| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 4,303,1884.3M | $310M | 15.00% | ADD 4155% |
| 2 | BVF INC/IL | 2,559,5952.6M | $184M | 8.92% | ADD 64% |
| 3 | Two Seas Capital LP | 1,959,1782.0M | $141M | 6.83% | ADD 163% |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 1,197,0551.2M | $86M | 4.17% | NEW† |
| 5 | TWO SIGMA INVESTMENTS, LP | 930,741930,741 | $67M | 3.24% | ADD 97% |
| 6 | Prosight Management, LP | 735,000735,000 | $53M | 2.56% | ADD 33% |
| 7 | BlackRock, Inc. | 692,650692,650 | $50M | 2.41% | ADD 7% |
| 8 | MORGAN STANLEY | 659,387659,387 | $47M | 2.30% | ADD 16% |
| 9 | ARMISTICE CAPITAL, LLC | 578,000578,000 | $42M | 2.01% | TRIM -3% |
| 10 | Invesco Ltd. | 567,458567,458 | $41M | 1.98% | ADD 21% |
| 11 | CITADEL ADVISORS LLC | 513,531513,531 | $37M | 1.79% | ADD 66% |
| 12 | Sofinnova Investments, Inc. | 509,546509,546 | $37M | 1.78% | ADD 16% |
| 13 | Woodline Partners LP | 415,335415,335 | $30M | 1.45% | ADD 299% |
| 14 | LORD, ABBETT & CO. LLC | 405,080405,080 | $29M | 1.41% | NEW |
| 15 | MILLENNIUM MANAGEMENT LLC | 404,277404,277 | $29M | 1.41% | TRIM -11% |
| 16 | EMERALD ADVISERS, LLC | 394,604394,604 | $28M | 1.38% | ADD 3% |
| 17 | Qube Research & Technologies Ltd | 390,675390,675 | $28M | 1.36% | ADD 21% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 346,795346,795 | $25M | 1.21% | ADD 36% |
| 19 | UBS Group AG | 320,172320,172 | $23M | 1.12% | ADD 11% |
| 20 | GREAT POINT PARTNERS LLC | 316,453316,453 | $23M | 1.10% | ADD 50% |
| 21 | Vestal Point Capital, LP | 285,000285,000 | $21M | 0.99% | NEW |
| 22 | 22NW, LP | 281,115281,115 | $20M | 0.98% | TRIM -15% |
| 23 | PRIMECAP MANAGEMENT CO/CA/ | 279,150279,150 | $20M | 0.97% | — |
| 24 | ORBIMED ADVISORS LLC | 275,000275,000 | $20M | 0.96% | NEW |
| 25 | GILDER GAGNON HOWE & CO LLC | 271,758271,758 | $20M | 0.95% | ADD 30% |
| 26 | Nearwater Capital Markets, Ltd | 261,500261,500 | $19M | 0.91% | ADD 325% |
| 27 | EMERALD MUTUAL FUND ADVISERS TRUST | 256,106256,106 | $18M | 0.89% | — |
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249,090249,090 | $18M | 0.87% | TRIM -35% |
| 29 | STATE STREET CORP | 244,727244,727 | $18M | 0.85% | ADD 25% |
| 30 | BRAIDWELL LP | 222,701222,701 | $16M | 0.78% | NEW |
| 31 | JPMORGAN CHASE & CO | 240,102240,102 | $16M | 0.84% | ADD 59% |
| 32 | Patient Square Capital LP | 210,000210,000 | $15M | 0.73% | NEW |
| 33 | Bronte Capital Management Pty Ltd. | 198,256198,256 | $14M | 0.69% | NEW |
| 34 | Quinn Opportunity Partners LLC | 179,247179,247 | $13M | 0.62% | ADD 109% |
| 35 | VANGUARD FIDUCIARY TRUST CO | 169,308169,308 | $12M | 0.59% | NEW |
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 168,007168,007 | $12M | 0.59% | ADD 40% |
| 37 | DAFNA Capital Management LLC | 165,178165,178 | $12M | 0.58% | ADD 120% |
| 38 | ADAR1 Capital Management, LLC | 161,252161,252 | $12M | 0.56% | ADD 124% |
| 39 | MARSHALL WACE, LLP | 140,588140,588 | $10M | 0.49% | ADD 485% |
| 40 | AMERIPRISE FINANCIAL INC | 136,730136,730 | $10M | 0.48% | NEW |
| 41 | GOLDMAN SACHS GROUP INC | 126,942126,942 | $9M | 0.44% | TRIM -14% |
| 42 | Creek Drive Management Group LLC | 126,400126,400 | $9M | 0.44% | TRIM -32% |
| 43 | SEVEN GRAND MANAGERS, LLC | 125,000125,000 | $9M | 0.44% | NEW |
| 44 | Squadron Capital Management LLC | 125,000125,000 | $9M | 0.44% | NEW |
| 45 | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 122,326122,326 | $9M | 0.43% | TRIM -35% |
| 46 | BNP PARIBAS FINANCIAL MARKETS | 121,539121,539 | $9M | 0.42% | TRIM -42% |
| 47 | JANE STREET GROUP, LLC | 112,652112,652 | $8M | 0.39% | TRIM -48% |
| 48 | Squarepoint Ops LLC | 107,385107,385 | $8M | 0.37% | ADD 430% |
| 49 | Russell Investments Group, Ltd. | 106,248106,248 | $8M | 0.37% | ADD 24% |
| 50 | Tetragon Partners GP Ltd | 103,037103,037 | $7M | 0.36% | ADD 49% |
| 51 | ING GROEP NV | 100,000100,000 | $7M | 0.35% | — |
| 52 | Monashee Investment Management LLC | 100,000100,000 | $7M | 0.35% | ADD 6% |
| 53 | Connor, Clark & Lunn Investment Management Ltd. | 98,74598,745 | $7M | 0.34% | TRIM -2% |
| 54 | DEUTSCHE BANK AG\ | 91,67191,671 | $7M | 0.32% | — |
| 55 | Moody Aldrich Partners LLC | 89,52789,527 | $6M | 0.31% | ADD 60% |
| 56 | Stonepine Capital Management, LLC | 85,00085,000 | $6M | 0.30% | — |
| 57 | NORTHERN TRUST CORP | 78,59878,598 | $6M | 0.27% | ADD 40% |
| 58 | Jump Financial, LLC | 77,40277,402 | $6M | 0.27% | ADD 45% |
| 59 | VANGUARD PORTFOLIO MANAGEMENT LLC | 72,49172,491 | $5M | 0.25% | NEW |
| 60 | ACT CAPITAL MANAGEMENT, LLC | 70,90070,900 | $5M | 0.25% | ADD 38% |
| 61 | HRT FINANCIAL LP | 70,66770,667 | $5M | 0.25% | TRIM -59% |
| 62 | Voleon Capital Management LP | 65,06365,063 | $5M | 0.23% | TRIM -5% |
| 63 | F/m Investments LLC | 61,10461,104 | $4M | 0.21% | ADD 5% |
| 64 | Rhenman & Partners Asset Management AB | 59,00059,000 | $4M | 0.21% | NEW |
| 65 | BANK OF AMERICA CORP /DE/ | 58,95858,958 | $4M | 0.21% | ADD 126% |
| 66 | Aquatic Capital Management LLC | 57,01457,014 | $4M | 0.20% | ADD 3% |
| 67 | Cambridge Investment Research Advisors, Inc. | 56,05556,055 | $4M | 0.20% | ADD 4% |
| 68 | Trexquant Investment LP | 55,47655,476 | $4M | 0.19% | ADD 195% |
| 69 | FRED ALGER MANAGEMENT, LLC | 53,17253,172 | $4M | 0.19% | — |
| 70 | Alyeska Investment Group, L.P. | 50,00050,000 | $4M | 0.17% | NEW |
| 71 | Brevan Howard Capital Management LP | 48,47448,474 | $3M | 0.17% | NEW |
| 72 | LMR Partners LLP | 48,29448,294 | $3M | 0.17% | NEW |
| 73 | Swiss National Bank | 47,90047,900 | $3M | 0.17% | ADD 50% |
| 74 | Atom Investors LP | 43,22743,227 | $3M | 0.15% | NEW |
| 75 | SummitTX Capital, L.P. | 42,62442,624 | $3M | 0.15% | ADD 36% |
| 76 | RENAISSANCE TECHNOLOGIES LLC | 41,78141,781 | $3M | 0.15% | TRIM -76% |
| 77 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36,90736,907 | $3M | 0.13% | TRIM -39% |
| 78 | Jain Global LLC | 36,18136,181 | $3M | 0.13% | ADD 109% |
| 79 | Informed Momentum Co LLC | 36,12636,126 | $3M | 0.13% | ADD 178% |
| 80 | Balyasny Asset Management L.P. | 35,85135,851 | $3M | 0.12% | TRIM -87% |
| 81 | ALGERT GLOBAL LLC | 34,78234,782 | $3M | 0.12% | ADD 127% |
| 82 | Susquehanna Portfolio Strategies, LLC | 34,52734,527 | $2M | 0.12% | ADD 115% |
| 83 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,02534,025 | $2M | 0.12% | ADD 110% |
| 84 | BARCLAYS PLC | 32,35632,356 | $2M | 0.11% | ADD 110% |
| 85 | IRIDIAN ASSET MANAGEMENT LLC/CT | 31,32031,320 | $2M | 0.11% | ADD 222% |
| 86 | Birchview Capital, LP | 31,00031,000 | $2M | 0.11% | — |
| 87 | JACOBS LEVY EQUITY MANAGEMENT, INC | 30,14130,141 | $2M | 0.11% | ADD 107% |
| 88 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,68228,682 | $2M | 0.10% | ADD 98% |
| 89 | Headlands Technologies LLC | 28,24428,244 | $2M | 0.10% | TRIM -31% |
| 90 | KVP Capital Advisors, LP | 26,90026,900 | $2M | 0.09% | — |
| 91 | Y-Intercept (Hong Kong) Ltd | 26,54526,545 | $2M | 0.09% | ADD 144% |
| 92 | Erste Asset Management GmbH | 28,00028,000 | $2M | 0.10% | — |
| 93 | CITIGROUP INC | 25,04825,048 | $2M | 0.09% | TRIM -30% |
| 94 | GSA CAPITAL PARTNERS LLP | 21,33121,331 | $2M | 0.07% | TRIM -8% |
| 95 | BIT Capital GmbH | 21,10021,100 | $2M | 0.07% | — |
| 96 | ExodusPoint Capital Management, LP | 20,45720,457 | $1M | 0.07% | NEW |
| 97 | AWM Investment Company, Inc. | 20,00020,000 | $1M | 0.07% | TRIM -50% |
| 98 | Man Group plc | 19,44619,446 | $1M | 0.07% | NEW |
| 99 | Deuterium Capital Management, LLC | 18,00018,000 | $1M | 0.06% | TRIM -52% |
| 100 | WINTON GROUP Ltd | 16,91016,910 | $1M | 0.06% | ADD 118% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 514K | 234K | 15K | 40K | 101K | 4.3M | $310M |
| BVF INC/IL | — | — | — | 1.3M | 1.6M | 2.6M | $184M |
| Two Seas Capital LP | — | — | — | — | 745K | 2.0M | $141M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $86M |
| TWO SIGMA INVESTMENTS, LP | 1.5M | 1.4M | 79K | 434K | 473K | 931K | $67M |
| Prosight Management, LP | — | — | — | — | 555K | 735K | $53M |
| BlackRock, Inc. | 16.1M | 15.7M | 415K | 609K | 646K | 693K | $50M |
| MORGAN STANLEY | 802K | 584K | 72K | 929K | 566K | 659K | $47M |
| ARMISTICE CAPITAL, LLC | 1.0M | 1.0M | 124K | 268K | 596K | 578K | $42M |
| Invesco Ltd. | 656K | 623K | 32K | 227K | 468K | 567K | $41M |
| CITADEL ADVISORS LLC | 397K | 491K | — | 361K | 310K | 514K | $37M |
| Sofinnova Investments, Inc. | — | — | — | 118K | 439K | 510K | $37M |
| Woodline Partners LP | 5.0M | 3.7M | 246K | 233K | 104K | 415K | $30M |
| LORD, ABBETT & CO. LLC | — | — | — | — | — | 405K | $29M |
| MILLENNIUM MANAGEMENT LLC | 4.5M | 2.3M | 649K | 546K | 454K | 404K | $29M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| BlackRock, Inc. | 7.8% | QII | 2026-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| FMR LLC | +4,202,059 | $302M | ADD |
| Two Seas Capital LP | +1,213,993 | $87M | ADD |
| VANGUARD CAPITAL MANAGEMENT LLC | +1,197,055 | $86M | OPEN |
| BVF INC/IL | +1,000,000 | $72M | ADD |
| TWO SIGMA INVESTMENTS, LP | +457,727 | $33M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,027,089 | $74M | CLOSE |
| Point72 Asset Management, L.P. | −420,055 | $30M | TRIM |
| TWO SIGMA ADVISERS, LP | −308,414 | $22M | CLOSE |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | −295,716 | $21M | CLOSE |
| Balyasny Asset Management L.P. | −246,170 | $18M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 216 | 26,700,241 | 93.1% | $1.9B |
| 2025-Q4 | 181 | 17,318,225 | 85.1% | $732M |
| 2025-Q3 | 154 | 14,413,112 | 75.8% | $820M |
| 2025-Q2 | 110 | 7,672,692 | 61.5% | $198M |
| 2025-Q1 | 157 | 124,066,895 | 66.7% | $84M |
| 2024-Q4 | 146 | 133,827,222 | 72.6% | $124M |
| 2024-Q3 | 139 | 141,642,340 | 76.9% | $184M |
| 2024-Q2 | 134 | 139,837,603 | 76.2% | $173M |
| 2024-Q1 | 122 | 113,299,471 | 61.7% | $106M |
| 2023-Q4 | 126 | 119,743,467 | 62.8% | $68M |
| 2023-Q3 | 138 | 143,210,519 | 75.3% | $85M |
| 2023-Q2 | 147 | 137,829,963 | 72.8% | $79M |
| 2023-Q1 | 195 | 173,215,551 | 91.5% | $122M |
| 2022-Q4 | 215 | 168,906,210 | 89.9% | $376M |
| 2022-Q3 | 230 | 175,719,661 | 93.8% | $563M |
| 2022-Q2 | 228 | 182,861,076 | 98.2% | $695M |
| 2022-Q1 | 241 | 175,832,248 | 94.4% | $951M |
| 2021-Q4 | 240 | 174,306,342 | 94.4% | $2.4B |
| 2021-Q3 | 241 | 167,564,328 | 91.2% | $3.0B |
| 2021-Q2 | 241 | 168,077,889 | 92.2% | $2.9B |
| 2021-Q1 | 237 | 169,754,293 | 93.2% | $3.4B |
| 2020-Q4 | 249 | 172,541,326 | 96.2% | $2.9B |
| 2020-Q3 | 249 | 173,269,177 | 96.9% | $2.9B |
| 2020-Q2 | 261 | 175,099,658 | 98.4% | $4.1B |
| 2020-Q1 | 247 | 177,259,446 | 99.8% | $3.2B |
| 2019-Q4 | 283 | 177,994,786 | 101.2% | $3.8B |
| 2019-Q3 | 289 | 178,295,614 | 101.7% | $3.2B |
| 2019-Q2 | 341 | 167,629,644 | 96.2% | $6.0B |
| 2019-Q1 | 355 | 163,214,975 | 93.7% | $5.5B |
| 2018-Q4 | 346 | 167,318,495 | 96.7% | $5.5B |
| 2018-Q3 | 389 | 160,978,118 | 93.3% | $9.8B |
| 2018-Q2 | 381 | 160,904,517 | 93.9% | $7.9B |
| 2018-Q1 | 361 | 157,117,779 | 97.6% | $16.7B |
| 2017-Q4 | 267 | 154,875,499 | 98.4% | $9.3B |
| 2017-Q3 | 203 | 153,912,097 | 98.5% | $3.7B |
| 2017-Q2 | 197 | 151,352,230 | 97.6% | $3.0B |
| 2017-Q1 | 201 | 147,241,930 | 95.7% | $3.5B |
| 2016-Q4 | 199 | 146,200,805 | 95.7% | $1.8B |
| 2016-Q3 | 194 | 133,565,472 | 97.7% | $2.3B |
| 2016-Q2 | 177 | 134,680,023 | 98.8% | $1.9B |
| 2016-Q1 | 176 | 139,139,243 | 102.4% | $1.9B |
| 2015-Q4 | 179 | 165,659,117 | — | $2.8B |
| 2015-Q3 | 167 | 144,560,631 | 109.2% | $1.6B |
| 2015-Q2 | 181 | 138,194,719 | 105.1% | $1.7B |
| 2015-Q1 | 153 | 126,317,196 | 96.1% | $1.4B |
| 2014-Q4 | 163 | 120,120,767 | 93.5% | $1.9B |
| 2014-Q3 | 145 | 118,419,376 | 93.0% | $1.4B |
| 2014-Q2 | 144 | 118,716,277 | 93.5% | $1.5B |
| 2014-Q1 | 138 | 115,845,123 | 91.5% | $1.4B |
| 2013-Q4 | 137 | 103,901,333 | 89.5% | $1.2B |
| 2013-Q3 | 142 | 103,346,153 | 89.3% | $1.1B |
| 2013-Q2 | 139 | 103,643,249 | 89.7% | $1.2B |
| 2013-Q1 | 9 | 46,779,277 | 40.6% | $515M |
