| 1 | 1SB INVESTMENT ADVISERS (UK) LTD | 27,904,96327.9M | $278M | 14.57% | — |
| 2 | 2Commodore Capital LP | 17,000,00017.0M | $169M | 8.87% | — |
| 3 | 3Casdin Capital, LLC | 14,418,57414.4M | $143M | 7.53% | ADD 11% |
| 4 | 4BlackRock, Inc. | 12,975,29913.0M | $129M | 6.77% | — |
| 5 | 5PERCEPTIVE ADVISORS LLC | 9,751,1419.8M | $97M | 5.09% | ADD 412% |
| 6 | 6Bellevue Group AG | 7,795,2427.8M | $78M | 4.07% | TRIM -7% |
| 7 | 7VANGUARD CAPITAL MANAGEMENT LLC | 7,387,4657.4M | $74M | 3.86% | NEW† |
| 8 | 8STATE STREET CORP | 6,233,5456.2M | $62M | 3.25% | TRIM -3% |
| 9 | 9Nextech Invest, Ltd. | 5,526,5065.5M | $55M | 2.88% | ADD 18% |
| 10 | 10TCG Crossover Management, LLC | 4,273,3564.3M | $43M | 2.23% | ADD 33% |
| 11 | 11FMR LLC | 3,695,4313.7M | $37M | 1.93% | ADD 2178% |
| 12 | 12GEODE CAPITAL MANAGEMENT, LLC | 3,510,6363.5M | $35M | 1.83% | ADD 3% |
| 13 | 13Balyasny Asset Management L.P. | 3,039,1793.0M | $30M | 1.59% | ADD 45% |
| 14 | 14Spruce Street Capital LP | 2,984,1253.0M | $30M | 1.56% | — |
| 15 | 15DIMENSIONAL FUND ADVISORS LP | 2,940,5362.9M | $29M | 1.53% | ADD 19% |
| 16 | 16ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,590,0002.6M | $26M | 1.35% | ADD 418% |
| 17 | 17GOLDMAN SACHS GROUP INC | 2,541,8612.5M | $25M | 1.33% | ADD 37% |
| 18 | 18MPM BIOIMPACT LLC | 2,359,5862.4M | $23M | 1.23% | ADD 6% |
| 19 | 19BANK OF AMERICA CORP /DE/ | 1,937,6951.9M | $19M | 1.01% | ADD 86% |
| 20 | 20PRICE T ROWE ASSOCIATES INC /MD/ | 1,924,9381.9M | $19M | 1.00% | ADD 17% |
| 21 | 21EcoR1 Capital, LLC | 1,904,7621.9M | $19M | 0.99% | NEW |
| 22 | 22VANGUARD PORTFOLIO MANAGEMENT LLC | 1,863,5651.9M | $19M | 0.97% | NEW |
| 23 | 23Kalehua Capital Management LLC | 1,802,9141.8M | $18M | 0.94% | ADD 100% |
| 24 | 24NORTHERN TRUST CORP | 1,675,3871.7M | $17M | 0.87% | ADD 47% |
| 25 | 25Alphabet Inc. | 1,564,1731.6M | $16M | 0.82% | — |
| 26 | 26MORGAN STANLEY | 1,432,0031.4M | $14M | 0.75% | TRIM -29% |
| 27 | 27Kynam Capital Management, LP | 1,424,2591.4M | $14M | 0.74% | — |
| 28 | 28TWO SIGMA INVESTMENTS, LP | 1,369,1491.4M | $14M | 0.71% | TRIM -12% |
| 29 | 29AQR CAPITAL MANAGEMENT LLC | 1,290,0321.3M | $13M | 0.67% | ADD 11% |
| 30 | 30BAKER BROS. ADVISORS LP | 1,160,1171.2M | $12M | 0.61% | — |
| 31 | 31CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,111,8911.1M | $11M | 0.58% | TRIM -2% |
| 32 | 32Foresite Capital Management IV, LLC | 1,000,0001.0M | $10M | 0.52% | — |
| 33 | 33MARSHALL WACE, LLP | 941,825941,825 | $9M | 0.49% | NEW |
| 34 | 34VANGUARD FIDUCIARY TRUST CO | 900,546900,546 | $9M | 0.47% | NEW |
| 35 | 35Connor, Clark & Lunn Investment Management Ltd. | 837,038837,038 | $8M | 0.44% | ADD 115% |
| 36 | 36PANAGORA ASSET MANAGEMENT INC | 818,041818,041 | $8M | 0.43% | NEW |
| 37 | 37Logos Global Management LP | 750,000750,000 | $7M | 0.39% | NEW |
| 38 | 38Woodline Partners LP | 679,342679,342 | $7M | 0.35% | — |
| 39 | 39RENAISSANCE TECHNOLOGIES LLC | 673,599673,599 | $7M | 0.35% | ADD 4% |
| 40 | 40Squadron Capital Management LLC | 672,500672,500 | $7M | 0.35% | NEW |
| 41 | 41Invesco Ltd. | 669,874669,874 | $7M | 0.35% | TRIM -23% |
| 42 | 42ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 668,289668,289 | $7M | 0.35% | NEW |
| 43 | 43Qube Research & Technologies Ltd | 619,652619,652 | $6M | 0.32% | NEW |
| 44 | 44CONGRESS ASSET MANAGEMENT CO | 618,938618,938 | $6M | 0.32% | ADD 49% |
| 45 | 45JPMORGAN CHASE & CO | 647,518647,518 | $6M | 0.34% | ADD 52% |
| 46 | 46ArrowMark Colorado Holdings LLC | 541,124541,124 | $5M | 0.28% | — |
| 47 | 47Elmind Capital, LP | 536,946536,946 | $5M | 0.28% | — |
| 48 | 48UBS Group AG | 527,611527,611 | $5M | 0.28% | ADD 78% |
| 49 | 49Longaeva Partners L.P. | 470,544470,544 | $5M | 0.25% | NEW |
| 50 | 50BESSEMER GROUP INC | 457,869457,869 | $5M | 0.24% | — |
| 51 | 51AMERICAN CENTURY COMPANIES INC | 440,185440,185 | $4M | 0.23% | — |
| 52 | 52JANE STREET GROUP, LLC | 423,536423,536 | $4M | 0.22% | ADD 454% |
| 53 | 53HighVista Strategies LLC | 421,881421,881 | $4M | 0.22% | TRIM -23% |
| 54 | 54SPHERA FUNDS MANAGEMENT LTD. | 408,436408,436 | $4M | 0.21% | NEW |
| 55 | 55Affinity Asset Advisors, LLC | 400,000400,000 | $4M | 0.21% | NEW |
| 56 | 56Bank of New York Mellon Corp | 382,920382,920 | $4M | 0.20% | — |
| 57 | 57Rhenman & Partners Asset Management AB | 360,000360,000 | $4M | 0.19% | TRIM -22% |
| 58 | 58AMERIPRISE FINANCIAL INC | 356,924356,924 | $4M | 0.19% | NEW |
| 59 | 59MILLENNIUM MANAGEMENT LLC | 347,733347,733 | $3M | 0.18% | TRIM -61% |
| 60 | 60RAYMOND JAMES FINANCIAL INC | 346,317346,317 | $3M | 0.18% | ADD 34% |
| 61 | 61Susquehanna Portfolio Strategies, LLC | 339,080339,080 | $3M | 0.18% | — |
| 62 | 62Hudson Bay Capital Management LP | 311,330311,330 | $3M | 0.16% | TRIM -31% |
| 63 | 63Nuveen, LLC | 302,196302,196 | $3M | 0.16% | — |
| 64 | 64ACADIAN ASSET MANAGEMENT LLC | 290,352290,352 | $3M | 0.15% | TRIM -36% |
| 65 | 65Exome Asset Management LLC | 278,302278,302 | $3M | 0.15% | NEW |
| 66 | 66Eversept Partners, LP | 270,705270,705 | $3M | 0.14% | TRIM -45% |
| 67 | 67Seven Fleet Capital Management LP | 257,738257,738 | $3M | 0.13% | ADD 253% |
| 68 | 68Swiss National Bank | 238,000238,000 | $2M | 0.12% | — |
| 69 | 69RHUMBLINE ADVISERS | 216,933216,933 | $2M | 0.11% | — |
| 70 | 70VOYA INVESTMENT MANAGEMENT LLC | 216,052216,052 | $2M | 0.11% | ADD 779% |
| 71 | 71TD Asset Management Inc | 214,170214,170 | $2M | 0.11% | ADD 18% |
| 72 | 72UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 210,468210,468 | $2M | 0.11% | — |
| 73 | 73MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,707209,707 | $2M | 0.11% | ADD 18% |
| 74 | 74IEQ CAPITAL, LLC | 205,310205,310 | $2M | 0.11% | ADD 27% |
| 75 | 75SG Americas Securities, LLC | 197,535197,535 | $2M | 0.10% | TRIM -11% |
| 76 | 76XTX Topco Ltd | 188,940188,940 | $2M | 0.10% | ADD 20% |
| 77 | 77OSAIC HOLDINGS, INC. | 186,123186,123 | $2M | 0.10% | — |
| 78 | 78Tetragon Partners GP Ltd | 181,543181,543 | $2M | 0.09% | NEW |
| 79 | 79Squarepoint Ops LLC | 180,298180,298 | $2M | 0.09% | ADD 91% |
| 80 | 80Raiffeisen Bank International AG | 190,000190,000 | $2M | 0.10% | TRIM -24% |
| 81 | 81CITADEL ADVISORS LLC | 176,265176,265 | $2M | 0.09% | ADD 54% |
| 82 | 82CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 174,099174,099 | $2M | 0.09% | ADD 48% |
| 83 | 83STATE OF WISCONSIN INVESTMENT BOARD | 162,236162,236 | $2M | 0.08% | ADD 60% |
| 84 | 84Tidal Investments LLC | 154,100154,100 | $2M | 0.08% | NEW |
| 85 | 85Tema ETFs LLC | 154,100154,100 | $2M | 0.08% | ADD 38% |
| 86 | 86Rafferty Asset Management, LLC | 150,618150,618 | $1M | 0.08% | TRIM -22% |
| 87 | 87SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,158147,158 | $1M | 0.08% | TRIM -34% |
| 88 | 88ALPS ADVISORS INC | 145,490145,490 | $1M | 0.08% | ADD 2% |
| 89 | 89Sanctuary Advisors, LLC | 143,816143,816 | $1M | 0.08% | — |
| 90 | 90Engineers Gate Manager LP | 141,452141,452 | $1M | 0.07% | ADD 80% |
| 91 | 91DEUTSCHE BANK AG\ | 129,612129,612 | $1M | 0.07% | ADD 5% |
| 92 | 92ALLIANCEBERNSTEIN L.P. | 145,251145,251 | $1M | 0.08% | — |
| 93 | 93Man Group plc | 112,843112,843 | $1M | 0.06% | ADD 30% |
| 94 | 94WELLS FARGO & COMPANY/MN | 109,952109,952 | $1M | 0.06% | TRIM -30% |
| 95 | 95Creative Planning | 101,349101,349 | $1M | 0.05% | ADD 18% |
| 96 | 96ICONIQ Capital, LLC | 94,69794,697 | $942,235 | 0.05% | — |
| 97 | 97Trexquant Investment LP | 94,24894,248 | $937,768 | 0.05% | TRIM -80% |
| 98 | 98HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 94,16994,169 | $936,982 | 0.05% | TRIM -10% |
| 99 | 99VANGUARD ASSET MANAGEMENT, Ltd | 82,30082,300 | $818,885 | 0.04% | NEW |
| 100 | 100Legal & General Group Plc | 82,05682,056 | $816,457 | 0.04% | TRIM -25% |
