| 1 | 1FMR LLC | 16,947,88816.9M | $421M | 8.25% | — |
| 2 | 2Deep Track Capital, LP | 11,526,97111.5M | $286M | 5.61% | — |
| 3 | 3BlackRock, Inc. | 6,574,4976.6M | $163M | 3.20% | ADD 9% |
| 4 | 4BAKER BROS. ADVISORS LP | 5,457,8815.5M | $136M | 2.66% | — |
| 5 | 5STATE STREET CORP | 4,537,9294.5M | $113M | 2.21% | ADD 20% |
| 6 | 6TCG Crossover Management, LLC | 4,457,9884.5M | $111M | 2.17% | ADD 168% |
| 7 | 7MORGAN STANLEY | 3,876,8773.9M | $96M | 1.89% | TRIM -20% |
| 8 | 8VANGUARD PORTFOLIO MANAGEMENT LLC | 3,704,9053.7M | $92M | 1.80% | NEW |
| 9 | 9VANGUARD CAPITAL MANAGEMENT LLC | 3,620,0503.6M | $90M | 1.76% | NEW |
| 10 | 10T. Rowe Price Investment Management, Inc. | 3,612,8603.6M | $90M | 1.76% | TRIM -36% |
| 11 | 11ARMISTICE CAPITAL, LLC | 3,564,9163.6M | $89M | 1.74% | TRIM -38% |
| 12 | 12Two Seas Capital LP | 3,201,9623.2M | $80M | 1.56% | ADD 12% |
| 13 | 13JENNISON ASSOCIATES LLC | 3,196,7053.2M | $79M | 1.56% | ADD 356% |
| 14 | 14RTW INVESTMENTS, LP | 3,177,8493.2M | $79M | 1.55% | — |
| 15 | 15ADAR1 Capital Management, LLC | 2,679,0102.7M | $67M | 1.30% | ADD 8% |
| 16 | 16Alpine Global Management, LLC | 2,636,9252.6M | $66M | 1.28% | — |
| 17 | 17GEODE CAPITAL MANAGEMENT, LLC | 2,092,1022.1M | $52M | 1.02% | ADD 13% |
| 18 | 18Woodline Partners LP | 1,975,8692.0M | $49M | 0.96% | — |
| 19 | 19GOLDMAN SACHS GROUP INC | 1,785,1071.8M | $44M | 0.87% | ADD 38% |
| 20 | 20PERCEPTIVE ADVISORS LLC | 1,597,3831.6M | $40M | 0.78% | TRIM -20% |
| 21 | 21FARALLON CAPITAL MANAGEMENT LLC | 1,546,0001.5M | $38M | 0.75% | ADD 12783% |
| 22 | 22STEMPOINT CAPITAL LP | 1,492,9881.5M | $37M | 0.73% | ADD 131% |
| 23 | 23Aberdeen Group plc | 1,160,7621.2M | $29M | 0.57% | — |
| 24 | 24Logos Global Management LP | 1,075,0001.1M | $27M | 0.52% | TRIM -22% |
| 25 | 25BANK OF AMERICA CORP /DE/ | 893,678893,678 | $22M | 0.44% | ADD 185% |
| 26 | 26UBS Group AG | 684,551684,551 | $17M | 0.33% | TRIM -7% |
| 27 | 27Candriam S.C.A. | 680,372680,372 | $17M | 0.33% | — |
| 28 | 28NORTHERN TRUST CORP | 672,774672,774 | $17M | 0.33% | ADD 19% |
| 29 | 29CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 660,438660,438 | $16M | 0.32% | ADD 3% |
| 30 | 30SUSQUEHANNA INTERNATIONAL GROUP, LLP | 617,807617,807 | $15M | 0.30% | ADD 138% |
| 31 | 31GREAT POINT PARTNERS LLC | 545,625545,625 | $14M | 0.27% | TRIM -27% |
| 32 | 32VANGUARD FIDUCIARY TRUST CO | 544,538544,538 | $14M | 0.27% | NEW |
| 33 | 33Connor, Clark & Lunn Investment Management Ltd. | 503,673503,673 | $13M | 0.25% | ADD 8% |
| 34 | 34Pictet Asset Management Holding SA | 472,381472,381 | $12M | 0.23% | ADD 24% |
| 35 | 35SILVERARC CAPITAL MANAGEMENT, LLC | 414,236414,236 | $10M | 0.20% | NEW |
| 36 | 36Trails Edge Capital Partners, LP | 414,054414,054 | $10M | 0.20% | ADD 72% |
| 37 | 37ADAGE CAPITAL PARTNERS GP, L.L.C. | 413,000413,000 | $10M | 0.20% | TRIM -52% |
| 38 | 38SUPERSTRING CAPITAL MANAGEMENT LP | 357,606357,606 | $9M | 0.17% | ADD 24% |
| 39 | 39PRICE T ROWE ASSOCIATES INC /MD/ | 339,607339,607 | $8M | 0.17% | TRIM -62% |
| 40 | 40BNP PARIBAS FINANCIAL MARKETS | 334,557334,557 | $8M | 0.16% | TRIM -5% |
| 41 | 41Granahan Investment Management, LLC | 244,430244,430 | $6M | 0.12% | ADD 6% |
| 42 | 42Nuveen, LLC | 241,195241,195 | $6M | 0.12% | ADD 6% |
| 43 | 43Soleus Capital Management, L.P. | 230,000230,000 | $6M | 0.11% | TRIM -79% |
| 44 | 44HighVista Strategies LLC | 225,139225,139 | $6M | 0.11% | — |
| 45 | 45Tetragon Partners GP Ltd | 218,507218,507 | $5M | 0.11% | ADD 31% |
| 46 | 46Bank of New York Mellon Corp | 216,225216,225 | $5M | 0.11% | ADD 8% |
| 47 | 47Assenagon Asset Management S.A. | 205,219205,219 | $5M | 0.10% | — |
| 48 | 48XTX Topco Ltd | 203,029203,029 | $5M | 0.10% | ADD 513% |
| 49 | 49RENAISSANCE TECHNOLOGIES LLC | 192,500192,500 | $5M | 0.09% | NEW |
| 50 | 50PLATINUM INVESTMENT MANAGEMENT LTD | 181,774181,774 | $5M | 0.09% | — |
| 51 | 51Prosight Management, LP | 175,825175,825 | $4M | 0.09% | TRIM -28% |
| 52 | 52MARSHALL WACE, LLP | 165,300165,300 | $4M | 0.08% | NEW |
| 53 | 53Swiss National Bank | 159,400159,400 | $4M | 0.08% | — |
| 54 | 54DAFNA Capital Management LLC | 150,524150,524 | $4M | 0.07% | — |
| 55 | 55CITADEL ADVISORS LLC | 144,398144,398 | $4M | 0.07% | TRIM -7% |
| 56 | 56UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 141,728141,728 | $4M | 0.07% | ADD 5% |
| 57 | 57Erste Asset Management GmbH | 144,500144,500 | $3M | 0.07% | ADD 12% |
| 58 | 58Rafferty Asset Management, LLC | 136,619136,619 | $3M | 0.07% | ADD 3% |
| 59 | 59TD Asset Management Inc | 131,352131,352 | $3M | 0.06% | TRIM -42% |
| 60 | 60NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 122,100122,100 | $3M | 0.06% | — |
| 61 | 61Blackstone Inc. | 107,297107,297 | $3M | 0.05% | ADD 35% |
| 62 | 62ALGERT GLOBAL LLC | 105,770105,770 | $3M | 0.05% | NEW |
| 63 | 63Affinity Asset Advisors, LLC | 100,000100,000 | $2M | 0.05% | TRIM -50% |
| 64 | 64RHUMBLINE ADVISERS | 97,49397,493 | $2M | 0.05% | ADD 12% |
| 65 | 65CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 94,28694,286 | $2M | 0.05% | ADD 10% |
| 66 | 66Invesco Ltd. | 93,89493,894 | $2M | 0.05% | ADD 6% |
| 67 | 67DME Capital Management, LP | 93,52093,520 | $2M | 0.05% | NEW |
| 68 | 68ALLIANCEBERNSTEIN L.P. | 90,41090,410 | $2M | 0.04% | — |
| 69 | 69JPMORGAN CHASE & CO | 96,88296,882 | $2M | 0.05% | ADD 21% |
| 70 | 70Hennion & Walsh Asset Management, Inc. | 91,00991,009 | $2M | 0.04% | ADD 27% |
| 71 | 71BANQUE PICTET & CIE SA | 88,66088,660 | $2M | 0.04% | TRIM -23% |
| 72 | 72JANE STREET GROUP, LLC | 84,31284,312 | $2M | 0.04% | NEW |
| 73 | 73DEUTSCHE BANK AG\ | 79,00079,000 | $2M | 0.04% | ADD 26% |
| 74 | 74Legal & General Group Plc | 74,45674,456 | $2M | 0.04% | TRIM -20% |
| 75 | 75GSA CAPITAL PARTNERS LLP | 72,82072,820 | $2M | 0.04% | ADD 65% |
| 76 | 76MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,80171,801 | $2M | 0.03% | ADD 78% |
| 77 | 77ArrowMark Colorado Holdings LLC | 70,00070,000 | $2M | 0.03% | — |
| 78 | 78VANGUARD ASSET MANAGEMENT, Ltd | 69,44269,442 | $2M | 0.03% | NEW |
| 79 | 79Amundi | 66,84866,848 | $2M | 0.03% | — |
| 80 | 80HRT FINANCIAL LP | 66,48566,485 | $2M | 0.03% | TRIM -22% |
| 81 | 81PROFUND ADVISORS LLC | 61,00861,008 | $2M | 0.03% | ADD 24% |
| 82 | 82DIMENSIONAL FUND ADVISORS LP | 57,08657,086 | $1M | 0.03% | TRIM -64% |
| 83 | 83HighTower Advisors, LLC | 56,74456,744 | $1M | 0.03% | ADD 70% |
| 84 | 84VOYA INVESTMENT MANAGEMENT LLC | 54,28654,286 | $1M | 0.03% | — |
| 85 | 85Alchemi Wealth, LLC | 54,01654,016 | $1M | 0.03% | TRIM -5% |
| 86 | 86MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,42151,421 | $1M | 0.03% | TRIM -47% |
| 87 | 87STATE OF WISCONSIN INVESTMENT BOARD | 51,02251,022 | $1M | 0.02% | ADD 31% |
| 88 | 88SIMPLEX TRADING, LLC | 50,27650,276 | $1M | 0.02% | ADD 4% |
| 89 | 89Creative Planning | 45,72945,729 | $1M | 0.02% | ADD 10% |
| 90 | 90MetLife Investment Management, LLC | 44,46144,461 | $1M | 0.02% | ADD 14% |
| 91 | 91Jump Financial, LLC | 44,20244,202 | $1M | 0.02% | TRIM -58% |
| 92 | 92Quantinno Capital Management LP | 40,03040,030 | $994,345 | 0.02% | ADD 181% |
| 93 | 93China Universal Asset Management Co., Ltd. | 37,71837,718 | $936,915 | 0.02% | ADD 32% |
| 94 | 94Quinn Opportunity Partners LLC | 37,50037,500 | $931,500 | 0.02% | TRIM -39% |
| 95 | 95JANUS HENDERSON GROUP PLC | 33,73133,731 | $838,215 | 0.02% | — |
| 96 | 96Vanguard Global Advisers, LLC | 33,62333,623 | $835,195 | 0.02% | NEW |
| 97 | 97Schonfeld Strategic Advisors LLC | 33,55333,553 | $833,456 | 0.02% | NEW |
| 98 | 98WELLS FARGO & COMPANY/MN | 33,22233,222 | $825,234 | 0.02% | TRIM -58% |
| 99 | 99Universal- Beteiligungs- und Servicegesellschaft mbH | 33,17333,173 | $824,017 | 0.02% | NEW |
| 100 | 100DekaBank Deutsche Girozentrale | 32,60032,600 | $811,000 | 0.02% | — |