| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Vivo Capital, LLC | 11,420,00011.4M | $44M | 14.94% | — |
| 2 | Caligan Partners LP | 7,967,2078.0M | $31M | 10.42% | NEW† |
| 3 | PERCEPTIVE ADVISORS LLC | 6,431,7436.4M | $25M | 8.41% | ADD 701% |
| 4 | RA CAPITAL MANAGEMENT, L.P. | 4,401,5004.4M | $17M | 5.76% | — |
| 5 | Commodore Capital LP | 4,401,5004.4M | $17M | 5.76% | — |
| 6 | Balyasny Asset Management L.P. | 3,760,4393.8M | $14M | 4.92% | ADD 691% |
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,405,5533.4M | $13M | 4.45% | NEW† |
| 8 | MILLENNIUM MANAGEMENT LLC | 3,032,6973.0M | $12M | 3.97% | ADD 836% |
| 9 | Woodline Partners LP | 2,851,7912.9M | $11M | 3.73% | — |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 2,493,7372.5M | $10M | 3.26% | NEW† |
| 11 | Spruce Street Capital LP | 2,198,5022.2M | $8M | 2.88% | — |
| 12 | Sessa Capital IM, L.P. | 2,198,4572.2M | $8M | 2.88% | — |
| 13 | BOOTHBAY FUND MANAGEMENT, LLC | 1,481,6601.5M | $6M | 1.94% | NEW |
| 14 | AMERIPRISE FINANCIAL INC | 1,476,1061.5M | $6M | 1.93% | ADD 420% |
| 15 | Ensign Peak Advisors, Inc | 1,375,6101.4M | $5M | 1.80% | NEW |
| 16 | Soleus Capital Management, L.P. | 1,050,0001.1M | $4M | 1.37% | NEW |
| 17 | Propel Bio Management, LLC | 1,012,7901.0M | $4M | 1.32% | ADD 55% |
| 18 | Jefferies Financial Group Inc. | 903,094903,094 | $3M | 1.18% | ADD 56% |
| 19 | Blackstone Inc. | 860,170860,170 | $3M | 1.12% | TRIM -60% |
| 20 | ExodusPoint Capital Management, LP | 768,627768,627 | $3M | 1.01% | ADD 793% |
| 21 | STEMPOINT CAPITAL LP | 750,000750,000 | $3M | 0.98% | ADD 412% |
| 22 | Affinity Asset Advisors, LLC | 575,000575,000 | $2M | 0.75% | NEW |
| 23 | Monashee Investment Management LLC | 500,000500,000 | $2M | 0.65% | NEW |
| 24 | MARSHALL WACE, LLP | 463,925463,925 | $2M | 0.61% | ADD 96% |
| 25 | AWM Investment Company, Inc. | 400,000400,000 | $2M | 0.52% | ADD 100% |
| 26 | DV Trading LLC | 400,000400,000 | $2M | 0.52% | NEW |
| 27 | HB Wealth Management, LLC | 307,500307,500 | $1M | 0.40% | — |
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 302,036302,036 | $1M | 0.40% | ADD 153% |
| 29 | BlackRock, Inc. | 301,326301,326 | $1M | 0.39% | ADD 1648% |
| 30 | SEVEN GRAND MANAGERS, LLC | 275,000275,000 | $1M | 0.36% | NEW |
| 31 | VANGUARD FIDUCIARY TRUST CO | 197,619197,619 | $756,881 | 0.26% | NEW |
| 32 | Simplify Asset Management Inc. | 187,230187,230 | $717,091 | 0.24% | TRIM -10% |
| 33 | TWO SIGMA INVESTMENTS, LP | 181,185181,185 | $693,939 | 0.24% | NEW |
| 34 | GOLDMAN SACHS GROUP INC | 113,940113,940 | $436,390 | 0.15% | ADD 122% |
| 35 | Seven Fleet Capital Management LP | 100,000100,000 | $383,000 | 0.13% | NEW |
| 36 | STATE STREET CORP | 74,23174,231 | $284,305 | 0.10% | ADD 466% |
| 37 | Persistent Asset Partners Ltd | 69,73269,732 | $267,074 | 0.09% | ADD 252% |
| 38 | Kestra Advisory Services, LLC | 61,74161,741 | $236,468 | 0.08% | ADD 435% |
| 39 | Brevan Howard Capital Management LP | 59,16159,161 | $226,587 | 0.08% | NEW |
| 40 | NORTHERN TRUST CORP | 57,42657,426 | $219,942 | 0.08% | ADD 250% |
| 41 | BANK OF AMERICA CORP /DE/ | 55,69755,697 | $213,320 | 0.07% | ADD 425% |
| 42 | Pathstone Holdings, LLC | 50,65050,650 | $193,991 | 0.07% | — |
| 43 | Stonepine Capital Management, LLC | 50,00050,000 | $191,500 | 0.07% | NEW |
| 44 | UBS Group AG | 46,62346,623 | $178,567 | 0.06% | ADD 530% |
| 45 | FIFTH LANE CAPITAL, LP | 46,50046,500 | $178,095 | 0.06% | ADD 210% |
| 46 | COMMONWEALTH EQUITY SERVICES, LLC | 46,45546,455 | $177,920 | 0.06% | NEW |
| 47 | Virtu Financial LLC | 37,94337,943 | $145,000 | 0.05% | NEW |
| 48 | AMERICAN CENTURY COMPANIES INC | 37,45537,455 | $143,453 | 0.05% | NEW |
| 49 | CITIGROUP INC | 36,80536,805 | $140,963 | 0.05% | ADD 23% |
| 50 | Quadrature Capital Ltd | 35,26435,264 | $135,061 | 0.05% | NEW |
| 51 | PRELUDE CAPITAL MANAGEMENT, LLC | 34,12434,124 | $130,695 | 0.04% | NEW |
| 52 | OMERS ADMINISTRATION Corp | 29,70029,700 | $113,751 | 0.04% | TRIM -29% |
| 53 | Qube Research & Technologies Ltd | 24,09824,098 | $92,295 | 0.03% | TRIM -23% |
| 54 | First PREMIER Bank | 18,98618,986 | $73,000 | 0.02% | — |
| 55 | Diametric Capital, LP | 16,29216,292 | $62,398 | 0.02% | NEW |
| 56 | Hudson Bay Capital Management LP | 16,10016,100 | $61,663 | 0.02% | NEW |
| 57 | Catalyst Funds Management Pty Ltd | 15,10015,100 | $57,833 | 0.02% | NEW |
| 58 | Focus Partners Wealth | 14,03614,036 | $53,758 | 0.02% | TRIM -27% |
| 59 | Miller Capital Partners, Inc. | 12,87012,870 | $49,293 | 0.02% | NEW |
| 60 | MORGAN STANLEY | 11,91111,911 | $45,619 | 0.02% | ADD 179% |
| 61 | Vanguard Global Advisers, LLC | 11,85211,852 | $45,393 | 0.02% | NEW |
| 62 | Scientech Research LLC | 10,81610,816 | $41,425 | 0.01% | NEW |
| 63 | State of Wyoming | 7,8997,899 | $30,253 | 0.01% | TRIM -12% |
| 64 | OSAIC HOLDINGS, INC. | 7,7757,775 | $29,777 | 0.01% | ADD 55% |
| 65 | PNC FINANCIAL SERVICES GROUP, INC. | 7,7007,700 | $29,491 | 0.01% | NEW |
| 66 | Plante Moran Financial Advisors, LLC | 5,9255,925 | $22,693 | 0.01% | NEW |
| 67 | SIMPLEX TRADING, LLC | 4,7134,713 | $18,050 | 0.01% | NEW |
| 68 | Tower Research Capital LLC (TRC) | 3,2693,269 | $12,520 | 0.00% | NEW |
| 69 | BNP PARIBAS FINANCIAL MARKETS | 889889 | $3,405 | 0.00% | NEW |
| 70 | BARCLAYS PLC | 496496 | $1,900 | 0.00% | NEW |
| 71 | MAI Capital Management | 217217 | $832 | 0.00% | — |
| 72 | GS Investments, Inc. | 200200 | $766 | 0.00% | — |
| 73 | Caitong International Asset Management Co., Ltd | 161161 | $617 | 0.00% | NEW |
| 74 | JPMORGAN CHASE & CO | 8787 | $329 | 0.00% | TRIM -96% |
| 75 | HARBOUR INVESTMENTS, INC. | 5050 | $192 | 0.00% | — |
| 76 | ROYAL BANK OF CANADA | 11 | $0 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | — | — | — | 11.4M | 11.4M | 11.4M | $44M |
| Caligan Partners LP | — | — | — | — | — | 8.0M | $31M |
| PERCEPTIVE ADVISORS LLC | — | — | — | — | 803K | 6.4M | $25M |
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | 4.4M | 4.4M | 4.4M | $17M |
| Commodore Capital LP | — | — | — | 4.4M | 4.4M | 4.4M | $17M |
| Balyasny Asset Management L.P. | — | — | — | — | 475K | 3.8M | $14M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | — | — | 3.4M | $13M |
| MILLENNIUM MANAGEMENT LLC | 29K | 16K | — | — | 324K | 3.0M | $12M |
| Woodline Partners LP | — | — | — | 2.9M | 2.9M | 2.9M | $11M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.5M | $10M |
| Spruce Street Capital LP | — | — | — | — | 2.2M | 2.2M | $8M |
| Sessa Capital IM, L.P. | 458K | 458K | 458K | 2.2M | 2.2M | 2.2M | $8M |
| BOOTHBAY FUND MANAGEMENT, LLC | — | — | — | — | — | 1.5M | $6M |
| AMERIPRISE FINANCIAL INC | — | — | — | — | 284K | 1.5M | $6M |
| Ensign Peak Advisors, Inc | — | — | — | — | — | 1.4M | $5M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 76 | 69,566,894 | 91.0% | $266M |
| 2025-Q4 | 48 | 36,342,111 | 47.5% | $136M |
| 2025-Q3 | 34 | 28,024,025 | 36.6% | $56M |
| 2025-Q2 | 25 | 1,923,874 | 2.5% | $3M |
| 2025-Q1 | 26 | 2,209,552 | 2.9% | $3M |
| 2024-Q4 | 25 | 2,633,099 | 3.4% | $10M |
| 2024-Q3 | 25 | 3,141,852 | 4.1% | $8M |
| 2024-Q2 | 22 | 3,127,263 | 4.1% | $10M |
| 2024-Q1 | 24 | 3,342,174 | 4.4% | $15M |
| 2023-Q4 | 3 | 8,791,109 | 11.5% | $6M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
