| 1 | 1BlackRock, Inc. | 11,553,75911.6M | $1.1B | 8.71% | ADD 2% |
| 2 | 2PRICE T ROWE ASSOCIATES INC /MD/ | 7,023,6897.0M | $649M | 5.30% | ADD 25% |
| 3 | 3VANGUARD PORTFOLIO MANAGEMENT LLC | 5,837,9925.8M | $539M | 4.40% | NEW† |
| 4 | 4VANGUARD CAPITAL MANAGEMENT LLC | 5,624,1805.6M | $520M | 4.24% | NEW† |
| 5 | 5Invesco Ltd. | 4,946,4694.9M | $457M | 3.73% | TRIM -7% |
| 6 | 6GOLDMAN SACHS GROUP INC | 4,435,8394.4M | $410M | 3.35% | ADD 69% |
| 7 | 7TWO SIGMA INVESTMENTS, LP | 4,229,5314.2M | $391M | 3.19% | ADD 95% |
| 8 | 8FMR LLC | 4,116,0814.1M | $380M | 3.10% | ADD 72% |
| 9 | 9BAILLIE GIFFORD & CO | 3,859,0463.9M | $356M | 2.91% | TRIM -21% |
| 10 | 10GEODE CAPITAL MANAGEMENT, LLC | 3,508,8833.5M | $324M | 2.65% | ADD 9% |
| 11 | 11Capital International Investors | 3,481,3183.5M | $322M | 2.63% | — |
| 12 | 12FRANKLIN RESOURCES INC | 3,448,1933.4M | $319M | 2.60% | ADD 3% |
| 13 | 13Deep Track Capital, LP | 3,338,2413.3M | $308M | 2.52% | ADD 19% |
| 14 | 14STATE STREET CORP | 2,884,6202.9M | $266M | 2.18% | ADD 3% |
| 15 | 15FULLER & THALER ASSET MANAGEMENT, INC. | 2,550,3142.6M | $236M | 1.92% | TRIM -48% |
| 16 | 16EVENTIDE ASSET MANAGEMENT, LLC | 2,362,3792.4M | $218M | 1.78% | TRIM -6% |
| 17 | 17ALLIANCEBERNSTEIN L.P. | 1,905,6371.9M | $195M | 1.44% | — |
| 18 | 18LORD, ABBETT & CO. LLC | 1,899,1131.9M | $175M | 1.43% | TRIM -5% |
| 19 | 19FEDERATED HERMES, INC. | 1,887,5841.9M | $174M | 1.42% | TRIM -7% |
| 20 | 20UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,623,5111.6M | $150M | 1.22% | TRIM -15% |
| 21 | 21Driehaus Capital Management LLC | 1,524,2821.5M | $141M | 1.15% | TRIM -29% |
| 22 | 22Alyeska Investment Group, L.P. | 1,489,5661.5M | $138M | 1.12% | ADD 11% |
| 23 | 23MORGAN STANLEY | 1,487,3241.5M | $137M | 1.12% | ADD 29% |
| 24 | 24RTW INVESTMENTS, LP | 1,481,0331.5M | $137M | 1.12% | — |
| 25 | 25CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,451,8031.5M | $134M | 1.09% | — |
| 26 | 26AMERIPRISE FINANCIAL INC | 1,414,8861.4M | $131M | 1.07% | ADD 86% |
| 27 | 27UBS Group AG | 1,405,8371.4M | $130M | 1.06% | TRIM -18% |
| 28 | 28Bank of New York Mellon Corp | 1,391,1871.4M | $129M | 1.05% | — |
| 29 | 29WESTFIELD CAPITAL MANAGEMENT CO LP | 1,362,5391.4M | $126M | 1.03% | ADD 153% |
| 30 | 30Hood River Capital Management LLC | 1,310,0651.3M | $121M | 0.99% | ADD 34% |
| 31 | 31MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,205,7011.2M | $111M | 0.91% | ADD 90% |
| 32 | 32NORTHERN TRUST CORP | 1,112,4391.1M | $103M | 0.84% | — |
| 33 | 33Temasek Holdings (Private) Ltd | 985,571985,571 | $91M | 0.74% | TRIM -6% |
| 34 | 34WELLINGTON MANAGEMENT GROUP LLP | 972,563972,563 | $90M | 0.73% | ADD 139% |
| 35 | 35WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 951,114951,114 | $88M | 0.72% | NEW |
| 36 | 36MILLENNIUM MANAGEMENT LLC | 921,395921,395 | $85M | 0.69% | ADD 58% |
| 37 | 37BANK OF AMERICA CORP /DE/ | 895,221895,221 | $83M | 0.68% | TRIM -12% |
| 38 | 38VANGUARD FIDUCIARY TRUST CO | 889,936889,936 | $82M | 0.67% | NEW |
| 39 | 39AMERICAN CENTURY COMPANIES INC | 867,537867,537 | $80M | 0.65% | ADD 990% |
| 40 | 40SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 862,915862,915 | $80M | 0.65% | — |
| 41 | 41EMERALD ADVISERS, LLC | 841,917841,917 | $78M | 0.63% | TRIM -2% |
| 42 | 42ADAGE CAPITAL PARTNERS GP, L.L.C. | 816,095816,095 | $75M | 0.62% | ADD 76% |
| 43 | 43Artisan Partners Limited Partnership | 814,571814,571 | $75M | 0.61% | ADD 181% |
| 44 | 44CADIAN CAPITAL MANAGEMENT, LP | 779,648779,648 | $72M | 0.59% | TRIM -15% |
| 45 | 45CITADEL ADVISORS LLC | 775,941775,941 | $72M | 0.59% | ADD 37% |
| 46 | 46Erste Asset Management GmbH | 815,917815,917 | $70M | 0.62% | TRIM -22% |
| 47 | 47T. Rowe Price Investment Management, Inc. | 755,707755,707 | $70M | 0.57% | NEW |
| 48 | 48Point72 Asset Management, L.P. | 695,940695,940 | $64M | 0.52% | TRIM -54% |
| 49 | 49FRED ALGER MANAGEMENT, LLC | 622,259622,259 | $57M | 0.47% | ADD 6% |
| 50 | 50Allspring Global Investments Holdings, LLC | 608,826608,826 | $55M | 0.46% | — |
| 51 | 51BNP PARIBAS FINANCIAL MARKETS | 572,650572,650 | $53M | 0.43% | TRIM -8% |
| 52 | 52EMERALD MUTUAL FUND ADVISERS TRUST | 519,545519,545 | $48M | 0.39% | — |
| 53 | 53VOYA INVESTMENT MANAGEMENT LLC | 505,034505,034 | $47M | 0.38% | ADD 53% |
| 54 | 54BRAIDWELL LP | 499,712499,712 | $46M | 0.38% | NEW |
| 55 | 55ARK Investment Management LLC | 486,675486,675 | $45M | 0.37% | TRIM -30% |
| 56 | 56Sumitomo Mitsui Trust Group, Inc. | 483,767483,767 | $45M | 0.36% | TRIM -24% |
| 57 | 57Amova Asset Management Americas, Inc. | 483,557483,557 | $45M | 0.36% | TRIM -24% |
| 58 | 58Aristotle Atlantic Partners, LLC | 445,530445,530 | $41M | 0.34% | TRIM -10% |
| 59 | 59Nuveen, LLC | 438,357438,357 | $40M | 0.33% | TRIM -7% |
| 60 | 60ORBIMED ADVISORS LLC | 435,200435,200 | $40M | 0.33% | NEW |
| 61 | 61D. E. Shaw & Co., Inc. | 427,475427,475 | $39M | 0.32% | TRIM -31% |
| 62 | 62VICTORY CAPITAL MANAGEMENT INC | 393,836393,836 | $36M | 0.30% | ADD 4% |
| 63 | 63SEI INVESTMENTS CO | 341,013341,013 | $31M | 0.26% | ADD 30% |
| 64 | 64RENAISSANCE TECHNOLOGIES LLC | 337,600337,600 | $31M | 0.25% | TRIM -44% |
| 65 | 65BROWN ADVISORY INC | 329,564329,564 | $30M | 0.25% | NEW |
| 66 | 66RAYMOND JAMES FINANCIAL INC | 338,389338,389 | $30M | 0.26% | ADD 3% |
| 67 | 67Casdin Capital, LLC | 315,000315,000 | $29M | 0.24% | TRIM -17% |
| 68 | 68Eagle Health Investments LP | 310,281310,281 | $29M | 0.23% | ADD 9% |
| 69 | 69PERCEPTIVE ADVISORS LLC | 300,000300,000 | $28M | 0.23% | ADD 88% |
| 70 | 70Styrax Capital, LP | 300,000300,000 | $28M | 0.23% | ADD 7% |
| 71 | 71Walleye Capital LLC | 291,926291,926 | $27M | 0.22% | ADD 15% |
| 72 | 72JPMORGAN CHASE & CO | 304,317304,317 | $26M | 0.23% | ADD 12% |
| 73 | 73First Light Asset Management, LLC | 280,299280,299 | $26M | 0.21% | TRIM -5% |
| 74 | 74DEUTSCHE BANK AG\ | 255,187255,187 | $24M | 0.19% | TRIM -24% |
| 75 | 75Connor, Clark & Lunn Investment Management Ltd. | 254,788254,788 | $24M | 0.19% | TRIM -4% |
| 76 | 76BARCLAYS PLC | 253,959253,959 | $23M | 0.19% | TRIM -24% |
| 77 | 77PICTON MAHONEY ASSET MANAGEMENT | 249,991249,991 | $23M | 0.19% | ADD 57% |
| 78 | 78SAMLYN CAPITAL, LLC | 249,137249,137 | $23M | 0.19% | NEW |
| 79 | 79Universal- Beteiligungs- und Servicegesellschaft mbH | 244,051244,051 | $23M | 0.18% | TRIM -15% |
| 80 | 80Blue Water Life Science Advisors, LP | 242,247242,247 | $22M | 0.18% | TRIM -32% |
| 81 | 81MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 238,462238,462 | $22M | 0.18% | — |
| 82 | 82NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 234,376234,376 | $22M | 0.18% | ADD 10% |
| 83 | 83SEGALL BRYANT & HAMILL, LLC | 232,222232,222 | $21M | 0.18% | TRIM -5% |
| 84 | 84Sicart Associates LLC | 230,103230,103 | $21M | 0.17% | — |
| 85 | 85Swiss National Bank | 222,100222,100 | $21M | 0.17% | — |
| 86 | 86California Public Employees Retirement System | 215,468215,468 | $20M | 0.16% | — |
| 87 | 87JENNISON ASSOCIATES LLC | 203,778203,778 | $19M | 0.15% | TRIM -83% |
| 88 | 88TD Asset Management Inc | 195,300195,300 | $18M | 0.15% | ADD 8% |
| 89 | 89Squarepoint Ops LLC | 191,740191,740 | $18M | 0.14% | ADD 40% |
| 90 | 90AGF MANAGEMENT LTD | 189,952189,952 | $18M | 0.14% | ADD 22% |
| 91 | 91Russell Investments Group, Ltd. | 188,140188,140 | $17M | 0.14% | TRIM -11% |
| 92 | 92PRINCIPAL FINANCIAL GROUP INC | 184,846184,846 | $17M | 0.14% | ADD 20% |
| 93 | 93DIMENSIONAL FUND ADVISORS LP | 182,727182,727 | $17M | 0.14% | TRIM -40% |
| 94 | 94CITIGROUP INC | 174,072174,072 | $16M | 0.13% | TRIM -8% |
| 95 | 95Polar Capital Holdings Plc | 173,326173,326 | $16M | 0.13% | ADD 10% |
| 96 | 96Rathbones Group PLC | 166,507166,507 | $15M | 0.13% | TRIM -19% |
| 97 | 97CASTLEARK MANAGEMENT LLC | 160,283160,283 | $15M | 0.12% | TRIM -3% |
| 98 | 98WCM INVESTMENT MANAGEMENT, LLC | 169,731169,731 | $15M | 0.13% | ADD 57% |
| 99 | 99RHUMBLINE ADVISERS | 157,909157,909 | $15M | 0.12% | — |
| 100 | 100AXIOM INVESTORS LLC /DE | 154,026154,026 | $14M | 0.12% | TRIM -24% |
