Institutional 13F holdings sum to 103.9% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 5,273,791 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 7,959,5388.0M | $312M | 13.07% | — |
| 2 | FMR LLC | 6,829,2466.8M | $268M | 11.21% | TRIM -4% |
| 3 | Polar Capital Holdings Plc | 5,065,9335.1M | $199M | 8.32% | ADD 44% |
| 4 | BlackRock, Inc. | 3,684,7073.7M | $144M | 6.05% | — |
| 5 | Commodore Capital LP | 3,275,0003.3M | $128M | 5.38% | TRIM -30% |
| 6 | Vestal Point Capital, LP | 3,250,0003.3M | $127M | 5.34% | TRIM -15% |
| 7 | Bellevue Group AG | 2,320,8672.3M | $91M | 3.81% | NEW† |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 2,168,1622.2M | $85M | 3.56% | NEW† |
| 9 | Fairmount Funds Management LLC | 1,855,6441.9M | $73M | 3.05% | TRIM -50% |
| 10 | CITADEL ADVISORS LLC | 1,743,9151.7M | $68M | 2.86% | ADD 22% |
| 11 | Venrock Adviser, LLC | 1,726,3311.7M | $68M | 2.83% | TRIM -46% |
| 12 | NOVO HOLDINGS A/S | 1,280,0001.3M | $50M | 2.10% | TRIM -14% |
| 13 | STATE STREET CORP | 1,091,1061.1M | $43M | 1.79% | ADD 4% |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 1,066,4201.1M | $42M | 1.75% | — |
| 15 | Pictet Asset Management Holding SA | 929,544929,544 | $36M | 1.53% | TRIM -29% |
| 16 | BAKER BROS. ADVISORS LP | 905,191905,191 | $35M | 1.49% | ADD 234% |
| 17 | Rock Springs Capital Management LP | 826,500826,500 | $32M | 1.36% | ADD 4% |
| 18 | Avidity Partners Management LP | 800,000800,000 | $32M | 1.31% | ADD 470% |
| 19 | Siren, L.L.C. | 746,226746,226 | $29M | 1.23% | NEW |
| 20 | STEMPOINT CAPITAL LP | 726,876726,876 | $28M | 1.19% | NEW |
| 21 | DIMENSIONAL FUND ADVISORS LP | 681,715681,715 | $27M | 1.12% | ADD 71% |
| 22 | First Turn Management, LLC | 623,839623,839 | $24M | 1.02% | NEW |
| 23 | Candriam S.C.A. | 594,079594,079 | $23M | 0.98% | ADD 31% |
| 24 | Jones Hill Capital LP | 593,040593,040 | $23M | 0.97% | NEW |
| 25 | Affinity Asset Advisors, LLC | 586,904586,904 | $23M | 0.96% | NEW |
| 26 | Logos Global Management LP | 540,000540,000 | $21M | 0.89% | ADD 59% |
| 27 | MORGAN STANLEY | 518,572518,572 | $20M | 0.85% | ADD 26% |
| 28 | GOLDMAN SACHS GROUP INC | 473,115473,115 | $19M | 0.78% | ADD 99% |
| 29 | NORTHERN TRUST CORP | 372,316372,316 | $15M | 0.61% | ADD 6% |
| 30 | Caption Management, LLC | 370,000370,000 | $15M | 0.61% | NEW |
| 31 | Capricorn Fund Managers Ltd | 369,400369,400 | $14M | 0.61% | NEW |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 360,577360,577 | $14M | 0.59% | — |
| 33 | MILLENNIUM MANAGEMENT LLC | 345,318345,318 | $14M | 0.57% | ADD 16% |
| 34 | VANGUARD PORTFOLIO MANAGEMENT LLC | 330,964330,964 | $13M | 0.54% | NEW |
| 35 | ADAR1 Capital Management, LLC | 329,540329,540 | $13M | 0.54% | ADD 998% |
| 36 | Spruce Street Capital LP | 329,006329,006 | $13M | 0.54% | TRIM -26% |
| 37 | VANGUARD FIDUCIARY TRUST CO | 312,763312,763 | $12M | 0.51% | NEW |
| 38 | Balyasny Asset Management L.P. | 310,025310,025 | $12M | 0.51% | NEW |
| 39 | JENNISON ASSOCIATES LLC | 309,180309,180 | $12M | 0.51% | NEW |
| 40 | ALLIANCEBERNSTEIN L.P. | 771,885771,885 | $12M | 1.27% | ADD 1995% |
| 41 | Woodline Partners LP | 301,673301,673 | $12M | 0.50% | — |
| 42 | UBS Group AG | 283,544283,544 | $11M | 0.47% | ADD 390% |
| 43 | Seven Fleet Capital Management LP | 259,283259,283 | $10M | 0.43% | ADD 159% |
| 44 | Soleus Capital Management, L.P. | 230,869230,869 | $9M | 0.38% | TRIM -77% |
| 45 | Exome Asset Management LLC | 220,091220,091 | $9M | 0.36% | — |
| 46 | Schonfeld Strategic Advisors LLC | 218,867218,867 | $9M | 0.36% | NEW |
| 47 | First Light Asset Management, LLC | 201,867201,867 | $8M | 0.33% | NEW |
| 48 | Patient Square Capital LP | 200,000200,000 | $8M | 0.33% | TRIM -35% |
| 49 | D. E. Shaw & Co., Inc. | 193,531193,531 | $8M | 0.32% | NEW |
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 191,293191,293 | $7M | 0.31% | — |
| 51 | Nicholas Investment Partners, LP | 182,728182,728 | $7M | 0.30% | NEW |
| 52 | JANE STREET GROUP, LLC | 163,519163,519 | $6M | 0.27% | ADD 60% |
| 53 | AMERIPRISE FINANCIAL INC | 160,577160,577 | $6M | 0.26% | ADD 747% |
| 54 | SPHERA FUNDS MANAGEMENT LTD. | 153,265153,265 | $6M | 0.25% | TRIM -32% |
| 55 | WELLINGTON MANAGEMENT GROUP LLP | 150,126150,126 | $6M | 0.25% | ADD 16% |
| 56 | Bank of New York Mellon Corp | 120,057120,057 | $5M | 0.20% | ADD 9% |
| 57 | Cinctive Capital Management LP | 113,342113,342 | $4M | 0.19% | NEW |
| 58 | Longaeva Partners L.P. | 113,065113,065 | $4M | 0.19% | NEW |
| 59 | Nuveen, LLC | 105,883105,883 | $4M | 0.17% | — |
| 60 | PRICE T ROWE ASSOCIATES INC /MD/ | 97,74797,747 | $4M | 0.16% | ADD 311% |
| 61 | DV Trading LLC | 95,25395,253 | $4M | 0.16% | NEW |
| 62 | Informed Momentum Co LLC | 82,79482,794 | $3M | 0.14% | NEW |
| 63 | Trexquant Investment LP | 78,24878,248 | $3M | 0.13% | NEW |
| 64 | Lighthouse Investment Partners, LLC | 75,00075,000 | $3M | 0.12% | ADD 15% |
| 65 | HighVista Strategies LLC | 73,10273,102 | $3M | 0.12% | TRIM -11% |
| 66 | SummitTX Capital, L.P. | 68,70668,706 | $3M | 0.11% | NEW |
| 67 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67,47567,475 | $3M | 0.11% | ADD 22% |
| 68 | PRUDENTIAL FINANCIAL INC | 66,94066,940 | $3M | 0.11% | ADD 88% |
| 69 | Swiss National Bank | 64,27364,273 | $3M | 0.11% | — |
| 70 | AMERICAN CENTURY COMPANIES INC | 62,11662,116 | $2M | 0.10% | ADD 36% |
| 71 | Invesco Ltd. | 61,75261,752 | $2M | 0.10% | ADD 150% |
| 72 | NEUBERGER BERMAN GROUP LLC | 61,63261,632 | $2M | 0.10% | NEW |
| 73 | PRELUDE CAPITAL MANAGEMENT, LLC | 52,57852,578 | $2M | 0.09% | — |
| 74 | RHUMBLINE ADVISERS | 50,18850,188 | $2M | 0.08% | — |
| 75 | Susquehanna Portfolio Strategies, LLC | 49,06149,061 | $2M | 0.08% | — |
| 76 | Tidal Investments LLC | 47,51547,515 | $2M | 0.08% | NEW |
| 77 | BANK OF AMERICA CORP /DE/ | 45,16245,162 | $2M | 0.07% | ADD 38% |
| 78 | TimesSquare Capital Management, LLC | 45,00045,000 | $2M | 0.07% | NEW |
| 79 | Tema ETFs LLC | 43,05643,056 | $2M | 0.07% | NEW |
| 80 | NEW YORK STATE COMMON RETIREMENT FUND | 38,64838,648 | $2M | 0.06% | ADD 325% |
| 81 | XTX Topco Ltd | 38,32338,323 | $2M | 0.06% | TRIM -37% |
| 82 | Walleye Capital LLC | 37,82737,827 | $1M | 0.06% | NEW |
| 83 | DEUTSCHE BANK AG\ | 35,31935,319 | $1M | 0.06% | ADD 12% |
| 84 | Legal & General Group Plc | 33,08333,083 | $1M | 0.05% | ADD 22% |
| 85 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,91431,914 | $1M | 0.05% | — |
| 86 | Legato Capital Management LLC | 31,17431,174 | $1M | 0.05% | NEW |
| 87 | ExodusPoint Capital Management, LP | 30,10130,101 | $1M | 0.05% | TRIM -50% |
| 88 | J. Goldman & Co LP | 28,66228,662 | $1M | 0.05% | NEW |
| 89 | STATE OF WISCONSIN INVESTMENT BOARD | 28,41528,415 | $1M | 0.05% | ADD 39% |
| 90 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,17225,172 | $986,742 | 0.04% | NEW |
| 91 | Virtu Financial LLC | 24,43424,434 | $958,000 | 0.04% | NEW |
| 92 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,44123,441 | $918,887 | 0.04% | ADD 21% |
| 93 | VANGUARD ASSET MANAGEMENT, Ltd | 23,05023,050 | $903,560 | 0.04% | NEW |
| 94 | Brevan Howard Capital Management LP | 22,23222,232 | $871,494 | 0.04% | NEW |
| 95 | MetLife Investment Management, LLC | 22,09422,094 | $866,085 | 0.04% | TRIM -10% |
| 96 | Artia Global Partners LP | 20,90020,900 | $819,280 | 0.03% | NEW |
| 97 | FRANKLIN RESOURCES INC | 20,18220,182 | $791,134 | 0.03% | — |
| 98 | JPMORGAN CHASE & CO | 20,82020,820 | $761,805 | 0.03% | — |
| 99 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,44918,449 | $723,201 | 0.03% | — |
| 100 | Vanguard Global Advisers, LLC | 17,75117,751 | $695,839 | 0.03% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 8.0M | 8.0M | 8.0M | 8.0M | 8.0M | 8.0M | $312M |
| FMR LLC | 6.5M | 6.6M | 7.6M | 7.1M | 7.1M | 6.8M | $268M |
| Polar Capital Holdings Plc | 2.4M | 2.4M | 3.1M | 3.1M | 3.5M | 5.1M | $199M |
| BlackRock, Inc. | 3.0M | 3.0M | 3.0M | 3.5M | 3.6M | 3.7M | $144M |
| Commodore Capital LP | 4.2M | 4.7M | 4.7M | 4.7M | 4.7M | 3.3M | $128M |
| Vestal Point Capital, LP | — | — | 250K | 1.2M | 3.8M | 3.3M | $127M |
| Bellevue Group AG | — | — | — | — | — | 2.3M | $91M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.2M | $85M |
| Fairmount Funds Management LLC | 3.2M | 3.2M | 3.7M | 3.7M | 3.7M | 1.9M | $73M |
| CITADEL ADVISORS LLC | 1.7M | 1.1M | 1.5M | 1.2M | 1.4M | 1.7M | $68M |
| Venrock Adviser, LLC | 4.0M | 4.0M | 4.0M | 3.2M | 3.2M | 1.7M | $68M |
| NOVO HOLDINGS A/S | — | — | 1.1M | 1.4M | 1.5M | 1.3M | $50M |
| STATE STREET CORP | 802K | 781K | 816K | 965K | 1.1M | 1.1M | $43M |
| GEODE CAPITAL MANAGEMENT, LLC | 763K | 819K | 883K | 1.1M | 1.0M | 1.1M | $42M |
| Pictet Asset Management Holding SA | 972K | 968K | 968K | 1.4M | 1.3M | 930K | $36M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 171 | 63,250,748 | 103.9% | $2.5B |
| 2025-Q4 | 126 | 62,395,499 | 102.4% | $961M |
| 2025-Q3 | 134 | 59,424,944 | 97.6% | $1.2B |
| 2025-Q2 | 125 | 59,502,790 | 97.7% | $1.2B |
| 2025-Q1 | 122 | 50,002,740 | 82.1% | $984M |
| 2024-Q4 | 114 | 49,624,934 | 81.5% | $1.1B |
| 2024-Q3 | 102 | 47,709,173 | 78.3% | $1.2B |
| 2024-Q2 | 93 | 48,934,702 | 80.3% | $1.1B |
| 2024-Q1 | 74 | 44,600,922 | 73.2% | $783M |
| 2023-Q4 | 62 | 39,104,145 | 64.2% | $541M |
| 2023-Q3 | 62 | 39,082,003 | 64.2% | $534M |
| 2023-Q2 | 63 | 39,131,894 | 64.3% | $798M |
| 2023-Q1 | 45 |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
| 36,760,793 |
| 60.4% |
| $804M |
| Commodore Capital LP | 7.7% | Passive | 2026-03-31 | SEC → |
| Vestal Point Capital, LP | 5.4% | QII | 2026-03-31 | SEC → |
| BlackRock, Inc. | 5.1% | QII | 2025-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
