| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,998,3334.0M | $17M | 9.90% | NEW† |
| 2 | ACORN CAPITAL ADVISORS, LLC | 2,839,6742.8M | $12M | 7.03% | — |
| 3 | StepStone Group LP | 2,660,6122.7M | $11M | 6.59% | ADD 441% |
| 4 | ADAR1 Capital Management, LLC | 2,434,9412.4M | $10M | 6.03% | ADD 140% |
| 5 | Prosight Management, LP | 2,154,3812.2M | $9M | 5.33% | ADD 164% |
| 6 | BVF INC/IL | 1,978,9722.0M | $8M | 4.90% | NEW† |
| 7 | Vivo Capital, LLC | 1,927,7101.9M | $8M | 4.77% | NEW† |
| 8 | Vestal Point Capital, LP | 1,839,8191.8M | $8M | 4.55% | ADD 190% |
| 9 | Foresite Capital Management VI LLC | 1,445,7831.4M | $6M | 3.58% | NEW† |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,204,8191.2M | $5M | 2.98% | NEW† |
| 11 | Sio Capital Management, LLC | 1,078,9651.1M | $4M | 2.67% | NEW† |
| 12 | VANGUARD CAPITAL MANAGEMENT LLC | 582,477582,477 | $2M | 1.44% | NEW |
| 13 | NEA Management Company, LLC | 478,548478,548 | $2M | 1.18% | — |
| 14 | Rosalind Advisors, Inc. | 443,763443,763 | $2M | 1.10% | TRIM -39% |
| 15 | RENAISSANCE TECHNOLOGIES LLC | 377,250377,250 | $2M | 0.93% | ADD 53% |
| 16 | Carlyle Group Inc. | 269,895269,895 | $1M | 0.67% | — |
| 17 | Affinity Asset Advisors, LLC | 240,963240,963 | $997,587 | 0.60% | NEW |
| 18 | Sofinnova Investments, Inc. | 141,700141,700 | $586,638 | 0.35% | NEW |
| 19 | Stonepine Capital Management, LLC | 132,578132,578 | $548,873 | 0.33% | NEW |
| 20 | Shay Capital LLC | 132,219132,219 | $547,387 | 0.33% | TRIM -83% |
| 21 | CANTOR FITZGERALD, L. P. | 99,90099,900 | $413,586 | 0.25% | TRIM -78% |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 98,75098,750 | $408,845 | 0.24% | ADD 27% |
| 23 | Rangeley Capital, LLC | 95,00095,000 | $393,300 | 0.24% | TRIM -34% |
| 24 | Aisling Capital Management LP | 88,60788,607 | $366,833 | 0.22% | — |
| 25 | BlackRock, Inc. | 49,58749,587 | $205,290 | 0.12% | TRIM -6% |
| 26 | VANGUARD FIDUCIARY TRUST CO | 43,37143,371 | $179,556 | 0.11% | NEW |
| 27 | Aldebaran Capital, LLC | 40,41940,419 | $167,335 | 0.10% | TRIM -2% |
| 28 | CITADEL ADVISORS LLC | 37,58737,587 | $155,610 | 0.09% | TRIM -83% |
| 29 | HRT FINANCIAL LP | 37,05537,055 | $153,000 | 0.09% | NEW |
| 30 | MARSHALL WACE, LLP | 36,44436,444 | $150,878 | 0.09% | NEW |
| 31 | XTX Topco Ltd | 34,12934,129 | $141,294 | 0.08% | ADD 92% |
| 32 | MILLENNIUM MANAGEMENT LLC | 30,49930,499 | $126,266 | 0.08% | NEW |
| 33 | JANE STREET GROUP, LLC | 26,81226,812 | $111,002 | 0.07% | ADD 38% |
| 34 | BARCLAYS PLC | 25,00025,000 | $103,500 | 0.06% | TRIM -8% |
| 35 | TWO SIGMA INVESTMENTS, LP | 24,26224,262 | $100,445 | 0.06% | ADD 114% |
| 36 | GSA CAPITAL PARTNERS LLP | 22,22422,224 | $92,000 | 0.06% | TRIM -52% |
| 37 | NORTHERN TRUST CORP | 19,90319,903 | $82,398 | 0.05% | — |
| 38 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,29316,293 | $67,453 | 0.04% | TRIM -16% |
| 39 | MORGAN STANLEY | 14,32714,327 | $59,314 | 0.04% | TRIM -43% |
| 40 | WELLS FARGO & COMPANY/MN | 13,50013,500 | $55,890 | 0.03% | ADD 23% |
| 41 | STATE STREET CORP | 13,46213,462 | $55,733 | 0.03% | NEW |
| 42 | NewEdge Advisors, LLC | 44,55144,551 | $44,551 | 0.11% | NEW |
| 43 | UBS Group AG | 3,3953,395 | $14,055 | 0.01% | ADD 181% |
| 44 | Vanguard Global Advisers, LLC | 745745 | $3,084 | 0.00% | NEW |
| 45 | BNP PARIBAS FINANCIAL MARKETS | 281281 | $1,163 | 0.00% | — |
| 46 | ROYAL BANK OF CANADA | 230230 | $1,000 | 0.00% | ADD 125% |
| 47 | TRUST CO OF TOLEDO NA /OH/ | 136136 | $563 | 0.00% | — |
| 48 | OSAIC HOLDINGS, INC. | 9090 | $372 | 0.00% | TRIM -17% |
| 49 | JPMORGAN CHASE & CO | 4545 | $171 | 0.00% | TRIM -92% |
| 50 | CITIGROUP INC | 11 | $4 | 0.00% | TRIM -100% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | — | — | 4.0M | $17M |
| ACORN CAPITAL ADVISORS, LLC | 1.4M | 1.4M | 2.8M | 2.8M | 2.8M | 2.8M | $12M |
| StepStone Group LP | 492K | 492K | 492K | 492K | 492K | 2.7M | $11M |
| ADAR1 Capital Management, LLC | — | 10K | 10K | — | 1.0M | 2.4M | $10M |
| Prosight Management, LP | 64K | 187K | 160K | 268K | 817K | 2.2M | $9M |
| BVF INC/IL | — | — | — | — | — | 2.0M | $8M |
| Vivo Capital, LLC | — | — | — | — | — | 1.9M | $8M |
| Vestal Point Capital, LP | 635K | 635K | 635K | 635K | 635K | 1.8M | $8M |
| Foresite Capital Management VI LLC | — | — | — | — | — | 1.4M | $6M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | — | — | 1.2M | $5M |
| Sio Capital Management, LLC | — | — | — | — | — | 1.1M | $4M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 582K | $2M |
| NEA Management Company, LLC | 479K | 479K | 479K | 479K | 479K | 479K | $2M |
| Rosalind Advisors, Inc. | — | — | — | — | 730K | 444K | $2M |
| RENAISSANCE TECHNOLOGIES LLC | 47K | 42K | 123K | 176K | 247K | 377K | $2M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 50 | 27,280,007 | 67.5% | $113M |
| 2025-Q4 | 43 | 11,075,514 | 27.4% | $32M |
| 2025-Q3 | 42 | 10,220,031 | 25.3% | $28M |
| 2025-Q2 | 49 | 10,779,359 | 26.7% | $26M |
| 2025-Q1 | 47 | 11,945,415 | 29.6% | $50M |
| 2024-Q4 | 51 | 11,839,496 | 29.3% | $99M |
| 2024-Q3 | 1 | 3,200 | 0.0% | $5,440 |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
