Institutional 13F holdings sum to 101.9% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 2,067,671 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 6,995,8587.0M | $168M | 15.52% | — |
| 2 | TRV GP V, LLC | 6,215,5916.2M | $149M | 13.79% | — |
| 3 | Driehaus Capital Management LLC | 4,395,5724.4M | $106M | 9.75% | TRIM -9% |
| 4 | TRV GP VI, LLC | 4,211,6594.2M | $101M | 9.34% | — |
| 5 | SAMSARA BIOCAPITAL, LLC | 3,149,1283.1M | $76M | 6.99% | — |
| 6 | GOLDMAN SACHS GROUP INC | 2,906,4272.9M | $70M | 6.45% | ADD 7% |
| 7 | Siren, L.L.C. | 2,000,0002.0M | $48M | 4.44% | — |
| 8 | BlackRock, Inc. | 1,822,1741.8M | $44M | 4.04% | — |
| 9 | BVF INC/IL | 1,353,2491.4M | $33M | 3.00% | TRIM -21% |
| 10 | Avoro Capital Advisors LLC | 1,337,5001.3M | $32M | 2.97% | — |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1,196,9621.2M | $29M | 2.66% | NEW† |
| 12 | ADAR1 Capital Management, LLC | 1,089,8181.1M | $26M | 2.42% | TRIM -6% |
| 13 | PRIMECAP MANAGEMENT CO/CA/ | 1,048,8341.0M | $25M | 2.33% | ADD 92% |
| 14 | JANUS HENDERSON GROUP PLC | 890,754890,754 | $21M | 1.98% | NEW |
| 15 | First Light Asset Management, LLC | 732,860732,860 | $18M | 1.63% | ADD 18% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 645,146645,146 | $16M | 1.43% | ADD 13% |
| 17 | STATE STREET CORP | 631,447631,447 | $15M | 1.40% | ADD 17% |
| 18 | Casdin Capital, LLC | 553,268553,268 | $13M | 1.23% | — |
| 19 | Venrock Adviser, LLC | 506,056506,056 | $12M | 1.12% | TRIM -17% |
| 20 | Kalehua Capital Management LLC | 389,088389,088 | $9M | 0.86% | ADD 100% |
| 21 | Catalio Capital Management, LP | 294,360294,360 | $7M | 0.65% | — |
| 22 | Soleus Capital Management, L.P. | 275,000275,000 | $7M | 0.61% | TRIM -28% |
| 23 | Balyasny Asset Management L.P. | 236,679236,679 | $6M | 0.53% | ADD 6528% |
| 24 | Universal- Beteiligungs- und Servicegesellschaft mbH | 223,995223,995 | $5M | 0.50% | — |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 195,043195,043 | $5M | 0.43% | NEW |
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,580181,580 | $4M | 0.40% | TRIM -3% |
| 27 | NORTHERN TRUST CORP | 164,530164,530 | $4M | 0.37% | ADD 7% |
| 28 | VANGUARD FIDUCIARY TRUST CO | 154,484154,484 | $4M | 0.34% | NEW |
| 29 | MILLENNIUM MANAGEMENT LLC | 124,101124,101 | $3M | 0.28% | ADD 15% |
| 30 | UBS Group AG | 116,979116,979 | $3M | 0.26% | ADD 70% |
| 31 | MORGAN STANLEY | 110,530110,530 | $3M | 0.25% | ADD 6% |
| 32 | HUSSMAN STRATEGIC ADVISORS, INC. | 105,000105,000 | $3M | 0.23% | NEW |
| 33 | Checkpoint Capital L.P. | 100,300100,300 | $2M | 0.22% | NEW |
| 34 | FEDERATED HERMES, INC. | 89,30189,301 | $2M | 0.20% | ADD 13% |
| 35 | Invesco Ltd. | 82,86882,868 | $2M | 0.18% | TRIM -49% |
| 36 | JPMORGAN CHASE & CO | 84,67484,674 | $2M | 0.19% | ADD 24% |
| 37 | TWO SIGMA INVESTMENTS, LP | 75,36775,367 | $2M | 0.17% | TRIM -19% |
| 38 | Longaeva Partners L.P. | 74,56774,567 | $2M | 0.17% | ADD 49% |
| 39 | AMERICAN CENTURY COMPANIES INC | 61,29061,290 | $1M | 0.14% | ADD 21% |
| 40 | Bank of New York Mellon Corp | 58,70958,709 | $1M | 0.13% | ADD 6% |
| 41 | Jump Financial, LLC | 53,01153,011 | $1M | 0.12% | ADD 531% |
| 42 | Sofinnova Investments, Inc. | 47,50647,506 | $1M | 0.11% | NEW |
| 43 | MARSHALL WACE, LLP | 39,84039,840 | $957,354 | 0.09% | TRIM -82% |
| 44 | Rangeley Capital, LLC | 39,80039,800 | $956,394 | 0.09% | TRIM -40% |
| 45 | RENAISSANCE TECHNOLOGIES LLC | 37,70037,700 | $905,931 | 0.08% | NEW |
| 46 | XTX Topco Ltd | 36,72336,723 | $882,454 | 0.08% | ADD 58% |
| 47 | Trexquant Investment LP | 35,30135,301 | $848,283 | 0.08% | TRIM -20% |
| 48 | Alyeska Investment Group, L.P. | 35,00035,000 | $841,050 | 0.08% | — |
| 49 | ACADIAN ASSET MANAGEMENT LLC | 30,97830,978 | $741,000 | 0.07% | — |
| 50 | Nuveen, LLC | 29,17629,176 | $701,099 | 0.06% | ADD 13% |
| 51 | JACOBS LEVY EQUITY MANAGEMENT, INC | 28,43628,436 | $683,317 | 0.06% | TRIM -54% |
| 52 | PRICE T ROWE ASSOCIATES INC /MD/ | 28,07628,076 | $675,000 | 0.06% | ADD 10% |
| 53 | RHUMBLINE ADVISERS | 26,60426,604 | $639,285 | 0.06% | — |
| 54 | BANK OF AMERICA CORP /DE/ | 25,97325,973 | $624,131 | 0.06% | TRIM -31% |
| 55 | Y-Intercept (Hong Kong) Ltd | 25,77025,770 | $619,253 | 0.06% | NEW |
| 56 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 24,00024,000 | $576,720 | 0.05% | NEW |
| 57 | Logos Global Management LP | 23,54823,548 | $565,858 | 0.05% | — |
| 58 | FMR LLC | 23,44623,446 | $563,407 | 0.05% | ADD 609% |
| 59 | ALLIANCEBERNSTEIN L.P. | 19,60019,600 | $546,448 | 0.04% | — |
| 60 | BARCLAYS PLC | 22,71422,714 | $545,818 | 0.05% | TRIM -40% |
| 61 | Swiss National Bank | 22,10022,100 | $531,063 | 0.05% | NEW |
| 62 | ALGERT GLOBAL LLC | 21,03521,035 | $505,000 | 0.05% | TRIM -40% |
| 63 | Squarepoint Ops LLC | 18,08318,083 | $434,534 | 0.04% | ADD 22% |
| 64 | STRS OHIO | 17,20017,200 | $413,316 | 0.04% | ADD 18% |
| 65 | DEUTSCHE BANK AG\ | 16,84316,843 | $404,737 | 0.04% | ADD 13% |
| 66 | VARCOV Co. | 16,75216,752 | $402,551 | 0.04% | TRIM -26% |
| 67 | Engineers Gate Manager LP | 16,52816,528 | $397,168 | 0.04% | NEW |
| 68 | Vanguard Global Advisers, LLC | 16,24716,247 | $390,415 | 0.04% | NEW |
| 69 | AQR CAPITAL MANAGEMENT LLC | 15,37515,375 | $369,461 | 0.03% | ADD 96% |
| 70 | Numerai GP LLC | 15,08215,082 | $362,420 | 0.03% | TRIM -67% |
| 71 | LOS ANGELES CAPITAL MANAGEMENT LLC | 14,21414,214 | $341,562 | 0.03% | TRIM -23% |
| 72 | MetLife Investment Management, LLC | 13,68513,685 | $328,851 | 0.03% | — |
| 73 | EntryPoint Capital, LLC | 12,77612,776 | $307,007 | 0.03% | NEW |
| 74 | OSAIC HOLDINGS, INC. | 12,69812,698 | $305,132 | 0.03% | — |
| 75 | Verition Fund Management LLC | 12,34312,343 | $296,602 | 0.03% | NEW |
| 76 | China Universal Asset Management Co., Ltd. | 11,94611,946 | $287,062 | 0.03% | ADD 16% |
| 77 | Man Group plc | 11,85811,858 | $284,948 | 0.03% | NEW |
| 78 | Russell Investments Group, Ltd. | 11,51511,515 | $276,708 | 0.03% | TRIM -25% |
| 79 | Seven Fleet Capital Management LP | 11,44511,445 | $275,023 | 0.03% | — |
| 80 | Virtus Investment Advisers, LLC | 10,71910,719 | $257,578 | 0.02% | ADD 3% |
| 81 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 10,38210,382 | $249,480 | 0.02% | NEW |
| 82 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,02110,021 | $240,805 | 0.02% | — |
| 83 | WELLS FARGO & COMPANY/MN | 9,8699,869 | $237,152 | 0.02% | TRIM -63% |
| 84 | CITIGROUP INC | 9,1959,195 | $220,956 | 0.02% | TRIM -4% |
| 85 | WINTON GROUP Ltd | 8,8428,842 | $212,473 | 0.02% | NEW |
| 86 | VANGUARD ASSET MANAGEMENT, Ltd | 7,4207,420 | $178,303 | 0.02% | NEW |
| 87 | Legal & General Group Plc | 5,7355,735 | $137,811 | 0.01% | ADD 195% |
| 88 | NEW YORK STATE COMMON RETIREMENT FUND | 5,6005,600 | $134,568 | 0.01% | — |
| 89 | BNP PARIBAS FINANCIAL MARKETS | 5,3615,361 | $128,825 | 0.01% | — |
| 90 | Police & Firemen's Retirement System of New Jersey | 5,1755,175 | $124,355 | 0.01% | — |
| 91 | Vanguard Investments Australia, Ltd. | 3,8953,895 | $93,597 | 0.01% | NEW |
| 92 | PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 3,3743,374 | $81,077 | 0.01% | TRIM -68% |
| 93 | KLP KAPITALFORVALTNING AS | 2,5002,500 | $60,075 | 0.01% | NEW |
| 94 | Mirae Asset Global Investments Co., Ltd. | 2,3352,335 | $56,110 | 0.01% | ADD 7% |
| 95 | Covestor Ltd | 2,2602,260 | $54,000 | 0.01% | ADD 16% |
| 96 | Ameritas Investment Partners, Inc. | 1,9441,944 | $46,714 | 0.00% | — |
| 97 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,1571,157 | $27,803 | 0.00% | TRIM -12% |
| 98 | GAMMA Investing LLC | 1,1101,110 | $26,673 | 0.00% | ADD 21% |
| 99 | GF FUND MANAGEMENT CO. LTD. | 1,0061,006 | $24,174 | 0.00% | ADD 15% |
| 100 | SIGNATUREFD, LLC | 966966 | $23,213 | 0.00% | TRIM -2% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 7.0M | 7.0M | 7.0M | 7.0M | 7.0M | 7.0M | $168M |
| TRV GP V, LLC | 6.2M | 6.2M | 6.2M | 6.2M | 6.2M | 6.2M | $149M |
| Driehaus Capital Management LLC | 2.6M | 3.1M | 4.7M | 4.9M | 4.8M | 4.4M | $106M |
| TRV GP VI, LLC | 3.2M | 4.2M | 4.2M | 4.2M | 4.2M | 4.2M | $101M |
| SAMSARA BIOCAPITAL, LLC | 2.8M | 3.1M | 3.1M | 3.1M | 3.1M | 3.1M | $76M |
| GOLDMAN SACHS GROUP INC | 1.7M | 1.4M | 1.4M | 1.5M | 2.7M | 2.9M | $70M |
| Siren, L.L.C. | 2.2M | 2.2M | 2.2M | 2.2M | 2.0M | 2.0M | $48M |
| BlackRock, Inc. | 1.7M | 1.3M | 1.4M | 1.5M | 1.8M | 1.8M | $44M |
| BVF INC/IL | 2.5M | 4.4M | 4.4M | 4.0M | 1.7M | 1.4M | $33M |
| Avoro Capital Advisors LLC | 1.1M | 1.3M | 1.2M | 1.3M | 1.3M | 1.3M | $32M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $29M |
| ADAR1 Capital Management, LLC | — | 721K | 847K | 1.2M | 1.2M | 1.1M | $26M |
| PRIMECAP MANAGEMENT CO/CA/ | — | — | — | — | 546K | 1.0M | $25M |
| JANUS HENDERSON GROUP PLC | 1.1M | — | — | — | — | 891K | $21M |
| First Light Asset Management, LLC | — | — | — | — | 621K | 733K | $18M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 124 | 45,916,212 | 101.9% | $1.1B |
| 2025-Q4 | 122 | 45,588,030 | 101.1% | $1.3B |
| 2025-Q3 | 82 | 44,557,769 | 98.9% | $838M |
| 2025-Q2 | 89 | 44,432,314 | 98.6% | $470M |
| 2025-Q1 | 71 | 45,290,478 | 100.5% | $262M |
| 2024-Q4 | 71 | 44,129,388 | 97.9% | $1.0B |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
