| 1 | 1SR One Capital Management, LP | 6,526,4766.5M | $69M | 10.58% | — |
| 2 | 2RA CAPITAL MANAGEMENT, L.P. | 2,972,9733.0M | $32M | 4.82% | ADD 103% |
| 3 | 3Point72 Asset Management, L.P. | 2,722,7542.7M | $29M | 4.41% | TRIM -49% |
| 4 | 4BAKER BROS. ADVISORS LP | 2,585,9782.6M | $28M | 4.19% | ADD 16% |
| 5 | 5BlackRock, Inc. | 2,133,7642.1M | $23M | 3.46% | — |
| 6 | 6Logos Global Management LP | 1,950,0001.9M | $21M | 3.16% | TRIM -22% |
| 7 | 7Driehaus Capital Management LLC | 1,744,9871.7M | $19M | 2.83% | ADD 48% |
| 8 | 8Vivo Capital, LLC | 1,612,9031.6M | $17M | 2.62% | — |
| 9 | 9Almitas Capital LLC | 1,530,3351.5M | $16M | 2.48% | — |
| 10 | 10VANGUARD CAPITAL MANAGEMENT LLC | 1,349,8501.3M | $14M | 2.19% | NEW† |
| 11 | 11Woodline Partners LP | 961,501961,501 | $10M | 1.56% | — |
| 12 | 12Trails Edge Capital Partners, LP | 852,013852,013 | $9M | 1.38% | NEW |
| 13 | 13FMR LLC | 798,411798,411 | $8M | 1.29% | ADD 4% |
| 14 | 14Kynam Capital Management, LP | 784,606784,606 | $8M | 1.27% | — |
| 15 | 15GEODE CAPITAL MANAGEMENT, LLC | 692,518692,518 | $7M | 1.12% | — |
| 16 | 16STATE STREET CORP | 659,575659,575 | $7M | 1.07% | — |
| 17 | 17MORGAN STANLEY | 656,565656,565 | $7M | 1.06% | TRIM -7% |
| 18 | 18ACADIAN ASSET MANAGEMENT LLC | 616,481616,481 | $7M | 1.00% | — |
| 19 | 19GOLDMAN SACHS GROUP INC | 504,718504,718 | $5M | 0.82% | ADD 86% |
| 20 | 20D. E. Shaw & Co., Inc. | 470,270470,270 | $5M | 0.76% | ADD 7% |
| 21 | 21DIMENSIONAL FUND ADVISORS LP | 431,840431,840 | $5M | 0.70% | ADD 45% |
| 22 | 22RENAISSANCE TECHNOLOGIES LLC | 408,200408,200 | $4M | 0.66% | ADD 42% |
| 23 | 23NORTHERN TRUST CORP | 300,279300,279 | $3M | 0.49% | ADD 5% |
| 24 | 24JACOBS LEVY EQUITY MANAGEMENT, INC | 289,385289,385 | $3M | 0.47% | ADD 49% |
| 25 | 25KENNEDY CAPITAL MANAGEMENT LLC | 271,554271,554 | $3M | 0.44% | ADD 443% |
| 26 | 26CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 241,485241,485 | $3M | 0.39% | — |
| 27 | 27CITADEL ADVISORS LLC | 231,513231,513 | $2M | 0.38% | TRIM -50% |
| 28 | 28Elmind Capital, LP | 207,900207,900 | $2M | 0.34% | — |
| 29 | 29ALGERT GLOBAL LLC | 204,739204,739 | $2M | 0.33% | ADD 9% |
| 30 | 30VANGUARD FIDUCIARY TRUST CO | 195,658195,658 | $2M | 0.32% | NEW |
| 31 | 31MARSHALL WACE, LLP | 151,008151,008 | $2M | 0.24% | TRIM -33% |
| 32 | 32ACUTA CAPITAL PARTNERS, LLC | 145,900145,900 | $2M | 0.24% | TRIM -3% |
| 33 | 33Invesco Ltd. | 141,920141,920 | $2M | 0.23% | TRIM -54% |
| 34 | 34VANGUARD PORTFOLIO MANAGEMENT LLC | 138,565138,565 | $1M | 0.22% | NEW |
| 35 | 35SEI INVESTMENTS CO | 133,203133,203 | $1M | 0.22% | ADD 153% |
| 36 | 36Nuveen, LLC | 126,815126,815 | $1M | 0.21% | — |
| 37 | 37Lynx1 Capital Management LP | 119,516119,516 | $1M | 0.19% | ADD 72% |
| 38 | 38Trexquant Investment LP | 117,111117,111 | $1M | 0.19% | ADD 17% |
| 39 | 39MILLENNIUM MANAGEMENT LLC | 108,928108,928 | $1M | 0.18% | TRIM -40% |
| 40 | 40RAYMOND JAMES FINANCIAL INC | 108,449108,449 | $1M | 0.18% | — |
| 41 | 41JANE STREET GROUP, LLC | 103,902103,902 | $1M | 0.17% | TRIM -54% |
| 42 | 42Verdad Advisers, LP | 92,31092,310 | $982,178 | 0.15% | NEW |
| 43 | 43Caption Management, LLC | 86,70886,708 | $922,573 | 0.14% | NEW |
| 44 | 44Squarepoint Ops LLC | 86,11786,117 | $916,285 | 0.14% | ADD 87% |
| 45 | 45Bank of New York Mellon Corp | 79,64579,645 | $847,424 | 0.13% | TRIM -6% |
| 46 | 46Informed Momentum Co LLC | 78,94978,949 | $840,017 | 0.13% | — |
| 47 | 47Palumbo Wealth Management LLC | 71,40871,408 | $759,782 | 0.12% | ADD 3% |
| 48 | 48AMERICAN CENTURY COMPANIES INC | 65,63865,638 | $698,388 | 0.11% | ADD 14% |
| 49 | 49XTX Topco Ltd | 60,93960,939 | $648,391 | 0.10% | ADD 73% |
| 50 | 50CANADA PENSION PLAN INVESTMENT BOARD | 60,40060,400 | $642,656 | 0.10% | ADD 11% |
| 51 | 51BARCLAYS PLC | 55,79055,790 | $593,604 | 0.09% | TRIM -36% |
| 52 | 52BRIDGEWAY CAPITAL MANAGEMENT, LLC | 52,00052,000 | $553,280 | 0.08% | TRIM -34% |
| 53 | 53BNP PARIBAS FINANCIAL MARKETS | 50,27250,272 | $534,894 | 0.08% | TRIM -47% |
| 54 | 54ALPS ADVISORS INC | 50,20950,209 | $534,224 | 0.08% | ADD 7% |
| 55 | 55STATE OF WISCONSIN INVESTMENT BOARD | 49,21449,214 | $523,637 | 0.08% | TRIM -3% |
| 56 | 56PRUDENTIAL FINANCIAL INC | 45,81045,810 | $487,418 | 0.07% | ADD 7% |
| 57 | 57STRS OHIO | 44,70044,700 | $475,608 | 0.07% | ADD 77% |
| 58 | 58ALLIANCEBERNSTEIN L.P. | 46,12046,120 | $432,606 | 0.07% | — |
| 59 | 59China Universal Asset Management Co., Ltd. | 35,10935,109 | $373,560 | 0.06% | ADD 2% |
| 60 | 60AMERIPRISE FINANCIAL INC | 34,99034,990 | $372,294 | 0.06% | TRIM -78% |
| 61 | 61RHUMBLINE ADVISERS | 34,86034,860 | $370,900 | 0.06% | — |
| 62 | 62Qube Research & Technologies Ltd | 34,18334,183 | $363,707 | 0.06% | NEW |
| 63 | 63Corient Private Wealth LLC | 27,16927,169 | $289,079 | 0.04% | TRIM -50% |
| 64 | 64AQR CAPITAL MANAGEMENT LLC | 25,95725,957 | $276,184 | 0.04% | ADD 89% |
| 65 | 65Russell Investments Group, Ltd. | 25,43725,437 | $270,648 | 0.04% | — |
| 66 | 66BANK OF AMERICA CORP /DE/ | 23,26423,264 | $247,529 | 0.04% | TRIM -15% |
| 67 | 67AlphaCentric Advisors LLC | 21,23121,231 | $225,898 | 0.03% | ADD 5% |
| 68 | 68DEUTSCHE BANK AG\ | 20,64420,644 | $219,652 | 0.03% | ADD 33% |
| 69 | 69Velan Capital Investment Management LP | 20,00020,000 | $212,800 | 0.03% | — |
| 70 | 70UBS Group AG | 17,09117,091 | $181,848 | 0.03% | TRIM -33% |
| 71 | 71PRICE T ROWE ASSOCIATES INC /MD/ | 16,37016,370 | $175,000 | 0.03% | ADD 4% |
| 72 | 72TWO SIGMA INVESTMENTS, LP | 16,30016,300 | $173,432 | 0.03% | TRIM -65% |
| 73 | 73Engineers Gate Manager LP | 16,09016,090 | $171,198 | 0.03% | ADD 15% |
| 74 | 74Brevan Howard Capital Management LP | 15,29415,294 | $162,728 | 0.02% | NEW |
| 75 | 75MetLife Investment Management, LLC | 15,24915,249 | $162,249 | 0.02% | — |
| 76 | 76PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,19315,193 | $161,654 | 0.02% | ADD 114% |
| 77 | 77NISA INVESTMENT ADVISORS, LLC | 14,82414,824 | $157,727 | 0.02% | ADD 25% |
| 78 | 78Dynamic Technology Lab Private Ltd | 14,74914,749 | $156,929 | 0.02% | NEW |
| 79 | 79Quantinno Capital Management LP | 14,12814,128 | $150,322 | 0.02% | NEW |
| 80 | 80JPMORGAN CHASE & CO | 14,13414,134 | $146,570 | 0.02% | TRIM -2% |
| 81 | 81Mariner, LLC | 13,06613,066 | $138,851 | 0.02% | — |
| 82 | 82Baader Bank Aktiengesellschaft | 12,79212,792 | $136,107 | 0.02% | TRIM -36% |
| 83 | 83Vanguard Global Advisers, LLC | 11,83911,839 | $125,967 | 0.02% | NEW |
| 84 | 84MIRABELLA FINANCIAL SERVICES LLP | 11,81411,814 | $125,701 | 0.02% | NEW |
| 85 | 85ROYAL BANK OF CANADA | 11,36611,366 | $121,000 | 0.02% | ADD 1682% |
| 86 | 86MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,36311,363 | $120,902 | 0.02% | ADD 2% |
| 87 | 87ADAR1 Capital Management, LLC | 10,00010,000 | $106,400 | 0.02% | NEW |
| 88 | 88WELLS FARGO & COMPANY/MN | 9,0279,027 | $96,047 | 0.01% | TRIM -66% |
| 89 | 89Police & Firemen's Retirement System of New Jersey | 6,5986,598 | $70,203 | 0.01% | — |
| 90 | 90CITIGROUP INC | 4,2634,263 | $45,359 | 0.01% | ADD 37% |
| 91 | 91Rockefeller Capital Management L.P. | 3,6843,684 | $39,197 | 0.01% | ADD 399% |
| 92 | 92CAZ INVESTMENTS LP | 3,5003,500 | $37,240 | 0.01% | — |
| 93 | 93Mirae Asset Global Investments Co., Ltd. | 2,9712,971 | $31,611 | 0.00% | ADD 7% |
| 94 | 94Ameritas Investment Partners, Inc. | 2,5702,570 | $27,345 | 0.00% | — |
| 95 | 95Legal & General Group Plc | 2,0772,077 | $22,099 | 0.00% | — |
| 96 | 96NEW YORK STATE COMMON RETIREMENT FUND | 2,0262,026 | $21,557 | 0.00% | — |
| 97 | 97PNC FINANCIAL SERVICES GROUP, INC. | 1,8161,816 | $19,322 | 0.00% | — |
| 98 | 98Zurcher Kantonalbank (Zurich Cantonalbank) | 1,5941,594 | $16,960 | 0.00% | ADD 30% |
| 99 | 99Tower Research Capital LLC (TRC) | 1,5451,545 | $16,439 | 0.00% | TRIM -64% |
| 100 | 100GAMMA Investing LLC | 1,4721,472 | $15,662 | 0.00% | ADD 96% |
