| 1 | 1DEERFIELD MANAGEMENT COMPANY, L.P. | 17,248,45017.2M | $1.8B | — | — |
| 2 | 2FMR LLC | 9,274,9599.3M | $950M | — | TRIM -15% |
| 3 | 3Paradigm Biocapital Advisors LP | 5,324,4335.3M | $545M | — | — |
| 4 | 4BlackRock, Inc. | 4,824,7854.8M | $494M | — | — |
| 5 | 5JPMORGAN CHASE & CO | 3,088,3493.1M | $299M | — | ADD 40% |
| 6 | 6RA CAPITAL MANAGEMENT, L.P. | 2,534,1452.5M | $260M | — | ADD 35% |
| 7 | 7VANGUARD PORTFOLIO MANAGEMENT LLC | 2,500,9072.5M | $256M | — | NEW |
| 8 | 8WELLINGTON MANAGEMENT GROUP LLP | 2,470,4912.5M | $253M | — | — |
| 9 | 9VANGUARD CAPITAL MANAGEMENT LLC | 2,428,4882.4M | $249M | — | NEW |
| 10 | 10PRICE T ROWE ASSOCIATES INC /MD/ | 2,056,1332.1M | $211M | — | TRIM -4% |
| 11 | 11STATE STREET CORP | 2,035,8312.0M | $209M | — | ADD 9% |
| 12 | 12Polar Capital Holdings Plc | 1,831,2531.8M | $188M | — | ADD 19% |
| 13 | 13PERCEPTIVE ADVISORS LLC | 1,580,5051.6M | $162M | — | TRIM -5% |
| 14 | 14T. Rowe Price Investment Management, Inc. | 1,413,6371.4M | $145M | — | TRIM -16% |
| 15 | 15Deep Track Capital, LP | 1,376,3241.4M | $141M | — | NEW |
| 16 | 16GEODE CAPITAL MANAGEMENT, LLC | 1,298,1071.3M | $133M | — | ADD 5% |
| 17 | 17JANUS HENDERSON GROUP PLC | 1,237,7791.2M | $127M | — | TRIM -17% |
| 18 | 18Bellevue Group AG | 1,053,2681.1M | $108M | — | — |
| 19 | 19Commodore Capital LP | 833,600833,600 | $85M | — | ADD 52% |
| 20 | 20ALLIANCEBERNSTEIN L.P. | 784,023784,023 | $79M | — | — |
| 21 | 21ADAGE CAPITAL PARTNERS GP, L.L.C. | 748,896748,896 | $77M | — | ADD 16% |
| 22 | 22BRAIDWELL LP | 700,429700,429 | $72M | — | TRIM -15% |
| 23 | 23Woodline Partners LP | 610,459610,459 | $63M | — | — |
| 24 | 24AMERIPRISE FINANCIAL INC | 563,768563,768 | $58M | — | — |
| 25 | 25GOLDMAN SACHS GROUP INC | 537,158537,158 | $55M | — | TRIM -10% |
| 26 | 26Vestal Point Capital, LP | 481,715481,715 | $49M | — | ADD 947% |
| 27 | 27Driehaus Capital Management LLC | 481,180481,180 | $49M | — | — |
| 28 | 28Hood River Capital Management LLC | 479,998479,998 | $49M | — | — |
| 29 | 29CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 450,801450,801 | $46M | — | — |
| 30 | 30FRANKLIN RESOURCES INC | 434,742434,742 | $45M | — | ADD 6% |
| 31 | 31AMERICAN CENTURY COMPANIES INC | 431,067431,067 | $44M | — | ADD 15% |
| 32 | 32NORTHERN TRUST CORP | 429,373429,373 | $44M | — | ADD 5% |
| 33 | 33Pictet Asset Management Holding SA | 410,485410,485 | $42M | — | ADD 15% |
| 34 | 34Invesco Ltd. | 408,285408,285 | $42M | — | TRIM -7% |
| 35 | 35FRONTIER CAPITAL MANAGEMENT CO LLC | 395,546395,546 | $41M | — | ADD 46% |
| 36 | 36Candriam S.C.A. | 391,306391,306 | $40M | — | ADD 9% |
| 37 | 37First Turn Management, LLC | 370,344370,344 | $38M | — | — |
| 38 | 38VANGUARD FIDUCIARY TRUST CO | 364,167364,167 | $37M | — | NEW |
| 39 | 39UBS Group AG | 363,098363,098 | $37M | — | TRIM -9% |
| 40 | 40SILVERARC CAPITAL MANAGEMENT, LLC | 354,914354,914 | $36M | — | ADD 14% |
| 41 | 41Tri Locum Partners LP | 308,506308,506 | $32M | — | — |
| 42 | 42Jones Hill Capital LP | 300,830300,830 | $31M | — | NEW |
| 43 | 43Affinity Asset Advisors, LLC | 300,000300,000 | $31M | — | TRIM -7% |
| 44 | 44BANK OF AMERICA CORP /DE/ | 216,516216,516 | $22M | — | ADD 20% |
| 45 | 45MORGAN STANLEY | 200,790200,790 | $21M | — | TRIM -25% |
| 46 | 46LORD, ABBETT & CO. LLC | 199,878199,878 | $20M | — | TRIM -29% |
| 47 | 47ArrowMark Colorado Holdings LLC | 186,850186,850 | $19M | — | TRIM -37% |
| 48 | 48VOYA INVESTMENT MANAGEMENT LLC | 178,438178,438 | $18M | — | ADD 3% |
| 49 | 49CITADEL ADVISORS LLC | 166,773166,773 | $17M | — | TRIM -15% |
| 50 | 50Bank of New York Mellon Corp | 161,509161,509 | $17M | — | — |
| 51 | 51Nicholas Investment Partners, LP | 159,721159,721 | $16M | — | — |
| 52 | 52BNP PARIBAS FINANCIAL MARKETS | 140,592140,592 | $14M | — | TRIM -19% |
| 53 | 53TD Asset Management Inc | 137,764137,764 | $14M | — | TRIM -10% |
| 54 | 54RAYMOND JAMES FINANCIAL INC | 145,288145,288 | $14M | — | TRIM -4% |
| 55 | 55Defilade Capital Management, L.P. | 129,950129,950 | $13M | — | TRIM -52% |
| 56 | 56Aberdeen Group plc | 123,577123,577 | $13M | — | TRIM -25% |
| 57 | 57UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,187122,187 | $13M | — | — |
| 58 | 58Nuveen, LLC | 109,820109,820 | $11M | — | ADD 2% |
| 59 | 59Squarepoint Ops LLC | 104,801104,801 | $11M | — | ADD 70% |
| 60 | 60Ensign Peak Advisors, Inc | 102,312102,312 | $10M | — | ADD 89% |
| 61 | 61TWO SIGMA INVESTMENTS, LP | 102,118102,118 | $10M | — | NEW |
| 62 | 62Fisher Asset Management, LLC | 97,51897,518 | $10M | — | TRIM -3% |
| 63 | 63Russell Investments Group, Ltd. | 92,50292,502 | $9M | — | — |
| 64 | 64RENAISSANCE TECHNOLOGIES LLC | 89,00089,000 | $9M | — | NEW |
| 65 | 65Parkman Healthcare Partners LLC | 88,07888,078 | $9M | — | TRIM -26% |
| 66 | 66DEUTSCHE BANK AG\ | 87,74687,746 | $9M | — | ADD 6% |
| 67 | 67FRED ALGER MANAGEMENT, LLC | 81,86781,867 | $8M | — | TRIM -11% |
| 68 | 68BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 81,77581,775 | $8M | — | ADD 34% |
| 69 | 69Rhenman & Partners Asset Management AB | 81,20081,200 | $8M | — | TRIM -50% |
| 70 | 70Swiss National Bank | 78,90078,900 | $8M | — | — |
| 71 | 71JANE STREET GROUP, LLC | 77,13877,138 | $8M | — | NEW |
| 72 | 72MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,29571,295 | $7M | — | TRIM -9% |
| 73 | 73Burkehill Global Management, LP | 70,00070,000 | $7M | — | — |
| 74 | 74NEUBERGER BERMAN GROUP LLC | 64,59964,599 | $7M | — | NEW |
| 75 | 75RHUMBLINE ADVISERS | 63,86763,867 | $7M | — | — |
| 76 | 76ExodusPoint Capital Management, LP | 63,72063,720 | $7M | — | NEW |
| 77 | 77HighVista Strategies LLC | 56,60256,602 | $6M | — | TRIM -23% |
| 78 | 78Tidal Investments LLC | 53,41553,415 | $5M | — | NEW |
| 79 | 79Tema ETFs LLC | 53,41553,415 | $5M | — | ADD 47% |
| 80 | 80XTX Topco Ltd | 53,35453,354 | $5M | — | ADD 244% |
| 81 | 81Connor, Clark & Lunn Investment Management Ltd. | 50,02650,026 | $5M | — | ADD 18% |
| 82 | 82CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,67049,670 | $5M | — | ADD 30% |
| 83 | 83FIRST TRUST ADVISORS LP | 47,61747,617 | $5M | — | ADD 115% |
| 84 | 84Universal- Beteiligungs- und Servicegesellschaft mbH | 46,38246,382 | $5M | — | — |
| 85 | 85Rafferty Asset Management, LLC | 45,08345,083 | $5M | — | — |
| 86 | 86Granahan Investment Management, LLC | 43,00343,003 | $4M | — | ADD 7% |
| 87 | 87Walleye Capital LLC | 41,87341,873 | $4M | — | ADD 426% |
| 88 | 88VANGUARD ASSET MANAGEMENT, Ltd | 39,24939,249 | $4M | — | NEW |
| 89 | 89Creative Planning | 38,42038,420 | $4M | — | ADD 28% |
| 90 | 90CITIGROUP INC | 36,68836,688 | $4M | — | ADD 2% |
| 91 | 91Legal & General Group Plc | 34,48234,482 | $4M | — | TRIM -17% |
| 92 | 92NEW YORK STATE COMMON RETIREMENT FUND | 33,46033,460 | $3M | — | ADD 3% |
| 93 | 93MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,93132,931 | $3M | — | — |
| 94 | 94BARCLAYS PLC | 30,84430,844 | $3M | — | TRIM -75% |
| 95 | 95SEI INVESTMENTS CO | 29,54029,540 | $3M | — | ADD 28% |
| 96 | 96Hudson Bay Capital Management LP | 28,48028,480 | $3M | — | NEW |
| 97 | 97SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,65327,653 | $3M | — | ADD 108% |
| 98 | 98MetLife Investment Management, LLC | 27,39727,397 | $3M | — | — |
| 99 | 99AQR CAPITAL MANAGEMENT LLC | 26,83126,831 | $3M | — | ADD 5% |
| 100 | 100WELLS FARGO & COMPANY/MN | 26,31026,310 | $3M | — | TRIM -58% |
