$17.39
-0.05 (-0.29%)
USD · as of 2026-08-18 · marketstack
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 11,300,93911.3M | $77M | 23.66% | — |
| 2 | MPM BIOIMPACT LLC | 2,593,4392.6M | $18M | 5.43% | TRIM -3% |
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,916,9681.9M | $13M | 4.01% | — |
| 4 | BRAIDWELL LP | 1,529,6751.5M | $10M | 3.20% | NEW† |
| 5 | GREAT POINT PARTNERS LLC | 1,334,1301.3M | $9M | 2.79% | ADD 36% |
| 6 | MILLENNIUM MANAGEMENT LLC | 1,276,2601.3M | $9M | 2.67% | ADD 331% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 1,178,6591.2M | $8M | 2.47% | NEW† |
| 8 | Kynam Capital Management, LP | 1,003,3411.0M | $7M | 2.10% | TRIM -2% |
| 9 | MARSHALL WACE, LLP | 773,123773,123 | $5M | 1.62% | ADD 154% |
| 10 | Affinity Asset Advisors, LLC | 700,000700,000 | $5M | 1.47% | TRIM -46% |
| 11 | SILVERARC CAPITAL MANAGEMENT, LLC | 684,908684,908 | $5M | 1.43% | NEW |
| 12 | Driehaus Capital Management LLC | 600,946600,946 | $4M | 1.26% | — |
| 13 | ADAR1 Capital Management, LLC | 597,662597,662 | $4M | 1.25% | TRIM -58% |
| 14 | NAN FUNG TRINITY (HK) LTD | 420,517420,517 | $3M | 0.88% | TRIM -9% |
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 419,247419,247 | $3M | 0.88% | TRIM -55% |
| 16 | BlackRock, Inc. | 401,649401,649 | $3M | 0.84% | ADD 3% |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 387,403387,403 | $3M | 0.81% | TRIM -13% |
| 18 | CITADEL ADVISORS LLC | 345,663345,663 | $2M | 0.72% | ADD 45% |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 312,999312,999 | $2M | 0.66% | — |
| 20 | TWO SIGMA INVESTMENTS, LP | 310,606310,606 | $2M | 0.65% | TRIM -45% |
| 21 | DIADEMA PARTNERS LP | 286,126286,126 | $2M | 0.60% | NEW |
| 22 | TD Asset Management Inc | 250,102250,102 | $2M | 0.52% | — |
| 23 | MORGAN STANLEY | 234,182234,182 | $2M | 0.49% | ADD 58% |
| 24 | Longaeva Partners L.P. | 217,768217,768 | $1M | 0.46% | NEW |
| 25 | RENAISSANCE TECHNOLOGIES LLC | 217,300217,300 | $1M | 0.45% | TRIM -32% |
| 26 | SUPERSTRING CAPITAL MANAGEMENT LP | 199,209199,209 | $1M | 0.42% | NEW |
| 27 | JANE STREET GROUP, LLC | 171,375171,375 | $1M | 0.36% | TRIM -9% |
| 28 | VANGUARD FIDUCIARY TRUST CO | 158,660158,660 | $1M | 0.33% | NEW |
| 29 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 156,317156,317 | $1M | 0.33% | ADD 11% |
| 30 | GOLDMAN SACHS GROUP INC | 149,970149,970 | $1M | 0.31% | TRIM -33% |
| 31 | Verdad Advisers, LP | 144,540144,540 | $990,099 | 0.30% | NEW |
| 32 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,300134,300 | $919,955 | 0.28% | TRIM -16% |
| 33 | STATE STREET CORP | 132,000132,000 | $904,200 | 0.28% | ADD 2% |
| 34 | Seven Fleet Capital Management LP | 130,654130,654 | $894,980 | 0.27% | ADD 71% |
| 35 | NORTHERN TRUST CORP | 127,904127,904 | $876,143 | 0.27% | ADD 3% |
| 36 | ArchPoint Investors | 121,400121,400 | $831,590 | 0.25% | — |
| 37 | Peapod Lane Capital LLC | 108,878108,878 | $739,799 | 0.23% | TRIM -81% |
| 38 | DIMENSIONAL FUND ADVISORS LP | 104,437104,437 | $714,543 | 0.22% | NEW |
| 39 | Qube Research & Technologies Ltd | 104,217104,217 | $713,886 | 0.22% | ADD 201% |
| 40 | BOOTHBAY FUND MANAGEMENT, LLC | 92,29792,297 | $632,234 | 0.19% | NEW |
| 41 | 683 Capital Management, LLC | 90,00090,000 | $616,500 | 0.19% | TRIM -55% |
| 42 | UBS Group AG | 85,94585,945 | $588,723 | 0.18% | ADD 21% |
| 43 | Persistent Asset Partners Ltd | 72,32572,325 | $495,426 | 0.15% | ADD 684% |
| 44 | LPL Financial LLC | 60,37960,379 | $413,596 | 0.13% | TRIM -3% |
| 45 | Point72 Asset Management, L.P. | 59,09059,090 | $404,767 | 0.12% | TRIM -92% |
| 46 | Brevan Howard Capital Management LP | 56,62456,624 | $387,874 | 0.12% | NEW |
| 47 | Hudson Bay Capital Management LP | 54,46054,460 | $373,051 | 0.11% | ADD 12% |
| 48 | BANK OF AMERICA CORP /DE/ | 52,92152,921 | $362,509 | 0.11% | ADD 945% |
| 49 | XTX Topco Ltd | 51,91251,912 | $355,597 | 0.11% | ADD 49% |
| 50 | BARCLAYS PLC | 48,93648,936 | $335,211 | 0.10% | TRIM -21% |
| 51 | Squarepoint Ops LLC | 42,97442,974 | $294,372 | 0.09% | NEW |
| 52 | HRT FINANCIAL LP | 37,16137,161 | $254,000 | 0.08% | NEW |
| 53 | CANTOR FITZGERALD, L. P. | 30,00030,000 | $205,500 | 0.06% | NEW |
| 54 | BNP PARIBAS FINANCIAL MARKETS | 29,12829,128 | $199,527 | 0.06% | ADD 5578% |
| 55 | Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 24,59024,590 | $168,442 | 0.05% | NEW |
| 56 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,05122,051 | $151,049 | 0.05% | NEW |
| 57 | FOX RUN MANAGEMENT, L.L.C. | 19,28719,287 | $126,137 | 0.04% | NEW |
| 58 | RAYMOND JAMES FINANCIAL INC | 17,72717,727 | $121,430 | 0.04% | NEW |
| 59 | OMERS ADMINISTRATION Corp | 16,70016,700 | $114,395 | 0.03% | TRIM -80% |
| 60 | BLAIR WILLIAM & CO/IL | 12,00012,000 | $82,200 | 0.03% | ADD 9% |
| 61 | Diametric Capital, LP | 11,21811,218 | $76,843 | 0.02% | NEW |
| 62 | Vanguard Personalized Indexing Management, LLC | 11,20411,204 | $76,747 | 0.02% | — |
| 63 | Susquehanna Portfolio Strategies, LLC | 11,05611,056 | $75,734 | 0.02% | NEW |
| 64 | Vanguard Global Advisers, LLC | 10,06110,061 | $68,918 | 0.02% | NEW |
| 65 | Balyasny Asset Management L.P. | 6,9596,959 | $47,669 | 0.01% | TRIM -51% |
| 66 | FMR LLC | 6,3976,397 | $43,819 | 0.01% | — |
| 67 | Tower Research Capital LLC (TRC) | 5,8365,836 | $39,977 | 0.01% | ADD 74% |
| 68 | CITIGROUP INC | 5,7945,794 | $39,689 | 0.01% | TRIM -44% |
| 69 | OSAIC HOLDINGS, INC. | 3,4003,400 | $23,290 | 0.01% | ADD 467% |
| 70 | Advisory Services Network, LLC | 2,0322,032 | $13,919 | 0.00% | NEW |
| 71 | NISA INVESTMENT ADVISORS, LLC | 573573 | $3,925 | 0.00% | — |
| 72 | JONES FINANCIAL COMPANIES LLLP | 266266 | $1,867 | 0.00% | NEW |
| 73 | Fortitude Family Office, LLC | 9292 | $630 | 0.00% | NEW |
| 74 | Russell Investments Group, Ltd. | 7979 | $541 | 0.00% | NEW |
| 75 | Allworth Financial LP | 4545 | $309 | 0.00% | NEW |
| 76 | JPMORGAN CHASE & CO | 4646 | $301 | 0.00% | — |
| 77 | CWM, LLC | 1818 | $123 | 0.00% | TRIM -38% |
| 78 | Arax Advisory Partners | 5151 | $110 | 0.00% | NEW |
| 79 | DEUTSCHE BANK AG\ | 11 | $7 | 0.00% | — |
| 80 | ROYAL BANK OF CANADA | 7979 | $0 | 0.00% | TRIM -81% |
† NEW this big is usually a rename.
Ranked by each filer’s own reported value, not shares.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| BRAIDWELL LP | +1,529,675 | $10M | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +1,178,659 | $8M | OPEN |
| MILLENNIUM MANAGEMENT LLC | +979,946 | $7M | ADD |
| SILVERARC CAPITAL MANAGEMENT, LLC | +684,908 | $5M | OPEN |
| MARSHALL WACE, LLP | +469,108 | $3M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,340,504 | $9M | CLOSE |
| ADAR1 Capital Management, LLC | −834,813 | $6M | TRIM |
| Point72 Asset Management, L.P. | −657,590 | $5M | TRIM |
| Affinity Asset Advisors, LLC | −600,000 | $4M | TRIM |
| SPHERA FUNDS MANAGEMENT LTD. | −513,000 | $4M | TRIM |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 31.4M | 31.4M | 31.4M | 31.4M | 11.3M | 11.3M | $77M |
| MPM BIOIMPACT LLC | — | — | — | — | 2.7M | 2.6M | $18M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 629K | 586K | 548K | 527K | 1.9M | 1.9M | $13M |
| BRAIDWELL LP | — | — | — | — | — | 1.5M | $10M |
| GREAT POINT PARTNERS LLC | — | — | — | — | 980K | 1.3M | $9M |
| MILLENNIUM MANAGEMENT LLC | — | 63K | 480K | 472K | 296K | 1.3M | $9M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $8M |
| Kynam Capital Management, LP | 547K | 1.0M | 1.0M | 1.0M | 1.0M | 1.0M | $7M |
| MARSHALL WACE, LLP | — | — | 37K | 230K | 304K | 773K | $5M |
| Affinity Asset Advisors, LLC | 500K | 1.5M | 1.5M | 1.3M | 1.3M | 700K | $5M |
| SILVERARC CAPITAL MANAGEMENT, LLC | — | — | — | — | — | 685K | $5M |
| Driehaus Capital Management LLC | — | — | — | — | 601K | 601K | $4M |
| ADAR1 Capital Management, LLC | 48K | 119K | 119K | 134K | 1.4M | 598K | $4M |
| NAN FUNG TRINITY (HK) LTD | — | — | 464K | 464K | 464K | 421K | $3M |
| SPHERA FUNDS MANAGEMENT LTD. | 252K | 242K | 210K | 435K | 932K | 419K | $3M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
“Item 4 of the Statement is hereby amended and supplemented as follows: On June 29, 2026 Dr. Breanna Celebi (O'Reilly), an Analyst of RA Capital, was appointed to the Board of Directors of the Issuer as the designee of RA Capital, replacing Dr. Andrew Levin, who resigned from the Board of Directors effective June 29, 2026.”
SEC Schedule 13D/G XML · group aggregate.