| 1 | 1FMR LLC | 11,699,95011.7M | $974M | — | ADD 31% |
| 2 | 2BAKER BROS. ADVISORS LP | 8,657,2428.7M | $721M | — | — |
| 3 | 3Avoro Capital Advisors LLC | 7,474,7477.5M | $623M | — | — |
| 4 | 4PRICE T ROWE ASSOCIATES INC /MD/ | 6,060,8476.1M | $505M | — | — |
| 5 | 5BVF INC/IL | 5,502,7105.5M | $458M | — | — |
| 6 | 6T. Rowe Price Investment Management, Inc. | 5,464,9975.5M | $455M | — | ADD 652% |
| 7 | 7BlackRock, Inc. | 5,060,8765.1M | $422M | — | — |
| 8 | 8Atlas Venture Life Science Advisors, LLC | 4,578,0084.6M | $381M | — | — |
| 9 | 9WELLINGTON MANAGEMENT GROUP LLP | 3,889,6873.9M | $324M | — | TRIM -12% |
| 10 | 10Siren, L.L.C. | 3,186,8303.2M | $265M | — | TRIM -3% |
| 11 | 11VANGUARD CAPITAL MANAGEMENT LLC | 2,880,3242.9M | $240M | — | NEW† |
| 12 | 12VANGUARD PORTFOLIO MANAGEMENT LLC | 2,874,0562.9M | $239M | — | NEW† |
| 13 | 13STATE STREET CORP | 2,389,7672.4M | $199M | — | ADD 8% |
| 14 | 14Capital Research Global Investors | 1,673,2751.7M | $139M | — | ADD 7% |
| 15 | 15GEODE CAPITAL MANAGEMENT, LLC | 1,645,3501.6M | $137M | — | ADD 16% |
| 16 | 16Driehaus Capital Management LLC | 1,043,5831.0M | $87M | — | TRIM -2% |
| 17 | 17UBS Group AG | 1,023,8521.0M | $85M | — | ADD 39% |
| 18 | 18GOLDMAN SACHS GROUP INC | 888,409888,409 | $74M | — | ADD 20% |
| 19 | 19UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 875,872875,872 | $73M | — | TRIM -4% |
| 20 | 20Holocene Advisors, LP | 836,759836,759 | $70M | — | ADD 10% |
| 21 | 21ALLIANCEBERNSTEIN L.P. | 888,035888,035 | $69M | — | TRIM -7% |
| 22 | 22Merck & Co., Inc. | 772,165772,165 | $64M | — | — |
| 23 | 23FRONTIER CAPITAL MANAGEMENT CO LLC | 759,848759,848 | $63M | — | ADD 19% |
| 24 | 24Commodore Capital LP | 750,000750,000 | $62M | — | — |
| 25 | 25EVENTIDE ASSET MANAGEMENT, LLC | 626,925626,925 | $52M | — | — |
| 26 | 26DIMENSIONAL FUND ADVISORS LP | 592,879592,879 | $49M | — | TRIM -5% |
| 27 | 27DEERFIELD MANAGEMENT COMPANY, L.P. | 561,170561,170 | $47M | — | — |
| 28 | 28FEDERATED HERMES, INC. | 536,680536,680 | $45M | — | TRIM -30% |
| 29 | 29JENNISON ASSOCIATES LLC | 508,999508,999 | $42M | — | ADD 2% |
| 30 | 30Rock Springs Capital Management LP | 496,871496,871 | $41M | — | — |
| 31 | 31CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 495,262495,262 | $41M | — | — |
| 32 | 32NORTHERN TRUST CORP | 494,439494,439 | $41M | — | ADD 6% |
| 33 | 33Pictet Asset Management Holding SA | 468,728468,728 | $39M | — | TRIM -3% |
| 34 | 34VANGUARD FIDUCIARY TRUST CO | 427,382427,382 | $36M | — | NEW |
| 35 | 35Octagon Capital Advisors LP | 425,000425,000 | $35M | — | TRIM -21% |
| 36 | 36FRANKLIN RESOURCES INC | 361,772361,772 | $30M | — | ADD 2% |
| 37 | 37Alyeska Investment Group, L.P. | 342,698342,698 | $29M | — | TRIM -8% |
| 38 | 38BRAIDWELL LP | 337,559337,559 | $28M | — | TRIM -26% |
| 39 | 39ADAGE CAPITAL PARTNERS GP, L.L.C. | 335,000335,000 | $28M | — | TRIM -22% |
| 40 | 40Boxer Capital Management, LLC | 329,100329,100 | $27M | — | — |
| 41 | 41BANK OF AMERICA CORP /DE/ | 289,416289,416 | $24M | — | TRIM -15% |
| 42 | 42TD Asset Management Inc | 287,100287,100 | $24M | — | ADD 30% |
| 43 | 43BNP PARIBAS FINANCIAL MARKETS | 285,871285,871 | $24M | — | ADD 3149% |
| 44 | 44Nextech Invest, Ltd. | 278,896278,896 | $23M | — | — |
| 45 | 45TWO SIGMA INVESTMENTS, LP | 256,501256,501 | $21M | — | TRIM -3% |
| 46 | 46First Turn Management, LLC | 254,672254,672 | $21M | — | ADD 23% |
| 47 | 47RTW INVESTMENTS, LP | 240,000240,000 | $20M | — | — |
| 48 | 48GILDER GAGNON HOWE & CO LLC | 235,433235,433 | $20M | — | — |
| 49 | 49Polar Capital Holdings Plc | 215,200215,200 | $18M | — | ADD 7% |
| 50 | 50MORGAN STANLEY | 212,702212,702 | $18M | — | TRIM -22% |
| 51 | 51MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 209,005209,005 | $17M | — | TRIM -28% |
| 52 | 52Woodline Partners LP | 203,585203,585 | $17M | — | — |
| 53 | 53Candriam S.C.A. | 201,672201,672 | $17M | — | — |
| 54 | 54VOYA INVESTMENT MANAGEMENT LLC | 198,808198,808 | $17M | — | ADD 587% |
| 55 | 55Bank of New York Mellon Corp | 193,200193,200 | $16M | — | — |
| 56 | 56TimesSquare Capital Management, LLC | 168,846168,846 | $14M | — | TRIM -11% |
| 57 | 57Freestone Grove Partners LP | 156,763156,763 | $13M | — | NEW |
| 58 | 58Foresite Capital Management VI LLC | 146,332146,332 | $12M | — | — |
| 59 | 59Eagle Health Investments LP | 145,816145,816 | $12M | — | ADD 7% |
| 60 | 60WCM INVESTMENT MANAGEMENT, LLC | 152,381152,381 | $12M | — | ADD 45% |
| 61 | 61Nuveen, LLC | 128,091128,091 | $11M | — | ADD 2% |
| 62 | 62Deer Management Co. LLC | 125,895125,895 | $10M | — | TRIM -45% |
| 63 | 63MANUFACTURERS LIFE INSURANCE COMPANY, THE | 120,151120,151 | $10M | — | TRIM -12% |
| 64 | 64JPMORGAN CHASE & CO | 125,419125,419 | $10M | — | TRIM -5% |
| 65 | 65CITADEL ADVISORS LLC | 118,597118,597 | $10M | — | TRIM -26% |
| 66 | 66Ensign Peak Advisors, Inc | 113,842113,842 | $9M | — | ADD 20% |
| 67 | 67Invesco Ltd. | 110,415110,415 | $9M | — | TRIM -5% |
| 68 | 68Connor, Clark & Lunn Investment Management Ltd. | 104,279104,279 | $9M | — | NEW |
| 69 | 69Universal- Beteiligungs- und Servicegesellschaft mbH | 103,200103,200 | $9M | — | TRIM -2% |
| 70 | 70Patient Square Capital LP | 100,000100,000 | $8M | — | TRIM -28% |
| 71 | 71Swiss National Bank | 94,50094,500 | $8M | — | — |
| 72 | 72FIRST TRUST ADVISORS LP | 93,61793,617 | $8M | — | ADD 59% |
| 73 | 73DEUTSCHE BANK AG\ | 91,88291,882 | $8M | — | ADD 15% |
| 74 | 74ARMISTICE CAPITAL, LLC | 83,87683,876 | $7M | — | ADD 3% |
| 75 | 75Burkehill Global Management, LP | 75,00075,000 | $6M | — | — |
| 76 | 76Yiheng Capital Management, L.P. | 73,44073,440 | $6M | — | — |
| 77 | 77RHUMBLINE ADVISERS | 71,67871,678 | $6M | — | — |
| 78 | 78NEUBERGER BERMAN GROUP LLC | 71,11671,116 | $6M | — | ADD 22% |
| 79 | 79VICTORY CAPITAL MANAGEMENT INC | 67,99567,995 | $6M | — | — |
| 80 | 80ALPS ADVISORS INC | 66,45766,457 | $6M | — | ADD 3% |
| 81 | 81BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 64,46764,467 | $5M | — | — |
| 82 | 82CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,28256,282 | $5M | — | ADD 23% |
| 83 | 83Rafferty Asset Management, LLC | 55,33155,331 | $5M | — | TRIM -6% |
| 84 | 84FIFTH THIRD BANCORP | 51,23851,238 | $4M | — | NEW |
| 85 | 85Russell Investments Group, Ltd. | 48,81248,812 | $4M | — | ADD 6% |
| 86 | 86VANGUARD ASSET MANAGEMENT, Ltd | 44,99044,990 | $4M | — | NEW |
| 87 | 87Informed Momentum Co LLC | 42,34142,341 | $4M | — | TRIM -25% |
| 88 | 88SCHRODER INVESTMENT MANAGEMENT GROUP | 43,24343,243 | $3M | — | TRIM -18% |
| 89 | 89Moody Aldrich Partners LLC | 38,19538,195 | $3M | — | — |
| 90 | 90MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,29938,299 | $3M | — | TRIM -6% |
| 91 | 91STATE OF WISCONSIN INVESTMENT BOARD | 37,18537,185 | $3M | — | ADD 40% |
| 92 | 92Legal & General Group Plc | 36,73436,734 | $3M | — | TRIM -15% |
| 93 | 93Monashee Investment Management LLC | 35,10035,100 | $3M | — | TRIM -65% |
| 94 | 94HARBOR CAPITAL ADVISORS, INC. | 33,94833,948 | $3M | — | ADD 11% |
| 95 | 95Rockefeller Capital Management L.P. | 32,36732,367 | $3M | — | ADD 27% |
| 96 | 96Sio Capital Management, LLC | 32,23532,235 | $3M | — | — |
| 97 | 97Zurcher Kantonalbank (Zurich Cantonalbank) | 32,06132,061 | $3M | — | ADD 105% |
| 98 | 98MetLife Investment Management, LLC | 31,50731,507 | $3M | — | — |
| 99 | 99Nan Fung Group Holdings Ltd | 30,87530,875 | $3M | — | — |
| 100 | 100SEVEN GRAND MANAGERS, LLC | 30,00030,000 | $2M | — | — |
