUARD PORTFOLIO MANAGEMENT LLC	510,551510,551	$4M	0.51%	NEW
29	Empire Life Investments Inc.	499,150499,150	$4M	0.50%	ADD 42%
30	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	464,681464,681	$4M	0.47%	ADD 53%
31	FIL Ltd	455,575455,575	$4M	0.46%	TRIM -44%
32	VANGUARD FIDUCIARY TRUST CO	446,307446,307	$4M	0.45%	NEW
33	AMERICAN CENTURY COMPANIES INC	428,599428,599	$3M	0.43%	TRIM -6%
34	FIRST TRUST ADVISORS LP	422,038422,038	$3M	0.42%	NEW
35	JPMORGAN CHASE & CO	382,801382,801	$3M	0.39%	TRIM -8%
36	INVESTMENT MANAGEMENT ASSOCIATES INC /ADV	359,074359,074	$3M	0.36%	ADD 15%
37	FMR LLC	342,042342,042	$3M	0.34%	TRIM -14%
38	MORGAN STANLEY	316,673316,673	$3M	0.32%	TRIM -43%
39	CenterBook Partners LP	291,179291,179	$2M	0.29%	TRIM -49%
40	BANK OF AMERICA CORP /DE/	285,728285,728	$2M	0.29%	TRIM -41%
41	XTX Topco Ltd	276,108276,108	$2M	0.28%	ADD 642%
42	BOOTHBAY FUND MANAGEMENT, LLC	250,597250,597	$2M	0.25%	ADD 24%
43	AMERICAN ASSETS INC	7,0007,000	$2M	0.01%	TRIM -87%
44	Tejara Capital Ltd	210,400210,400	$2M	0.21%	NEW
45	DIMENSIONAL FUND ADVISORS LP	172,339172,339	$1M	0.17%	TRIM -2%
46	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	168,789168,789	$1M	0.17%	NEW
47	Bank of New York Mellon Corp	164,064164,064	$1M	0.17%	—
48	Quinn Opportunity Partners LLC	155,000155,000	$1M	0.16%	—
49	Nuveen, LLC	150,696150,696	$1M	0.15%	—
50	Steward Partners Investment Advisory, LLC	146,453146,453	$1M	0.15%	TRIM -32%
51	DAFNA Capital Management LLC	139,285139,285	$1M	0.14%	TRIM -27%
52	Eversept Partners, LP	136,235136,235	$1M	0.14%	TRIM -46%
53	WEXFORD CAPITAL LP	130,313130,313	$1M	0.13%	TRIM -21%
54	Knights of Columbus Asset Advisors LLC	130,032130,032	$1M	0.13%	—
55	Rafferty Asset Management, LLC	117,635117,635	$944,609	0.12%	—
56	Squarepoint Ops LLC	114,273114,273	$917,612	0.12%	NEW
57	Swiss National Bank	107,200107,200	$860,816	0.11%	—
58	MARSHALL WACE, LLP	105,006105,006	$843,198	0.11%	ADD 33%
59	Quantinno Capital Management LP	101,412101,412	$814,338	0.10%	ADD 91%
60	ExodusPoint Capital Management, LP	96,09396,093	$771,627	0.10%	NEW
61	SIT INVESTMENT ASSOCIATES INC	92,87592,875	$746,000	0.09%	—
62	Cambridge Investment Research Advisors, Inc.	87,16187,161	$700,000	0.09%	—
63	SECTORAL ASSET MANAGEMENT INC	79,15079,150	$676,672	0.08%	ADD 166%
64	BARCLAYS PLC	84,16984,169	$675,878	0.08%	TRIM -57%
65	VALLEY FORGE INVESTMENT CONSULTANTS INC ADV	83,22583,225	$668,297	0.08%	—
66	Corient Private Wealth LLC	80,94380,943	$649,973	0.08%	NEW
67	ALPS ADVISORS INC	80,83080,830	$649,065	0.08%	—
68	AssuredPartners Investment Advisors, LLC	76,21076,210	$639,405	0.08%	—
69	RHUMBLINE ADVISERS	72,25772,257	$580,215	0.07%	—
70	STATE OF WISCONSIN INVESTMENT BOARD	71,62771,627	$575,165	0.07%	NEW
71	Matisse Capital	67,22967,229	$539,849	0.07%	ADD 21%
72	AXQ CAPITAL, LP	64,30464,304	$516,361	0.06%	NEW
73	Balyasny Asset Management L.P.	61,75261,752	$495,869	0.06%	NEW
74	ALLIANCEBERNSTEIN L.P.	41,98041,980	$489,067	0.04%	TRIM -30%
75	SUSQUEHANNA INTERNATIONAL GROUP, LLP	60,53760,537	$486,112	0.06%	NEW
76	VOYA INVESTMENT MANAGEMENT LLC	58,37358,373	$468,735	0.06%	ADD 71%
77	Coastal Bridge Advisors, LLC	55,73055,730	$447,512	0.06%	ADD 4%
78	DEUTSCHE BANK AG\	54,49154,491	$437,563	0.05%	ADD 12%
79	ROYCE & ASSOCIATES LP	54,02454,024	$433,813	0.05%	TRIM -74%
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	53,65853,658	$430,874	0.05%	—
81	PROFUND ADVISORS LLC	52,32852,328	$420,194	0.05%	ADD 22%
82	SCHULHOFF & CO INC	51,15051,150	$410,734	0.05%	—
83	Headlands Technologies LLC	48,20648,206	$387,094	0.05%	NEW
84	Legal & General Group Plc	47,88547,885	$384,517	0.05%	TRIM -18%
85	Engineers Gate Manager LP	47,25647,256	$379,466	0.05%	NEW
86	Brevan Howard Capital Management LP	46,55846,558	$373,861	0.05%	NEW
87	DRW Securities, LLC	43,66543,665	$350,629	0.04%	NEW
88	Kestra Advisory Services, LLC	40,92040,920	$328,588	0.04%	ADD 1079%
89	PRICE T ROWE ASSOCIATES INC /MD/	40,77940,779	$328,000	0.04%	ADD 21%
90	VANGUARD ASSET MANAGEMENT, Ltd	40,38840,388	$324,316	0.04%	NEW
91	Norman Fields, Gottscho Capital Management, LLC	39,85039,850	$319,996	0.04%	NEW
92	Belpointe Asset Management LLC	38,44538,445	$308,713	0.04%	ADD 51%
93	Invesco Ltd.	38,18638,186	$306,633	0.04%	ADD 3%
94	Permanent Capital Management, LP	35,11535,115	$290,050	0.04%	TRIM -33%
95	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	35,86735,867	$286,253	0.04%	ADD 5%
96	MetLife Investment Management, LLC	34,33834,338	$275,734	0.03%	—
97	DIKER MANAGEMENT LLC	33,50833,508	$269,069	0.03%	—
98	Schonfeld Strategic Advisors LLC	33,03233,032	$265,245	0.03%	NEW
99	VARCOV Co.	32,39332,393	$260,116	0.03%	ADD 45%
100	Empirical Financial Services, LLC d.b.a. Empirical Wealth Management	31,56831,568	$253,492	0.03%	ADD 46%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

RA CAPITAL MANAGEMENT, L.P.

10.9M

$87M

ORBIMED ADVISORS LLC

8.3M

$67M

Rubric Capital Management LP

—

1.0M

1.3M

4.5M

6.2M

8.0M

$64M

DEERFIELD MANAGEMENT COMPANY, L.P.

10.5M

9.7M

7.5M

$60M

MILLENNIUM MANAGEMENT LLC

939K

807K

878K

—

3.2M

6.0M

$48M

BlackRock, Inc.

4.6M

4.3M

4.4M

4.8M

5.1M

5.0M

$40M

Aberdeen Group plc

—

1.0M

1.5M

3.1M

3.6M

4.1M

$33M

SR One Capital Management, LP

4.0M

$32M

STATE STREET CORP

2.7M

2.0M

2.2M

2.9M

3.2M

3.6M

$29M

FRANKLIN RESOURCES INC

2.0M

1.9M

1.8M

2.4M

2.5M

3.3M

$26M

Tyro Capital Management LLC

—

2.0M

3.0M

$24M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.5M

$20M

UBS Group AG

1.0M

591K

867K

660K

2.2M

2.3M

$18M

Janney Montgomery Scott LLC

27K

449K

591K

1.2M

1.3M

2.0M

$16M

CITADEL ADVISORS LLC

805K

801K

2.2M

1.6M

2.0M

1.8M

$14M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	201	93,325,304	94.0%	$751M
2025-Q4	190	88,986,236	89.6%	$1.0B
2025-Q3	188	83,667,811	84.3%	$841M
2025-Q2	188	84,624,097	85.2%	$1.5B
2025-Q1	185	76,338,815	76.9%	$960M
2024-Q4	166	71,304,900	71.8%	$752M
2024-Q3	150	64,086,181	64.5%	$929M
2024-Q2	115	62,623,406	63.1%	$533M
2024-Q1	113	60,138,435	60.6%	$615M
2023-Q4	100	67,165,019	67.6%	$368M

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · SPRY

Activists — 13D, active intent

RA CAPITAL MANAGEMENT, L.P.11.1%NEWSCHEDULE 13D/A · Amd 3 · event 2025-09-29SEC →

10,940,977 shares · 4 reporting persons

Flynn James E7.75%▼ -1.04ppSCHEDULE 13D/A · Amd 5 · event 2025-07-30SEC →

7,610,217 shares · 6 reporting persons

Large holders — 13G, passive (top 3 by % of class)

Holder

% of class

Type

As of

Rubric Capital Management LP

8.06%

QII

2026-03-31

SPRY US Equity☆

Institutional ownership· 13F filers holding SPRY · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · SPRY

Institutional ownership· 13F filers holding SPRY · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · SPRY

SPRY US Equity