| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | NOVO HOLDINGS A/S | 3,686,6223.7M | $75M | 8.69% | — |
| 2 | FCPM III SERVICES B.V. | 3,226,4003.2M | $66M | 7.60% | — |
| 3 | T. Rowe Price Investment Management, Inc. | 2,801,9372.8M | $57M | 6.60% | TRIM -50% |
| 4 | GOLDMAN SACHS GROUP INC | 1,994,8732.0M | $41M | 4.70% | ADD 3% |
| 5 | BlackRock, Inc. | 1,339,7311.3M | $27M | 3.16% | ADD 22% |
| 6 | Blue Owl Capital Holdings LP | 1,005,9291.0M | $20M | 2.37% | ADD 208% |
| 7 | Nan Fung Group Holdings Ltd | 971,253971,253 | $20M | 2.29% | — |
| 8 | 5AM Venture Management, LLC | 950,011950,011 | $19M | 2.24% | — |
| 9 | Sanofi | 912,041912,041 | $19M | 2.15% | — |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 719,820719,820 | $15M | 1.70% | NEW |
| 11 | Pivotal bioVenture Partners Investment Advisor LLC | 611,447611,447 | $12M | 1.44% | — |
| 12 | Velan Capital Investment Management LP | 492,893492,893 | $10M | 1.16% | TRIM -6% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 481,201481,201 | $10M | 1.13% | ADD 24% |
| 14 | Siren, L.L.C. | 450,000450,000 | $9M | 1.06% | — |
| 15 | Vestal Point Capital, LP | 420,000420,000 | $9M | 0.99% | ADD 9% |
| 16 | ADAR1 Capital Management, LLC | 374,909374,909 | $8M | 0.88% | NEW |
| 17 | BAKER BROS. ADVISORS LP | 364,705364,705 | $7M | 0.86% | — |
| 18 | STATE STREET CORP | 339,116339,116 | $7M | 0.80% | ADD 48% |
| 19 | Freestone Grove Partners LP | 313,957313,957 | $6M | 0.74% | ADD 71% |
| 20 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 267,746267,746 | $5M | 0.63% | ADD 81% |
| 21 | RA CAPITAL MANAGEMENT, L.P. | 248,294248,294 | $5M | 0.59% | NEW |
| 22 | UBS Group AG | 236,512236,512 | $5M | 0.56% | ADD 1193% |
| 23 | FMR LLC | 204,501204,501 | $4M | 0.48% | ADD 22522% |
| 24 | STEMPOINT CAPITAL LP | 200,000200,000 | $4M | 0.47% | ADD 100% |
| 25 | Board of Trustees of The Leland Stanford Junior University | 199,231199,231 | $4M | 0.47% | — |
| 26 | SUPERSTRING CAPITAL MANAGEMENT LP | 192,139192,139 | $4M | 0.45% | NEW |
| 27 | DAFNA Capital Management LLC | 171,006171,006 | $3M | 0.40% | ADD 19% |
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,146161,146 | $3M | 0.38% | ADD 16% |
| 29 | NORTHERN TRUST CORP | 146,172146,172 | $3M | 0.34% | ADD 22% |
| 30 | LAZARD ASSET MANAGEMENT LLC | 142,016142,016 | $3M | 0.33% | TRIM -32% |
| 31 | VANGUARD FIDUCIARY TRUST CO | 131,231131,231 | $3M | 0.31% | NEW |
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 112,708112,708 | $2M | 0.27% | NEW |
| 33 | VANGUARD PORTFOLIO MANAGEMENT LLC | 112,604112,604 | $2M | 0.27% | NEW |
| 34 | Tetragon Partners GP Ltd | 112,115112,115 | $2M | 0.26% | TRIM -32% |
| 35 | SEVEN GRAND MANAGERS, LLC | 100,000100,000 | $2M | 0.24% | — |
| 36 | Burkehill Global Management, LP | 75,00075,000 | $2M | 0.18% | — |
| 37 | JANUS HENDERSON GROUP PLC | 54,75254,752 | $1M | 0.13% | NEW |
| 38 | TD Asset Management Inc | 47,76847,768 | $971,123 | 0.11% | ADD 29% |
| 39 | WELLINGTON MANAGEMENT GROUP LLP | 46,20846,208 | $939,409 | 0.11% | NEW |
| 40 | Bank of New York Mellon Corp | 39,46539,465 | $802,323 | 0.09% | ADD 10% |
| 41 | BNP PARIBAS FINANCIAL MARKETS | 37,30137,301 | $758,329 | 0.09% | ADD 980% |
| 42 | TUDOR INVESTMENT CORP ET AL | 36,74036,740 | $746,924 | 0.09% | TRIM -23% |
| 43 | MORGAN STANLEY | 30,50530,505 | $620,167 | 0.07% | ADD 31% |
| 44 | Nuveen, LLC | 23,08923,089 | $469,399 | 0.05% | ADD 14% |
| 45 | RHUMBLINE ADVISERS | 20,36820,368 | $414,074 | 0.05% | ADD 49% |
| 46 | Ghisallo Capital Management LLC | 20,00020,000 | $406,600 | 0.05% | — |
| 47 | BANK OF AMERICA CORP /DE/ | 18,86918,869 | $383,607 | 0.04% | TRIM -50% |
| 48 | MARKET STREET WEALTH MANAGEMENT ADVISORS LLC | 14,12414,124 | $287,141 | 0.03% | NEW |
| 49 | TWO SIGMA INVESTMENTS, LP | 14,09814,098 | $286,612 | 0.03% | NEW |
| 50 | DEUTSCHE BANK AG\ | 13,67913,679 | $278,094 | 0.03% | ADD 15% |
| 51 | Invesco Ltd. | 12,25212,252 | $249,083 | 0.03% | TRIM -6% |
| 52 | Walleye Capital LLC | 11,57211,572 | $235,259 | 0.03% | — |
| 53 | XTX Topco Ltd | 10,26110,261 | $208,606 | 0.02% | NEW |
| 54 | LMR Partners LLP | 10,00010,000 | $203,300 | 0.02% | — |
| 55 | MetLife Investment Management, LLC | 9,7989,798 | $199,193 | 0.02% | — |
| 56 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,0619,061 | $184,210 | 0.02% | ADD 16% |
| 57 | Vanguard Global Advisers, LLC | 8,4288,428 | $171,341 | 0.02% | NEW |
| 58 | JPMORGAN CHASE & CO | 7,8697,869 | $147,229 | 0.02% | ADD 17% |
| 59 | WELLS FARGO & COMPANY/MN | 7,1637,163 | $145,624 | 0.02% | TRIM -62% |
| 60 | BARCLAYS PLC | 5,7895,789 | $117,690 | 0.01% | TRIM -78% |
| 61 | NEW YORK STATE COMMON RETIREMENT FUND | 5,3005,300 | $107,749 | 0.01% | — |
| 62 | Police & Firemen's Retirement System of New Jersey | 3,9863,986 | $81,035 | 0.01% | — |
| 63 | STRS OHIO | 3,0003,000 | $60,990 | 0.01% | — |
| 64 | Tower Research Capital LLC (TRC) | 1,9281,928 | $39,196 | 0.00% | TRIM -33% |
| 65 | Legal & General Group Plc | 1,8051,805 | $36,696 | 0.00% | ADD 9% |
| 66 | Ameritas Investment Partners, Inc. | 1,3711,371 | $27,872 | 0.00% | — |
| 67 | Russell Investments Group, Ltd. | 1,3371,337 | $27,181 | 0.00% | — |
| 68 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,0621,062 | $21,590 | 0.00% | ADD 2% |
| 69 | CITIGROUP INC | 960960 | $19,516 | 0.00% | ADD 151% |
| 70 | SBI Securities Co., Ltd. | 557557 | $11,324 | 0.00% | TRIM -8% |
| 71 | Sterling Capital Management LLC | 370370 | $7,522 | 0.00% | TRIM -29% |
| 72 | Farther Finance Advisors, LLC | 120120 | $2,500 | 0.00% | — |
| 73 | GAMMA Investing LLC | 9494 | $1,911 | 0.00% | NEW |
| 74 | CWM, LLC | 5757 | $1,159 | 0.00% | NEW |
| 75 | Versant Capital Management, Inc | 5050 | $1,017 | 0.00% | NEW |
| 76 | Root Financial Partners, LLC | 2828 | $569 | 0.00% | NEW |
| 77 | MAI Capital Management | 1212 | $244 | 0.00% | NEW |
| 78 | Allworth Financial LP | 66 | $122 | 0.00% | NEW |
| 79 | EverSource Wealth Advisors, LLC | 66 | $122 | 0.00% | NEW |
| 80 | True Wealth Design, LLC | 33 | $61 | 0.00% | NEW |
| 81 | Arax Advisory Partners | 55 | $20 | 0.00% | NEW |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| NOVO HOLDINGS A/S | — | — | — | — | 3.7M | 3.7M | $75M |
| FCPM III SERVICES B.V. | — | — | — | — | 3.2M | 3.2M | $66M |
| T. Rowe Price Investment Management, Inc. | — | — | — | — | 5.6M | 2.8M | $57M |
| GOLDMAN SACHS GROUP INC | — | — | — | — | 1.9M | 2.0M | $41M |
| BlackRock, Inc. | — | — | — | — | 1.1M | 1.3M | $27M |
| Blue Owl Capital Holdings LP | — | — | — | — | 327K | 1.0M | $20M |
| Nan Fung Group Holdings Ltd | — | — | — | — | 971K | 971K | $20M |
| 5AM Venture Management, LLC | — | — | — | — | 950K | 950K | $19M |
| Sanofi | — | — | — | — | 912K | 912K | $19M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 720K | $15M |
| Pivotal bioVenture Partners Investment Advisor LLC | — | — | — | — | 611K | 611K | $12M |
| Velan Capital Investment Management LP | — | — | — | — | 522K | 493K | $10M |
| GEODE CAPITAL MANAGEMENT, LLC | — | — | — | — | 389K | 481K | $10M |
| Siren, L.L.C. | — | — | — | — | 450K | 450K | $9M |
| Vestal Point Capital, LP | — | — | — | — | 385K | 420K | $9M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 81 | 24,800,482 | 58.4% | $504M |
| 2025-Q4 | 74 | 25,864,891 | 60.9% | $454M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Catalyst has acquired the Issuer's common stock owned by it for investment purposes. Subject to the factors discussed below, Catalyst may purchase additional shares of the Issuer's common stock, or rights to purchase shares of the Issuer's common stock, through open market or privately negotiated transactions, or otherwise, depending upon existing market conditions, the price and availability of such shares or rights and other considerations discussed in this paragraph. Catalyst intends to revie”
“Novo Holdings A/S purchased the aforementioned securities for investment purposes with the aim of increasing the value of its investments and the Issuer. Subject to applicable legal requirements, Novo Holdings A/S may purchase additional securities of the Issuer from time to time in open market or private transactions, depending on its evaluation of the Issuer's business, prospects and financial condition, the market for the Issuer's securities, other developments concerning the Issuer, other op”
| Holder | % of class | Type | As of |
|---|
| T. Rowe Price Investment Management, Inc. | 7.4% | QII | 2026-03-31 | SEC → |
| Forbion Growth Opportunities Fund III Cooperatief U.A. | 7.1% | Exempt | 2025-12-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
