| 1 | 1FARALLON CAPITAL MANAGEMENT LLC | 13,604,79613.6M | $1.3B | 6.40% | TRIM -7% |
| 2 | 2BlackRock, Inc. | 11,212,70611.2M | $1.1B | 5.27% | ADD 26% |
| 3 | 3JANUS HENDERSON GROUP PLC | 9,766,4969.8M | $950M | 4.59% | TRIM -21% |
| 4 | 4BAKER BROS. ADVISORS LP | 9,555,3579.6M | $929M | 4.49% | — |
| 5 | 5FMR LLC | 8,464,3148.5M | $823M | 3.98% | — |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 8,362,2848.4M | $813M | 3.93% | NEW† |
| 7 | 7Nextech Invest, Ltd. | 7,601,0877.6M | $739M | 3.58% | — |
| 8 | 8VANGUARD PORTFOLIO MANAGEMENT LLC | 7,502,6237.5M | $730M | 3.53% | NEW† |
| 9 | 9Paradigm Biocapital Advisors LP | 6,655,7036.7M | $647M | 3.13% | — |
| 10 | 10WELLINGTON MANAGEMENT GROUP LLP | 6,027,8196.0M | $586M | 2.84% | TRIM -14% |
| 11 | 11ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,475,6115.5M | $533M | 2.58% | ADD 148% |
| 12 | 12STATE STREET CORP | 4,402,6624.4M | $428M | 2.07% | ADD 7% |
| 13 | 13UBS Group AG | 4,386,7914.4M | $427M | 2.06% | ADD 42% |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 3,338,1423.3M | $324M | 1.57% | ADD 6% |
| 15 | 15Alphabet Inc. | 3,292,5253.3M | $320M | 1.55% | — |
| 16 | 16PRICE T ROWE ASSOCIATES INC /MD/ | 3,232,2133.2M | $314M | 1.52% | TRIM -5% |
| 17 | 17BVF INC/IL | 2,856,7822.9M | $278M | 1.34% | TRIM -15% |
| 18 | 18Casdin Capital, LLC | 2,577,3332.6M | $251M | 1.21% | — |
| 19 | 19Woodline Partners LP | 2,506,5702.5M | $244M | 1.18% | — |
| 20 | 20Holocene Advisors, LP | 2,468,6442.5M | $240M | 1.16% | ADD 29% |
| 21 | 21Vestal Point Capital, LP | 2,375,0002.4M | $231M | 1.12% | ADD 705% |
| 22 | 22Avoro Capital Advisors LLC | 2,344,4442.3M | $228M | 1.10% | ADD 8% |
| 23 | 23DEERFIELD MANAGEMENT COMPANY, L.P. | 2,297,0002.3M | $223M | 1.08% | TRIM -21% |
| 24 | 24GOLDMAN SACHS GROUP INC | 2,185,5002.2M | $213M | 1.03% | TRIM -12% |
| 25 | 25Darwin Global Management, Ltd. | 2,211,0182.2M | $205M | 1.04% | NEW |
| 26 | 26Logos Global Management LP | 2,000,0002.0M | $195M | 0.94% | — |
| 27 | 27Alyeska Investment Group, L.P. | 1,885,8211.9M | $183M | 0.89% | ADD 689% |
| 28 | 28NATIONAL BANK OF CANADA /FI/ | 1,749,0001.7M | $170M | 0.82% | NEW |
| 29 | 29CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,735,4761.7M | $169M | 0.82% | ADD 3% |
| 30 | 30Caligan Partners LP | 1,652,8081.7M | $161M | 0.78% | ADD 29% |
| 31 | 31AMERIPRISE FINANCIAL INC | 1,579,7931.6M | $154M | 0.74% | TRIM -23% |
| 32 | 32TWO SIGMA INVESTMENTS, LP | 1,558,8071.6M | $152M | 0.73% | ADD 270% |
| 33 | 33WESTFIELD CAPITAL MANAGEMENT CO LP | 1,556,5781.6M | $151M | 0.73% | TRIM -45% |
| 34 | 34Bellevue Group AG | 1,544,4561.5M | $150M | 0.73% | TRIM -69% |
| 35 | 35Integral Health Asset Management, LLC | 1,500,0001.5M | $146M | 0.71% | ADD 25% |
| 36 | 36Rock Springs Capital Management LP | 1,209,4651.2M | $118M | 0.57% | TRIM -9% |
| 37 | 37Polar Capital Holdings Plc | 1,133,9301.1M | $110M | 0.53% | TRIM -44% |
| 38 | 38FRANKLIN RESOURCES INC | 1,133,5461.1M | $110M | 0.53% | ADD 7% |
| 39 | 39VANGUARD FIDUCIARY TRUST CO | 1,133,3191.1M | $110M | 0.53% | NEW |
| 40 | 40Siren, L.L.C. | 1,110,9801.1M | $108M | 0.52% | TRIM -17% |
| 41 | 41D. E. Shaw & Co., Inc. | 1,022,2981.0M | $99M | 0.48% | TRIM -37% |
| 42 | 42NORTHERN TRUST CORP | 954,256954,256 | $93M | 0.45% | ADD 12% |
| 43 | 43a16z Capital Management, L.L.C. | 921,099921,099 | $90M | 0.43% | — |
| 44 | 44DIMENSIONAL FUND ADVISORS LP | 844,614844,614 | $82M | 0.40% | TRIM -27% |
| 45 | 45AIHC Capital Management Ltd | 828,974828,974 | $81M | 0.39% | TRIM -8% |
| 46 | 46MIC Capital Management UK LLP | 795,733795,733 | $77M | 0.37% | ADD 56% |
| 47 | 47GENERAL ATLANTIC, L.P. | 707,791707,791 | $69M | 0.33% | TRIM -75% |
| 48 | 48MORGAN STANLEY | 705,793705,793 | $69M | 0.33% | ADD 8% |
| 49 | 49Nearwater Capital Markets, Ltd | 678,000678,000 | $66M | 0.32% | NEW |
| 50 | 50Frazier Life Sciences Management, L.P. | 675,686675,686 | $66M | 0.32% | TRIM -15% |
| 51 | 51T. Rowe Price Investment Management, Inc. | 664,047664,047 | $65M | 0.31% | TRIM -81% |
| 52 | 52Bank of New York Mellon Corp | 635,366635,366 | $62M | 0.30% | ADD 17% |
| 53 | 53WORLDQUANT MILLENNIUM ADVISORS LLC | 622,304622,304 | $61M | 0.29% | ADD 562% |
| 54 | 54BANK OF AMERICA CORP /DE/ | 614,157614,157 | $60M | 0.29% | TRIM -30% |
| 55 | 55DAFNA Capital Management LLC | 580,678580,678 | $56M | 0.27% | TRIM -4% |
| 56 | 56Candriam S.C.A. | 580,677580,677 | $56M | 0.27% | TRIM -44% |
| 57 | 57TCG Crossover Management, LLC | 576,473576,473 | $56M | 0.27% | ADD 32% |
| 58 | 58STEMPOINT CAPITAL LP | 563,264563,264 | $55M | 0.26% | ADD 808% |
| 59 | 59Qube Research & Technologies Ltd | 553,290553,290 | $54M | 0.26% | NEW |
| 60 | 60Pictet Asset Management Holding SA | 557,560557,560 | $54M | 0.26% | TRIM -51% |
| 61 | 61Lunate Capital Ltd | 549,050549,050 | $53M | 0.26% | TRIM -75% |
| 62 | 62MPM BIOIMPACT LLC | 506,776506,776 | $49M | 0.24% | — |
| 63 | 63UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 500,595500,595 | $49M | 0.24% | ADD 43% |
| 64 | 64Boxer Capital Management, LLC | 500,000500,000 | $49M | 0.24% | ADD 25% |
| 65 | 65Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 479,080479,080 | $47M | 0.23% | NEW |
| 66 | 66First Turn Management, LLC | 468,376468,376 | $46M | 0.22% | TRIM -27% |
| 67 | 67DEUTSCHE BANK AG\ | 465,758465,758 | $45M | 0.22% | ADD 1346% |
| 68 | 68BOOTHBAY FUND MANAGEMENT, LLC | 438,595438,595 | $43M | 0.21% | ADD 34% |
| 69 | 69Swiss National Bank | 425,431425,431 | $41M | 0.20% | ADD 54% |
| 70 | 70BNP PARIBAS FINANCIAL MARKETS | 422,443422,443 | $41M | 0.20% | TRIM -32% |
| 71 | 71CITADEL ADVISORS LLC | 400,053400,053 | $39M | 0.19% | TRIM -69% |
| 72 | 72Invesco Ltd. | 392,844392,844 | $38M | 0.18% | ADD 7% |
| 73 | 73BARCLAYS PLC | 383,179383,179 | $37M | 0.18% | ADD 182% |
| 74 | 74MILLENNIUM MANAGEMENT LLC | 377,332377,332 | $37M | 0.18% | TRIM -53% |
| 75 | 75SAMLYN CAPITAL, LLC | 371,948371,948 | $36M | 0.17% | NEW |
| 76 | 76ROYAL BANK OF CANADA | 371,743371,743 | $36M | 0.17% | TRIM -26% |
| 77 | 77VOLORIDGE INVESTMENT MANAGEMENT, LLC | 368,325368,325 | $36M | 0.17% | ADD 14% |
| 78 | 78Mass General Brigham, Inc | 344,091344,091 | $33M | 0.16% | — |
| 79 | 79Legal & General Group Plc | 341,148341,148 | $33M | 0.16% | ADD 122% |
| 80 | 80Nuveen, LLC | 340,611340,611 | $33M | 0.16% | TRIM -16% |
| 81 | 81AMERICAN CENTURY COMPANIES INC | 335,528335,528 | $33M | 0.16% | TRIM -28% |
| 82 | 82TD Asset Management Inc | 317,811317,811 | $31M | 0.15% | TRIM -14% |
| 83 | 83Defilade Capital Management, L.P. | 315,972315,972 | $31M | 0.15% | TRIM -13% |
| 84 | 84Duquesne Family Office LLC | 315,860315,860 | $31M | 0.15% | NEW |
| 85 | 85JENNISON ASSOCIATES LLC | 307,377307,377 | $30M | 0.14% | — |
| 86 | 86JPMORGAN CHASE & CO | 301,393301,393 | $28M | 0.14% | TRIM -29% |
| 87 | 87California Public Employees Retirement System | 281,960281,960 | $27M | 0.13% | TRIM -3% |
| 88 | 88Man Group plc | 275,270275,270 | $27M | 0.13% | ADD 182% |
| 89 | 89Sumitomo Mitsui Trust Group, Inc. | 270,972270,972 | $26M | 0.13% | ADD 4829% |
| 90 | 90Melqart Asset Management (UK) Ltd | 270,363270,363 | $26M | 0.13% | NEW |
| 91 | 91Checkpoint Capital L.P. | 262,539262,539 | $26M | 0.12% | TRIM -29% |
| 92 | 92EVENTIDE ASSET MANAGEMENT, LLC | 261,425261,425 | $25M | 0.12% | TRIM -31% |
| 93 | 93Nicholas Investment Partners, LP | 261,166261,166 | $25M | 0.12% | TRIM -18% |
| 94 | 94PERCEPTIVE ADVISORS LLC | 258,600258,600 | $25M | 0.12% | NEW |
| 95 | 95Trails Edge Capital Partners, LP | 245,000245,000 | $24M | 0.12% | NEW |
| 96 | 96FRONTIER CAPITAL MANAGEMENT CO LLC | 243,804243,804 | $24M | 0.11% | TRIM -43% |
| 97 | 97Ensign Peak Advisors, Inc | 227,940227,940 | $22M | 0.11% | TRIM -3% |
| 98 | 98MARSICO CAPITAL MANAGEMENT LLC | 219,460219,460 | $21M | 0.10% | — |
| 99 | 99MARSHALL WACE, LLP | 216,661216,661 | $21M | 0.10% | TRIM -44% |
| 100 | 100Fisher Asset Management, LLC | 215,947215,947 | $21M | 0.10% | TRIM -10% |
