Institutional 13F holdings sum to 101.7% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 13,065,123 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Paradigm Biocapital Advisors LP | 6,184,1346.2M | $35M | 7.88% | ADD 30% |
| 2 | BlackRock, Inc. | 5,110,8715.1M | $29M | 6.51% | ADD 4% |
| 3 | Affinity Asset Advisors, LLC | 5,050,2115.1M | $29M | 6.43% | ADD 58% |
| 4 | RA CAPITAL MANAGEMENT, L.P. | 5,000,0005.0M | $29M | 6.37% | — |
| 5 | JANUS HENDERSON GROUP PLC | 4,976,4295.0M | $29M | 6.34% | TRIM -10% |
| 6 | Vestal Point Capital, LP | 4,475,0004.5M | $26M | 5.70% | — |
| 7 | Frazier Life Sciences Management, L.P. | 4,424,7254.4M | $25M | 5.64% | — |
| 8 | CITADEL ADVISORS LLC | 3,834,9993.8M | $22M | 4.88% | — |
| 9 | ORBIMED ADVISORS LLC | 3,602,4503.6M | $21M | 4.59% | ADD 70% |
| 10 | STATE STREET CORP | 3,568,2423.6M | $20M | 4.54% | ADD 12% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 3,007,0933.0M | $17M | 3.83% | NEW† |
| 12 | Woodline Partners LP | 2,750,5322.8M | $16M | 3.50% | TRIM -14% |
| 13 | GOLDMAN SACHS GROUP INC | 1,949,8851.9M | $11M | 2.48% | ADD 149% |
| 14 | Avoro Capital Advisors LLC | 1,875,0001.9M | $11M | 2.39% | TRIM -43% |
| 15 | Point72 Asset Management, L.P. | 1,680,4491.7M | $10M | 2.14% | TRIM -11% |
| 16 | MILLENNIUM MANAGEMENT LLC | 1,612,7801.6M | $9M | 2.05% | ADD 78% |
| 17 | Balyasny Asset Management L.P. | 1,589,5851.6M | $9M | 2.02% | TRIM -3% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 1,513,7771.5M | $9M | 1.93% | ADD 5% |
| 19 | ADAR1 Capital Management, LLC | 1,467,3501.5M | $8M | 1.87% | ADD 5% |
| 20 | SUVRETTA CAPITAL MANAGEMENT, LLC | 1,250,0001.3M | $7M | 1.59% | — |
| 21 | 683 Capital Management, LLC | 1,200,0001.2M | $7M | 1.53% | ADD 7% |
| 22 | Nantahala Capital Management, LLC | 1,200,0001.2M | $7M | 1.53% | ADD 20% |
| 23 | DIMENSIONAL FUND ADVISORS LP | 1,103,5841.1M | $6M | 1.41% | ADD 28% |
| 24 | Octagon Capital Advisors LP | 1,100,0001.1M | $6M | 1.40% | TRIM -36% |
| 25 | Spruce Street Capital LP | 928,593928,593 | $5M | 1.18% | ADD 431% |
| 26 | Blackstone Inc. | 904,959904,959 | $5M | 1.15% | — |
| 27 | VANGUARD PORTFOLIO MANAGEMENT LLC | 577,192577,192 | $3M | 0.74% | NEW |
| 28 | Ikarian Capital, LLC | 513,011513,011 | $3M | 0.65% | — |
| 29 | NORTHERN TRUST CORP | 493,666493,666 | $3M | 0.63% | ADD 8% |
| 30 | BANK OF AMERICA CORP /DE/ | 491,532491,532 | $3M | 0.63% | ADD 207% |
| 31 | Qube Research & Technologies Ltd | 465,515465,515 | $3M | 0.59% | ADD 249% |
| 32 | MORGAN STANLEY | 402,924402,924 | $2M | 0.51% | ADD 187% |
| 33 | VANGUARD FIDUCIARY TRUST CO | 384,734384,734 | $2M | 0.49% | NEW |
| 34 | DAFNA Capital Management LLC | 377,059377,059 | $2M | 0.48% | ADD 11% |
| 35 | AQR CAPITAL MANAGEMENT LLC | 339,623339,623 | $2M | 0.43% | — |
| 36 | UBS Group AG | 321,737321,737 | $2M | 0.41% | ADD 14% |
| 37 | Squarepoint Ops LLC | 319,090319,090 | $2M | 0.41% | ADD 245% |
| 38 | Aberdeen Group plc | 245,904245,904 | $1M | 0.31% | NEW |
| 39 | BNP PARIBAS FINANCIAL MARKETS | 228,201228,201 | $1M | 0.29% | TRIM -11% |
| 40 | Privium Fund Management B.V. | 205,000205,000 | $1M | 0.26% | ADD 6% |
| 41 | Nuveen, LLC | 182,975182,975 | $1M | 0.23% | TRIM -13% |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 182,069182,069 | $1M | 0.23% | TRIM -5% |
| 43 | TWO SIGMA INVESTMENTS, LP | 181,676181,676 | $1M | 0.23% | TRIM -55% |
| 44 | WELLINGTON MANAGEMENT GROUP LLP | 172,703172,703 | $991,315 | 0.22% | ADD 108% |
| 45 | Bank of New York Mellon Corp | 158,899158,899 | $912,080 | 0.20% | TRIM -5% |
| 46 | Y-Intercept (Hong Kong) Ltd | 142,571142,571 | $818,358 | 0.18% | TRIM -38% |
| 47 | BOOTHBAY FUND MANAGEMENT, LLC | 136,377136,377 | $782,804 | 0.17% | — |
| 48 | Burkehill Global Management, LP | 125,000125,000 | $717,500 | 0.16% | — |
| 49 | Susquehanna Portfolio Strategies, LLC | 112,982112,982 | $648,517 | 0.14% | ADD 331% |
| 50 | ExodusPoint Capital Management, LP | 112,172112,172 | $643,867 | 0.14% | NEW |
| 51 | ALLIANCEBERNSTEIN L.P. | 61,81061,810 | $613,773 | 0.08% | — |
| 52 | Rafferty Asset Management, LLC | 100,896100,896 | $579,143 | 0.13% | — |
| 53 | XTX Topco Ltd | 100,607100,607 | $577,484 | 0.13% | ADD 803% |
| 54 | JPMORGAN CHASE & CO | 93,16393,163 | $490,969 | 0.12% | ADD 212% |
| 55 | RHUMBLINE ADVISERS | 72,08272,082 | $413,743 | 0.09% | ADD 4% |
| 56 | Creative Planning | 67,07967,079 | $385,033 | 0.09% | ADD 548% |
| 57 | Invesco Ltd. | 63,51863,518 | $364,593 | 0.08% | TRIM -86% |
| 58 | DEUTSCHE BANK AG\ | 63,05163,051 | $361,913 | 0.08% | ADD 10% |
| 59 | DRW Securities, LLC | 47,98847,988 | $275,451 | 0.06% | NEW |
| 60 | Bleakley Financial Group, LLC | 47,96447,964 | $275,313 | 0.06% | NEW |
| 61 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,99846,998 | $269,769 | 0.06% | ADD 27% |
| 62 | PROFUND ADVISORS LLC | 45,16145,161 | $259,224 | 0.06% | ADD 19% |
| 63 | PRICE T ROWE ASSOCIATES INC /MD/ | 43,13243,132 | $248,000 | 0.05% | ADD 27% |
| 64 | Vanguard Global Advisers, LLC | 42,57542,575 | $244,381 | 0.05% | NEW |
| 65 | LOS ANGELES CAPITAL MANAGEMENT LLC | 37,07137,071 | $212,788 | 0.05% | ADD 221% |
| 66 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,07137,071 | $209,488 | 0.05% | ADD 5% |
| 67 | MetLife Investment Management, LLC | 35,58435,584 | $204,252 | 0.05% | — |
| 68 | GSA CAPITAL PARTNERS LLP | 34,26934,269 | $197,000 | 0.04% | ADD 199% |
| 69 | PANAGORA ASSET MANAGEMENT INC | 34,29734,297 | $196,865 | 0.04% | — |
| 70 | D. E. Shaw & Co., Inc. | 30,47730,477 | $174,938 | 0.04% | TRIM -94% |
| 71 | Virtus Investment Advisers, LLC | 27,91027,910 | $160,203 | 0.04% | ADD 2% |
| 72 | AXQ CAPITAL, LP | 26,11926,119 | $149,923 | 0.03% | NEW |
| 73 | Mitsubishi UFJ Asset Management Co., Ltd. | 25,57725,577 | $146,812 | 0.03% | TRIM -2% |
| 74 | WELLS FARGO & COMPANY/MN | 24,99324,993 | $143,460 | 0.03% | TRIM -65% |
| 75 | FMR LLC | 24,38824,388 | $139,987 | 0.03% | ADD 82% |
| 76 | Schonfeld Strategic Advisors LLC | 24,22124,221 | $139,028 | 0.03% | NEW |
| 77 | Cerity Partners LLC | 21,02721,027 | $120,695 | 0.03% | TRIM -6% |
| 78 | Soltis Investment Advisors LLC | 20,00020,000 | $114,800 | 0.03% | — |
| 79 | NEW YORK STATE COMMON RETIREMENT FUND | 19,88719,887 | $114,151 | 0.03% | — |
| 80 | CWM, LLC | 18,31718,317 | $105,140 | 0.02% | TRIM -3% |
| 81 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,73817,738 | $101,816 | 0.02% | TRIM -7% |
| 82 | Vanguard Personalized Indexing Management, LLC | 17,56517,565 | $100,823 | 0.02% | ADD 7% |
| 83 | EntryPoint Capital, LLC | 16,56016,560 | $95,054 | 0.02% | NEW |
| 84 | INTECH INVESTMENT MANAGEMENT LLC | 16,50416,504 | $94,733 | 0.02% | ADD 16% |
| 85 | Police & Firemen's Retirement System of New Jersey | 16,37316,373 | $93,981 | 0.02% | — |
| 86 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 15,99115,991 | $91,469 | 0.02% | ADD 12% |
| 87 | RAYMOND JAMES FINANCIAL INC | 15,58515,585 | $89,458 | 0.02% | ADD 24% |
| 88 | CAXTON CORP | 13,94313,943 | $80,032 | 0.02% | — |
| 89 | COMMONWEALTH EQUITY SERVICES, LLC | 13,62013,620 | $78,180 | 0.02% | ADD 21% |
| 90 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 13,40013,400 | $76,916 | 0.02% | — |
| 91 | CITIGROUP INC | 13,32013,320 | $76,457 | 0.02% | TRIM -13% |
| 92 | China Universal Asset Management Co., Ltd. | 12,95212,952 | $74,344 | 0.02% | ADD 9% |
| 93 | ProShare Advisors LLC | 12,85212,852 | $73,771 | 0.02% | TRIM -13% |
| 94 | E Fund Management Co., Ltd. | 12,68312,683 | $72,800 | 0.02% | NEW |
| 95 | BARCLAYS PLC | 12,16512,165 | $69,828 | 0.02% | TRIM -94% |
| 96 | Virtu Financial LLC | 11,90111,901 | $68,000 | 0.02% | NEW |
| 97 | Ethic Inc. | 11,13211,132 | $63,898 | 0.01% | TRIM -3% |
| 98 | VOYA INVESTMENT MANAGEMENT LLC | 10,70510,705 | $61,447 | 0.01% | TRIM -2% |
| 99 | Tower Research Capital LLC (TRC) | 9,4859,485 | $54,444 | 0.01% | ADD 1048% |
| 100 | Russell Investments Group, Ltd. | 6,6396,639 | $38,108 | 0.01% | ADD 13% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | — | — | — | — | 4.8M | 6.2M | $35M |
| BlackRock, Inc. | 1.8M | 1.8M | 1.8M | 2.2M | 4.9M | 5.1M | $29M |
| Affinity Asset Advisors, LLC | — | 1.5M | 3.6M | 3.9M | 3.2M | 5.1M | $29M |
| RA CAPITAL MANAGEMENT, L.P. | 547K | 547K | — | — | 5.0M | 5.0M | $29M |
| JANUS HENDERSON GROUP PLC | 4.3M | 4.6M | 3.7M | 6.1M | 5.5M | 5.0M | $29M |
| Vestal Point Capital, LP | 1.2M | 1.1M | 3.2M | 3.3M | 4.5M | 4.5M | $26M |
| Frazier Life Sciences Management, L.P. | 956K | 956K | 4.4M | 4.4M | 4.4M | 4.4M | $25M |
| CITADEL ADVISORS LLC | 2.7M | 2.7M | 3.6M | 3.7M | 3.8M | 3.8M | $22M |
| ORBIMED ADVISORS LLC | — | — | — | — | 2.1M | 3.6M | $21M |
| STATE STREET CORP | 457K | 470K | 513K | 545K | 3.2M | 3.6M | $20M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 3.0M | $17M |
| Woodline Partners LP | 859K | 837K | 2.6M | 2.6M | 3.2M | 2.8M | $16M |
| GOLDMAN SACHS GROUP INC | 91K | 79K | 36K | 142K | 782K | 1.9M | $11M |
| Avoro Capital Advisors LLC | — | — | — | — | 3.3M | 1.9M | $11M |
| Point72 Asset Management, L.P. | 750K | 1.1M | 648K | 1.9M | 1.9M | 1.7M | $10M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 138 | 79,889,989 | 101.7% | $459M |
| 2025-Q4 | 145 | 76,461,109 | 97.4% | $759M |
| 2025-Q3 | 109 | 49,337,609 | 62.8% | $328M |
| 2025-Q2 | 90 | 42,246,488 | 53.8% | $170M |
| 2025-Q1 | 88 | 28,007,979 | 35.7% | $100M |
| 2024-Q4 | 90 | 29,519,192 | 37.6% | $194M |
| 2024-Q3 | 69 | 29,833,583 | 38.0% | $270M |
| 2024-Q2 | 59 | 26,571,038 | 33.8% | $426M |
| 2024-Q1 | 54 | 23,153,734 | 29.5% | $362M |
| 2023-Q4 | 31 | 16,184,080 | 20.6% | $217M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| 2025-09-30 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
