| 1 | 1FMR LLC | 77,981,25378.0M | $2.2B | 10.84% | ADD 19% |
| 2 | 2MORGAN STANLEY | 51,828,32551.8M | $1.4B | 7.21% | TRIM -11% |
| 3 | 3BlackRock, Inc. | 44,254,26044.3M | $1.2B | 6.15% | ADD 7% |
| 4 | 4QVT Financial LP | 25,161,23725.2M | $697M | 3.50% | TRIM -5% |
| 5 | 5UBS Group AG | 22,619,47222.6M | $627M | 3.14% | ADD 23% |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 20,680,57220.7M | $573M | 2.88% | NEW† |
| 7 | 7VANGUARD PORTFOLIO MANAGEMENT LLC | 19,838,69819.8M | $550M | 2.76% | NEW† |
| 8 | 8STATE STREET CORP | 16,186,61316.2M | $448M | 2.25% | TRIM -7% |
| 9 | 9ADAGE CAPITAL PARTNERS GP, L.L.C. | 12,794,09712.8M | $354M | 1.78% | ADD 20% |
| 10 | 10GOLDMAN SACHS GROUP INC | 11,111,59111.1M | $308M | 1.54% | — |
| 11 | 11GEODE CAPITAL MANAGEMENT, LLC | 10,182,47710.2M | $282M | 1.42% | ADD 25% |
| 12 | 12FARALLON CAPITAL MANAGEMENT LLC | 9,675,0009.7M | $268M | 1.35% | ADD 26049% |
| 13 | 13Two Seas Capital LP | 9,328,2919.3M | $258M | 1.30% | TRIM -5% |
| 14 | 14PERCEPTIVE ADVISORS LLC | 8,285,4618.3M | $230M | 1.15% | ADD 4% |
| 15 | 15Patient Square Capital LP | 8,166,0478.2M | $226M | 1.14% | — |
| 16 | 16DIMENSIONAL FUND ADVISORS LP | 7,475,8667.5M | $207M | 1.04% | TRIM -19% |
| 17 | 17Assenagon Asset Management S.A. | 7,076,4887.1M | $196M | 0.98% | ADD 2% |
| 18 | 18PRICE T ROWE ASSOCIATES INC /MD/ | 6,992,1367.0M | $194M | 0.97% | ADD 31% |
| 19 | 19VIKING GLOBAL INVESTORS LPtracked | 6,652,4486.7M | $184M | 0.92% | ADD 3% |
| 20 | 20Darwin Global Management, Ltd. | 6,797,3006.8M | $180M | 0.95% | NEW |
| 21 | 21Invesco Ltd. | 6,439,1456.4M | $178M | 0.90% | ADD 182% |
| 22 | 22NATIONAL BANK OF CANADA /FI/ | 6,298,0006.3M | $174M | 0.88% | ADD 209% |
| 23 | 23AQR CAPITAL MANAGEMENT LLC | 5,946,8585.9M | $162M | 0.83% | ADD 575% |
| 24 | 24Rubric Capital Management LP | 5,000,0005.0M | $139M | 0.70% | TRIM -44% |
| 25 | 25BAKER BROS. ADVISORS LP | 4,867,7234.9M | $135M | 0.68% | TRIM -12% |
| 26 | 26NORTHERN TRUST CORP | 3,520,4523.5M | $98M | 0.49% | ADD 7% |
| 27 | 27CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,457,4483.5M | $96M | 0.48% | ADD 7% |
| 28 | 28Qube Research & Technologies Ltd | 3,450,9043.5M | $96M | 0.48% | ADD 355% |
| 29 | 29ADAR1 Capital Management, LLC | 3,285,9063.3M | $91M | 0.46% | TRIM -4% |
| 30 | 30BANK OF AMERICA CORP /DE/ | 3,163,8213.2M | $88M | 0.44% | ADD 8% |
| 31 | 31JANUS HENDERSON GROUP PLC | 3,095,4483.1M | $86M | 0.43% | ADD 6% |
| 32 | 32JENNISON ASSOCIATES LLC | 2,982,7993.0M | $83M | 0.41% | ADD 27% |
| 33 | 33VANGUARD FIDUCIARY TRUST CO | 2,811,1212.8M | $78M | 0.39% | NEW |
| 34 | 34Affinity Asset Advisors, LLC | 2,800,0002.8M | $78M | 0.39% | ADD 65% |
| 35 | 35Bank of New York Mellon Corp | 2,735,8242.7M | $76M | 0.38% | TRIM -6% |
| 36 | 36Pictet Asset Management Holding SA | 2,673,2332.7M | $74M | 0.37% | ADD 16% |
| 37 | 37SB INVESTMENT ADVISERS (UK) LTD | 2,671,7322.7M | $74M | 0.37% | TRIM -84% |
| 38 | 38BNP PARIBAS FINANCIAL MARKETS | 2,516,3532.5M | $70M | 0.35% | ADD 10% |
| 39 | 39CITADEL ADVISORS LLC | 2,515,9982.5M | $70M | 0.35% | ADD 10% |
| 40 | 40BlackBarn Capital Partners LP | 2,285,1172.3M | $63M | 0.32% | TRIM -26% |
| 41 | 41MARSHALL WACE, LLP | 2,246,9432.2M | $62M | 0.31% | TRIM -35% |
| 42 | 42DME Capital Management, LP | 2,152,6692.2M | $60M | 0.30% | ADD 4% |
| 43 | 43Clearbridge Investments, LLC | 2,005,5652.0M | $56M | 0.28% | — |
| 44 | 44Candriam S.C.A. | 2,001,9762.0M | $55M | 0.28% | TRIM -20% |
| 45 | 45Integral Health Asset Management, LLC | 2,000,0002.0M | $55M | 0.28% | ADD 135% |
| 46 | 46Nuveen, LLC | 1,955,0462.0M | $54M | 0.27% | TRIM -13% |
| 47 | 47Woodline Partners LP | 1,750,0171.8M | $48M | 0.24% | — |
| 48 | 48UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,741,4801.7M | $48M | 0.24% | TRIM -16% |
| 49 | 49MAVERICK CAPITAL LTD | 1,626,9401.6M | $45M | 0.23% | NEW |
| 50 | 50PENN DAVIS MCFARLAND INC | 1,592,6231.6M | $44M | 0.22% | TRIM -14% |
| 51 | 51Polar Capital Holdings Plc | 1,578,3081.6M | $44M | 0.22% | TRIM -41% |
| 52 | 52CITIGROUP INC | 1,536,1101.5M | $43M | 0.21% | TRIM -10% |
| 53 | 53Amundi | 1,480,9701.5M | $41M | 0.21% | ADD 42% |
| 54 | 54JPMORGAN CHASE & CO | 1,537,5191.5M | $41M | 0.21% | ADD 65% |
| 55 | 55Whitefort Capital Management, LP | 1,419,0001.4M | $39M | 0.20% | TRIM -33% |
| 56 | 56Gotham Asset Management, LLC | 1,416,0911.4M | $39M | 0.20% | ADD 53% |
| 57 | 57BARCLAYS PLC | 1,415,8481.4M | $39M | 0.20% | ADD 69% |
| 58 | 58D. E. Shaw & Co., Inc. | 1,392,7481.4M | $39M | 0.19% | ADD 252% |
| 59 | 59Parkside Financial Bank & Trust | 1,329,1641.3M | $37M | 0.18% | ADD 14% |
| 60 | 60BANK OF NOVA SCOTIA | 1,310,3871.3M | $36M | 0.18% | TRIM -8% |
| 61 | 61First Turn Management, LLC | 1,190,1181.2M | $33M | 0.17% | — |
| 62 | 62RHUMBLINE ADVISERS | 1,113,2661.1M | $31M | 0.15% | ADD 7% |
| 63 | 63JANE STREET GROUP, LLC | 1,020,7071.0M | $28M | 0.14% | TRIM -22% |
| 64 | 64Ensign Peak Advisors, Inc | 1,018,8421.0M | $28M | 0.14% | ADD 2854% |
| 65 | 65PRINCIPAL FINANCIAL GROUP INC | 1,005,5331.0M | $28M | 0.14% | ADD 7% |
| 66 | 66WELLINGTON MANAGEMENT GROUP LLP | 963,282963,282 | $27M | 0.13% | NEW |
| 67 | 67FRED ALGER MANAGEMENT, LLC | 925,186925,186 | $26M | 0.13% | ADD 727% |
| 68 | 68Point72 Asset Management, L.P. | 890,900890,900 | $25M | 0.12% | NEW |
| 69 | 69Davern Capital Partners, LP | 873,398873,398 | $24M | 0.12% | TRIM -15% |
| 70 | 70Man Group plc | 852,204852,204 | $24M | 0.12% | TRIM -42% |
| 71 | 71ALGERT GLOBAL LLC | 827,454827,454 | $23M | 0.12% | ADD 17% |
| 72 | 72MILLENNIUM MANAGEMENT LLC | 803,801803,801 | $22M | 0.11% | TRIM -33% |
| 73 | 73STEMPOINT CAPITAL LP | 771,600771,600 | $21M | 0.11% | TRIM -20% |
| 74 | 74Cormorant Asset Management, LP | 750,000750,000 | $21M | 0.10% | NEW |
| 75 | 75Swiss National Bank | 743,446743,446 | $21M | 0.10% | — |
| 76 | 76CAPITOLIS LIQUID GLOBAL MARKETS LLC | 725,000725,000 | $20M | 0.10% | NEW |
| 77 | 77TD Asset Management Inc | 715,282715,282 | $20M | 0.10% | ADD 30% |
| 78 | 78Russell Investments Group, Ltd. | 707,171707,171 | $20M | 0.10% | ADD 687% |
| 79 | 79MANUFACTURERS LIFE INSURANCE COMPANY, THE | 699,137699,137 | $19M | 0.10% | ADD 17% |
| 80 | 80California Public Employees Retirement System | 691,463691,463 | $19M | 0.10% | NEW |
| 81 | 81ENVESTNET ASSET MANAGEMENT INC | 678,518678,518 | $19M | 0.09% | ADD 6% |
| 82 | 82SG Americas Securities, LLC | 640,923640,923 | $18M | 0.09% | ADD 2651% |
| 83 | 83Dorsey Wright & Associates | 577,147577,147 | $16M | 0.08% | ADD 53% |
| 84 | 84Legal & General Group Plc | 561,307561,307 | $16M | 0.08% | TRIM -5% |
| 85 | 85Retirement Systems of Alabama | 552,771552,771 | $15M | 0.08% | ADD 5% |
| 86 | 86ALLIANCEBERNSTEIN L.P. | 676,344676,344 | $15M | 0.09% | ADD 25% |
| 87 | 87Sofinnova Investments, Inc. | 477,995477,995 | $13M | 0.07% | TRIM -35% |
| 88 | 88FIRST TRUST ADVISORS LP | 455,865455,865 | $13M | 0.06% | ADD 75% |
| 89 | 89CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 440,634440,634 | $12M | 0.06% | ADD 23% |
| 90 | 90AMERIPRISE FINANCIAL INC | 438,565438,565 | $12M | 0.06% | TRIM -32% |
| 91 | 91ING GROEP NV | 391,500391,500 | $11M | 0.05% | TRIM -33% |
| 92 | 92LPL Financial LLC | 378,656378,656 | $10M | 0.05% | ADD 8% |
| 93 | 93PDT Partners, LLC | 376,509376,509 | $10M | 0.05% | TRIM -19% |
| 94 | 94VANGUARD ASSET MANAGEMENT, Ltd | 351,869351,869 | $10M | 0.05% | NEW |
| 95 | 95STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 325,757325,757 | $9M | 0.05% | — |
| 96 | 96VOYA INVESTMENT MANAGEMENT LLC | 314,440314,440 | $9M | 0.04% | ADD 20% |
| 97 | 97Impax Asset Management Group plc | 300,000300,000 | $8M | 0.04% | TRIM -45% |
| 98 | 98Empowered Funds, LLC | 285,915285,915 | $8M | 0.04% | ADD 1468% |
| 99 | 99Nicholas Investment Partners, LP | 278,425278,425 | $8M | 0.04% | — |
| 100 | 100Pine Ridge Advisers LLC | 276,530276,530 | $8M | 0.04% | — |
