$209.46
-2.28 (-1.07%)
USD · as of 2026-08-21 · marketstack
Institutional 13F holdings sum to 100.2% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 11,075,199 shares (settlement 2026-05-15) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FARALLON CAPITAL MANAGEMENT LLC | 13,604,79613.6M | $1.3B | 6.87% | TRIM -7% |
| 2 | BlackRock, Inc. | 11,212,70611.2M | $1.1B | 5.66% | ADD 26% |
| 3 | JANUS HENDERSON GROUP PLC | 9,766,4969.8M | $950M | 4.93% | TRIM -21% |
| 4 | BAKER BROS. ADVISORS LP | 9,555,3579.6M | $929M | 4.82% | — |
| 5 | FMR LLC | 8,464,3148.5M | $823M | 4.27% | — |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 8,362,2848.4M | $813M | 4.22% | NEW† |
| 7 | Nextech Invest, Ltd. | 7,601,0877.6M | $739M | 3.84% | — |
| 8 | VANGUARD PORTFOLIO MANAGEMENT LLC | 7,502,6237.5M | $730M | 3.79% | NEW† |
| 9 | Paradigm Biocapital Advisors LP | 6,655,7036.7M | $647M | 3.36% | — |
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 6,027,8196.0M | $586M | 3.04% | TRIM -14% |
| 11 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,475,6115.5M | $533M | 2.76% | ADD 148% |
| 12 | STATE STREET CORP | 4,402,6624.4M | $428M | 2.22% | ADD 7% |
| 13 | UBS Group AG | 4,386,7914.4M | $427M | 2.21% | ADD 42% |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 3,338,1423.3M | $324M | 1.68% | ADD 6% |
| 15 | Alphabet Inc. | 3,292,5253.3M | $320M | 1.66% | — |
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,232,2133.2M | $314M | 1.63% | TRIM -5% |
| 17 | BVF INC/IL | 2,856,7822.9M | $278M | 1.44% | TRIM -15% |
| 18 | Casdin Capital, LLC | 2,577,3332.6M | $251M | 1.30% | — |
| 19 | Woodline Partners LP | 2,506,5702.5M | $244M | 1.26% | — |
| 20 | Holocene Advisors, LP | 2,468,6442.5M | $240M | 1.25% | ADD 29% |
| 21 | Vestal Point Capital, LP | 2,375,0002.4M | $231M | 1.20% | ADD 705% |
| 22 | Avoro Capital Advisors LLC | 2,344,4442.3M | $228M | 1.18% | ADD 8% |
| 23 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,0002.3M | $223M | 1.16% | TRIM -21% |
| 24 | GOLDMAN SACHS GROUP INC | 2,185,5002.2M | $213M | 1.10% | TRIM -12% |
| 25 | Darwin Global Management, Ltd. | 2,211,0182.2M | $205M | 1.12% | NEW |
| 26 | Logos Global Management LP | 2,000,0002.0M | $195M | 1.01% | — |
| 27 | Alyeska Investment Group, L.P. | 1,885,8211.9M | $183M | 0.95% | ADD 689% |
| 28 | NATIONAL BANK OF CANADA /FI/ | 1,749,0001.7M | $170M | 0.88% | NEW |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,735,4761.7M | $169M | 0.88% | ADD 3% |
| 30 | Caligan Partners LP | 1,652,8081.7M | $161M | 0.83% | ADD 29% |
| 31 | AMERIPRISE FINANCIAL INC | 1,579,7931.6M | $154M | 0.80% | TRIM -23% |
| 32 | TWO SIGMA INVESTMENTS, LP | 1,558,8071.6M | $152M | 0.79% | ADD 270% |
| 33 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,556,5781.6M | $151M | 0.79% | TRIM -45% |
| 34 | Bellevue Group AG | 1,544,4561.5M | $150M | 0.78% | TRIM -69% |
| 35 | Integral Health Asset Management, LLC | 1,500,0001.5M | $146M | 0.76% | ADD 25% |
| 36 | Rock Springs Capital Management LP | 1,209,4651.2M | $118M | 0.61% | TRIM -9% |
| 37 | Polar Capital Holdings Plc | 1,133,9301.1M | $110M | 0.57% | TRIM -44% |
| 38 | FRANKLIN RESOURCES INC | 1,133,5461.1M | $110M | 0.57% | ADD 7% |
| 39 | VANGUARD FIDUCIARY TRUST CO | 1,133,3191.1M | $110M | 0.57% | NEW |
| 40 | Siren, L.L.C. | 1,110,9801.1M | $108M | 0.56% | TRIM -17% |
| 41 | D. E. Shaw & Co., Inc. | 1,022,2981.0M | $99M | 0.52% | TRIM -37% |
| 42 | NORTHERN TRUST CORP | 954,256954,256 | $93M | 0.48% | ADD 12% |
| 43 | a16z Capital Management, L.L.C. | 921,099921,099 | $90M | 0.46% | — |
| 44 | DIMENSIONAL FUND ADVISORS LP | 844,614844,614 | $82M | 0.43% | TRIM -27% |
| 45 | AIHC Capital Management Ltd | 828,974828,974 | $81M | 0.42% | TRIM -8% |
| 46 | MIC Capital Management UK LLP | 795,733795,733 | $77M | 0.40% | ADD 56% |
| 47 | GENERAL ATLANTIC, L.P. | 707,791707,791 | $69M | 0.36% | TRIM -75% |
| 48 | MORGAN STANLEY | 705,793705,793 | $69M | 0.36% | ADD 8% |
| 49 | Nearwater Capital Markets, Ltd | 678,000678,000 | $66M | 0.34% | NEW |
| 50 | Frazier Life Sciences Management, L.P. | 675,686675,686 | $66M | 0.34% | TRIM -15% |
| 51 | T. Rowe Price Investment Management, Inc. | 664,047664,047 | $65M | 0.34% | TRIM -81% |
| 52 | Bank of New York Mellon Corp | 635,366635,366 | $62M | 0.32% | ADD 17% |
| 53 | WORLDQUANT MILLENNIUM ADVISORS LLC | 622,304622,304 | $61M | 0.31% | ADD 562% |
| 54 | BANK OF AMERICA CORP /DE/ | 614,157614,157 | $60M | 0.31% | TRIM -30% |
| 55 | DAFNA Capital Management LLC | 580,678580,678 | $56M | 0.29% | TRIM -4% |
| 56 | Candriam S.C.A. | 580,677580,677 | $56M | 0.29% | TRIM -44% |
| 57 | TCG Crossover Management, LLC | 576,473576,473 | $56M | 0.29% | ADD 32% |
| 58 | STEMPOINT CAPITAL LP | 563,264563,264 | $55M | 0.28% | ADD 808% |
| 59 | Qube Research & Technologies Ltd | 553,290553,290 | $54M | 0.28% | NEW |
| 60 | Pictet Asset Management Holding SA | 557,560557,560 | $54M | 0.28% | TRIM -51% |
| 61 | Lunate Capital Ltd | 549,050549,050 | $53M | 0.28% | TRIM -75% |
| 62 | MPM BIOIMPACT LLC | 506,776506,776 | $49M | 0.26% | — |
| 63 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 500,595500,595 | $49M | 0.25% | ADD 43% |
| 64 | Boxer Capital Management, LLC | 500,000500,000 | $49M | 0.25% | ADD 25% |
| 65 | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 479,080479,080 | $47M | 0.24% | NEW |
| 66 | First Turn Management, LLC | 468,376468,376 | $46M | 0.24% | TRIM -27% |
| 67 | DEUTSCHE BANK AG\ | 465,758465,758 | $45M | 0.24% | ADD 1346% |
| 68 | BOOTHBAY FUND MANAGEMENT, LLC | 438,595438,595 | $43M | 0.22% | ADD 34% |
| 69 | Swiss National Bank | 425,431425,431 | $41M | 0.21% | ADD 54% |
| 70 | BNP PARIBAS FINANCIAL MARKETS | 422,443422,443 | $41M | 0.21% | TRIM -32% |
| 71 | CITADEL ADVISORS LLC | 400,053400,053 | $39M | 0.20% | TRIM -69% |
| 72 | Invesco Ltd. | 392,844392,844 | $38M | 0.20% | ADD 7% |
| 73 | BARCLAYS PLC | 383,179383,179 | $37M | 0.19% | ADD 182% |
| 74 | MILLENNIUM MANAGEMENT LLC | 377,332377,332 | $37M | 0.19% | TRIM -53% |
| 75 | SAMLYN CAPITAL, LLC | 371,948371,948 | $36M | 0.19% | NEW |
| 76 | ROYAL BANK OF CANADA | 371,743371,743 | $36M | 0.19% | TRIM -26% |
| 77 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 368,325368,325 | $36M | 0.19% | ADD 14% |
| 78 | Mass General Brigham, Inc | 344,091344,091 | $33M | 0.17% | — |
| 79 | Legal & General Group Plc | 341,148341,148 | $33M | 0.17% | ADD 122% |
| 80 | Nuveen, LLC | 340,611340,611 | $33M | 0.17% | TRIM -16% |
| 81 | AMERICAN CENTURY COMPANIES INC | 335,528335,528 | $33M | 0.17% | TRIM -28% |
| 82 | TD Asset Management Inc | 317,811317,811 | $31M | 0.16% | TRIM -14% |
| 83 | Defilade Capital Management, L.P. | 315,972315,972 | $31M | 0.16% | TRIM -13% |
| 84 | Duquesne Family Office LLC | 315,860315,860 | $31M | 0.16% | NEW |
| 85 | JENNISON ASSOCIATES LLC | 307,377307,377 | $30M | 0.16% | — |
| 86 | JPMORGAN CHASE & CO | 301,393301,393 | $28M | 0.15% | TRIM -29% |
| 87 | California Public Employees Retirement System | 281,960281,960 | $27M | 0.14% | TRIM -3% |
| 88 | Man Group plc | 275,270275,270 | $27M | 0.14% | ADD 182% |
| 89 | Sumitomo Mitsui Trust Group, Inc. | 270,972270,972 | $26M | 0.14% | ADD 4829% |
| 90 | Melqart Asset Management (UK) Ltd | 270,363270,363 | $26M | 0.14% | NEW |
| 91 | Checkpoint Capital L.P. | 262,539262,539 | $26M | 0.13% | TRIM -29% |
| 92 | EVENTIDE ASSET MANAGEMENT, LLC | 261,425261,425 | $25M | 0.13% | TRIM -31% |
| 93 | Nicholas Investment Partners, LP | 261,166261,166 | $25M | 0.13% | TRIM -18% |
| 94 | PERCEPTIVE ADVISORS LLC | 258,600258,600 | $25M | 0.13% | NEW |
| 95 | Trails Edge Capital Partners, LP | 245,000245,000 | $24M | 0.12% | NEW |
| 96 | FRONTIER CAPITAL MANAGEMENT CO LLC | 243,804243,804 | $24M | 0.12% | TRIM -43% |
| 97 | Ensign Peak Advisors, Inc | 227,940227,940 | $22M | 0.12% | TRIM -3% |
| 98 | MARSICO CAPITAL MANAGEMENT LLC | 219,460219,460 | $21M | 0.11% | — |
| 99 | MARSHALL WACE, LLP | 216,661216,661 | $21M | 0.11% | TRIM -44% |
| 100 | Fisher Asset Management, LLC | 215,947215,947 | $21M | 0.11% | TRIM -10% |
† NEW this big is usually a rename.
Ranked by each filer’s own reported value, not shares.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +8,362,284 | $813M | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +7,502,623 | $730M | OPEN |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | +3,270,056 | $318M | ADD |
| BlackRock, Inc. | +2,286,050 | $222M | ADD |
| Darwin Global Management, Ltd. | +2,211,018 | $215M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −16,719,886 | $1.6B | CLOSE |
| Bellevue Group AG | −3,461,263 | $337M | TRIM |
| T. Rowe Price Investment Management, Inc. | −2,836,586 | $276M | TRIM |
| JANUS HENDERSON GROUP PLC | −2,537,006 | $247M | TRIM |
| NORGES BANK | −2,455,347 | $239M | CLOSE |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 13.2M | 13.5M | 14.3M | 14.6M | 14.6M | 13.6M | $1.3B |
| BlackRock, Inc. | 14.7M | 14.7M | 8.7M | 8.3M | 8.9M | 11.2M | $1.1B |
| JANUS HENDERSON GROUP PLC | 9.5M | 10.2M | 10.6M | 11.4M | 12.3M | 9.8M | $950M |
| BAKER BROS. ADVISORS LP | 7.9M | 7.9M | 9.4M | 9.5M | 9.5M | 9.6M | $929M |
| FMR LLC | 6.7M | 7.5M | 8.3M | 9.4M | 8.6M | 8.5M | $823M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 8.4M | $813M |
| Nextech Invest, Ltd. | — | 7.6M | 7.6M | 7.6M | 7.6M | 7.6M | $739M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 7.5M | $730M |
| Paradigm Biocapital Advisors LP | 6.6M | 6.2M | 6.1M | 6.2M | 6.6M | 6.7M | $647M |
| WELLINGTON MANAGEMENT GROUP LLP | 10.8M | 11.8M | 10.3M | 9.8M | 7.0M | 6.0M | $586M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 650K | 394K | 397K | 742K | 2.2M | 5.5M | $533M |
| STATE STREET CORP | 5.8M | 5.8M | 4.7M | 5.3M | 4.1M | 4.4M | $428M |
| UBS Group AG | 300K | 482K | 515K | 1.1M | 3.1M | 4.4M | $427M |
| GEODE CAPITAL MANAGEMENT, LLC | 4.1M | 4.1M | 3.0M | 3.1M | 3.2M | 3.3M | $324M |
| Alphabet Inc. | 4.1M | 4.1M | 4.1M | 4.1M | 3.3M | 3.3M | $320M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
SEC Schedule 13D/G XML · group aggregate.